{"id":"https://openalex.org/W4390792279","doi":"https://doi.org/10.3233/faia231191","title":"Convolutional Neural Network Image Segmentation of Alzheimer\u2019s Disease Based on Multi-Order 3D U-NET","display_name":"Convolutional Neural Network Image Segmentation of Alzheimer\u2019s Disease Based on Multi-Order 3D U-NET","publication_year":2024,"publication_date":"2024-01-12","ids":{"openalex":"https://openalex.org/W4390792279","doi":"https://doi.org/10.3233/faia231191"},"language":"en","primary_location":{"id":"doi:10.3233/faia231191","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3233/faia231191","pdf_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/FAIA231191","source":{"id":"https://openalex.org/S4210201731","display_name":"Frontiers in artificial intelligence and applications","issn_l":"0922-6389","issn":["0922-6389","1879-8314"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Artificial Intelligence and Applications","raw_type":"book-chapter"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/FAIA231191","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101291238","display_name":"Ningsen Sun","orcid":null},"institutions":[{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ningsen Sun","raw_affiliation_strings":["School of Medical Information and Engineering, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai\u2019an, 271016, China","School of Medical Information and Engineering, Shandong First Medical University and Shandong Academy of Medical Sciences","School of Medical Information and Engineering, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai'an, 271016, China"],"affiliations":[{"raw_affiliation_string":"School of Medical Information and Engineering, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai\u2019an, 271016, China","institution_ids":["https://openalex.org/I4210163399"]},{"raw_affiliation_string":"School of Medical Information and Engineering, Shandong First Medical University and Shandong Academy of Medical Sciences","institution_ids":[]},{"raw_affiliation_string":"School of Medical Information and Engineering, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai'an, 271016, China","institution_ids":["https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100334733","display_name":"Yuan Yuan","orcid":"https://orcid.org/0000-0001-7964-6514"},"institutions":[{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan Yuan","raw_affiliation_strings":["School of Medical Information and Engineering, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai\u2019an, 271016, China","School of Medical Information and Engineering, Shandong First Medical University and Shandong Academy of Medical Sciences","School of Medical Information and Engineering, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai'an, 271016, China"],"affiliations":[{"raw_affiliation_string":"School of Medical Information and Engineering, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai\u2019an, 271016, China","institution_ids":["https://openalex.org/I4210163399"]},{"raw_affiliation_string":"School of Medical Information and Engineering, Shandong First Medical University and Shandong Academy of Medical Sciences","institution_ids":[]},{"raw_affiliation_string":"School of Medical Information and Engineering, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai'an, 271016, China","institution_ids":["https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108144132","display_name":"Lanhua Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lanhua Zhang","raw_affiliation_strings":["School of Medical Information and Engineering, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai\u2019an, 271016, China","School of Medical Information and Engineering, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai'an, 271016, China","School of Medical Information and Engineering, Shandong First Medical University and Shandong Academy of Medical Sciences"],"affiliations":[{"raw_affiliation_string":"School of Medical Information and Engineering, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai\u2019an, 271016, China","institution_ids":["https://openalex.org/I4210163399"]},{"raw_affiliation_string":"School of Medical Information and Engineering, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai'an, 271016, China","institution_ids":["https://openalex.org/I4210163399"]},{"raw_affiliation_string":"School of Medical Information and Engineering, Shandong First Medical University and Shandong Academy of Medical Sciences","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101334122","display_name":"Zhongdong Han","orcid":null},"institutions":[{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhongdong Han","raw_affiliation_strings":["School of Medical Information and Engineering, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai\u2019an, 271016, China","School of Medical Information and Engineering, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai'an, 271016, China","School of Medical Information and Engineering, Shandong First Medical University and Shandong Academy of Medical Sciences"],"affiliations":[{"raw_affiliation_string":"School of Medical Information and Engineering, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai\u2019an, 271016, China","institution_ids":["https://openalex.org/I4210163399"]},{"raw_affiliation_string":"School of Medical Information and Engineering, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai'an, 271016, China","institution_ids":["https://openalex.org/I4210163399"]},{"raw_affiliation_string":"School of Medical Information and Engineering, Shandong First Medical University and Shandong Academy of Medical Sciences","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5101291238"],"corresponding_institution_ids":["https://openalex.org/I4210163399"],"apc_list":null,"apc_paid":null,"fwci":13.5622,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.97673683,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":95},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13731","display_name":"Advanced Computing and Algorithms","score":0.9801999926567078,"subfield":{"id":"https://openalex.org/subfields/3322","display_name":"Urban Studies"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T13731","display_name":"Advanced Computing and Algorithms","score":0.9801999926567078,"subfield":{"id":"https://openalex.org/subfields/3322","display_name":"Urban Studies"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T12702","display_name":"Brain Tumor Detection and Classification","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.9354000091552734,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.7526057362556458},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6877905130386353},{"id":"https://openalex.org/keywords/convolutional-neural-network","display_name":"Convolutional neural network","score":0.6855018138885498},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.6824265718460083},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.6135079264640808},{"id":"https://openalex.org/keywords/hippocampus","display_name":"Hippocampus","score":0.5203113555908203},{"id":"https://openalex.org/keywords/image-segmentation","display_name":"Image segmentation","score":0.5192863345146179},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.4888019263744354},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.4799523651599884},{"id":"https://openalex.org/keywords/convolution","display_name":"Convolution (computer science)","score":0.45258837938308716},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.4470599591732025},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.21490859985351562},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.21338453888893127},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.1528168022632599},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.13974016904830933}],"concepts":[{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.7526057362556458},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6877905130386353},{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.6855018138885498},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.6824265718460083},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.6135079264640808},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.5203113555908203},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.5192863345146179},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.4888019263744354},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.4799523651599884},{"id":"https://openalex.org/C45347329","wikidata":"https://www.wikidata.org/wiki/Q5166604","display_name":"Convolution (computer science)","level":3,"score":0.45258837938308716},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.4470599591732025},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21490859985351562},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.21338453888893127},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.1528168022632599},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.13974016904830933}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3233/faia231191","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3233/faia231191","pdf_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/FAIA231191","source":{"id":"https://openalex.org/S4210201731","display_name":"Frontiers in artificial intelligence and applications","issn_l":"0922-6389","issn":["0922-6389","1879-8314"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Artificial Intelligence and Applications","raw_type":"book-chapter"}],"best_oa_location":{"id":"doi:10.3233/faia231191","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3233/faia231191","pdf_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/FAIA231191","source":{"id":"https://openalex.org/S4210201731","display_name":"Frontiers in artificial intelligence and applications","issn_l":"0922-6389","issn":["0922-6389","1879-8314"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Artificial Intelligence and Applications","raw_type":"book-chapter"},"sustainable_development_goals":[{"display_name":"Reduced inequalities","score":0.6299999952316284,"id":"https://metadata.un.org/sdg/10"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320328999","display_name":"Shandong First Medical University","ror":null},{"id":"https://openalex.org/F4320329000","display_name":"Shandong Academy of Medical Sciences","ror":"https://ror.org/05jb9pq57"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4390792279.pdf","grobid_xml":"https://content.openalex.org/works/W4390792279.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1917489321","https://openalex.org/W1998075519","https://openalex.org/W2084009613","https://openalex.org/W2086978209","https://openalex.org/W2112796928","https://openalex.org/W2183159415","https://openalex.org/W2650395120","https://openalex.org/W2783126785","https://openalex.org/W2903554604","https://openalex.org/W3018093250","https://openalex.org/W3165584499","https://openalex.org/W3177602233","https://openalex.org/W3179190612","https://openalex.org/W3181149587","https://openalex.org/W3182609974","https://openalex.org/W3209037005","https://openalex.org/W4310285951","https://openalex.org/W4311424446","https://openalex.org/W4319231503","https://openalex.org/W4320728002","https://openalex.org/W4360964957"],"related_works":["https://openalex.org/W4293226380","https://openalex.org/W2370029582","https://openalex.org/W4313906399","https://openalex.org/W4321487865","https://openalex.org/W2811106690","https://openalex.org/W4239306820","https://openalex.org/W2964954556","https://openalex.org/W2890372105","https://openalex.org/W3019910406","https://openalex.org/W1522196789"],"abstract_inverted_index":{"Alzheimer\u2019s":[0,100],"disease":[1],"will":[2],"lead":[3],"to":[4,12,44,91],"the":[5,8,14,20,26,32,46,75,80,89,93,96],"atrophy":[6],"of":[7,17,28,34,99],"Hippocampus.":[9],"In":[10],"order":[11],"recognize":[13,45,92],"position":[15],"changes":[16],"Hippocampus,":[18],"improve":[19,25],"image":[21,37],"contour":[22],"quality,":[23],"further":[24],"accuracy":[27,82],"convolution,":[29],"and":[30,54,95],"achieve":[31],"purpose":[33],"accurately":[35],"extracting":[36],"information,":[38],"convolutional":[39],"neural":[40],"network":[41],"is":[42,61],"introduced":[43],"Hippocampus":[47,94],"region":[48],"with":[49],"brain":[50,90],"magnetic":[51],"resonance":[52],"imaging,":[53],"a":[55],"method":[56],"combining":[57],"multi-level":[58],"3D":[59],"U-NET":[60],"proposed":[62],"based":[63],"on":[64],"single-stage":[65],"U-NET.":[66],"The":[67],"results":[68],"showed":[69],"that":[70],"this":[71],"model":[72],"could":[73],"enhance":[74],"segmentation":[76,81],"performance,":[77],"significantly":[78],"improved":[79],"which":[83],"had":[84],"certain":[85],"clinical":[86],"significance":[87],"for":[88],"automatic":[97],"discrimination":[98],"disease.":[101]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2025-12-25T23:11:45.687758","created_date":"2025-10-10T00:00:00"}
