{"id":"https://openalex.org/W4385454825","doi":"https://doi.org/10.3233/fi-222157","title":"Diffuse and Localized Functional Dysconnectivity in Schizophrenia: a Bootstrapped Top-Down Approach","display_name":"Diffuse and Localized Functional Dysconnectivity in Schizophrenia: a Bootstrapped Top-Down Approach","publication_year":2023,"publication_date":"2023-08-01","ids":{"openalex":"https://openalex.org/W4385454825","doi":"https://doi.org/10.3233/fi-222157"},"language":"en","primary_location":{"id":"doi:10.3233/fi-222157","is_oa":false,"landing_page_url":"https://doi.org/10.3233/fi-222157","pdf_url":null,"source":{"id":"https://openalex.org/S39012697","display_name":"Fundamenta Informaticae","issn_l":"0169-2968","issn":["0169-2968","1875-8681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fundamenta Informaticae","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://re.public.polimi.it/bitstream/11311/1249799/1/Coluzzi%20Baselli%20-%20FC%20Schizophrenia%20-%20Fund%20Inf%202023%20preprint.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088589071","display_name":"Davide Coluzzi","orcid":"https://orcid.org/0000-0002-8237-2443"},"institutions":[{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Davide Coluzzi","raw_affiliation_strings":["Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Italy, davide.coluzzi@polimi.it, giuseppe.baselli@polimi.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Italy, davide.coluzzi@polimi.it, giuseppe.baselli@polimi.it","institution_ids":["https://openalex.org/I93860229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012150223","display_name":"Giuseppe Baselli","orcid":"https://orcid.org/0000-0003-2978-1704"},"institutions":[{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppe Baselli","raw_affiliation_strings":["Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Italy, davide.coluzzi@polimi.it, giuseppe.baselli@polimi.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Italy, davide.coluzzi@polimi.it, giuseppe.baselli@polimi.it","institution_ids":["https://openalex.org/I93860229"]}]},{"author_position":"last","author":{"id":null,"display_name":"Giuseppe Baselli","orcid":null},"institutions":[{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Giuseppe Baselli","raw_affiliation_strings":["Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Italy, davide.coluzzi@polimi.it, giuseppe.baselli@polimi.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Italy, davide.coluzzi@polimi.it, giuseppe.baselli@polimi.it","institution_ids":["https://openalex.org/I93860229"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5088589071"],"corresponding_institution_ids":["https://openalex.org/I93860229"],"apc_list":null,"apc_paid":null,"fwci":0.1681,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.48074239,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"189","issue":"2","first_page":"171","last_page":"198"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13283","display_name":"Mental Health Research Topics","score":0.9944999814033508,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.6832186579704285},{"id":"https://openalex.org/keywords/default-mode-network","display_name":"Default mode network","score":0.6568233966827393},{"id":"https://openalex.org/keywords/functional-connectivity","display_name":"Functional connectivity","score":0.5170367360115051},{"id":"https://openalex.org/keywords/modularity","display_name":"Modularity (biology)","score":0.5109335780143738},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"Schizophrenia (object-oriented programming)","score":0.49977993965148926},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.4982306957244873},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.49648338556289673},{"id":"https://openalex.org/keywords/human-connectome-project","display_name":"Human Connectome Project","score":0.43339356780052185},{"id":"https://openalex.org/keywords/bridging","display_name":"Bridging (networking)","score":0.43323010206222534},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.42503809928894043},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.39064905047416687},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3580498695373535},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.333039790391922},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.32736140489578247},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.13449165225028992},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.10948586463928223}],"concepts":[{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.6832186579704285},{"id":"https://openalex.org/C141516989","wikidata":"https://www.wikidata.org/wiki/Q1182555","display_name":"Default mode network","level":3,"score":0.6568233966827393},{"id":"https://openalex.org/C3018011982","wikidata":"https://www.wikidata.org/wiki/Q7316120","display_name":"Functional connectivity","level":2,"score":0.5170367360115051},{"id":"https://openalex.org/C2779478453","wikidata":"https://www.wikidata.org/wiki/Q6889748","display_name":"Modularity (biology)","level":2,"score":0.5109335780143738},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.49977993965148926},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.4982306957244873},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.49648338556289673},{"id":"https://openalex.org/C97820695","wikidata":"https://www.wikidata.org/wiki/Q387749","display_name":"Human Connectome Project","level":3,"score":0.43339356780052185},{"id":"https://openalex.org/C174348530","wikidata":"https://www.wikidata.org/wiki/Q188635","display_name":"Bridging (networking)","level":2,"score":0.43323010206222534},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.42503809928894043},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.39064905047416687},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3580498695373535},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.333039790391922},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.32736140489578247},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.13449165225028992},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10948586463928223},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3233/fi-222157","is_oa":false,"landing_page_url":"https://doi.org/10.3233/fi-222157","pdf_url":null,"source":{"id":"https://openalex.org/S39012697","display_name":"Fundamenta Informaticae","issn_l":"0169-2968","issn":["0169-2968","1875-8681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fundamenta Informaticae","raw_type":"journal-article"},{"id":"pmh:oai:re.public.polimi.it:11311/1249799","is_oa":true,"landing_page_url":"https://hdl.handle.net/11311/1249799","pdf_url":"https://re.public.polimi.it/bitstream/11311/1249799/1/Coluzzi%20Baselli%20-%20FC%20Schizophrenia%20-%20Fund%20Inf%202023%20preprint.pdf","source":{"id":"https://openalex.org/S4306400312","display_name":"Virtual Community of Pathological Anatomy (University of Castilla La Mancha)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I79189158","host_organization_name":"University of Castilla-La Mancha","host_organization_lineage":["https://openalex.org/I79189158"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:air.unimi.it:2434/1070570","is_oa":true,"landing_page_url":"https://hdl.handle.net/2434/1070570","pdf_url":null,"source":{"id":"https://openalex.org/S4306400516","display_name":"Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I189158943","host_organization_name":"University of Milan","host_organization_lineage":["https://openalex.org/I189158943"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:re.public.polimi.it:11311/1249799","is_oa":true,"landing_page_url":"https://hdl.handle.net/11311/1249799","pdf_url":"https://re.public.polimi.it/bitstream/11311/1249799/1/Coluzzi%20Baselli%20-%20FC%20Schizophrenia%20-%20Fund%20Inf%202023%20preprint.pdf","source":{"id":"https://openalex.org/S4306400312","display_name":"Virtual Community of Pathological Anatomy (University of Castilla La Mancha)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I79189158","host_organization_name":"University of Castilla-La Mancha","host_organization_lineage":["https://openalex.org/I79189158"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/17","score":0.44999998807907104,"display_name":"Partnerships for the goals"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4385454825.pdf","grobid_xml":"https://content.openalex.org/works/W4385454825.grobid-xml"},"referenced_works_count":82,"referenced_works":["https://openalex.org/W1519637725","https://openalex.org/W1760829075","https://openalex.org/W1973705647","https://openalex.org/W1976623182","https://openalex.org/W1983183710","https://openalex.org/W1991315230","https://openalex.org/W1996196481","https://openalex.org/W1996498097","https://openalex.org/W2007581301","https://openalex.org/W2007894316","https://openalex.org/W2011611054","https://openalex.org/W2015738173","https://openalex.org/W2017033087","https://openalex.org/W2034207011","https://openalex.org/W2038205749","https://openalex.org/W2041092145","https://openalex.org/W2041951497","https://openalex.org/W2047975465","https://openalex.org/W2051703334","https://openalex.org/W2053463150","https://openalex.org/W2058187841","https://openalex.org/W2062596688","https://openalex.org/W2064598115","https://openalex.org/W2066108304","https://openalex.org/W2068252829","https://openalex.org/W2076805502","https://openalex.org/W2080163334","https://openalex.org/W2084009541","https://openalex.org/W2084978329","https://openalex.org/W2088993043","https://openalex.org/W2090357978","https://openalex.org/W2095491050","https://openalex.org/W2101135654","https://openalex.org/W2103543063","https://openalex.org/W2113189656","https://openalex.org/W2126838454","https://openalex.org/W2127070446","https://openalex.org/W2130419668","https://openalex.org/W2133750612","https://openalex.org/W2142566135","https://openalex.org/W2146853248","https://openalex.org/W2150442066","https://openalex.org/W2151936673","https://openalex.org/W2159242554","https://openalex.org/W2159929956","https://openalex.org/W2167822639","https://openalex.org/W2180423080","https://openalex.org/W2212230184","https://openalex.org/W2337246121","https://openalex.org/W2416658370","https://openalex.org/W2500024275","https://openalex.org/W2511999769","https://openalex.org/W2519496013","https://openalex.org/W2565049982","https://openalex.org/W2583548943","https://openalex.org/W2735271602","https://openalex.org/W2771470486","https://openalex.org/W2775832640","https://openalex.org/W2788702716","https://openalex.org/W2806270588","https://openalex.org/W2889467305","https://openalex.org/W2899648010","https://openalex.org/W2911816422","https://openalex.org/W2919731394","https://openalex.org/W2949345077","https://openalex.org/W2950917864","https://openalex.org/W2965294816","https://openalex.org/W2977740913","https://openalex.org/W2979923937","https://openalex.org/W3011161467","https://openalex.org/W3014686944","https://openalex.org/W3045299130","https://openalex.org/W3106889297","https://openalex.org/W3109484268","https://openalex.org/W3116749766","https://openalex.org/W3183473315","https://openalex.org/W3213862742","https://openalex.org/W4210744095","https://openalex.org/W4211091012","https://openalex.org/W4220791715","https://openalex.org/W4233154356","https://openalex.org/W4375870277"],"related_works":["https://openalex.org/W3205149984","https://openalex.org/W2042557239","https://openalex.org/W4253292488","https://openalex.org/W4389437801","https://openalex.org/W2735521735","https://openalex.org/W4402630632","https://openalex.org/W2086686577","https://openalex.org/W2118864139","https://openalex.org/W2926660217","https://openalex.org/W4311145604"],"abstract_inverted_index":{"Schizophrenia":[0],"is":[1,58,312],"a":[2,61,94,192,283],"brain":[3,106],"disorder":[4],"leading":[5],"to":[6,20,41,138,172,186,233,272],"detached":[7],"mind\u2019s":[8],"normally":[9],"integrated":[10],"processes.":[11],"Hence,":[12],"the":[13,16,28,72,76,82,128,150,173,181,198,203,234,244,262,280,287,295],"exploration":[14],"of":[15,46,71,75,84,89,108,197,205],"symptoms":[17],"in":[18,27,68,243,261,279,286,327],"relation":[19],"functional":[21],"connectivity":[22,67,253,301],"(FC)":[23],"had":[24],"great":[25],"relevance":[26],"field.":[29],"Connectivity":[30],"can":[31],"be":[32,273,325],"investigated":[33,326],"on":[34],"different":[35,62,275],"levels,":[36],"going":[37],"from":[38],"global":[39,63,140,193],"features":[40],"single":[42,296],"edges":[43],"between":[44,103,302],"pairs":[45],"regions,":[47],"revealing":[48],"diffuse":[49,320],"and":[50,113,149,167,202,224,254,321],"localized":[51,322],"dysconnection":[52],"patterns.":[53],"In":[54,305],"this":[55],"context,":[56],"schizophrenia":[57,118],"characterized":[59],"by":[60,127,145,154,213,310],"integration":[64],"with":[65,116],"reduced":[66,252],"specific":[69],"areas":[70,107,269],"brain,":[73],"part":[74],"Default":[77],"Mode":[78],"Network":[79],"(DMN).":[80],"However,":[81],"assessment":[83,220],"FC":[85,101],"presents":[86],"various":[87],"sources":[88],"uncertainty.":[90],"This":[91],"study":[92],"proposes":[93],"multi-level":[95,307],"approach":[96],"for":[97,230],"more":[98,227],"robust":[99],"group-comparison.":[100],"data":[102,148,236],"74":[104],"AAL":[105],"15":[109],"healthy":[110],"controls":[111],"(HC)":[112],"12":[114],"subjects":[115,160],"chronic":[117],"(SZ)":[119],"were":[120,124,136,177,184,200,241,270,292],"used.":[121],"Multi-level":[122],"analyses":[123],"carried":[125],"out":[126],"previously":[129],"published":[130],"SPIDER-NET":[131],"tool.":[132],"Graph":[133],"topological":[134],"indexes":[135,176,199],"evaluated":[137,153],"assess":[139],"abnormalities.":[141],"Robustness":[142],"was":[143,152,165,210],"augmented":[144],"bootstrapped":[146],"(BOOT)":[147],"stability":[151],"removing":[155],"one":[156],"(RST1)":[157],"or":[158],"two":[159],"(RST2).":[161],"The":[162,218,249],"DMN":[163,250],"subgraph":[164],"extracted":[166],"specifically":[168],"evaluated.":[169],"Changes":[170],"relevant":[171],"overall":[174],"local":[175,266],"also":[178],"analyzed.":[179],"Finally,":[180],"connection":[182],"weights":[183],"explored":[185],"enhance":[187],"common":[188],"strongest":[189],"activations/deactivations.":[190],"At":[191,265],"level,":[194,267],"expected":[195],"trends":[196],"found":[201,242,271],"significance":[204],"modularity":[206],"(p":[207,215,276],"=":[208,216],"0.043)":[209],"not":[211],"confirmed":[212,293],"BOOT":[214,231,311],"0.133).":[217],"robustness":[219],"tests":[221],"(both":[222],"RST1":[223],"RST2)":[225],"highlighted":[226,251],"stable":[228],"results":[229,240,291],"compared":[232],"direct":[235],"testing.":[237],"Conversely,":[238],"significant":[239],"analysis":[245,308],"at":[246],"lower":[247],"levels.":[248],"strength":[255],"as":[256,258],"well":[257],"increased":[259],"deactivation":[260],"SZ":[263],"group.":[264],"13":[268],"significantly":[274],"<":[277],"0.05)":[278],"groups,":[281],"highlighting":[282],"greater":[284],"divergence":[285],"frontal":[288],"lobe.":[289],"These":[290],"analyzing":[294,316],"negative":[297],"edges,":[298],"suggesting":[299],"inverted":[300],"prefronto-temporal":[303],"areas.":[304],"conclusion,":[306],"supported":[309],"highly":[313],"recommended":[314],"when":[315,319],"FC,":[317],"especially":[318],"dysconnections":[323],"must":[324],"limited":[328],"samples.":[329]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-05-19T08:33:51.333923","created_date":"2025-10-10T00:00:00"}