{"id":"https://openalex.org/W2981806891","doi":"https://doi.org/10.3233/shti190824","title":"Utilizing Molecular Network Information via Graph Convolutional Neural Networks to Predict Metastatic Event in Breast Cancer","display_name":"Utilizing Molecular Network Information via Graph Convolutional Neural Networks to Predict Metastatic Event in Breast Cancer","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2981806891","doi":"https://doi.org/10.3233/shti190824","mag":"2981806891","pmid":"https://pubmed.ncbi.nlm.nih.gov/31483271"},"language":"en","primary_location":{"id":"doi:10.3233/shti190824","is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti190824","pdf_url":null,"source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.3233/shti190824","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035739356","display_name":"Hryhorii Chereda","orcid":"https://orcid.org/0000-0003-1103-0136"},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Chereda Hryhorii","raw_affiliation_strings":["Medical Bioinformatics, University Medical Center G\u00f6ttingen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Bioinformatics, University Medical Center G\u00f6ttingen","institution_ids":["https://openalex.org/I4210116730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031452348","display_name":"Annalen Bleckmann","orcid":"https://orcid.org/0000-0001-5809-9507"},"institutions":[{"id":"https://openalex.org/I4210103666","display_name":"University Hospital M\u00fcnster","ror":"https://ror.org/01856cw59","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210103666"]},{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bleckmann Annalen","raw_affiliation_strings":["Hematology & Medical Oncology, University Medical Center G\u00f6ttingen","Internal Medicine-A (Hematology, Oncology, Hemostaseology and Pulmonology), University Hospital Muenster","Medical Bioinformatics, University Medical Center G\u00f6ttingen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology & Medical Oncology, University Medical Center G\u00f6ttingen","institution_ids":["https://openalex.org/I4210116730"]},{"raw_affiliation_string":"Internal Medicine-A (Hematology, Oncology, Hemostaseology and Pulmonology), University Hospital Muenster","institution_ids":["https://openalex.org/I4210103666"]},{"raw_affiliation_string":"Medical Bioinformatics, University Medical Center G\u00f6ttingen","institution_ids":["https://openalex.org/I4210116730"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kramer Frank","orcid":null},"institutions":[{"id":"https://openalex.org/I179225836","display_name":"University of Augsburg","ror":"https://ror.org/03p14d497","country_code":"DE","type":"education","lineage":["https://openalex.org/I179225836"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kramer Frank","raw_affiliation_strings":["IT Infrastructure for Translational Medical Research, University of Augsburg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IT Infrastructure for Translational Medical Research, University of Augsburg","institution_ids":["https://openalex.org/I179225836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023940205","display_name":"Andreas Leha","orcid":"https://orcid.org/0000-0002-8072-1988"},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Leha Andreas","raw_affiliation_strings":["Medical Bioinformatics, University Medical Center G\u00f6ttingen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Bioinformatics, University Medical Center G\u00f6ttingen","institution_ids":["https://openalex.org/I4210116730"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017944645","display_name":"Tim Bei\u00dfbarth","orcid":"https://orcid.org/0000-0001-6509-2143"},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Beissbarth Tim","raw_affiliation_strings":["Medical Bioinformatics, University Medical Center G\u00f6ttingen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Bioinformatics, University Medical Center G\u00f6ttingen","institution_ids":["https://openalex.org/I4210116730"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":17.8784,"has_fulltext":true,"cited_by_count":36,"citation_normalized_percentile":{"value":0.99180048,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"267","issue":null,"first_page":"181","last_page":"186"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9950000047683716,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/convolutional-neural-network","display_name":"Convolutional neural network","score":0.7038567066192627},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6682312488555908},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.5280250906944275},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"Breast cancer","score":0.5080239772796631},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4838598966598511},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.46767839789390564},{"id":"https://openalex.org/keywords/snapshot","display_name":"Snapshot (computer storage)","score":0.42356956005096436},{"id":"https://openalex.org/keywords/data-set","display_name":"Data set","score":0.4228667616844177},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.41553357243537903},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.39976704120635986},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.24919983744621277},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.23677241802215576},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.16161182522773743}],"concepts":[{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.7038567066192627},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6682312488555908},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.5280250906944275},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5080239772796631},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4838598966598511},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.46767839789390564},{"id":"https://openalex.org/C55282118","wikidata":"https://www.wikidata.org/wiki/Q252683","display_name":"Snapshot (computer storage)","level":2,"score":0.42356956005096436},{"id":"https://openalex.org/C58489278","wikidata":"https://www.wikidata.org/wiki/Q1172284","display_name":"Data set","level":2,"score":0.4228667616844177},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.41553357243537903},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.39976704120635986},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.24919983744621277},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.23677241802215576},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16161182522773743},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3233/shti190824","is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti190824","pdf_url":null,"source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},{"id":"pmid:31483271","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31483271","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in health technology and informatics","raw_type":null},{"id":"pmh:oai:uni-augsburg.opus-bayern.de:117365","is_oa":true,"landing_page_url":"https://nbn-resolving.org/urn:nbn:de:bvb:384-opus4-1173653","pdf_url":"https://opus.bibliothek.uni-augsburg.de/opus4/files/117365/SHTI-267-SHTI190824.pdf","source":{"id":"https://openalex.org/S4306400930","display_name":"OPUS (Augsburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I119916105","host_organization_name":"Augsburg University","host_organization_lineage":["https://openalex.org/I119916105"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"conferenceobject"}],"best_oa_location":{"id":"doi:10.3233/shti190824","is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti190824","pdf_url":null,"source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7099999785423279}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2542847180","https://openalex.org/W3034994054","https://openalex.org/W2805712290","https://openalex.org/W2155226960","https://openalex.org/W2548022288","https://openalex.org/W4226493464","https://openalex.org/W3133861977","https://openalex.org/W2951211570","https://openalex.org/W3103566983","https://openalex.org/W3185156046"],"abstract_inverted_index":{"Gene":[0,91],"expression":[1,92,117,137],"data":[2,24,93,118,138,153],"is":[3,170],"commonly":[4,83],"available":[5],"in":[6,56],"cancer":[7,141],"research":[8],"and":[9,31,103,110],"provides":[10],"a":[11,18,47,156],"snapshot":[12],"of":[13,17,49,62,100,139,147,179],"the":[14,98,104,145,152,163,167,177],"molecular":[15,124],"status":[16],"specific":[19],"tumor":[20],"tissue.":[21],"This":[22],"high-dimensional":[23],"can":[25,94,106,119],"be":[26,95,120],"analyzed":[27],"for":[28,43,176],"diagnoses,":[29],"prognoses,":[30],"to":[32,75,97,135,143,172,183],"suggest":[33],"treatment":[34],"options.":[35],"Machine":[36],"learning":[37,51],"based":[38],"methods":[39],"are":[40,66,73,82],"widely":[41],"used":[42],"such":[44],"analysis.":[45],"Recently,":[46],"set":[48],"deep":[50],"techniques":[52,65],"was":[53],"successfully":[54],"applied":[55,132],"different":[57],"domains":[58,77],"including":[59],"bioinformatics.":[60],"One":[61],"these":[63,101],"prominent":[64],"convolutional":[67],"neural":[68],"networks":[69,81],"(CNN).":[70],"Currently,":[71],"CNNs":[72],"extending":[74],"non-Euclidean":[76],"like":[78],"graphs.":[79],"Molecular":[80],"represented":[84],"as":[85,127],"graphs":[86],"detailing":[87],"interactions":[88],"between":[89],"molecules.":[90],"assigned":[96],"vertices":[99],"graphs,":[102],"edges":[105],"depict":[107],"interactions,":[108],"regulations":[109],"signal":[111],"flow.":[112],"In":[113],"other":[114],"words,":[115],"gene":[116,136],"structured":[121],"by":[122],"utilizing":[123],"network":[125],"information":[126],"prior":[128,168],"knowledge.":[129],"Here,":[130],"we":[131,154],"graph":[133,164],"CNN":[134,165],"breast":[140],"patients":[142],"predict":[144],"occurrence":[146],"metastatic":[148,180],"events.":[149],"To":[150],"structure":[151],"utilized":[155],"protein-protein":[157],"interaction":[158],"network.":[159],"We":[160],"show":[161],"that":[162],"exploiting":[166],"knowledge":[169],"able":[171],"provide":[173],"classification":[174],"improvements":[175],"prediction":[178],"events":[181],"compared":[182],"existing":[184],"methods.":[185]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":4}],"updated_date":"2026-07-15T18:14:33.161393","created_date":"2025-10-10T00:00:00"}