{"id":"https://openalex.org/W2991187871","doi":"https://doi.org/10.3233/shti190245","title":"Early Prediction of Acute Kidney Injury in Critical Care Setting Using Clinical Notes and Structured Multivariate Physiological Measurements","display_name":"Early Prediction of Acute Kidney Injury in Critical Care Setting Using Clinical Notes and Structured Multivariate Physiological Measurements","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2991187871","doi":"https://doi.org/10.3233/shti190245","mag":"2991187871","pmid":"https://pubmed.ncbi.nlm.nih.gov/31437947"},"language":"en","primary_location":{"id":"doi:10.3233/shti190245","is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti190245","pdf_url":null,"source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.3233/shti190245","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036740170","display_name":"Mengxin Sun","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sun Mengxin","raw_affiliation_strings":["Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chicago, IL, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077175492","display_name":"Jason M. Baron","orcid":"https://orcid.org/0000-0002-4182-6349"},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Baron Jason","raw_affiliation_strings":["Department of Pathology, Massachusetts General Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010332288","display_name":"Anand S. Dighe","orcid":"https://orcid.org/0000-0003-4130-0758"},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dighe Anand","raw_affiliation_strings":["Department of Pathology, Massachusetts General Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006650843","display_name":"Peter Szolovits","orcid":"https://orcid.org/0000-0001-8411-6403"},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Szolovits Peter","raw_affiliation_strings":["Computer Science and Artificial Intelligence Lab, MIT, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computer Science and Artificial Intelligence Lab, MIT, Cambridge, MA, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040669754","display_name":"Richard G. Wunderink","orcid":"https://orcid.org/0000-0002-8527-4195"},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wunderink Richard G.","raw_affiliation_strings":["Feinberg School of Medicine, Northwestern University, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Feinberg School of Medicine, Northwestern University, Chicago, IL, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003850042","display_name":"Tamara Isakova","orcid":"https://orcid.org/0000-0002-9763-2367"},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Isakova Tamara","raw_affiliation_strings":["Feinberg School of Medicine, Northwestern University, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Feinberg School of Medicine, Northwestern University, Chicago, IL, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100452550","display_name":"Yuan Luo","orcid":"https://orcid.org/0000-0003-0195-7456"},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luo Yuan","raw_affiliation_strings":["Feinberg School of Medicine, Northwestern University, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Feinberg School of Medicine, Northwestern University, Chicago, IL, USA","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":17.319,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.99207786,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"264","issue":null,"first_page":"368","last_page":"372"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9261000156402588,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9261000156402588,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"Acute kidney injury","score":0.7377333641052246},{"id":"https://openalex.org/keywords/intensive-care-unit","display_name":"Intensive care unit","score":0.6327787041664124},{"id":"https://openalex.org/keywords/construct","display_name":"Construct (python library)","score":0.5657392740249634},{"id":"https://openalex.org/keywords/multivariate-statistics","display_name":"Multivariate statistics","score":0.5528938174247742},{"id":"https://openalex.org/keywords/intensive-care-medicine","display_name":"Intensive care medicine","score":0.5504282712936401},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5203635096549988},{"id":"https://openalex.org/keywords/multivariate-analysis","display_name":"Multivariate analysis","score":0.50118088722229},{"id":"https://openalex.org/keywords/feature-engineering","display_name":"Feature engineering","score":0.46352678537368774},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4371555745601654},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.41322576999664307},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4018246531486511},{"id":"https://openalex.org/keywords/emergency-medicine","display_name":"Emergency medicine","score":0.35143017768859863},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.29795289039611816},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.22599276900291443}],"concepts":[{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.7377333641052246},{"id":"https://openalex.org/C2776376669","wikidata":"https://www.wikidata.org/wiki/Q5094647","display_name":"Intensive care unit","level":2,"score":0.6327787041664124},{"id":"https://openalex.org/C2780801425","wikidata":"https://www.wikidata.org/wiki/Q5164392","display_name":"Construct (python library)","level":2,"score":0.5657392740249634},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.5528938174247742},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5504282712936401},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5203635096549988},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.50118088722229},{"id":"https://openalex.org/C2778827112","wikidata":"https://www.wikidata.org/wiki/Q22245680","display_name":"Feature engineering","level":3,"score":0.46352678537368774},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4371555745601654},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.41322576999664307},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4018246531486511},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.35143017768859863},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.29795289039611816},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22599276900291443},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003422","descriptor_name":"Critical Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003422","descriptor_name":"Critical Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003422","descriptor_name":"Critical Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007362","descriptor_name":"Intensive Care Units","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007362","descriptor_name":"Intensive Care Units","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007362","descriptor_name":"Intensive Care Units","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016638","descriptor_name":"Critical Illness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016638","descriptor_name":"Critical Illness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016638","descriptor_name":"Critical Illness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.3233/shti190245","is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti190245","pdf_url":null,"source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},{"id":"pmid:31437947","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31437947","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in health technology and informatics","raw_type":null}],"best_oa_location":{"id":"doi:10.3233/shti190245","is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti190245","pdf_url":null,"source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},"sustainable_development_goals":[{"score":0.8100000023841858,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2406638334","https://openalex.org/W40745829","https://openalex.org/W4318262572","https://openalex.org/W1978357124","https://openalex.org/W1578824628","https://openalex.org/W2032728545","https://openalex.org/W1570805059","https://openalex.org/W4250754046","https://openalex.org/W4243682621","https://openalex.org/W2036849593"],"abstract_inverted_index":{"The":[0,94],"onset":[1,28,62,135],"of":[2,30,59,132],"acute":[3],"kidney":[4],"injury":[5],"(AKI)":[6],"during":[7],"an":[8],"intensive":[9],"care":[10],"unit":[11],"(ICU)":[12],"admission":[13,140],"is":[14,29],"associated":[15],"with":[16],"increased":[17],"morbidity":[18],"and":[19,41,51,55,77,83,101,105,117],"mortality.":[20],"Developing":[21],"novel":[22],"methods":[23],"to":[24,47,90,125,141],"identify":[25],"early":[26],"AKI":[27,37,61,134],"critical":[31],"importance":[32],"in":[33,128,136],"preventing":[34],"or":[35],"reducing":[36],"complications.":[38],"We":[39],"built":[40],"applied":[42,124],"multiple":[43],"machine":[44],"learning":[45,81,86],"models":[46],"integrate":[48],"clinical":[49,69,103,119],"notes":[50],"structured":[52,100,116],"physiological":[53],"measurements":[54],"estimate":[56],"the":[57,64,68,130,142],"risk":[58,131],"new":[60],"using":[63],"MIMIC-III":[65],"database.":[66],"From":[67],"notes,":[70],"we":[71],"generated":[72],"clinically":[73],"meaningful":[74],"word":[75],"representations":[76],"embeddings.":[78],"Four":[79],"supervised":[80],"classifiers":[82],"mixed-feature":[84],"deep":[85],"architecture":[87],"were":[88],"used":[89],"construct":[91],"prediction":[92],"models.":[93],"best":[95],"configurations":[96],"consistently":[97],"utilized":[98],"both":[99],"unstructured":[102,118],"features":[104,120],"yielded":[106],"competitive":[107],"AUCs":[108],"above":[109],"0.83.":[110],"Our":[111],"work":[112],"suggests":[113],"that":[114],"integrating":[115],"can":[121],"be":[122],"effectively":[123],"assist":[126],"clinicians":[127],"identifying":[129],"incident":[133],"critically-ill":[137],"patients":[138],"upon":[139],"ICU.":[143]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1}],"updated_date":"2026-07-15T18:14:33.161393","created_date":"2025-10-10T00:00:00"}