{"id":"https://openalex.org/W4407809959","doi":"https://doi.org/10.3233/978-1-60750-072-8-271","title":"Computational Intelligence Methods for Discovering Diagnostic Gene Targets about aGVHD","display_name":"Computational Intelligence Methods for Discovering Diagnostic Gene Targets about aGVHD","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W4407809959","doi":"https://doi.org/10.3233/978-1-60750-072-8-271"},"language":"en","primary_location":{"id":"doi:10.3233/978-1-60750-072-8-271","is_oa":false,"landing_page_url":"https://doi.org/10.3233/978-1-60750-072-8-271","pdf_url":null,"source":{"id":"https://openalex.org/S4210201731","display_name":"Frontiers in artificial intelligence and applications","issn_l":"0922-6389","issn":["0922-6389","1879-8314"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Artificial Intelligence and Applications","raw_type":"book-chapter"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5116362678","display_name":"Fiasch eacute Maurizio","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fiasché Maurizio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087812412","display_name":"Cuzzola Maria","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cuzzola Maria","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116362679","display_name":"Fedele Roberta","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fedele Roberta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116362680","display_name":"Princi Domenica","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Princi Domenica","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102589275","display_name":"Cacciola Matteo","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cacciola Matteo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028728397","display_name":"Megali Giuseppe","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Megali Giuseppe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063564306","display_name":"Pasquale Iacopino","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Iacopino Pasquale","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5116362681","display_name":"Morabito Francesco C.","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Morabito Francesco C.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.65617301,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.8371999859809875,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.8371999859809875,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5538640022277832},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4356808662414551},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2997315526008606}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5538640022277832},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4356808662414551},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2997315526008606}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3233/978-1-60750-072-8-271","is_oa":false,"landing_page_url":"https://doi.org/10.3233/978-1-60750-072-8-271","pdf_url":null,"source":{"id":"https://openalex.org/S4210201731","display_name":"Frontiers in artificial intelligence and applications","issn_l":"0922-6389","issn":["0922-6389","1879-8314"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Artificial Intelligence and Applications","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W4391913857","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052"],"abstract_inverted_index":{"This":[0,33,102],"is":[1,34,49,103],"an":[2,45],"application":[3],"paper":[4,65],"of":[5,13,24,70,99,110,123,127,131],"applying":[6],"classical":[7],"statistical":[8],"methods":[9],"and":[10,107,117],"standard":[11],"technique":[12],"computational":[14,116],"intelligence":[15],"to":[16,80,93],"identify":[17],"gene":[18],"diagnostic":[19],"targets":[20],"for":[21,120,129,134],"accurate":[22],"diagnosis":[23,130],"a":[25,91,104,124],"medical":[26],"problem":[27],"–":[28],"acute":[29],"graft-versus-host":[30],"disease":[31],"(aGVHD).":[32],"the":[35,95,108,121],"major":[36],"complication":[37],"after":[38,59],"allogeneic":[39],"haematopoietic":[40],"stem":[41],"cell":[42],"transplantation":[43],"(HSCT),":[44],"immunomediated":[46],"disorder":[47],"that":[48],"driven":[50],"by":[51],"allospecific":[52],"lymphocytes":[53],"since":[54],"aGVHD":[55,96],"does":[56],"not":[57],"occur":[58],"autologous":[60],"stem-cell":[61],"transplantation.":[62],"In":[63],"this":[64],"we":[66],"analyzed":[67],"gene-expression":[68],"profiles":[69],"47":[71],"genes":[72,128],"associated":[73],"with":[74,90],"allo-reactivity":[75],"in":[76],"59":[77],"patients":[78],"submitted":[79],"HSCT.":[81],"We":[82],"have":[83],"applied":[84],"2":[85],"feature":[86],"selection":[87],"algorithms":[88],"combined":[89],"classifier":[92],"detect":[94],"at":[97],"on-set":[98],"clinical":[100],"signs.":[101],"preliminary":[105],"study":[106],"continuance":[109],"our":[111],"works":[112],"which":[113],"tackles":[114],"both":[115],"biological":[118],"evidence":[119],"involvement":[122],"limited":[125],"number":[126],"aGVHD.":[132],"Directions":[133],"further":[135],"studies":[136],"are":[137],"outlined.":[138]},"counts_by_year":[],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}