{"id":"https://openalex.org/W4409152727","doi":"https://doi.org/10.26599/bdma.2024.9020094","title":"Predicting the Imbalanced Impact of Drugs on Microbial Abundance Using Multi-View Learning and Data Augmentation","display_name":"Predicting the Imbalanced Impact of Drugs on Microbial Abundance Using Multi-View Learning and Data Augmentation","publication_year":2025,"publication_date":"2025-04-04","ids":{"openalex":"https://openalex.org/W4409152727","doi":"https://doi.org/10.26599/bdma.2024.9020094"},"language":"en","primary_location":{"id":"doi:10.26599/bdma.2024.9020094","is_oa":true,"landing_page_url":"https://doi.org/10.26599/bdma.2024.9020094","pdf_url":null,"source":{"id":"https://openalex.org/S4210209060","display_name":"Big Data Mining and Analytics","issn_l":"2096-0654","issn":["2096-0654"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311901","host_organization_name":"Tsinghua University Press","host_organization_lineage":["https://openalex.org/P4310311901"],"host_organization_lineage_names":["Tsinghua University Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Big Data Mining and Analytics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.26599/bdma.2024.9020094","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051632368","display_name":"Bei Zhu","orcid":"https://orcid.org/0000-0003-4411-6841"},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bei Zhu","raw_affiliation_strings":["School of Life Sciences, Northwestern Polytechnical University,Xi'an,China,710072"],"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Northwestern Polytechnical University,Xi'an,China,710072","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041687590","display_name":"Haoyang Yu","orcid":"https://orcid.org/0000-0001-7317-726X"},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haoyang Yu","raw_affiliation_strings":["School of Computer Science, Northwestern Polytechnical University,Xi'an,China,710129","School of Life Sciences, Northwestern Polytechnical University,Xi'an,China,710072"],"affiliations":[{"raw_affiliation_string":"School of Computer Science, Northwestern Polytechnical University,Xi'an,China,710129","institution_ids":["https://openalex.org/I17145004"]},{"raw_affiliation_string":"School of Life Sciences, Northwestern Polytechnical University,Xi'an,China,710072","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042932446","display_name":"Bing-Xue Du","orcid":null},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bingxue Du","raw_affiliation_strings":["School of Life Sciences, Northwestern Polytechnical University,Xi'an,China,710072"],"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Northwestern Polytechnical University,Xi'an,China,710072","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014009982","display_name":"Hui Yu","orcid":"https://orcid.org/0000-0002-5314-8127"},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Yu","raw_affiliation_strings":["School of Computer Science, Northwestern Polytechnical University,Xi'an,China,710129","School of Life Sciences, Northwestern Polytechnical University,Xi'an,China,710072"],"affiliations":[{"raw_affiliation_string":"School of Computer Science, Northwestern Polytechnical University,Xi'an,China,710129","institution_ids":["https://openalex.org/I17145004"]},{"raw_affiliation_string":"School of Life Sciences, Northwestern Polytechnical University,Xi'an,China,710072","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000609872","display_name":"Jian\u2010Yu Shi","orcid":"https://orcid.org/0000-0002-2303-273X"},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianyu Shi","raw_affiliation_strings":["School of Life Sciences, Northwestern Polytechnical University,Xi'an,China,710072"],"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Northwestern Polytechnical University,Xi'an,China,710072","institution_ids":["https://openalex.org/I17145004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5051632368"],"corresponding_institution_ids":["https://openalex.org/I17145004"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.08676976,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"3","first_page":"678","last_page":"693"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9646000266075134,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9646000266075134,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.902899980545044,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/abundance","display_name":"Abundance (ecology)","score":0.7242960929870605},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.40300071239471436},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.3887462913990021},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.3547530472278595},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.35016483068466187},{"id":"https://openalex.org/keywords/ecology","display_name":"Ecology","score":0.3217654824256897},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.31113922595977783},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2679929733276367}],"concepts":[{"id":"https://openalex.org/C77077793","wikidata":"https://www.wikidata.org/wiki/Q336019","display_name":"Abundance (ecology)","level":2,"score":0.7242960929870605},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.40300071239471436},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3887462913990021},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.3547530472278595},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.35016483068466187},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.3217654824256897},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.31113922595977783},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2679929733276367}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.26599/bdma.2024.9020094","is_oa":true,"landing_page_url":"https://doi.org/10.26599/bdma.2024.9020094","pdf_url":null,"source":{"id":"https://openalex.org/S4210209060","display_name":"Big Data Mining and Analytics","issn_l":"2096-0654","issn":["2096-0654"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311901","host_organization_name":"Tsinghua University Press","host_organization_lineage":["https://openalex.org/P4310311901"],"host_organization_lineage_names":["Tsinghua University Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Big Data Mining and Analytics","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:6b2798070ac94fb0b228177aa6bdb4e5","is_oa":true,"landing_page_url":"https://doaj.org/article/6b2798070ac94fb0b228177aa6bdb4e5","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Big Data Mining and Analytics, Vol 8, Iss 3, Pp 678-693 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.26599/bdma.2024.9020094","is_oa":true,"landing_page_url":"https://doi.org/10.26599/bdma.2024.9020094","pdf_url":null,"source":{"id":"https://openalex.org/S4210209060","display_name":"Big Data Mining and Analytics","issn_l":"2096-0654","issn":["2096-0654"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311901","host_organization_name":"Tsinghua University Press","host_organization_lineage":["https://openalex.org/P4310311901"],"host_organization_lineage_names":["Tsinghua University Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Big Data Mining and Analytics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.699999988079071}],"awards":[{"id":"https://openalex.org/G4276050119","display_name":null,"funder_award_id":"62372375","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1938013375","https://openalex.org/W1989470004","https://openalex.org/W2006255103","https://openalex.org/W2016988498","https://openalex.org/W2024165284","https://openalex.org/W2055043387","https://openalex.org/W2087064593","https://openalex.org/W2091110954","https://openalex.org/W2103704311","https://openalex.org/W2124685890","https://openalex.org/W2127218421","https://openalex.org/W2128728535","https://openalex.org/W2145578524","https://openalex.org/W2153294515","https://openalex.org/W2604314403","https://openalex.org/W2767891136","https://openalex.org/W2799504468","https://openalex.org/W2800240433","https://openalex.org/W2802200505","https://openalex.org/W2892880750","https://openalex.org/W2963566126","https://openalex.org/W3024321726","https://openalex.org/W3082059448","https://openalex.org/W3095002965","https://openalex.org/W3113162058","https://openalex.org/W3157889929","https://openalex.org/W3182924514","https://openalex.org/W3194560733","https://openalex.org/W4223609654","https://openalex.org/W4238732480","https://openalex.org/W4239510810","https://openalex.org/W4282919843","https://openalex.org/W4282926996","https://openalex.org/W4289274885","https://openalex.org/W4294216483","https://openalex.org/W4296044817","https://openalex.org/W4300672471","https://openalex.org/W4304116809","https://openalex.org/W4307468223","https://openalex.org/W4379967792","https://openalex.org/W4381051893","https://openalex.org/W4395447498","https://openalex.org/W4400762160","https://openalex.org/W6750729320","https://openalex.org/W6766978945","https://openalex.org/W6839071637"],"related_works":["https://openalex.org/W2961085424","https://openalex.org/W4306674287","https://openalex.org/W4387369504","https://openalex.org/W4394896187","https://openalex.org/W3170094116","https://openalex.org/W4386462264","https://openalex.org/W3107602296","https://openalex.org/W4364306694","https://openalex.org/W4312192474","https://openalex.org/W4283697347"],"abstract_inverted_index":{"The":[0],"interactions":[1],"between":[2],"drugs":[3,155,191],"and":[4,31,86,118,145,156,165,181,207],"microbes":[5,157],"affecting":[6],"microbial":[7,193],"abundance":[8,74,227],"can":[9,64],"lead":[10],"to":[11,46,139,150,167,177,186],"various":[12],"diseases":[13],"or":[14,71],"reduce":[15],"the":[16,34,73,80,106,188,197,211,226],"effectiveness":[17],"of":[18,36,75,109,128,154,190,199,213,229],"pharmaceutical":[19],"treatments.":[20],"Traditional":[21],"Microbe-Drug":[22],"Association":[23],"(MDA)":[24],"determination":[25],"through":[26,201],"biological":[27],"assays":[28],"is":[29],"time-consuming":[30],"costly.":[32],"With":[33],"accumulation":[35],"MDA":[37],"data,":[38],"computational":[39,93],"methods":[40,52],"have":[41],"become":[42],"a":[43,57,61,68,76,90,102,125,130,134,173,183,221],"promising":[44],"approach":[45],"infer":[47,66],"potential":[48],"MDAs.":[49],"Although":[50],"existing":[51],"focus":[53],"on":[54,111,192],"predicting":[55,105],"whether":[56,67],"drug":[58,69],"interacts":[59],"with":[60,203],"microbe,":[62],"they":[63],"rarely":[65],"promotes":[70],"inhibits":[72],"given":[77],"microbe.":[78],"Moreover,":[79],"extreme":[81],"imbalance":[82],"among":[83],"abundance-promoted,":[84],"abundance-inhibited,":[85],"non-impacted":[87],"cases":[88],"remains":[89],"challenge":[91],"for":[92,104],"prediction":[94],"methods.":[95],"To":[96],"address":[97],"these":[98],"issues,":[99],"we":[100],"propose":[101],"framework":[103],"imbalanced":[107],"Impact":[108],"Drugs":[110],"Microbial":[112],"Abundance":[113],"by":[114,233],"leveraging":[115],"Multi-view":[116],"Learning":[117],"Data":[119],"Augmentation,":[120],"named":[121],"IDMA-MLDA.":[122,234],"IDMA-MLDA":[123,200],"employs":[124,146],"novel":[126],"method":[127],"transforming":[129],"bipartite":[131],"graph":[132,147],"into":[133],"hypergraph,":[135],"uses":[136,182],"hypergraph":[137],"convolutions":[138],"capture":[140],"high-order":[141],"vertex":[142],"neighborhoods":[143],"(macro-view),":[144],"neural":[148],"networks":[149],"learn":[151],"individual":[152],"features":[153,161],"(micro-view).":[158],"It":[159],"integrates":[160],"from":[162],"both":[163],"macro-view":[164],"micro-view":[166],"obtain":[168],"more":[169],"comprehensive":[170,222],"representations,":[171],"incorporates":[172],"data":[174],"augmentation":[175],"module":[176,216],"handle":[178],"class":[179],"imbalance,":[180],"multilayer":[184],"perceptron":[185],"predict":[187],"impact":[189],"abundance.":[194],"We":[195],"demonstrate":[196],"superiority":[198],"comparisons":[202],"six":[204],"baseline":[205],"methods,":[206],"ablation":[208],"studies":[209],"affirm":[210],"contributions":[212],"each":[214],"key":[215],"in":[217],"IDMA-MLDA's":[218],"prediction.":[219],"Furthermore,":[220],"literature":[223],"review":[224],"verifies":[225],"types":[228],"twelve":[230],"MDAs":[231],"predicted":[232]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}