{"id":"https://openalex.org/W2522620124","doi":"https://doi.org/10.3233/978-1-61499-678-1-745","title":"Constructing an ROC Curve to Assess a Treatment-Predictive Continuous Biomarker","display_name":"Constructing an ROC Curve to Assess a Treatment-Predictive Continuous Biomarker","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2522620124","doi":"https://doi.org/10.3233/978-1-61499-678-1-745","mag":"2522620124","pmid":"https://pubmed.ncbi.nlm.nih.gov/27577485"},"language":"en","primary_location":{"id":"doi:10.3233/978-1-61499-678-1-745","is_oa":false,"landing_page_url":"https://doi.org/10.3233/978-1-61499-678-1-745","pdf_url":null,"source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035864933","display_name":"Alexander Engelhardt","orcid":null},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Engelhardt Alexander","raw_affiliation_strings":["IBE, University of Munich"],"affiliations":[{"raw_affiliation_string":"IBE, University of Munich","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107953132","display_name":"Yuming Shen","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shen Yu-Ming","raw_affiliation_strings":["IBE, University of Munich"],"affiliations":[{"raw_affiliation_string":"IBE, University of Munich","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057302175","display_name":"Ulrich Mansmann","orcid":"https://orcid.org/0000-0002-9955-8906"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mansmann Ulrich","raw_affiliation_strings":["IBE, University of Munich"],"affiliations":[{"raw_affiliation_string":"IBE, University of Munich","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5035864933"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0412,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.78120411,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"228","issue":null,"first_page":"745","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14400","display_name":"Medical Coding and Health Information","score":0.9736999869346619,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T14400","display_name":"Medical Coding and Health Information","score":0.9736999869346619,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13309","display_name":"Reliability and Agreement in Measurement","score":0.9718999862670898,"subfield":{"id":"https://openalex.org/subfields/1804","display_name":"Statistics, Probability and Uncertainty"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/receiver-operating-characteristic","display_name":"Receiver operating characteristic","score":0.743396520614624},{"id":"https://openalex.org/keywords/estimator","display_name":"Estimator","score":0.7053233981132507},{"id":"https://openalex.org/keywords/biomarker","display_name":"Biomarker","score":0.6847468018531799},{"id":"https://openalex.org/keywords/parametric-statistics","display_name":"Parametric statistics","score":0.5952873826026917},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4844820201396942},{"id":"https://openalex.org/keywords/outcome","display_name":"Outcome (game theory)","score":0.45890066027641296},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.4410223960876465},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.4118272662162781},{"id":"https://openalex.org/keywords/econometrics","display_name":"Econometrics","score":0.32459574937820435},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.28650522232055664},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.28459328413009644}],"concepts":[{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.743396520614624},{"id":"https://openalex.org/C185429906","wikidata":"https://www.wikidata.org/wiki/Q1130160","display_name":"Estimator","level":2,"score":0.7053233981132507},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6847468018531799},{"id":"https://openalex.org/C117251300","wikidata":"https://www.wikidata.org/wiki/Q1849855","display_name":"Parametric statistics","level":2,"score":0.5952873826026917},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4844820201396942},{"id":"https://openalex.org/C148220186","wikidata":"https://www.wikidata.org/wiki/Q7111912","display_name":"Outcome (game theory)","level":2,"score":0.45890066027641296},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.4410223960876465},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.4118272662162781},{"id":"https://openalex.org/C149782125","wikidata":"https://www.wikidata.org/wiki/Q160039","display_name":"Econometrics","level":1,"score":0.32459574937820435},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.28650522232055664},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.28459328413009644},{"id":"https://openalex.org/C144237770","wikidata":"https://www.wikidata.org/wiki/Q747534","display_name":"Mathematical economics","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020000","descriptor_name":"Decision Support Systems, Clinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020000","descriptor_name":"Decision Support Systems, Clinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020000","descriptor_name":"Decision Support Systems, Clinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.3233/978-1-61499-678-1-745","is_oa":false,"landing_page_url":"https://doi.org/10.3233/978-1-61499-678-1-745","pdf_url":null,"source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},{"id":"pmid:27577485","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27577485","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in health technology and informatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Reduced inequalities","id":"https://metadata.un.org/sdg/10","score":0.7699999809265137}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4385649027","https://openalex.org/W2978999882","https://openalex.org/W4287880334","https://openalex.org/W4400094315","https://openalex.org/W4366700029","https://openalex.org/W4285230481","https://openalex.org/W3141031773","https://openalex.org/W4385769873","https://openalex.org/W1595686156","https://openalex.org/W2181392282"],"abstract_inverted_index":{"This":[0],"paper":[1],"presents":[2],"the":[3,11,22,48,65,82,125],"idea":[4],"of":[5,14],"an":[6,43],"ROC":[7,44],"curve,":[8],"which":[9],"quantifies":[10],"discriminatory":[12],"potential":[13],"a":[15,31,51,69,73,86,91,96,103,108,112],"continuous":[16],"biomarker":[17,70,113],"for":[18,118],"treatment":[19,59,66,119],"selection":[20],"when":[21],"outcome":[23],"is":[24],"continuous.":[25],"The":[26],"analysis":[27],"assumes":[28],"data":[29,98],"from":[30],"randomized":[32],"parallel":[33],"group":[34,67],"design.":[35],"We":[36],"use":[37],"non-parametric":[38,77],"density":[39],"estimators":[40],"to":[41,58,62,81,95,127],"construct":[42],"curve":[45],"based":[46,89],"on":[47,90],"probabilities":[49],"that":[50,101],"(non-)responder,":[52],"defined":[53],"by":[54],"better":[55],"(worse)":[56],"response":[57],"as":[60],"opposed":[61],"control,":[63],"in":[64,85,107],"has":[68],"value":[71,74],"above":[72],"c.":[75],"Our":[76,121],"approach":[78],"comes":[79],"close":[80],"true":[83],"AUC":[84],"simulation":[87],"study":[88,123],"normal":[92],"distribution.":[93],"Application":[94],"real":[97],"set":[99],"shows":[100],"despite":[102],"significant":[104],"interaction":[105],"term":[106],"proportional":[109],"hazards":[110],"model,":[111],"may":[114],"not":[115],"be":[116],"helpful":[117],"decisions.":[120],"proof-of-principle":[122],"opens":[124],"door":[126],"further":[128],"developments":[129],"and":[130],"generalizations.":[131]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
