{"id":"https://openalex.org/W3165865719","doi":"https://doi.org/10.3233/shti210120","title":"APERITIF \u2013 Automatic Patient Recruiting for Clinical Trials Based on HL7 FHIR","display_name":"APERITIF \u2013 Automatic Patient Recruiting for Clinical Trials Based on HL7 FHIR","publication_year":2021,"publication_date":"2021-05-27","ids":{"openalex":"https://openalex.org/W3165865719","doi":"https://doi.org/10.3233/shti210120","mag":"3165865719","pmid":"https://pubmed.ncbi.nlm.nih.gov/34042705"},"language":"en","primary_location":{"id":"doi:10.3233/shti210120","is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti210120","pdf_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/SHTI210120","source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/SHTI210120","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048661981","display_name":"Alexandra Banach","orcid":null},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Alexandra Banach","raw_affiliation_strings":["IT Center for Clinical Research, L\u00fcbeck, University of L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IT Center for Clinical Research, L\u00fcbeck, University of L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002813701","display_name":"Hannes Ulrich","orcid":"https://orcid.org/0000-0002-8349-6798"},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hannes Ulrich","raw_affiliation_strings":["IT Center for Clinical Research, L\u00fcbeck, University of L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IT Center for Clinical Research, L\u00fcbeck, University of L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016057728","display_name":"Bj\u00f6rn Kroll","orcid":"https://orcid.org/0000-0002-8861-8993"},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bj\u00f6rn Kroll","raw_affiliation_strings":["IT Center for Clinical Research, L\u00fcbeck, University of L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IT Center for Clinical Research, L\u00fcbeck, University of L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019284700","display_name":"Alexander Kiel","orcid":"https://orcid.org/0000-0003-0461-8185"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexander Kiel","raw_affiliation_strings":["LIFE \u2013 Leipzig Research Centre for Civilization Diseases, University of Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LIFE \u2013 Leipzig Research Centre for Civilization Diseases, University of Leipzig, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074605677","display_name":"Josef Ingenerf","orcid":"https://orcid.org/0000-0002-3274-8422"},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Josef Ingenerf","raw_affiliation_strings":["IT Center for Clinical Research, L\u00fcbeck, University of L\u00fcbeck, Germany","Institute of Medical Informatics, University of L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IT Center for Clinical Research, L\u00fcbeck, University of L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]},{"raw_affiliation_string":"Institute of Medical Informatics, University of L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047911926","display_name":"Ann-Kristin Kock-Schoppenhauer","orcid":"https://orcid.org/0000-0001-6685-4429"},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ann-Kristin Kock-Schoppenhauer","raw_affiliation_strings":["IT Center for Clinical Research, L\u00fcbeck, University of L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IT Center for Clinical Research, L\u00fcbeck, University of L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5048661981"],"corresponding_institution_ids":["https://openalex.org/I9341345"],"apc_list":null,"apc_paid":null,"fwci":5.7498,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.96805029,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"281","issue":null,"first_page":"58","last_page":"62"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.9843000173568726,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.9614999890327454,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inclusion-and-exclusion-criteria","display_name":"Inclusion and exclusion criteria","score":0.716124415397644},{"id":"https://openalex.org/keywords/clinical-trial","display_name":"Clinical trial","score":0.6555891036987305},{"id":"https://openalex.org/keywords/informatics","display_name":"Informatics","score":0.6192900538444519},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5625531673431396},{"id":"https://openalex.org/keywords/health-informatics","display_name":"Health informatics","score":0.5051127076148987},{"id":"https://openalex.org/keywords/inclusion","display_name":"Inclusion (mineral)","score":0.48921942710876465},{"id":"https://openalex.org/keywords/psychological-intervention","display_name":"Psychological intervention","score":0.467195987701416},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.45318835973739624},{"id":"https://openalex.org/keywords/medical-physics","display_name":"Medical physics","score":0.45159268379211426},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.331345796585083},{"id":"https://openalex.org/keywords/alternative-medicine","display_name":"Alternative medicine","score":0.1480332314968109},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.08640289306640625},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.0796571671962738},{"id":"https://openalex.org/keywords/nursing","display_name":"Nursing","score":0.07867273688316345}],"concepts":[{"id":"https://openalex.org/C2777596629","wikidata":"https://www.wikidata.org/wiki/Q10858520","display_name":"Inclusion and exclusion criteria","level":3,"score":0.716124415397644},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.6555891036987305},{"id":"https://openalex.org/C191630685","wikidata":"https://www.wikidata.org/wiki/Q4027615","display_name":"Informatics","level":2,"score":0.6192900538444519},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5625531673431396},{"id":"https://openalex.org/C145642194","wikidata":"https://www.wikidata.org/wiki/Q870895","display_name":"Health informatics","level":3,"score":0.5051127076148987},{"id":"https://openalex.org/C109359841","wikidata":"https://www.wikidata.org/wiki/Q728944","display_name":"Inclusion (mineral)","level":2,"score":0.48921942710876465},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.467195987701416},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.45318835973739624},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.45159268379211426},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.331345796585083},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.1480332314968109},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.08640289306640625},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0796571671962738},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.07867273688316345},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C138816342","wikidata":"https://www.wikidata.org/wiki/Q189603","display_name":"Public health","level":2,"score":0.0},{"id":"https://openalex.org/C107993555","wikidata":"https://www.wikidata.org/wiki/Q1662673","display_name":"Gender studies","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005858","descriptor_name":"Germany","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005858","descriptor_name":"Germany","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005858","descriptor_name":"Germany","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008490","descriptor_name":"Medical Informatics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008490","descriptor_name":"Medical Informatics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008490","descriptor_name":"Medical Informatics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057286","descriptor_name":"Electronic Health Records","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057286","descriptor_name":"Electronic Health Records","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057286","descriptor_name":"Electronic Health Records","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.3233/shti210120","is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti210120","pdf_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/SHTI210120","source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},{"id":"pmid:34042705","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34042705","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in health technology and informatics","raw_type":null}],"best_oa_location":{"id":"doi:10.3233/shti210120","is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti210120","pdf_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/SHTI210120","source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3590280981","display_name":null,"funder_award_id":"01ZZ1802Z","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"}],"funders":[{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3165865719.pdf","grobid_xml":"https://content.openalex.org/works/W3165865719.grobid-xml"},"referenced_works_count":7,"referenced_works":["https://openalex.org/W2100281619","https://openalex.org/W2582146834","https://openalex.org/W2890827016","https://openalex.org/W2893348798","https://openalex.org/W2911489562","https://openalex.org/W4301655662","https://openalex.org/W6664903230"],"related_works":["https://openalex.org/W2397677514","https://openalex.org/W2914293784","https://openalex.org/W1495820741","https://openalex.org/W4323056170","https://openalex.org/W2401910071","https://openalex.org/W2126732312","https://openalex.org/W4302329558","https://openalex.org/W1971571384","https://openalex.org/W2229314870","https://openalex.org/W2993510912"],"abstract_inverted_index":{"Clinical":[0],"trials":[1],"are":[2],"carried":[3],"out":[4],"to":[5,22,49,64,72,82,90],"prove":[6],"the":[7,51,58,66,93,111,129,142,150],"safety":[8],"and":[9,14,18,29,69,80,147,164],"effectiveness":[10],"of":[11,54,113,131,158,167],"new":[12],"interventions":[13],"therapies.":[15],"As":[16],"diseases":[17],"their":[19],"causes":[20],"continue":[21],"become":[23],"more":[24],"specific,":[25],"so":[26],"do":[27],"inclusion":[28,162],"exclusion":[30,171],"criteria":[31,163],"for":[32,105,110,161,170],"trials.":[33,116],"Patient":[34],"recruitment":[35],"has":[36],"always":[37],"been":[38],"a":[39,98,120,156,165],"challenge,":[40],"but":[41],"with":[42],"medical":[43],"progress,":[44],"it":[45,101],"becomes":[46],"increasingly":[47],"difficult":[48],"achieve":[50],"necessary":[52],"number":[53,108,130],"cases.":[55],"In":[56],"Germany,":[57],"Medical":[59],"Informatics":[60],"Initiative":[61],"is":[62],"planning":[63,112],"use":[65],"central":[67],"application":[68],"registration":[70],"office":[71],"conduct":[73],"feasibility":[74],"analyses":[75],"at":[76],"an":[77],"early":[78],"stage":[79],"thus":[81],"identify":[83,128],"suitable":[84],"project":[85],"partners.":[86],"This":[87],"approach":[88],"aims":[89],"technically":[91],"adapt/integrate":[92],"envisioned":[94],"infrastructure":[95],"in":[96],"such":[97],"way":[99],"that":[100,126],"can":[102,127],"be":[103],"used":[104],"trial":[106],"case":[107],"estimation":[109],"multicenter":[114],"clinical":[115],"We":[117],"have":[118],"developed":[119],"fully":[121],"automated":[122],"solution":[123],"called":[124],"APERITIF":[125],"eligible":[132],"patients":[133],"based":[134,148],"on":[135,149],"free-text":[136],"eligibility":[137],"criteria,":[138],"taking":[139],"into":[140],"account":[141],"MII":[143],"core":[144],"data":[145],"set":[146],"FHIR":[151],"standard.":[152],"The":[153],"evaluation":[154],"showed":[155],"precision":[157,166],"62.64":[159],"%":[160,169],"66.45":[168],"criteria.":[172]},"counts_by_year":[{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}
