{"id":"https://openalex.org/W2952455424","doi":"https://doi.org/10.3233/isb-190471","title":"Calibration, Selection and Identifiability Analysis of a Mathematical Model of the <i>in vitro</i> Erythropoiesis in Normal and Perturbed Contexts","display_name":"Calibration, Selection and Identifiability Analysis of a Mathematical Model of the <i>in vitro</i> Erythropoiesis in Normal and Perturbed Contexts","publication_year":2019,"publication_date":"2019-04-19","ids":{"openalex":"https://openalex.org/W2952455424","doi":"https://doi.org/10.3233/isb-190471","mag":"2952455424","pmid":"https://pubmed.ncbi.nlm.nih.gov/31006682"},"language":"en","primary_location":{"id":"doi:10.3233/isb-190471","is_oa":true,"landing_page_url":"https://doi.org/10.3233/isb-190471","pdf_url":"https://content.iospress.com:443/download/in-silico-biology/isb190471?id=in-silico-biology%2Fisb190471","source":{"id":"https://openalex.org/S120694666","display_name":"In Silico Biology","issn_l":"1386-6338","issn":["1386-6338","1434-3207"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In Silico Biology: Journal of Biological Systems Modeling and Multi-Scale Simulation","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://content.iospress.com:443/download/in-silico-biology/isb190471?id=in-silico-biology%2Fisb190471","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007065416","display_name":"Ronan Duchesne","orcid":null},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Universit\u00e9 Claude Bernard Lyon 1","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I113428412","display_name":"\u00c9cole Normale Sup\u00e9rieure de Lyon","ror":"https://ror.org/04zmssz18","country_code":"FR","type":"education","lineage":["https://openalex.org/I113428412","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1326498283","display_name":"Institut national de recherche en sciences et technologies du num\u00e9rique","ror":"https://ror.org/02kvxyf05","country_code":"FR","type":"government","lineage":["https://openalex.org/I1326498283"]},{"id":"https://openalex.org/I4210100775","display_name":"Laboratoire de Biologie et Mod\u00e9lisation de la Cellule","ror":"https://ror.org/01bj4fd12","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I203339264","https://openalex.org/I203339264","https://openalex.org/I4210100775"]},{"id":"https://openalex.org/I4210101348","display_name":"Centre Inria de l'Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/00n8d6z93","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1326498283","https://openalex.org/I4210101348"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Ronan Duchesne","raw_affiliation_strings":["Inria team Dracula, Inria center Grenoble-Rh\u00f4ne Alpes, 56 Boulevard Niels Bohr, Villeurbanne","Laboratoire de Biologie et Mod\u00e9lisation de la Cellule, CNRS UMR 5239, \u00c9cole Normale Sup\u00e9rieure de Lyon, 46 all\u00e9e d\u2019Italie, Lyon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inria team Dracula, Inria center Grenoble-Rh\u00f4ne Alpes, 56 Boulevard Niels Bohr, Villeurbanne","institution_ids":["https://openalex.org/I1326498283","https://openalex.org/I4210101348","https://openalex.org/I899635006"]},{"raw_affiliation_string":"Laboratoire de Biologie et Mod\u00e9lisation de la Cellule, CNRS UMR 5239, \u00c9cole Normale Sup\u00e9rieure de Lyon, 46 all\u00e9e d\u2019Italie, Lyon","institution_ids":["https://openalex.org/I4210100775","https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I113428412"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044342058","display_name":"Anissa Guillemin","orcid":"https://orcid.org/0000-0002-7989-200X"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Universit\u00e9 Claude Bernard Lyon 1","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I113428412","display_name":"\u00c9cole Normale Sup\u00e9rieure de Lyon","ror":"https://ror.org/04zmssz18","country_code":"FR","type":"education","lineage":["https://openalex.org/I113428412","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210100775","display_name":"Laboratoire de Biologie et Mod\u00e9lisation de la Cellule","ror":"https://ror.org/01bj4fd12","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I203339264","https://openalex.org/I203339264","https://openalex.org/I4210100775"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Anissa Guillemin","raw_affiliation_strings":["Laboratoire de Biologie et Mod\u00e9lisation de la Cellule, CNRS UMR 5239, \u00c9cole Normale Sup\u00e9rieure de Lyon, 46 all\u00e9e d\u2019Italie, Lyon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Biologie et Mod\u00e9lisation de la Cellule, CNRS UMR 5239, \u00c9cole Normale Sup\u00e9rieure de Lyon, 46 all\u00e9e d\u2019Italie, Lyon","institution_ids":["https://openalex.org/I4210100775","https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I113428412"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073384277","display_name":"Fabien Crauste","orcid":"https://orcid.org/0000-0002-9979-9638"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I4210166017","display_name":"Institut de Math\u00e9matiques de Bordeaux","ror":"https://ror.org/05m3r1b84","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I1326498283","https://openalex.org/I15057530","https://openalex.org/I4210141950","https://openalex.org/I4210160189","https://openalex.org/I4210166017"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fabien Crauste","raw_affiliation_strings":["Institut Math\u00e9matiques de Bordeaux, CNRS UMR5251, Universit\u00e9 de Bordeaux, Talence, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Math\u00e9matiques de Bordeaux, CNRS UMR5251, Universit\u00e9 de Bordeaux, Talence, France","institution_ids":["https://openalex.org/I4210166017","https://openalex.org/I15057530","https://openalex.org/I1294671590"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089245484","display_name":"Olivier Gandrillon","orcid":"https://orcid.org/0000-0002-3676-6513"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Universit\u00e9 Claude Bernard Lyon 1","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I113428412","display_name":"\u00c9cole Normale Sup\u00e9rieure de Lyon","ror":"https://ror.org/04zmssz18","country_code":"FR","type":"education","lineage":["https://openalex.org/I113428412","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1326498283","display_name":"Institut national de recherche en sciences et technologies du num\u00e9rique","ror":"https://ror.org/02kvxyf05","country_code":"FR","type":"government","lineage":["https://openalex.org/I1326498283"]},{"id":"https://openalex.org/I4210100775","display_name":"Laboratoire de Biologie et Mod\u00e9lisation de la Cellule","ror":"https://ror.org/01bj4fd12","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I203339264","https://openalex.org/I203339264","https://openalex.org/I4210100775"]},{"id":"https://openalex.org/I4210101348","display_name":"Centre Inria de l'Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/00n8d6z93","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1326498283","https://openalex.org/I4210101348"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Olivier Gandrillon","raw_affiliation_strings":["Inria team Dracula, Inria center Grenoble-Rh\u00f4ne Alpes, 56 Boulevard Niels Bohr, Villeurbanne","Laboratoire de Biologie et Mod\u00e9lisation de la Cellule, CNRS UMR 5239, \u00c9cole Normale Sup\u00e9rieure de Lyon, 46 all\u00e9e d\u2019Italie, Lyon"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inria team Dracula, Inria center Grenoble-Rh\u00f4ne Alpes, 56 Boulevard Niels Bohr, Villeurbanne","institution_ids":["https://openalex.org/I1326498283","https://openalex.org/I4210101348","https://openalex.org/I899635006"]},{"raw_affiliation_string":"Laboratoire de Biologie et Mod\u00e9lisation de la Cellule, CNRS UMR 5239, \u00c9cole Normale Sup\u00e9rieure de Lyon, 46 all\u00e9e d\u2019Italie, Lyon","institution_ids":["https://openalex.org/I4210100775","https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I113428412"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5007065416"],"corresponding_institution_ids":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I1326498283","https://openalex.org/I4210100775","https://openalex.org/I4210101348","https://openalex.org/I899635006"],"apc_list":null,"apc_paid":null,"fwci":1.1614,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.84182497,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"13","issue":"1-2","first_page":"55","last_page":"69"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14351","display_name":"Statistical and Computational Modeling","score":0.9510999917984009,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T14351","display_name":"Statistical and Computational Modeling","score":0.9510999917984009,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11236","display_name":"Control Systems and Identification","score":0.9398000240325928,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9344000220298767,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/identifiability","display_name":"Identifiability","score":0.9295551776885986},{"id":"https://openalex.org/keywords/selection","display_name":"Selection (genetic algorithm)","score":0.7129038572311401},{"id":"https://openalex.org/keywords/erythropoiesis","display_name":"Erythropoiesis","score":0.694264829158783},{"id":"https://openalex.org/keywords/calibration","display_name":"Calibration","score":0.6285786628723145},{"id":"https://openalex.org/keywords/in-vitro","display_name":"In vitro","score":0.4511156380176544},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.40946292877197266},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3942474126815796},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3853873312473297},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3233659267425537},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.2909708321094513},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2716030478477478},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.25025463104248047},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.23837891221046448},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.16615945100784302},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.12761321663856506},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.1275947391986847}],"concepts":[{"id":"https://openalex.org/C122770356","wikidata":"https://www.wikidata.org/wiki/Q1656753","display_name":"Identifiability","level":2,"score":0.9295551776885986},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.7129038572311401},{"id":"https://openalex.org/C2779703530","wikidata":"https://www.wikidata.org/wiki/Q837174","display_name":"Erythropoiesis","level":3,"score":0.694264829158783},{"id":"https://openalex.org/C165838908","wikidata":"https://www.wikidata.org/wiki/Q736777","display_name":"Calibration","level":2,"score":0.6285786628723145},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4511156380176544},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.40946292877197266},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3942474126815796},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3853873312473297},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3233659267425537},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2909708321094513},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2716030478477478},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.25025463104248047},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.23837891221046448},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16615945100784302},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12761321663856506},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1275947391986847},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004920","descriptor_name":"Erythropoiesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004920","descriptor_name":"Erythropoiesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004920","descriptor_name":"Erythropoiesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004920","descriptor_name":"Erythropoiesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004920","descriptor_name":"Erythropoiesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004920","descriptor_name":"Erythropoiesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015672","descriptor_name":"Erythroid Precursor Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D015672","descriptor_name":"Erythroid Precursor Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D015672","descriptor_name":"Erythroid Precursor Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D015672","descriptor_name":"Erythroid Precursor Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015672","descriptor_name":"Erythroid Precursor Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015672","descriptor_name":"Erythroid Precursor Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015672","descriptor_name":"Erythroid Precursor Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015672","descriptor_name":"Erythroid Precursor Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015672","descriptor_name":"Erythroid Precursor Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.3233/isb-190471","is_oa":true,"landing_page_url":"https://doi.org/10.3233/isb-190471","pdf_url":"https://content.iospress.com:443/download/in-silico-biology/isb190471?id=in-silico-biology%2Fisb190471","source":{"id":"https://openalex.org/S120694666","display_name":"In Silico Biology","issn_l":"1386-6338","issn":["1386-6338","1434-3207"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In Silico Biology: Journal of Biological Systems Modeling and Multi-Scale Simulation","raw_type":"journal-article"},{"id":"pmid:31006682","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31006682","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In silico biology","raw_type":null},{"id":"pmh:oai:HAL:hal-02309925v1","is_oa":false,"landing_page_url":"https://hal.science/hal-02309925","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"In Silico Biology, 2019, 13 (1-2), pp.55-69. &#x27E8;10.3233/ISB-190471&#x27E9;","raw_type":"Journal articles"},{"id":"pmh:oai:oskar-bordeaux.fr:20.500.12278/192762","is_oa":false,"landing_page_url":"https://oskar-bordeaux.fr/handle/20.500.12278/192762","pdf_url":null,"source":{"id":"https://openalex.org/S4306402569","display_name":"Oskar-Bordeaux (Universite de Bordeaux)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article de revue"},{"id":"pmh:oai:oskar-bordeaux.fr:20.500.12278/9269","is_oa":false,"landing_page_url":"https://oskar-bordeaux.fr/handle/20.500.12278/9269","pdf_url":null,"source":{"id":"https://openalex.org/S4306402569","display_name":"Oskar-Bordeaux (Universite de Bordeaux)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article de revue"},{"id":"pmh:oai:pubmedcentral.nih.gov:6597985","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6597985","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"In Silico Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3233/isb-190471","is_oa":true,"landing_page_url":"https://doi.org/10.3233/isb-190471","pdf_url":"https://content.iospress.com:443/download/in-silico-biology/isb190471?id=in-silico-biology%2Fisb190471","source":{"id":"https://openalex.org/S120694666","display_name":"In Silico Biology","issn_l":"1386-6338","issn":["1386-6338","1434-3207"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In Silico Biology: Journal of Biological Systems Modeling and Multi-Scale Simulation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.41999998688697815,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G3785575267","display_name":null,"funder_award_id":"ANR-11-LABX-0048","funder_id":"https://openalex.org/F4320330080","funder_display_name":"Laboratoire d'Excellence Ecofect"},{"id":"https://openalex.org/G4717252311","display_name":null,"funder_award_id":"ANR-11-LABX-0048","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G5649854608","display_name":null,"funder_award_id":"ANR-11-LABX-0048","funder_id":"https://openalex.org/F4320326804","funder_display_name":"Universit\u00e9 de Lyon"}],"funders":[{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320321966","display_name":"Universit\u00e0 degli Studi di Padova","ror":"https://ror.org/00240q980"},{"id":"https://openalex.org/F4320322363","display_name":"Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905"},{"id":"https://openalex.org/F4320326804","display_name":"Universit\u00e9 de Lyon","ror":"https://ror.org/01rk35k63"},{"id":"https://openalex.org/F4320330080","display_name":"Laboratoire d'Excellence Ecofect","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2952455424.pdf","grobid_xml":"https://content.openalex.org/works/W2952455424.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W44278768","https://openalex.org/W86498711","https://openalex.org/W1802153259","https://openalex.org/W1833514140","https://openalex.org/W1862800359","https://openalex.org/W1967864078","https://openalex.org/W1986762912","https://openalex.org/W1987694764","https://openalex.org/W1996418705","https://openalex.org/W2002941209","https://openalex.org/W2009435671","https://openalex.org/W2010817192","https://openalex.org/W2012500654","https://openalex.org/W2029784397","https://openalex.org/W2033783472","https://openalex.org/W2035297696","https://openalex.org/W2039457417","https://openalex.org/W2047681355","https://openalex.org/W2047737896","https://openalex.org/W2048110904","https://openalex.org/W2049316691","https://openalex.org/W2058892595","https://openalex.org/W2065000345","https://openalex.org/W2066403664","https://openalex.org/W2079777306","https://openalex.org/W2092663493","https://openalex.org/W2094391162","https://openalex.org/W2102434872","https://openalex.org/W2112688502","https://openalex.org/W2124089215","https://openalex.org/W2125255512","https://openalex.org/W2140514146","https://openalex.org/W2160363502","https://openalex.org/W2168648059","https://openalex.org/W2174806048","https://openalex.org/W2239860981","https://openalex.org/W2279648767","https://openalex.org/W2319885746","https://openalex.org/W2413899142","https://openalex.org/W2552320392","https://openalex.org/W2561513855","https://openalex.org/W2570629027","https://openalex.org/W2760415787","https://openalex.org/W2765993499","https://openalex.org/W2770718418","https://openalex.org/W2791058611","https://openalex.org/W2802291136","https://openalex.org/W2964032982","https://openalex.org/W3098527589","https://openalex.org/W4238063882"],"related_works":["https://openalex.org/W2724847603","https://openalex.org/W2034041141","https://openalex.org/W2184661725","https://openalex.org/W2573470972","https://openalex.org/W112856298","https://openalex.org/W2105626102","https://openalex.org/W2131038454","https://openalex.org/W4240568257","https://openalex.org/W2900187352","https://openalex.org/W1964893445"],"abstract_inverted_index":{"The":[0],"in":[1,13,29,35,43,64,83,153,173],"vivo":[2],"erythropoiesis,":[3,37],"which":[4,38,147,177,192,199],"is":[5,94,129,178,200],"the":[6,14,30,34,51,59,75,139,154,166,170,197,203,208],"generation":[7],"of":[8,17,26,63,82,99,106,111,120,141,151,172],"mature":[9],"red":[10,40],"blood":[11,41],"cells":[12,42,107],"bone":[15],"marrow":[16],"whole":[18],"organisms,":[19],"has":[20,45],"been":[21],"described":[22],"by":[23,69],"a":[24,97,142,187,190],"variety":[25],"mathematical":[27,61],"models":[28,72],"past":[31],"decades.":[32],"However,":[33],"vitro":[36,65,84,174],"produces":[39],"cultures,":[44],"received":[46],"much":[47],"less":[48],"attention":[49],"from":[50,88],"modelling":[52],"community.":[53],"In":[54],"this":[55,135],"paper,":[56],"we":[57,133],"propose":[58],"first":[60,167],"model":[62,128,136,168,191,209],"erythropoiesis.":[66],"We":[67,113,164],"start":[68],"formulating":[70],"different":[71,109],"and":[73,124,156],"select":[74],"best":[76],"one":[77],"at":[78,108],"fitting":[79],"experimental":[80,204],"data":[81],"erythropoietic":[85],"differentiation":[86,152,176],"obtained":[87],"chicken":[89],"erythroid":[90],"progenitor":[91],"cells.":[92],"It":[93,183],"based":[95],"on":[96],"set":[98],"linear":[100],"ODE,":[101],"describing":[102],"3":[103],"hypothetical":[104],"populations":[105],"stages":[110],"differentiation.":[112],"then":[114],"compute":[115,138],"confidence":[116],"intervals":[117],"for":[118,169,189,196,207],"all":[119,149],"its":[121],"parameters":[122],"estimates,":[123],"conclude":[125],"that":[126],"our":[127],"fully":[130],"identifiable.":[131,182],"Finally,":[132],"use":[134],"to":[137,160,180,202],"effect":[140],"chemical":[143],"drug":[144],"called":[145],"Rapamycin,":[146],"affects":[148],"states":[150],"culture,":[155],"relate":[157],"these":[158],"effects":[159],"specific":[161],"parameter":[162],"variations.":[163],"provide":[165],"kinetics":[171],"cellular":[175],"proven":[179],"be":[181],"will":[184,193],"serve":[185],"as":[186],"basis":[188],"better":[194],"account":[195],"variability":[198],"inherent":[201],"protocol":[205],"used":[206],"calibration.":[210]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-05-07T13:39:58.223016","created_date":"2025-10-10T00:00:00"}