{"id":"https://openalex.org/W4221001579","doi":"https://doi.org/10.3233/idt-200185","title":"Graph analysis and clustering of proteins linked with COVID-19","display_name":"Graph analysis and clustering of proteins linked with COVID-19","publication_year":2022,"publication_date":"2022-03-15","ids":{"openalex":"https://openalex.org/W4221001579","doi":"https://doi.org/10.3233/idt-200185"},"language":"en","primary_location":{"id":"doi:10.3233/idt-200185","is_oa":true,"landing_page_url":"https://doi.org/10.3233/idt-200185","pdf_url":"https://content.iospress.com:443/download/intelligent-decision-technologies/idt200185?id=intelligent-decision-technologies%2Fidt200185","source":{"id":"https://openalex.org/S119727669","display_name":"Intelligent Decision Technologies","issn_l":"1872-4981","issn":["1872-4981","1875-8843"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Intelligent Decision Technologies","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://content.iospress.com:443/download/intelligent-decision-technologies/idt200185?id=intelligent-decision-technologies%2Fidt200185","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021234960","display_name":"J. Susymary","orcid":null},"institutions":[{"id":"https://openalex.org/I98499257","display_name":"Kalasalingam Academy of Research and Education","ror":"https://ror.org/04fm2fn75","country_code":"IN","type":"education","lineage":["https://openalex.org/I98499257"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"J. Susymary","raw_affiliation_strings":["Department of Computer Applications, Kalasalingam Academy of Research and Education, Krishnankoil, Virdhunagar District, Tamil Nadu, India"],"affiliations":[{"raw_affiliation_string":"Department of Computer Applications, Kalasalingam Academy of Research and Education, Krishnankoil, Virdhunagar District, Tamil Nadu, India","institution_ids":["https://openalex.org/I98499257"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045159488","display_name":"P. Deepalakshmi","orcid":null},"institutions":[{"id":"https://openalex.org/I98499257","display_name":"Kalasalingam Academy of Research and Education","ror":"https://ror.org/04fm2fn75","country_code":"IN","type":"education","lineage":["https://openalex.org/I98499257"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"P. Deepalakshmi","raw_affiliation_strings":["Department of Computer Science and Engineering, Kalasalingam Academy of Research and Education, Krishnankoil, Virdhunagar District, Tamil Nadu, India"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, Kalasalingam Academy of Research and Education, Krishnankoil, Virdhunagar District, Tamil Nadu, India","institution_ids":["https://openalex.org/I98499257"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5021234960"],"corresponding_institution_ids":["https://openalex.org/I98499257"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.02350995,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"1","first_page":"145","last_page":"158"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9968000054359436,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.941100001335144,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.5698000192642212},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5203834772109985},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.5128329396247864},{"id":"https://openalex.org/keywords/uniprot","display_name":"UniProt","score":0.4196656048297882},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.38511765003204346},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.36094406247138977},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.2648673951625824},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1962546706199646},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1944619119167328},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.13783827424049377}],"concepts":[{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.5698000192642212},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5203834772109985},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.5128329396247864},{"id":"https://openalex.org/C202264299","wikidata":"https://www.wikidata.org/wiki/Q905695","display_name":"UniProt","level":3,"score":0.4196656048297882},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.38511765003204346},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36094406247138977},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.2648673951625824},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1962546706199646},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1944619119167328},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.13783827424049377}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3233/idt-200185","is_oa":true,"landing_page_url":"https://doi.org/10.3233/idt-200185","pdf_url":"https://content.iospress.com:443/download/intelligent-decision-technologies/idt200185?id=intelligent-decision-technologies%2Fidt200185","source":{"id":"https://openalex.org/S119727669","display_name":"Intelligent Decision Technologies","issn_l":"1872-4981","issn":["1872-4981","1875-8843"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Intelligent Decision Technologies","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3233/idt-200185","is_oa":true,"landing_page_url":"https://doi.org/10.3233/idt-200185","pdf_url":"https://content.iospress.com:443/download/intelligent-decision-technologies/idt200185?id=intelligent-decision-technologies%2Fidt200185","source":{"id":"https://openalex.org/S119727669","display_name":"Intelligent Decision Technologies","issn_l":"1872-4981","issn":["1872-4981","1875-8843"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Intelligent Decision Technologies","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8500000238418579,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4221001579.pdf","grobid_xml":"https://content.openalex.org/works/W4221001579.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W158117962","https://openalex.org/W1475339879","https://openalex.org/W1971013885","https://openalex.org/W1973508741","https://openalex.org/W2052301877","https://openalex.org/W2075220720","https://openalex.org/W2084898653","https://openalex.org/W2106060578","https://openalex.org/W2133098435","https://openalex.org/W2410618082","https://openalex.org/W2781869913","https://openalex.org/W2895962782","https://openalex.org/W2897787634","https://openalex.org/W2900569176","https://openalex.org/W2907825062","https://openalex.org/W2908670560","https://openalex.org/W2911115880","https://openalex.org/W2913262853","https://openalex.org/W2914622179","https://openalex.org/W2918402879","https://openalex.org/W2919845799","https://openalex.org/W2925169498","https://openalex.org/W2931240559","https://openalex.org/W2940518587","https://openalex.org/W2969529490","https://openalex.org/W2972464396","https://openalex.org/W2996038193","https://openalex.org/W3003422837","https://openalex.org/W3010839841","https://openalex.org/W3011072970","https://openalex.org/W3013933578","https://openalex.org/W3017299903","https://openalex.org/W3022013351","https://openalex.org/W3022285953"],"related_works":["https://openalex.org/W24553703","https://openalex.org/W4211000692","https://openalex.org/W4212920271","https://openalex.org/W2612240612","https://openalex.org/W4324018414","https://openalex.org/W4211208250","https://openalex.org/W4211054902","https://openalex.org/W2472351724","https://openalex.org/W3145366215","https://openalex.org/W2170381940"],"abstract_inverted_index":{"A":[0],"remarkable":[1],"number":[2],"of":[3,17,43,49,61,71,111,186,213,219,230,239],"scientific":[4],"initiatives":[5],"are":[6,165],"in":[7,26,37,58,65,146,200],"practice":[8],"to":[9,75,84,120,139],"encounter":[10],"the":[11,18,23,27,31,34,53,62,80,86,89,125,133,152,172,176],"new":[12],"coronavirus":[13],"epidemic":[14],"(COVID-19).":[15],"One":[16],"biggest":[19],"challenges":[20],"faced":[21],"by":[22,102],"COVID-19":[24,44,90,100,160,190],"researchers":[25],"therapeutic":[28],"field":[29],"is":[30,74],"knowledge":[32,87,169],"about":[33,88],"biological":[35,55,63,82,127,144],"functions":[36,83],"disease-human":[38,91,105,161,191],"interacting":[39,92],"proteins.":[40,93],"The":[41,68,94,195],"detection":[42],"protein":[45,134,162,204],"complexes,":[46],"a":[47,104,142,147,180],"group":[48,121],"proteins":[50,77,97,122],"that":[51,78,123,136,164],"possess":[52,124],"same":[54,81,126],"functions,":[56],"helps":[57],"better":[59],"understanding":[60],"processes":[64],"our":[66],"body.":[67],"main":[69],"contribution":[70],"this":[72],"work":[73,137],"cluster":[76,153,207],"perform":[79],"increase":[85],"authors":[95,173],"investigated":[96],"linked":[98],"with":[99],"disease":[101],"creating":[103],"protein-protein":[106,192],"interaction":[107,193],"graph.":[108,194],"Topological":[109],"means":[110],"graph":[112,115],"analysis":[113],"and":[114,235],"clustering":[116],"have":[117],"been":[118],"employed":[119],"functions.":[128],"These":[129],"clusters":[130],"will":[131],"be":[132],"complexes":[135],"together":[138],"carry":[140],"out":[141],"specific":[143],"function":[145],"human":[148],"cell.":[149],"Moreover,":[150],"through":[151],"analysis,":[154],"we":[155],"can":[156],"uncover":[157],"previously":[158],"unknown":[159],"links":[163],"beneficial":[166],"for":[167],"promising":[168],"discovery.":[170],"Also,":[171],"evaluated":[174],"how":[175],"Markov":[177,196],"Cluster":[178,197],"algorithm,":[179],"graph-based":[181],"algorithm":[182,198],"finds":[183],"interesting":[184],"patterns":[185],"similar":[187],"features":[188],"from":[189],"results":[199],"six":[201],"statistically":[202],"significant":[203],"clusters,":[205],"including":[206],"(A):":[208],"keratinization":[209],"(3.50E-71),":[210],"(B):":[211],"regulation":[212,218,229],"cellular":[214],"process":[215],"(6.62E-05),":[216],"(C):":[217],"cell":[220,225,241],"cycle":[221,226,242],"(1.31E-27),":[222],"(D):":[223],"mitotic":[224,240],"(1.66E-06),":[227],"(E):":[228],"phosphoprotein":[231],"phosphatase":[232],"activity":[233],"(1.15E-09),":[234],"(G):":[236],"G2/M":[237],"transition":[238],"(3.03E-07).":[243]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}