{"id":"https://openalex.org/W2991561566","doi":"https://doi.org/10.3233/shti190364","title":"Finding Options Beyond Standard of Care in Oncology: A Proposal for Workflows Utilizing Knowledge Databases","display_name":"Finding Options Beyond Standard of Care in Oncology: A Proposal for Workflows Utilizing Knowledge Databases","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2991561566","doi":"https://doi.org/10.3233/shti190364","mag":"2991561566","pmid":"https://pubmed.ncbi.nlm.nih.gov/31438064"},"language":"en","primary_location":{"id":"doi:10.3233/shti190364","is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti190364","pdf_url":null,"source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.3233/shti190364","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091896497","display_name":"Katrin Glocker","orcid":null},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Glocker Katrin","raw_affiliation_strings":["Division of Medical Informatics for Translational Oncology, German Cancer Research Center (DKFZ), Heidelberg, Baden W\u00fcrttemberg, Germany"],"affiliations":[{"raw_affiliation_string":"Division of Medical Informatics for Translational Oncology, German Cancer Research Center (DKFZ), Heidelberg, Baden W\u00fcrttemberg, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038946581","display_name":"Janko Ahlbrandt","orcid":null},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ahlbrandt Janko","raw_affiliation_strings":["Division of Medical Informatics for Translational Oncology, German Cancer Research Center (DKFZ), Heidelberg, Baden W\u00fcrttemberg, Germany"],"affiliations":[{"raw_affiliation_string":"Division of Medical Informatics for Translational Oncology, German Cancer Research Center (DKFZ), Heidelberg, Baden W\u00fcrttemberg, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029417083","display_name":"Alexander Knurr","orcid":null},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Knurr Alexander","raw_affiliation_strings":["Division of Medical Informatics for Translational Oncology, German Cancer Research Center (DKFZ), Heidelberg, Baden W\u00fcrttemberg, Germany"],"affiliations":[{"raw_affiliation_string":"Division of Medical Informatics for Translational Oncology, German Cancer Research Center (DKFZ), Heidelberg, Baden W\u00fcrttemberg, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040334309","display_name":"Peter Horak","orcid":"https://orcid.org/0000-0003-4536-9306"},"institutions":[{"id":"https://openalex.org/I4210111460","display_name":"National Center for Tumor Diseases","ror":"https://ror.org/01txwsw02","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210111460"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Horak Peter","raw_affiliation_strings":["National Center for Tumor Diseases (NCT), Heidelberg, Baden W\u00fcrttemberg, Germany"],"affiliations":[{"raw_affiliation_string":"National Center for Tumor Diseases (NCT), Heidelberg, Baden W\u00fcrttemberg, Germany","institution_ids":["https://openalex.org/I4210111460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061025683","display_name":"Christoph Heining","orcid":"https://orcid.org/0000-0002-1256-8387"},"institutions":[{"id":"https://openalex.org/I4210111460","display_name":"National Center for Tumor Diseases","ror":"https://ror.org/01txwsw02","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210111460"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Heining Christoph","raw_affiliation_strings":["National Center for Tumor Diseases (NCT) Partner Site Dresden University Cancer Center UCC, Dresden, Saxony, Germany"],"affiliations":[{"raw_affiliation_string":"National Center for Tumor Diseases (NCT) Partner Site Dresden University Cancer Center UCC, Dresden, Saxony, Germany","institution_ids":["https://openalex.org/I4210111460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039000576","display_name":"Frank \u00dcckert","orcid":"https://orcid.org/0000-0001-8362-5636"},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"\u00dcckert Frank","raw_affiliation_strings":["Division of Medical Informatics for Translational Oncology, German Cancer Research Center (DKFZ), Heidelberg, Baden W\u00fcrttemberg, Germany"],"affiliations":[{"raw_affiliation_string":"Division of Medical Informatics for Translational Oncology, German Cancer Research Center (DKFZ), Heidelberg, Baden W\u00fcrttemberg, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I223822909"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5091896497"],"corresponding_institution_ids":["https://openalex.org/I17937529","https://openalex.org/I223822909"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.26532663,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"264","issue":null,"first_page":"950","last_page":"953"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.9628000259399414,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9510999917984009,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/workflow","display_name":"Workflow","score":0.7977404594421387},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.6375417709350586},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.5848188996315002},{"id":"https://openalex.org/keywords/database","display_name":"Database","score":0.5775063037872314},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5232514142990112},{"id":"https://openalex.org/keywords/precision-oncology","display_name":"Precision oncology","score":0.48517948389053345},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.4471021592617035},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.4012982249259949},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.38419824838638306},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"Precision medicine","score":0.2973432242870331},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.09989947080612183},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.09744808077812195}],"concepts":[{"id":"https://openalex.org/C177212765","wikidata":"https://www.wikidata.org/wiki/Q627335","display_name":"Workflow","level":2,"score":0.7977404594421387},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6375417709350586},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5848188996315002},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.5775063037872314},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5232514142990112},{"id":"https://openalex.org/C3020497934","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision oncology","level":3,"score":0.48517948389053345},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.4471021592617035},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.4012982249259949},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38419824838638306},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.2973432242870331},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09989947080612183},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09744808077812195},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008495","descriptor_name":"Medical Oncology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008495","descriptor_name":"Medical Oncology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008495","descriptor_name":"Medical Oncology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057188","descriptor_name":"Workflow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057188","descriptor_name":"Workflow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057188","descriptor_name":"Workflow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059039","descriptor_name":"Standard of Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059039","descriptor_name":"Standard of Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059039","descriptor_name":"Standard of Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3233/shti190364","is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti190364","pdf_url":null,"source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},{"id":"pmid:31438064","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31438064","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in health technology and informatics","raw_type":null}],"best_oa_location":{"id":"doi:10.3233/shti190364","is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti190364","pdf_url":null,"source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1981780420","https://openalex.org/W2182707996","https://openalex.org/W45233828","https://openalex.org/W2964988449","https://openalex.org/W2397952901","https://openalex.org/W2029380707","https://openalex.org/W188202134","https://openalex.org/W4255934811","https://openalex.org/W2465382974","https://openalex.org/W2010229520"],"abstract_inverted_index":{"With":[0],"the":[1,15,57,68,100,109],"novel":[2],"approach":[3],"of":[4,12,53,70,80,102],"molecularly":[5],"stratified":[6],"therapies":[7,130],"based":[8],"on":[9,21,59],"genetic":[10],"characteristics":[11],"individual":[13],"tumors,":[14],"need":[16],"for":[17,44,89],"databases":[18,55,81,104,117],"providing":[19],"information":[20,58],"molecular":[22,38,124],"alterations":[23,39,125],"and":[24,40,56,66,87,126],"targeted":[25,129],"treatment":[26],"options":[27,46],"is":[28,118],"increasing":[29],"rapidly.":[30],"In":[31,73],"Molecular":[32],"Tumor":[33],"Boards":[34],"(MTB)":[35],"professionals":[36],"discuss":[37],"provide":[41],"biological":[42],"context":[43],"therapeutic":[45],"using":[47],"external":[48],"knowledge":[49],"databases.":[50],"The":[51],"identification":[52],"informative":[54],"their":[60],"specific":[61,103],"contents":[62],"can":[63],"greatly":[64],"facilitate":[65],"standardize":[67],"functioning":[69],"a":[71,78,92,119],"MTB.":[72,132],"this":[74],"work":[75],"we":[76],"present":[77],"list":[79],"which":[82],"have":[83],"been":[84],"deemed":[85],"useful":[86],"relevant":[88],"MTB":[90],"in":[91,108,131],"clinical":[93,110],"setting.":[94],"We":[95],"describe":[96],"workflows":[97],"to":[98,122],"recommend":[99],"use":[101],"at":[105],"different":[106],"steps":[107],"curation":[111],"process.":[112],"Information":[113],"obtained":[114],"from":[115],"these":[116],"necessary":[120],"prerequisite":[121],"evaluate":[123],"devise":[127],"rational":[128]},"counts_by_year":[],"updated_date":"2026-02-25T21:11:00.739837","created_date":"2025-10-10T00:00:00"}