{"id":"https://openalex.org/W1097776622","doi":"https://doi.org/10.3233/ao-150147","title":"Causality and the ontology of disease","display_name":"Causality and the ontology of disease","publication_year":2015,"publication_date":"2015-09-15","ids":{"openalex":"https://openalex.org/W1097776622","doi":"https://doi.org/10.3233/ao-150147","mag":"1097776622"},"language":"en","primary_location":{"id":"doi:10.3233/ao-150147","is_oa":true,"landing_page_url":"https://doi.org/10.3233/ao-150147","pdf_url":"https://content.iospress.com:443/download/applied-ontology/ao147?id=applied-ontology%2Fao147","source":{"id":"https://openalex.org/S31619775","display_name":"Applied Ontology","issn_l":"1570-5838","issn":["1570-5838","1875-8533"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Ontology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://content.iospress.com:443/download/applied-ontology/ao147?id=applied-ontology%2Fao147","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083819814","display_name":"Robert J. Rovetto","orcid":"https://orcid.org/0000-0003-3835-7817"},"institutions":[{"id":"https://openalex.org/I177738480","display_name":"Japan Advanced Institute of Science and Technology","ror":"https://ror.org/03frj4r98","country_code":"JP","type":"education","lineage":["https://openalex.org/I177738480"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Robert J. Rovetto","raw_affiliation_strings":["Research Center for Service Science, School of Knowledge Science, Japan Advanced Institute of Science and Technology, Nomi, Japan. E-mails:\u00a0rrovetto@buffalo.edu,\u00a0ontologos@yahoo.com; mizo@jaist.ac.jp"],"affiliations":[{"raw_affiliation_string":"Research Center for Service Science, School of Knowledge Science, Japan Advanced Institute of Science and Technology, Nomi, Japan. E-mails:\u00a0rrovetto@buffalo.edu,\u00a0ontologos@yahoo.com; mizo@jaist.ac.jp","institution_ids":["https://openalex.org/I177738480"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078525116","display_name":"Riichiro Mizoguchi","orcid":"https://orcid.org/0000-0001-7048-2904"},"institutions":[{"id":"https://openalex.org/I177738480","display_name":"Japan Advanced Institute of Science and Technology","ror":"https://ror.org/03frj4r98","country_code":"JP","type":"education","lineage":["https://openalex.org/I177738480"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Riichiro Mizoguchi","raw_affiliation_strings":["Research Center for Service Science, School of Knowledge Science, Japan Advanced Institute of Science and Technology, Nomi, Japan. E-mails:\u00a0rrovetto@buffalo.edu,\u00a0ontologos@yahoo.com; mizo@jaist.ac.jp"],"affiliations":[{"raw_affiliation_string":"Research Center for Service Science, School of Knowledge Science, Japan Advanced Institute of Science and Technology, Nomi, Japan. E-mails:\u00a0rrovetto@buffalo.edu,\u00a0ontologos@yahoo.com; mizo@jaist.ac.jp","institution_ids":["https://openalex.org/I177738480"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5083819814"],"corresponding_institution_ids":["https://openalex.org/I177738480"],"apc_list":null,"apc_paid":null,"fwci":1.2074,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.77918741,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"10","issue":"2","first_page":"79","last_page":"105"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10215","display_name":"Semantic Web and Ontologies","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.9807000160217285,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/causality","display_name":"Causality (physics)","score":0.8527892827987671},{"id":"https://openalex.org/keywords/ontology","display_name":"Ontology","score":0.7441841959953308},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6382830142974854},{"id":"https://openalex.org/keywords/formal-ontology","display_name":"Formal ontology","score":0.6335515379905701},{"id":"https://openalex.org/keywords/representation","display_name":"Representation (politics)","score":0.5379847288131714},{"id":"https://openalex.org/keywords/interoperability","display_name":"Interoperability","score":0.5335628986358643},{"id":"https://openalex.org/keywords/analogy","display_name":"Analogy","score":0.5316159129142761},{"id":"https://openalex.org/keywords/epistemology","display_name":"Epistemology","score":0.45556214451789856},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.4346825182437897},{"id":"https://openalex.org/keywords/causal-chain","display_name":"Causal chain","score":0.4207676351070404},{"id":"https://openalex.org/keywords/upper-ontology","display_name":"Upper ontology","score":0.3544309139251709},{"id":"https://openalex.org/keywords/information-retrieval","display_name":"Information retrieval","score":0.2930416464805603},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.17454037070274353},{"id":"https://openalex.org/keywords/philosophy","display_name":"Philosophy","score":0.12383899092674255},{"id":"https://openalex.org/keywords/world-wide-web","display_name":"World Wide Web","score":0.09869065880775452},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.06936794519424438},{"id":"https://openalex.org/keywords/semantic-web","display_name":"Semantic Web","score":0.06381940841674805}],"concepts":[{"id":"https://openalex.org/C64357122","wikidata":"https://www.wikidata.org/wiki/Q1149766","display_name":"Causality (physics)","level":2,"score":0.8527892827987671},{"id":"https://openalex.org/C25810664","wikidata":"https://www.wikidata.org/wiki/Q44325","display_name":"Ontology","level":2,"score":0.7441841959953308},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6382830142974854},{"id":"https://openalex.org/C2778177438","wikidata":"https://www.wikidata.org/wiki/Q1437388","display_name":"Formal ontology","level":4,"score":0.6335515379905701},{"id":"https://openalex.org/C2776359362","wikidata":"https://www.wikidata.org/wiki/Q2145286","display_name":"Representation (politics)","level":3,"score":0.5379847288131714},{"id":"https://openalex.org/C20136886","wikidata":"https://www.wikidata.org/wiki/Q749647","display_name":"Interoperability","level":2,"score":0.5335628986358643},{"id":"https://openalex.org/C521332185","wikidata":"https://www.wikidata.org/wiki/Q185816","display_name":"Analogy","level":2,"score":0.5316159129142761},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.45556214451789856},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4346825182437897},{"id":"https://openalex.org/C79897977","wikidata":"https://www.wikidata.org/wiki/Q5054568","display_name":"Causal chain","level":2,"score":0.4207676351070404},{"id":"https://openalex.org/C78726541","wikidata":"https://www.wikidata.org/wiki/Q3882785","display_name":"Upper ontology","level":3,"score":0.3544309139251709},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.2930416464805603},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17454037070274353},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.12383899092674255},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.09869065880775452},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.06936794519424438},{"id":"https://openalex.org/C2129575","wikidata":"https://www.wikidata.org/wiki/Q54837","display_name":"Semantic Web","level":2,"score":0.06381940841674805},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C94625758","wikidata":"https://www.wikidata.org/wiki/Q7163","display_name":"Politics","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3233/ao-150147","is_oa":true,"landing_page_url":"https://doi.org/10.3233/ao-150147","pdf_url":"https://content.iospress.com:443/download/applied-ontology/ao147?id=applied-ontology%2Fao147","source":{"id":"https://openalex.org/S31619775","display_name":"Applied Ontology","issn_l":"1570-5838","issn":["1570-5838","1875-8533"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Ontology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3233/ao-150147","is_oa":true,"landing_page_url":"https://doi.org/10.3233/ao-150147","pdf_url":"https://content.iospress.com:443/download/applied-ontology/ao147?id=applied-ontology%2Fao147","source":{"id":"https://openalex.org/S31619775","display_name":"Applied Ontology","issn_l":"1570-5838","issn":["1570-5838","1875-8533"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Ontology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G5256887504","display_name":null,"funder_award_id":"Japan Society for the Promotion of Science (JSPS)","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6200307566","display_name":null,"funder_award_id":"Funding Program for World-Leading I","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7126264696","display_name":null,"funder_award_id":"FIRST","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G916815637","display_name":null,"funder_award_id":"Funding Program for World-Leading Innovative R&D on Science and Technology","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1097776622.pdf","grobid_xml":"https://content.openalex.org/works/W1097776622.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W78386069","https://openalex.org/W78705842","https://openalex.org/W611029849","https://openalex.org/W1425333412","https://openalex.org/W1497370332","https://openalex.org/W1516237339","https://openalex.org/W1520281416","https://openalex.org/W1568122425","https://openalex.org/W1604608156","https://openalex.org/W1831078002","https://openalex.org/W1964851455","https://openalex.org/W1971076812","https://openalex.org/W1984168288","https://openalex.org/W2002296893","https://openalex.org/W2012639032","https://openalex.org/W2012881519","https://openalex.org/W2020718817","https://openalex.org/W2066378469","https://openalex.org/W2074174254","https://openalex.org/W2076581021","https://openalex.org/W2086168608","https://openalex.org/W2100920507","https://openalex.org/W2103000060","https://openalex.org/W2103260426","https://openalex.org/W2104591793","https://openalex.org/W2106361952","https://openalex.org/W2118369690","https://openalex.org/W2123257486","https://openalex.org/W2135140530","https://openalex.org/W2139159290","https://openalex.org/W2140080033","https://openalex.org/W2147714160","https://openalex.org/W2148876986","https://openalex.org/W2161484642","https://openalex.org/W2168247166","https://openalex.org/W2344667314","https://openalex.org/W2394642699","https://openalex.org/W2397263652","https://openalex.org/W2398647009","https://openalex.org/W2401349301","https://openalex.org/W2403183664","https://openalex.org/W2403559332","https://openalex.org/W2555296462","https://openalex.org/W2625159393","https://openalex.org/W2789165999","https://openalex.org/W2799987999","https://openalex.org/W3009247984","https://openalex.org/W3021292282","https://openalex.org/W4230026809","https://openalex.org/W4230870106","https://openalex.org/W4236565667","https://openalex.org/W4236868658","https://openalex.org/W4236893848","https://openalex.org/W4245086050","https://openalex.org/W4285719527","https://openalex.org/W6618970685","https://openalex.org/W6629705125","https://openalex.org/W6635948805","https://openalex.org/W6680145453","https://openalex.org/W6712379504","https://openalex.org/W6713174072","https://openalex.org/W6729552377"],"related_works":["https://openalex.org/W2910876652","https://openalex.org/W1509244320","https://openalex.org/W2364487718","https://openalex.org/W2118281964","https://openalex.org/W2127701157","https://openalex.org/W4386929681","https://openalex.org/W2170920069","https://openalex.org/W1994780253","https://openalex.org/W2174149409","https://openalex.org/W2253640873"],"abstract_inverted_index":{"The":[0,41,67,94,124],"goal":[1],"of":[2,23,38,47,53,59,64,70,91,135],"this":[3],"paper":[4],"is":[5,43,72,83,96,126],"two-fold:":[6],"first,":[7],"to":[8,30,98,113,131],"emphasize":[9],"causality":[10,24,60],"in":[11,89,106,117,129],"disease":[12,71,81],"ontology":[13],"and":[14,20,25,28,32,78,121],"knowledge":[15,58],"representation,":[16],"presenting":[17],"a":[18],"general":[19,57],"cursory":[21],"discussion":[22],"causal":[26,51,65,87,92],"chains;":[27],"second,":[29],"clarify":[31],"develop":[33],"the":[34,50,62,79,101,122],"River":[35],"Flow":[36],"Model":[37],"Diseases":[39],"(RFM).":[40],"RFM":[42,80,103,125],"an":[44],"ontological":[45,133],"account":[46,134],"disease,":[48],"representing":[49],"structure":[52],"pathology.":[54],"It":[55],"applies":[56],"using":[61],"concept":[63],"chains.":[66],"river":[68],"analogy":[69],"explained,":[73],"formal":[74],"descriptions":[75],"are":[76,138],"offered,":[77],"definition":[82,95],"refined":[84],"by":[85],"describing":[86],"chains":[88],"terms":[90],"relations.":[93],"updated":[97],"coincide":[99],"with":[100],"actual":[102],"classes":[104],"found":[105],"its":[107],"upper-level":[108],"ontology,":[109],"YAMATO,":[110],"which":[111],"brings":[112],"light":[114],"some":[115],"challenges":[116],"developing":[118],"both":[119],"YAMATO":[120],"RFM.":[123],"also":[127],"discussed":[128],"relation":[130],"another":[132],"disease.":[136],"Strategies":[137],"offered":[139],"toward":[140],"interoperability":[141],"between":[142],"these":[143],"theories.":[144]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2015,"cited_by_count":2}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}