{"id":"https://openalex.org/W4402993391","doi":"https://doi.org/10.3233/faia240422","title":"Open Source Cardiac Digital Twinning of Human Ventricular Repolarisation from 12-Lead ECG and MRI","display_name":"Open Source Cardiac Digital Twinning of Human Ventricular Repolarisation from 12-Lead ECG and MRI","publication_year":2024,"publication_date":"2024-09-25","ids":{"openalex":"https://openalex.org/W4402993391","doi":"https://doi.org/10.3233/faia240422"},"language":"en","primary_location":{"id":"doi:10.3233/faia240422","is_oa":true,"landing_page_url":"https://doi.org/10.3233/faia240422","pdf_url":null,"source":{"id":"https://openalex.org/S4210201731","display_name":"Frontiers in artificial intelligence and applications","issn_l":"0922-6389","issn":["0922-6389","1879-8314"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Artificial Intelligence and Applications","raw_type":"book-chapter"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.3233/faia240422","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076288422","display_name":"Juli\u00e0 Camps","orcid":"https://orcid.org/0000-0002-6491-2565"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Julia Camps","raw_affiliation_strings":["Department of Computer Science, University of Oxford, UK"],"raw_orcid":"https://orcid.org/0000-0002-6491-2565","affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064912674","display_name":"Zhinuo Jenny Wang","orcid":"https://orcid.org/0000-0001-5325-909X"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Zhinuo Jenny Wang","raw_affiliation_strings":["Department of Computer Science, University of Oxford, UK"],"raw_orcid":"https://orcid.org/0000-0001-5325-909X","affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086827712","display_name":"Rub\u00e9n Doste","orcid":"https://orcid.org/0000-0003-4187-4970"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ruben Doste","raw_affiliation_strings":["Department of Computer Science, University of Oxford, UK"],"raw_orcid":"https://orcid.org/0000-0003-4187-4970","affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012447652","display_name":"Lucas Arantes Berg","orcid":"https://orcid.org/0000-0002-8777-0125"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lucas Arantes Berg","raw_affiliation_strings":["Department of Computer Science, University of Oxford, UK"],"raw_orcid":"https://orcid.org/0000-0002-8777-0125","affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103889815","display_name":"Maxx Holmes","orcid":"https://orcid.org/0000-0002-2299-9455"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Maxx Holmes","raw_affiliation_strings":["Department of Computer Science, University of Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068185600","display_name":"Brodie Lawson","orcid":"https://orcid.org/0000-0003-1317-5988"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Brodie Lawson","raw_affiliation_strings":["Department of Physiology, Anatomy & Genetics, University of Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Anatomy & Genetics, University of Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010242386","display_name":"Jakub Tomek","orcid":"https://orcid.org/0000-0002-0157-4386"},"institutions":[{"id":"https://openalex.org/I160993911","display_name":"Queensland University of Technology","ror":"https://ror.org/03pnv4752","country_code":"AU","type":"education","lineage":["https://openalex.org/I160993911"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jakub Tomek","raw_affiliation_strings":["Queensland University of Technology, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queensland University of Technology, Australia","institution_ids":["https://openalex.org/I160993911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003330950","display_name":"Kevin Burrage","orcid":"https://orcid.org/0000-0002-8111-1137"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kevin Burrage","raw_affiliation_strings":["Department of Physiology, Anatomy & Genetics, University of Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Anatomy & Genetics, University of Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016393422","display_name":"Alfonso Bueno\u2010Orovio","orcid":"https://orcid.org/0000-0002-1634-3601"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alfonso Bueno-Orovio","raw_affiliation_strings":["Department of Computer Science, University of Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101862653","display_name":"Blanca Rodr\u00edguez","orcid":"https://orcid.org/0000-0002-3435-7388"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Blanca Rodriguez","raw_affiliation_strings":["Department of Computer Science, University of Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5076288422"],"corresponding_institution_ids":["https://openalex.org/I40120149"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.45816555,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.972000002861023,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.972000002861023,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.911300003528595,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.6772622466087341},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.6451805830001831},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.52447509765625}],"concepts":[{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6772622466087341},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6451805830001831},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.52447509765625}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3233/faia240422","is_oa":true,"landing_page_url":"https://doi.org/10.3233/faia240422","pdf_url":null,"source":{"id":"https://openalex.org/S4210201731","display_name":"Frontiers in artificial intelligence and applications","issn_l":"0922-6389","issn":["0922-6389","1879-8314"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Artificial Intelligence and Applications","raw_type":"book-chapter"}],"best_oa_location":{"id":"doi:10.3233/faia240422","is_oa":true,"landing_page_url":"https://doi.org/10.3233/faia240422","pdf_url":null,"source":{"id":"https://openalex.org/S4210201731","display_name":"Frontiers in artificial intelligence and applications","issn_l":"0922-6389","issn":["0922-6389","1879-8314"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Artificial Intelligence and Applications","raw_type":"book-chapter"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W3183948672","https://openalex.org/W3173606202","https://openalex.org/W3110381201","https://openalex.org/W2948807893","https://openalex.org/W2935909890","https://openalex.org/W2778153218","https://openalex.org/W2758277628","https://openalex.org/W2748952813","https://openalex.org/W1531601525"],"abstract_inverted_index":{"Cardiac":[0],"digital":[1,24,43,152],"twins":[2,25],"represent":[3],"the":[4,60,86,138],"required":[5],"functional":[6],"mechanisms":[7],"of":[8,22,103,146],"patient":[9],"hearts":[10],"to":[11,34,71,119],"evaluate":[12],"therapies":[13],"and":[14,59,89,175],"inform":[15],"clinical":[16,29],"decision-making":[17],"virtually.":[18],"A":[19],"scalable":[20],"generation":[21],"cardiac":[23,151],"can":[26,116],"enable":[27],"virtual":[28,32,120,161],"trials":[30],"on":[31,51,180],"cohorts":[33],"fast-track":[35],"therapy":[36,121,162],"development.":[37],"Here,":[38],"we":[39],"present":[40],"an":[41],"open-source":[42],"twinning":[44,153],"framework":[45,70,124],"for":[46,150,167],"personalising":[47],"electrophysiological":[48],"function":[49],"based":[50],"routinely":[52],"acquired":[53],"magnetic":[54],"resonance":[55],"imaging":[56],"(MRI)":[57],"data":[58],"standard":[61],"12-lead":[62],"electrocardiogram":[63],"(ECG).":[64],"We":[65],"extended":[66],"a":[67,81,101,108,128,142,157],"Bayesian-based":[68],"inference":[69],"infer":[72],"electrical":[73],"repolarisation":[74],"characteristics.":[75],"Fast":[76],"simulations":[77],"are":[78,156,170],"conducted":[79],"with":[80,141],"decoupled":[82],"reaction-Eikonal":[83,135],"model,":[84],"including":[85],"Purkinje":[87],"network":[88],"biophysically-detailed":[90],"subcellular":[91],"ionic":[92],"current":[93],"dynamics.":[94],"Parameter":[95],"uncertainty":[96,115],"is":[97,125,178],"represented":[98],"by":[99],"inferring":[100],"population":[102],"ventricular":[104],"models":[105,136],"rather":[106],"than":[107],"single":[109],"one,":[110],"which":[111],"means":[112],"that":[113],"parameter":[114],"be":[117],"propagated":[118],"evaluations.":[122],"The":[123,148,164],"demonstrated":[126],"in":[127],"healthy":[129],"female":[130],"subject,":[131],"where":[132],"our":[133],"inferred":[134],"reproduced":[137],"patient\u2019s":[139],"ECG":[140],"Pearson\u2019s":[143],"correlation":[144],"coefficient":[145],"0.93.":[147],"methodologies":[149],"presented":[154],"here":[155],"step":[158],"towards":[159],"personalised":[160],"testing.":[163],"tools":[165],"developed":[166],"this":[168,177],"study":[169],"open-source,":[171],"ensuring":[172],"accessibility,":[173],"inclusivity,":[174],"reproducibility,":[176],"available":[179],"GitHub.":[181]},"counts_by_year":[],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}
