{"id":"https://openalex.org/W2401123894","doi":"https://doi.org/10.3233/978-1-61499-432-9-970","title":"PAT: An Intelligent Authoring Tool for Facilitating Clinical Trial Design","display_name":"PAT: An Intelligent Authoring Tool for Facilitating Clinical Trial Design","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2401123894","doi":"https://doi.org/10.3233/978-1-61499-432-9-970","mag":"2401123894","pmid":"https://pubmed.ncbi.nlm.nih.gov/25160332"},"language":"en","primary_location":{"id":"doi:10.3233/978-1-61499-432-9-970","is_oa":false,"landing_page_url":"https://doi.org/10.3233/978-1-61499-432-9-970","pdf_url":null,"source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108240995","display_name":"Anastasios Tagaris","orcid":null},"institutions":[{"id":"https://openalex.org/I174458059","display_name":"National Technical University of Athens","ror":"https://ror.org/03cx6bg69","country_code":"GR","type":"education","lineage":["https://openalex.org/I174458059"]},{"id":"https://openalex.org/I4210144519","display_name":"Institute of Communication and Computer Systems","ror":"https://ror.org/0483fn738","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4210144519"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Tagaris Anastasios","raw_affiliation_strings":["Institute of Communication and Computer Systems (ICCS), National Technical University of Athens, (NTUA), Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Communication and Computer Systems (ICCS), National Technical University of Athens, (NTUA), Greece","institution_ids":["https://openalex.org/I174458059","https://openalex.org/I4210144519"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Andronikou Vassiliki","orcid":null},"institutions":[{"id":"https://openalex.org/I174458059","display_name":"National Technical University of Athens","ror":"https://ror.org/03cx6bg69","country_code":"GR","type":"education","lineage":["https://openalex.org/I174458059"]},{"id":"https://openalex.org/I4210144519","display_name":"Institute of Communication and Computer Systems","ror":"https://ror.org/0483fn738","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4210144519"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Andronikou Vassiliki","raw_affiliation_strings":["Institute of Communication and Computer Systems (ICCS), National Technical University of Athens, (NTUA), Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Communication and Computer Systems (ICCS), National Technical University of Athens, (NTUA), Greece","institution_ids":["https://openalex.org/I174458059","https://openalex.org/I4210144519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064880228","display_name":"Efstathios Karanastasis","orcid":"https://orcid.org/0000-0003-0460-4648"},"institutions":[{"id":"https://openalex.org/I174458059","display_name":"National Technical University of Athens","ror":"https://ror.org/03cx6bg69","country_code":"GR","type":"education","lineage":["https://openalex.org/I174458059"]},{"id":"https://openalex.org/I4210144519","display_name":"Institute of Communication and Computer Systems","ror":"https://ror.org/0483fn738","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4210144519"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Karanastasis Efstathios","raw_affiliation_strings":["Institute of Communication and Computer Systems (ICCS), National Technical University of Athens, (NTUA), Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Communication and Computer Systems (ICCS), National Technical University of Athens, (NTUA), Greece","institution_ids":["https://openalex.org/I174458059","https://openalex.org/I4210144519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068960664","display_name":"Efthymios Chondrogiannis","orcid":"https://orcid.org/0000-0003-3865-2277"},"institutions":[{"id":"https://openalex.org/I174458059","display_name":"National Technical University of Athens","ror":"https://ror.org/03cx6bg69","country_code":"GR","type":"education","lineage":["https://openalex.org/I174458059"]},{"id":"https://openalex.org/I4210144519","display_name":"Institute of Communication and Computer Systems","ror":"https://ror.org/0483fn738","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4210144519"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Chondrogiannis Efthymios","raw_affiliation_strings":["Institute of Communication and Computer Systems (ICCS), National Technical University of Athens, (NTUA), Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Communication and Computer Systems (ICCS), National Technical University of Athens, (NTUA), Greece","institution_ids":["https://openalex.org/I174458059","https://openalex.org/I4210144519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005150979","display_name":"Charalambos Tsirmpas","orcid":null},"institutions":[{"id":"https://openalex.org/I174458059","display_name":"National Technical University of Athens","ror":"https://ror.org/03cx6bg69","country_code":"GR","type":"education","lineage":["https://openalex.org/I174458059"]},{"id":"https://openalex.org/I4210144519","display_name":"Institute of Communication and Computer Systems","ror":"https://ror.org/0483fn738","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4210144519"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Tsirmpas Charalambos","raw_affiliation_strings":["Institute of Communication and Computer Systems (ICCS), National Technical University of Athens, (NTUA), Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Communication and Computer Systems (ICCS), National Technical University of Athens, (NTUA), Greece","institution_ids":["https://openalex.org/I174458059","https://openalex.org/I4210144519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089215627","display_name":"Theodora Varvarigou","orcid":null},"institutions":[{"id":"https://openalex.org/I174458059","display_name":"National Technical University of Athens","ror":"https://ror.org/03cx6bg69","country_code":"GR","type":"education","lineage":["https://openalex.org/I174458059"]},{"id":"https://openalex.org/I4210144519","display_name":"Institute of Communication and Computer Systems","ror":"https://ror.org/0483fn738","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4210144519"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Varvarigou Theodora","raw_affiliation_strings":["Institute of Communication and Computer Systems (ICCS), National Technical University of Athens, (NTUA), Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Communication and Computer Systems (ICCS), National Technical University of Athens, (NTUA), Greece","institution_ids":["https://openalex.org/I174458059","https://openalex.org/I4210144519"]}]},{"author_position":"last","author":{"id":null,"display_name":"Koutsouris Dimitris","orcid":null},"institutions":[{"id":"https://openalex.org/I174458059","display_name":"National Technical University of Athens","ror":"https://ror.org/03cx6bg69","country_code":"GR","type":"education","lineage":["https://openalex.org/I174458059"]},{"id":"https://openalex.org/I4210144519","display_name":"Institute of Communication and Computer Systems","ror":"https://ror.org/0483fn738","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4210144519"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Koutsouris Dimitris","raw_affiliation_strings":["Institute of Communication and Computer Systems (ICCS), National Technical University of Athens, (NTUA), Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Communication and Computer Systems (ICCS), National Technical University of Athens, (NTUA), Greece","institution_ids":["https://openalex.org/I174458059","https://openalex.org/I4210144519"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5108240995"],"corresponding_institution_ids":["https://openalex.org/I174458059","https://openalex.org/I4210144519"],"apc_list":null,"apc_paid":null,"fwci":0.4991,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.69373353,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":95},"biblio":{"volume":"205","issue":null,"first_page":"970","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11986","display_name":"Scientific Computing and Data Management","score":0.9807000160217285,"subfield":{"id":"https://openalex.org/subfields/1802","display_name":"Information Systems and Management"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10215","display_name":"Semantic Web and Ontologies","score":0.9787999987602234,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pipeline","display_name":"Pipeline (software)","score":0.6049268841743469},{"id":"https://openalex.org/keywords/clinical-trial","display_name":"Clinical trial","score":0.6041120290756226},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5753102898597717},{"id":"https://openalex.org/keywords/domain","display_name":"Domain (mathematical analysis)","score":0.5343443751335144},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.5222110152244568},{"id":"https://openalex.org/keywords/knowledge-management","display_name":"Knowledge management","score":0.36616024374961853},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.18602243065834045}],"concepts":[{"id":"https://openalex.org/C43521106","wikidata":"https://www.wikidata.org/wiki/Q2165493","display_name":"Pipeline (software)","level":2,"score":0.6049268841743469},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.6041120290756226},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5753102898597717},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.5343443751335144},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.5222110152244568},{"id":"https://openalex.org/C56739046","wikidata":"https://www.wikidata.org/wiki/Q192060","display_name":"Knowledge management","level":1,"score":0.36616024374961853},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18602243065834045},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001319","descriptor_name":"Authorship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001319","descriptor_name":"Authorship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001319","descriptor_name":"Authorship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D009323","descriptor_name":"Natural Language Processing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009323","descriptor_name":"Natural Language Processing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009323","descriptor_name":"Natural Language Processing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012042","descriptor_name":"Registries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012042","descriptor_name":"Registries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012042","descriptor_name":"Registries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012985","descriptor_name":"Software Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012985","descriptor_name":"Software Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012985","descriptor_name":"Software Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014956","descriptor_name":"Writing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014956","descriptor_name":"Writing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014956","descriptor_name":"Writing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018579","descriptor_name":"Patient Selection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018579","descriptor_name":"Patient Selection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018579","descriptor_name":"Patient Selection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.3233/978-1-61499-432-9-970","is_oa":false,"landing_page_url":"https://doi.org/10.3233/978-1-61499-432-9-970","pdf_url":null,"source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Health Technology and Informatics","raw_type":"book-chapter"},{"id":"pmid:25160332","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25160332","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in health technology and informatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3037187668","https://openalex.org/W4234772502","https://openalex.org/W2380685755","https://openalex.org/W2252100032","https://openalex.org/W2963436428","https://openalex.org/W4400978025","https://openalex.org/W2918743509","https://openalex.org/W2734796617","https://openalex.org/W3083218341","https://openalex.org/W3034087822"],"abstract_inverted_index":{"Great":[0],"investments":[1],"are":[2,52],"made":[3],"by":[4,71],"both":[5],"private":[6],"and":[7,10,20,27,43,64,82],"public":[8],"funds":[9],"a":[11,35,55,104],"wealth":[12],"of":[13,58],"research":[14,19],"findings":[15],"is":[16],"published,":[17],"the":[18,85],"development":[21],"pipeline":[22],"phases":[23],"quite":[24],"low":[25],"productivity":[26],"tremendous":[28],"delays.":[29],"In":[30],"this":[31],"paper,":[32],"we":[33],"present":[34],"novel":[36],"authoring":[37],"tool":[38,106],"which":[39],"has":[40],"been":[41],"designed":[42],"developed":[44],"for":[45],"facilitating":[46],"study":[47,86],"design.":[48,115],"Its":[49],"underlying":[50],"models":[51],"based":[53],"on":[54],"thorough":[56],"analysis":[57],"existing":[59],"clinical":[60,113],"trial":[61,114],"protocols":[62],"(CTPs)":[63],"eligibility":[65],"criteria":[66],"(EC)":[67],"published":[68],"in":[69],"clinicaltrials.gov":[70],"domain":[72],"experts.":[73],"Moreover,":[74],"its":[75,96],"integration":[76],"with":[77,89],"intelligent":[78],"decision":[79],"support":[80,109],"services":[81],"mechanisms":[83],"linking":[84],"design":[87],"process":[88],"healthcare":[90],"patient":[91],"data":[92],"as":[93,95,103],"well":[94],"direct":[97],"access":[98],"to":[99,110],"literature":[100],"designate":[101],"it":[102],"powerful":[105],"offering":[107],"great":[108],"researchers":[111],"during":[112]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}