{"id":"https://openalex.org/W3194327178","doi":"https://doi.org/10.3233/jcm-215442","title":"In vitro detection of nanoparticle cytotoxicity based on big data technology","display_name":"In vitro detection of nanoparticle cytotoxicity based on big data technology","publication_year":2021,"publication_date":"2021-08-24","ids":{"openalex":"https://openalex.org/W3194327178","doi":"https://doi.org/10.3233/jcm-215442","mag":"3194327178"},"language":"en","primary_location":{"id":"doi:10.3233/jcm-215442","is_oa":false,"landing_page_url":"https://doi.org/10.3233/jcm-215442","pdf_url":null,"source":{"id":"https://openalex.org/S2765058733","display_name":"Journal of Computational Methods in Sciences and Engineering","issn_l":"1472-7978","issn":["1472-7978","1875-8983"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computational Methods in Sciences and Engineering","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100406403","display_name":"Xueping Li","orcid":"https://orcid.org/0000-0003-4198-7860"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Xueping Li","raw_affiliation_strings":[],"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100406403"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0789,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.33672545,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"21","issue":"6","first_page":"1797","last_page":"1808"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"Cytotoxicity","score":0.9543647766113281},{"id":"https://openalex.org/keywords/cytotoxic-t-cell","display_name":"Cytotoxic T cell","score":0.7051988840103149},{"id":"https://openalex.org/keywords/biocompatibility","display_name":"Biocompatibility","score":0.6752020716667175},{"id":"https://openalex.org/keywords/in-vitro","display_name":"In vitro","score":0.6048398017883301},{"id":"https://openalex.org/keywords/nanoparticle","display_name":"Nanoparticle","score":0.5570762157440186},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5273082256317139},{"id":"https://openalex.org/keywords/toxicity","display_name":"Toxicity","score":0.5220820307731628},{"id":"https://openalex.org/keywords/colloidal-gold","display_name":"Colloidal gold","score":0.45798459649086},{"id":"https://openalex.org/keywords/apoptosis","display_name":"Apoptosis","score":0.45215392112731934},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.3865436315536499},{"id":"https://openalex.org/keywords/nuclear-chemistry","display_name":"Nuclear chemistry","score":0.3237220048904419},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.2588820457458496},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.18478360772132874},{"id":"https://openalex.org/keywords/organic-chemistry","display_name":"Organic chemistry","score":0.06818312406539917}],"concepts":[{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.9543647766113281},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.7051988840103149},{"id":"https://openalex.org/C2777230088","wikidata":"https://www.wikidata.org/wiki/Q864426","display_name":"Biocompatibility","level":2,"score":0.6752020716667175},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6048398017883301},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.5570762157440186},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5273082256317139},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5220820307731628},{"id":"https://openalex.org/C104819515","wikidata":"https://www.wikidata.org/wiki/Q900961","display_name":"Colloidal gold","level":3,"score":0.45798459649086},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.45215392112731934},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3865436315536499},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.3237220048904419},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2588820457458496},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18478360772132874},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.06818312406539917}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3233/jcm-215442","is_oa":false,"landing_page_url":"https://doi.org/10.3233/jcm-215442","pdf_url":null,"source":{"id":"https://openalex.org/S2765058733","display_name":"Journal of Computational Methods in Sciences and Engineering","issn_l":"1472-7978","issn":["1472-7978","1875-8983"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computational Methods in Sciences and Engineering","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1752868515","https://openalex.org/W1869905001","https://openalex.org/W1955843064","https://openalex.org/W2114514219","https://openalex.org/W2144080900","https://openalex.org/W2194502287","https://openalex.org/W2284409111","https://openalex.org/W2383688450","https://openalex.org/W2486115690","https://openalex.org/W2524757370","https://openalex.org/W2532385050","https://openalex.org/W2541176365","https://openalex.org/W2560286492","https://openalex.org/W2560378140","https://openalex.org/W2573759722","https://openalex.org/W2591553463","https://openalex.org/W2752262173","https://openalex.org/W2788219194","https://openalex.org/W2791042850","https://openalex.org/W2801167769","https://openalex.org/W2801302030","https://openalex.org/W2808238902","https://openalex.org/W2906474335","https://openalex.org/W2920890745","https://openalex.org/W2949436061","https://openalex.org/W2961026687","https://openalex.org/W2963926128"],"related_works":["https://openalex.org/W1990434843","https://openalex.org/W2563359967","https://openalex.org/W2187248412","https://openalex.org/W4200627009","https://openalex.org/W1973470802","https://openalex.org/W2389756890","https://openalex.org/W2083428302","https://openalex.org/W2809944477","https://openalex.org/W2948877668","https://openalex.org/W2159472222"],"abstract_inverted_index":{"Nanoparticles":[0],"have":[1],"been":[2],"used":[3,139],"in":[4,32,187],"the":[5,31,49,60,84,95,104,108,114,124,130,143,146,150,156,166,171,174,177,180,183,188,195],"cytotoxic":[6,34,74],"test":[7,35],"for":[8,30,163],"many":[9],"times":[10],"because":[11],"of":[12,36,73,76,87,99,116,135,170,185,197],"their":[13],"easy":[14],"size":[15,98],"control,":[16],"good":[17],"biocompatibility":[18],"and":[19,59,97,121,149,168,176,182],"other":[20],"characteristics.":[21],"Therefore,":[22],"a":[23],"method":[24],"based":[25],"on":[26],"big":[27],"data":[28],"technology":[29],"vitro":[33],"nanoparticles":[37,78],"is":[38],"proposed.":[39],"The":[40,90],"cells":[41,157,172],"were":[42,101,118,158,173],"evenly":[43],"inoculated":[44],"into":[45,64],"96":[46],"well":[47],"plate,":[48],"prepared":[50],"AuNPs":[51,100,117],"was":[52,62,80,107,111,127,138,153,179,191],"diluted":[53],"with":[54,160],"DMEM":[55,133,161],"cell":[56,189],"culture":[57],"medium,":[58],"cytotoxicity":[61,105,125,144],"divided":[63],"5":[65],"levels":[66],"by":[67],"5-point":[68],"system.":[69],"A":[70],"database":[71],"model":[72],"characteristics":[75,86],"gold":[77],"(AuNPs)":[79],"built":[81],"to":[82,140],"mine":[83],"toxic":[85],"cultured":[88],"cells.":[89],"results":[91],"showed":[92],"that":[93],"when":[94],"diameter":[96],"1.8":[102],"nm,":[103,123],"rating":[106,126],"highest,":[109],"which":[110],"4.":[112],"When":[113,129,155],"diameters":[115],"18":[119],"nm":[120],"27":[122],"0.":[128],"high":[131],"concentration":[132],"solution":[134,162],"90":[136],"\u03bcg/mL":[137],"treat":[141],"AuNPs,":[142],"reached":[145],"highest":[147],"value,":[148],"lowest":[151],"activity":[152,167],"12%.":[154],"treated":[159],"24":[164],"hours,":[165],"toxicity":[169,178],"least":[175],"strongest,":[181],"number":[184],"apoptosis":[186],"community":[190],"significantly":[192],"reduced":[193],"under":[194],"action":[196],"AuNPs.":[198]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}