{"id":"https://openalex.org/W4405022357","doi":"https://doi.org/10.26599/bdma.2024.9020054","title":"MHCLSyn: Multi-View Hypergraph Contrastive Learning for Synergistic Drug Combination Prediction","display_name":"MHCLSyn: Multi-View Hypergraph Contrastive Learning for Synergistic Drug Combination Prediction","publication_year":2024,"publication_date":"2024-12-01","ids":{"openalex":"https://openalex.org/W4405022357","doi":"https://doi.org/10.26599/bdma.2024.9020054"},"language":"en","primary_location":{"id":"doi:10.26599/bdma.2024.9020054","is_oa":true,"landing_page_url":"https://doi.org/10.26599/bdma.2024.9020054","pdf_url":null,"source":{"id":"https://openalex.org/S4210209060","display_name":"Big Data Mining and Analytics","issn_l":"2096-0654","issn":["2096-0654"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311901","host_organization_name":"Tsinghua University Press","host_organization_lineage":["https://openalex.org/P4310311901"],"host_organization_lineage_names":["Tsinghua University Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Big Data Mining and Analytics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.26599/bdma.2024.9020054","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5092005330","display_name":"Lei Li","orcid":"https://orcid.org/0009-0009-9491-9547"},"institutions":[{"id":"https://openalex.org/I143868143","display_name":"Anhui University","ror":"https://ror.org/05th6yx34","country_code":"CN","type":"education","lineage":["https://openalex.org/I143868143"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lei Li","raw_affiliation_strings":["School of Artificial Intelligence, Anhui University,Hefei,China,230601","Institute of Artificial Intelligence, Hefei Comprehensive National Science Center, Hefei, China"],"affiliations":[{"raw_affiliation_string":"School of Artificial Intelligence, Anhui University,Hefei,China,230601","institution_ids":["https://openalex.org/I143868143"]},{"raw_affiliation_string":"Institute of Artificial Intelligence, Hefei Comprehensive National Science Center, Hefei, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112435955","display_name":"Guodong L\u00fc","orcid":"https://orcid.org/0009-0004-8833-5071"},"institutions":[{"id":"https://openalex.org/I2802734952","display_name":"First Affiliated Hospital of Xinjiang Medical University","ror":"https://ror.org/02qx1ae98","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802734952"]},{"id":"https://openalex.org/I154093214","display_name":"Xinjiang Medical University","ror":"https://ror.org/01p455v08","country_code":"CN","type":"education","lineage":["https://openalex.org/I154093214"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guodong L\u00fc","raw_affiliation_strings":["Clinical Medical Research Institute, The First Affiliated Hospital of Xinjiang Medical University,State Key Laboratory of Pathogenesis, Prevention, and Treatment of Central Asian High Incidence Diseases,Urumqi,China,830054"],"affiliations":[{"raw_affiliation_string":"Clinical Medical Research Institute, The First Affiliated Hospital of Xinjiang Medical University,State Key Laboratory of Pathogenesis, Prevention, and Treatment of Central Asian High Incidence Diseases,Urumqi,China,830054","institution_ids":["https://openalex.org/I2802734952","https://openalex.org/I154093214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064185915","display_name":"Chun-Hou Zheng","orcid":"https://orcid.org/0000-0002-2695-1926"},"institutions":[{"id":"https://openalex.org/I143868143","display_name":"Anhui University","ror":"https://ror.org/05th6yx34","country_code":"CN","type":"education","lineage":["https://openalex.org/I143868143"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunhou Zheng","raw_affiliation_strings":["School of Artificial Intelligence, Anhui University,Hefei,China,230601","Institute of Artificial Intelligence, Hefei Comprehensive National Science Center, Hefei, China"],"affiliations":[{"raw_affiliation_string":"School of Artificial Intelligence, Anhui University,Hefei,China,230601","institution_ids":["https://openalex.org/I143868143"]},{"raw_affiliation_string":"Institute of Artificial Intelligence, Hefei Comprehensive National Science Center, Hefei, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102883741","display_name":"Renyong Lin","orcid":"https://orcid.org/0000-0001-8073-2495"},"institutions":[{"id":"https://openalex.org/I154093214","display_name":"Xinjiang Medical University","ror":"https://ror.org/01p455v08","country_code":"CN","type":"education","lineage":["https://openalex.org/I154093214"]},{"id":"https://openalex.org/I2802734952","display_name":"First Affiliated Hospital of Xinjiang Medical University","ror":"https://ror.org/02qx1ae98","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802734952"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Renyong Lin","raw_affiliation_strings":["Clinical Medical Research Institute, The First Affiliated Hospital of Xinjiang Medical University,State Key Laboratory of Pathogenesis, Prevention, and Treatment of Central Asian High Incidence Diseases,Urumqi,China,830054"],"affiliations":[{"raw_affiliation_string":"Clinical Medical Research Institute, The First Affiliated Hospital of Xinjiang Medical University,State Key Laboratory of Pathogenesis, Prevention, and Treatment of Central Asian High Incidence Diseases,Urumqi,China,830054","institution_ids":["https://openalex.org/I2802734952","https://openalex.org/I154093214"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071754273","display_name":"Yansen Su","orcid":"https://orcid.org/0000-0002-3855-7133"},"institutions":[{"id":"https://openalex.org/I143868143","display_name":"Anhui University","ror":"https://ror.org/05th6yx34","country_code":"CN","type":"education","lineage":["https://openalex.org/I143868143"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yansen Su","raw_affiliation_strings":["School of Artificial Intelligence, Anhui University,Hefei,China,230601","Institute of Artificial Intelligence, Hefei Comprehensive National Science Center, Hefei, China"],"affiliations":[{"raw_affiliation_string":"School of Artificial Intelligence, Anhui University,Hefei,China,230601","institution_ids":["https://openalex.org/I143868143"]},{"raw_affiliation_string":"Institute of Artificial Intelligence, Hefei Comprehensive National Science Center, Hefei, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5092005330"],"corresponding_institution_ids":["https://openalex.org/I143868143"],"apc_list":null,"apc_paid":null,"fwci":1.1385,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.81719506,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"7","issue":"4","first_page":"1273","last_page":"1286"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13937","display_name":"Genetics, Bioinformatics, and Biomedical Research","score":0.914900004863739,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypergraph","display_name":"Hypergraph","score":0.631969690322876},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.49226465821266174},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.49184608459472656},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4618337154388428},{"id":"https://openalex.org/keywords/contrastive-analysis","display_name":"Contrastive analysis","score":0.4352928400039673},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.35281237959861755},{"id":"https://openalex.org/keywords/natural-language-processing","display_name":"Natural language processing","score":0.3494080901145935},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2573793828487396},{"id":"https://openalex.org/keywords/linguistics","display_name":"Linguistics","score":0.18530809879302979},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.14255261421203613},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.12836307287216187},{"id":"https://openalex.org/keywords/discrete-mathematics","display_name":"Discrete mathematics","score":0.10171699523925781},{"id":"https://openalex.org/keywords/philosophy","display_name":"Philosophy","score":0.054423242807388306}],"concepts":[{"id":"https://openalex.org/C2781221856","wikidata":"https://www.wikidata.org/wiki/Q840247","display_name":"Hypergraph","level":2,"score":0.631969690322876},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.49226465821266174},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.49184608459472656},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4618337154388428},{"id":"https://openalex.org/C2777629044","wikidata":"https://www.wikidata.org/wiki/Q614959","display_name":"Contrastive analysis","level":2,"score":0.4352928400039673},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.35281237959861755},{"id":"https://openalex.org/C204321447","wikidata":"https://www.wikidata.org/wiki/Q30642","display_name":"Natural language processing","level":1,"score":0.3494080901145935},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2573793828487396},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.18530809879302979},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.14255261421203613},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12836307287216187},{"id":"https://openalex.org/C118615104","wikidata":"https://www.wikidata.org/wiki/Q121416","display_name":"Discrete mathematics","level":1,"score":0.10171699523925781},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.054423242807388306}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.26599/bdma.2024.9020054","is_oa":true,"landing_page_url":"https://doi.org/10.26599/bdma.2024.9020054","pdf_url":null,"source":{"id":"https://openalex.org/S4210209060","display_name":"Big Data Mining and Analytics","issn_l":"2096-0654","issn":["2096-0654"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311901","host_organization_name":"Tsinghua University Press","host_organization_lineage":["https://openalex.org/P4310311901"],"host_organization_lineage_names":["Tsinghua University Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Big Data Mining and Analytics","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:45930274d9284b7ab0d159cd0a7f11d2","is_oa":true,"landing_page_url":"https://doaj.org/article/45930274d9284b7ab0d159cd0a7f11d2","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Big Data Mining and Analytics, Vol 7, Iss 4, Pp 1273-1286 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.26599/bdma.2024.9020054","is_oa":true,"landing_page_url":"https://doi.org/10.26599/bdma.2024.9020054","pdf_url":null,"source":{"id":"https://openalex.org/S4210209060","display_name":"Big Data Mining and Analytics","issn_l":"2096-0654","issn":["2096-0654"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311901","host_organization_name":"Tsinghua University Press","host_organization_lineage":["https://openalex.org/P4310311901"],"host_organization_lineage_names":["Tsinghua University Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Big Data Mining and Analytics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4399999976158142,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"awards":[{"id":"https://openalex.org/G2229195774","display_name":null,"funder_award_id":"62322301,62172002,82060373","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8625284979","display_name":null,"funder_award_id":"2021YFE0102100","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1592483428","https://openalex.org/W1996486545","https://openalex.org/W2044025814","https://openalex.org/W2062604619","https://openalex.org/W2064132522","https://openalex.org/W2115147179","https://openalex.org/W2116462976","https://openalex.org/W2118151336","https://openalex.org/W2131487381","https://openalex.org/W2140239055","https://openalex.org/W2155041167","https://openalex.org/W2299417213","https://openalex.org/W2335854816","https://openalex.org/W2344726805","https://openalex.org/W2606771446","https://openalex.org/W2608863179","https://openalex.org/W2724799126","https://openalex.org/W2761590517","https://openalex.org/W2762514363","https://openalex.org/W2769426045","https://openalex.org/W2775061087","https://openalex.org/W2783897572","https://openalex.org/W2803908182","https://openalex.org/W2892880750","https://openalex.org/W2899070097","https://openalex.org/W2922229918","https://openalex.org/W2960677646","https://openalex.org/W2963420686","https://openalex.org/W3092034553","https://openalex.org/W3102269903","https://openalex.org/W3120627169","https://openalex.org/W3127930610","https://openalex.org/W3172095419","https://openalex.org/W3199618438","https://openalex.org/W3203908308","https://openalex.org/W4223909865","https://openalex.org/W4293214728","https://openalex.org/W4367673946","https://openalex.org/W4385767936","https://openalex.org/W4386033873","https://openalex.org/W6703221619"],"related_works":["https://openalex.org/W4376608589","https://openalex.org/W1537073411","https://openalex.org/W1948107826","https://openalex.org/W3138003926","https://openalex.org/W1630514295","https://openalex.org/W4300037846","https://openalex.org/W4288275998","https://openalex.org/W2963081352","https://openalex.org/W4376608938","https://openalex.org/W2472555608"],"abstract_inverted_index":{"In":[0],"the":[1,33,41,51,62,71,87,101,121,152],"field":[2],"of":[3,21,53,65,73,154,200],"cancer":[4],"treatment,":[5],"drug":[6,30,45,97,110,122,147,188,204],"combination":[7,98],"therapy":[8],"appears":[9],"to":[10,17,27,61,75,162,186],"be":[11],"a":[12,109,128],"promising":[13],"treatment":[14],"strategy":[15],"compared":[16],"monotherapy.":[18],"Recently,":[19],"plenty":[20],"computational":[22],"models":[23,36,74,179],"are":[24,106,117,160],"gradually":[25],"applied":[26],"prioritize":[28],"synergistic":[29,96,102,203],"combinations.":[31,205],"However,":[32],"existing":[34],"prediction":[35,178],"have":[37],"not":[38],"fully":[39,163],"exploited":[40],"multi-way":[42,79],"relations":[43],"between":[44],"combinations":[46,189],"and":[47,77,113,141,183],"cell":[48,191],"lines.":[49,192],"Besides,":[50],"number":[52],"identified":[54],"drug-drug-cell":[55,103,157],"line":[56,104,158],"triplets":[57,105,159],"is":[58,184,198],"insufficient":[59],"owning":[60],"high":[63],"cost":[64],"in":[66],"vitro":[67],"screening,":[68],"which":[69,136],"affects":[70],"ability":[72],"capture":[76],"utilize":[78],"relations.":[80],"To":[81],"address":[82],"this":[83],"challenge,":[84],"we":[85,126],"design":[86,127],"multi-view":[88,129],"hypergraph":[89,130],"contrastive":[90,131],"learning":[91,132,145],"model,":[92],"termed":[93],"MHCLSyn,":[94],"for":[95,138,166],"prediction.":[99],"First,":[100],"formulated":[107],"as":[108],"synergy":[111,123,148],"hypergraph,":[112],"three":[114],"task-specific":[115],"hypergraphs":[116],"designed":[118],"based":[119],"on":[120,146,180],"hypergraph.":[124,149],"Then,":[125],"with":[133],"enhancement":[134],"schemes,":[135],"allows":[137],"more":[139],"expressive":[140],"discriminative":[142],"node":[143],"representation":[144],"After":[150],"that,":[151],"representations":[153],"nodes":[155],"indicating":[156],"inputted":[161],"connected":[164],"network":[165],"making":[167],"predictions.":[168],"Extensive":[169],"experiments":[170],"show":[171],"MHCLSyn":[172,197],"achieves":[173],"better":[174],"performance":[175],"than":[176],"state-of-the-art":[177],"benchmark":[181],"datasets":[182],"applicable":[185],"unseen":[187],"or":[190],"Case":[193],"study":[194],"indicates":[195],"that":[196],"capable":[199],"detecting":[201],"potential":[202]},"counts_by_year":[{"year":2025,"cited_by_count":3}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}