{"id":"https://openalex.org/W1559085096","doi":"https://doi.org/10.3166/ejc.15.389-397","title":"Engineering Principles in Bio-molecular Systems: From Retroactivity to Modularity","display_name":"Engineering Principles in Bio-molecular Systems: From Retroactivity to Modularity","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W1559085096","doi":"https://doi.org/10.3166/ejc.15.389-397","mag":"1559085096"},"language":"en","primary_location":{"id":"doi:10.3166/ejc.15.389-397","is_oa":false,"landing_page_url":"https://doi.org/10.3166/ejc.15.389-397","pdf_url":null,"source":{"id":"https://openalex.org/S21401918","display_name":"European Journal of Control","issn_l":"0947-3580","issn":["0947-3580","1435-5671"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Control","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036095256","display_name":"Domitilla Del Vecchio","orcid":"https://orcid.org/0000-0001-6472-8576"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Domitilla Del Vecchio","raw_affiliation_strings":["Faculty of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, Michigan, USA","Faculty of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Faculty of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068753451","display_name":"Eduardo D. Sontag","orcid":"https://orcid.org/0000-0001-8020-5783"},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eduardo D. Sontag","raw_affiliation_strings":["Faculty of Mathematics, Rutgers University, Piscataway, New Jersey, USA","Faculty of Mathematics, Rutgers University, Piscataway, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Mathematics, Rutgers University, Piscataway, New Jersey, USA","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"Faculty of Mathematics, Rutgers University, Piscataway, USA","institution_ids":["https://openalex.org/I102322142"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5036095256"],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":{"value":2850,"currency":"USD","value_usd":2850},"apc_paid":null,"fwci":0.8813,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.71024715,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"15","issue":"3-4","first_page":"389","last_page":"397"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10502","display_name":"Advanced Memory and Neural Computing","score":0.9836999773979187,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.9787999987602234,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/modularity","display_name":"Modularity (biology)","score":0.9182400107383728},{"id":"https://openalex.org/keywords/realization","display_name":"Realization (probability)","score":0.5660752058029175},{"id":"https://openalex.org/keywords/electronics","display_name":"Electronics","score":0.5239022970199585},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.519464910030365},{"id":"https://openalex.org/keywords/complex-system","display_name":"Complex system","score":0.51099693775177},{"id":"https://openalex.org/keywords/modular-design","display_name":"Modular design","score":0.4853323996067047},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.44452568888664246},{"id":"https://openalex.org/keywords/interconnection","display_name":"Interconnection","score":0.43676140904426575},{"id":"https://openalex.org/keywords/control-engineering","display_name":"Control engineering","score":0.4158180356025696},{"id":"https://openalex.org/keywords/topology","display_name":"Topology (electrical circuits)","score":0.3481740355491638},{"id":"https://openalex.org/keywords/distributed-computing","display_name":"Distributed computing","score":0.34626665711402893},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.27276474237442017},{"id":"https://openalex.org/keywords/electrical-engineering","display_name":"Electrical engineering","score":0.20752352476119995},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.13431718945503235},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.13041892647743225},{"id":"https://openalex.org/keywords/telecommunications","display_name":"Telecommunications","score":0.122158944606781},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.10132288932800293},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.09689563512802124}],"concepts":[{"id":"https://openalex.org/C2779478453","wikidata":"https://www.wikidata.org/wiki/Q6889748","display_name":"Modularity (biology)","level":2,"score":0.9182400107383728},{"id":"https://openalex.org/C2781089630","wikidata":"https://www.wikidata.org/wiki/Q21856745","display_name":"Realization (probability)","level":2,"score":0.5660752058029175},{"id":"https://openalex.org/C138331895","wikidata":"https://www.wikidata.org/wiki/Q11650","display_name":"Electronics","level":2,"score":0.5239022970199585},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.519464910030365},{"id":"https://openalex.org/C47822265","wikidata":"https://www.wikidata.org/wiki/Q854457","display_name":"Complex system","level":2,"score":0.51099693775177},{"id":"https://openalex.org/C101468663","wikidata":"https://www.wikidata.org/wiki/Q1620158","display_name":"Modular design","level":2,"score":0.4853323996067047},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.44452568888664246},{"id":"https://openalex.org/C123745756","wikidata":"https://www.wikidata.org/wiki/Q1665949","display_name":"Interconnection","level":2,"score":0.43676140904426575},{"id":"https://openalex.org/C133731056","wikidata":"https://www.wikidata.org/wiki/Q4917288","display_name":"Control engineering","level":1,"score":0.4158180356025696},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.3481740355491638},{"id":"https://openalex.org/C120314980","wikidata":"https://www.wikidata.org/wiki/Q180634","display_name":"Distributed computing","level":1,"score":0.34626665711402893},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.27276474237442017},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.20752352476119995},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13431718945503235},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.13041892647743225},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.122158944606781},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.10132288932800293},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.09689563512802124},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3166/ejc.15.389-397","is_oa":false,"landing_page_url":"https://doi.org/10.3166/ejc.15.389-397","pdf_url":null,"source":{"id":"https://openalex.org/S21401918","display_name":"European Journal of Control","issn_l":"0947-3580","issn":["0947-3580","1435-5671"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Control","raw_type":"journal-article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.152.2053","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.152.2053","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.eecs.umich.edu/~ddv/papers/EJC-ddv.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Affordable and clean energy","id":"https://metadata.un.org/sdg/7","score":0.4399999976158142}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1968782","https://openalex.org/W55814457","https://openalex.org/W1484739396","https://openalex.org/W1548148540","https://openalex.org/W1577364748","https://openalex.org/W1599969036","https://openalex.org/W1644749979","https://openalex.org/W1645305843","https://openalex.org/W1672455078","https://openalex.org/W1965623622","https://openalex.org/W1968286256","https://openalex.org/W1980396134","https://openalex.org/W2023120194","https://openalex.org/W2029018540","https://openalex.org/W2041886753","https://openalex.org/W2056732290","https://openalex.org/W2067160012","https://openalex.org/W2070658593","https://openalex.org/W2071928210","https://openalex.org/W2076232693","https://openalex.org/W2080149251","https://openalex.org/W2090167557","https://openalex.org/W2095387858","https://openalex.org/W2095477585","https://openalex.org/W2096337402","https://openalex.org/W2104203658","https://openalex.org/W2120966441","https://openalex.org/W2123097315","https://openalex.org/W2134759932","https://openalex.org/W2134800568","https://openalex.org/W2140347764","https://openalex.org/W2144355672","https://openalex.org/W2144588155","https://openalex.org/W2166499263","https://openalex.org/W2476238858","https://openalex.org/W2485242274","https://openalex.org/W2755764480","https://openalex.org/W2950097110","https://openalex.org/W3140388948","https://openalex.org/W4214690803","https://openalex.org/W4298691646","https://openalex.org/W6602273323","https://openalex.org/W6641563210","https://openalex.org/W6681364125"],"related_works":["https://openalex.org/W2297768894","https://openalex.org/W2378076731","https://openalex.org/W3109014690","https://openalex.org/W2122405502","https://openalex.org/W2884798239","https://openalex.org/W2114254072","https://openalex.org/W2127721729","https://openalex.org/W1531253727","https://openalex.org/W2366669483","https://openalex.org/W2080845967"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":1}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}