{"id":"https://openalex.org/W2886886281","doi":"https://doi.org/10.25080/majora-4af1f417-000","title":"Dynamic Social Network Modeling of Diffuse Subcellular Morphologies","display_name":"Dynamic Social Network Modeling of Diffuse Subcellular Morphologies","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2886886281","doi":"https://doi.org/10.25080/majora-4af1f417-000","mag":"2886886281"},"language":"en","primary_location":{"id":"doi:10.25080/majora-4af1f417-000","is_oa":true,"landing_page_url":"https://doi.org/10.25080/majora-4af1f417-000","pdf_url":"http://conference.scipy.org/proceedings/scipy2018/pdfs/Andrew_Durden.pdf","source":{"id":"https://openalex.org/S4220651651","display_name":"Proceedings of the Python in Science Conferences","issn_l":"2575-9752","issn":["2575-9752"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the Python in Science Conference","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://conference.scipy.org/proceedings/scipy2018/pdfs/Andrew_Durden.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023368328","display_name":"Andrew Durden","orcid":null},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrew Durden","raw_affiliation_strings":["|| Department of Computer Science, University of Georgia, Athens, GA 30602 USA"],"affiliations":[{"raw_affiliation_string":"|| Department of Computer Science, University of Georgia, Athens, GA 30602 USA","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022854334","display_name":"Allyson Loy","orcid":null},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allyson Loy","raw_affiliation_strings":["Department of Microbiology, University of Georgia, Athens, GA 30602 USA"],"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Georgia, Athens, GA 30602 USA","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066658370","display_name":"Barbara J. Reaves","orcid":"https://orcid.org/0000-0002-6757-280X"},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara Reaves","raw_affiliation_strings":["Department of Infectious Diseases, University of Georgia, Athens, GA 30602 USA"],"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, University of Georgia, Athens, GA 30602 USA","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033887560","display_name":"Mojtaba S. Fazli","orcid":"https://orcid.org/0000-0002-6082-2538"},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mojtaba Fazli","raw_affiliation_strings":["|| Department of Computer Science, University of Georgia, Athens, GA 30602 USA"],"affiliations":[{"raw_affiliation_string":"|| Department of Computer Science, University of Georgia, Athens, GA 30602 USA","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015864527","display_name":"Abigail J. Courtney","orcid":"https://orcid.org/0000-0001-5319-2630"},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abigail Courtney","raw_affiliation_strings":["Department of Microbiology, University of Georgia, Athens, GA 30602 USA"],"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Georgia, Athens, GA 30602 USA","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112392640","display_name":"Frederick D. Quinn","orcid":null},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frederick Quinn","raw_affiliation_strings":["Department of Cellular Biology, University of Georgia, Athens, GA 30602 USA","Department of Infectious Diseases, University of Georgia, Athens, GA 30602 USA"],"affiliations":[{"raw_affiliation_string":"Department of Cellular Biology, University of Georgia, Athens, GA 30602 USA","institution_ids":["https://openalex.org/I165733156"]},{"raw_affiliation_string":"Department of Infectious Diseases, University of Georgia, Athens, GA 30602 USA","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024948606","display_name":"S. Chakra Chennubhotla","orcid":"https://orcid.org/0000-0002-0024-1627"},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]},{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Chennubhotla","raw_affiliation_strings":["Department of Cellular Biology, University of Georgia, Athens, GA 30602 USA","Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA 15232 USA"],"affiliations":[{"raw_affiliation_string":"Department of Cellular Biology, University of Georgia, Athens, GA 30602 USA","institution_ids":["https://openalex.org/I165733156"]},{"raw_affiliation_string":"Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA 15232 USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046164250","display_name":"Shannon Quinn","orcid":"https://orcid.org/0000-0002-8916-6335"},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shannon Quinn","raw_affiliation_strings":["Department of Cellular Biology, University of Georgia, Athens, GA 30602 USA"],"affiliations":[{"raw_affiliation_string":"Department of Cellular Biology, University of Georgia, Athens, GA 30602 USA","institution_ids":["https://openalex.org/I165733156"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5023368328"],"corresponding_institution_ids":["https://openalex.org/I165733156"],"apc_list":null,"apc_paid":null,"fwci":0.7635,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.70107052,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9661999940872192,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9388999938964844,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leverage","display_name":"Leverage (statistics)","score":0.7762812376022339},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6355295181274414},{"id":"https://openalex.org/keywords/network-topology","display_name":"Network topology","score":0.5140479803085327},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.5038387179374695},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.4874284565448761},{"id":"https://openalex.org/keywords/gaussian","display_name":"Gaussian","score":0.4606833755970001},{"id":"https://openalex.org/keywords/centrality","display_name":"Centrality","score":0.4386020302772522},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4350894093513489},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.4194851517677307},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.4109342694282532},{"id":"https://openalex.org/keywords/graph-theory","display_name":"Graph theory","score":0.4106695055961609},{"id":"https://openalex.org/keywords/topology","display_name":"Topology (electrical circuits)","score":0.3964320719242096},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3291514217853546},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.22543078660964966},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2229364812374115},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.1588490605354309},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.14963167905807495}],"concepts":[{"id":"https://openalex.org/C153083717","wikidata":"https://www.wikidata.org/wiki/Q6535263","display_name":"Leverage (statistics)","level":2,"score":0.7762812376022339},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6355295181274414},{"id":"https://openalex.org/C199845137","wikidata":"https://www.wikidata.org/wiki/Q145490","display_name":"Network topology","level":2,"score":0.5140479803085327},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.5038387179374695},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.4874284565448761},{"id":"https://openalex.org/C163716315","wikidata":"https://www.wikidata.org/wiki/Q901177","display_name":"Gaussian","level":2,"score":0.4606833755970001},{"id":"https://openalex.org/C53811970","wikidata":"https://www.wikidata.org/wiki/Q5062194","display_name":"Centrality","level":2,"score":0.4386020302772522},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4350894093513489},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.4194851517677307},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.4109342694282532},{"id":"https://openalex.org/C88230418","wikidata":"https://www.wikidata.org/wiki/Q131476","display_name":"Graph theory","level":2,"score":0.4106695055961609},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.3964320719242096},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3291514217853546},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.22543078660964966},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2229364812374115},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1588490605354309},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.14963167905807495},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.25080/majora-4af1f417-000","is_oa":true,"landing_page_url":"https://doi.org/10.25080/majora-4af1f417-000","pdf_url":"http://conference.scipy.org/proceedings/scipy2018/pdfs/Andrew_Durden.pdf","source":{"id":"https://openalex.org/S4220651651","display_name":"Proceedings of the Python in Science Conferences","issn_l":"2575-9752","issn":["2575-9752"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the Python in Science Conference","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.25080/majora-4af1f417-000","is_oa":true,"landing_page_url":"https://doi.org/10.25080/majora-4af1f417-000","pdf_url":"http://conference.scipy.org/proceedings/scipy2018/pdfs/Andrew_Durden.pdf","source":{"id":"https://openalex.org/S4220651651","display_name":"Proceedings of the Python in Science Conferences","issn_l":"2575-9752","issn":["2575-9752"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the Python in Science Conference","raw_type":"proceedings-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/10","score":0.4399999976158142,"display_name":"Reduced inequalities"}],"awards":[{"id":"https://openalex.org/G5961315509","display_name":"Collaborative Research: ABI Innovation:Large-scale Analysis of the Evolution of Organellar Networks","funder_award_id":"1458766","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G848032724","display_name":null,"funder_award_id":"Science","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2886886281.pdf","grobid_xml":"https://content.openalex.org/works/W2886886281.grobid-xml"},"referenced_works_count":9,"referenced_works":["https://openalex.org/W616025253","https://openalex.org/W1975556022","https://openalex.org/W2059009119","https://openalex.org/W2074052524","https://openalex.org/W2127890285","https://openalex.org/W2229506676","https://openalex.org/W2560565629","https://openalex.org/W2617667835","https://openalex.org/W2619737983"],"related_works":["https://openalex.org/W4229078645","https://openalex.org/W1977345676","https://openalex.org/W4282032776","https://openalex.org/W2047552823","https://openalex.org/W4321606905","https://openalex.org/W2322248538","https://openalex.org/W118100147","https://openalex.org/W2135602072","https://openalex.org/W3013212210","https://openalex.org/W2002039869"],"abstract_inverted_index":{"The":[0,211],"use":[1],"of":[2,16,77,92,100,108,123,139,150,153,169,194,205,232,239,280,292],"fluorescence":[3,278],"microscopy":[4],"has":[5],"catalyzed":[6],"new":[7],"insights":[8],"into":[9,88],"biological":[10,39,81],"function,":[11],"and":[12,34,111,128,162,177,226,297],"spurred":[13],"the":[14,113,136,140,151,157,182,202,206,227,230,233,240,261],"development":[15],"quantitative":[17,36,290],"models":[18,91,274],"from":[19,38,79,275],"rich":[20],"biomedical":[21],"image":[22,25],"datasets.":[23],"While":[24],"processing":[26],"in":[27,167,229,260],"some":[28],"capacity":[29],"is":[30,197],"commonplace":[31],"for":[32,46],"extracting":[33],"modeling":[35,49,69],"knowledge":[37],"systems":[40],"at":[41],"varying":[42],"scales,":[43],"general-purpose":[44],"approaches":[45],"more":[47],"advanced":[48],"are":[50],"few.":[51],"In":[52],"particular,":[53],"diffuse":[54,93,114,281],"organellar":[55],"morphologies,":[56,95],"such":[57,173],"as":[58,117,174],"mitochondria":[59,158],"or":[60],"actin":[61],"microtubules,":[62],"have":[63],"few":[64],"if":[65],"any":[66],"established":[67],"spatiotemporal":[68,90,203],"strategies,":[70],"all":[71],"but":[72],"discarding":[73],"critically":[74],"important":[75],"sources":[76],"signal":[78],"a":[80,118,121,147,191,224,252,288],"system.":[82],"Here,":[83],"we":[84,145],"discuss":[85],"initial":[86],"work":[87],"building":[89],"subcellular":[94,282],"using":[96,190,255],"mitochondrial":[97,115,183,207],"protein":[98,283],"patterns":[99,116,208],"cervical":[101],"epithelial":[102],"(HeLa)":[103],"cells.":[104],"We":[105,179,243],"leverage":[106,246],"principles":[107],"graph":[109,170,220],"theory":[110],"consider":[112],"social":[119,141,272],"network:":[120],"collection":[122],"vertices":[124],"interconnected":[125],"by":[126,159],"weighted":[127],"directed":[129],"edges,":[130],"indicating":[131],"spatial":[132],"relationships.":[133],"By":[134],"studying":[135],"changing":[137],"topology":[138,231],"networks":[142],"over":[143,209,295],"time,":[144],"gain":[146],"mechanistic":[148],"understanding":[149],"types":[152],"stresses":[154],"imposed":[155],"on":[156],"external":[160],"stimuli,":[161],"can":[163,185,215,235],"relate":[164],"these":[165,247],"effects":[166],"terms":[168],"theoretic":[171],"quantities":[172],"centrality,":[175],"connectivity,":[176],"flow.":[178],"demonstrate":[180],"how":[181],"pattern":[184],"be":[186,217],"faithfully":[187],"represented":[188],"parametrically":[189],"learned":[192,212],"mixture":[193],"Gaussians,":[195],"which":[196,269],"then":[198,216],"perturbed":[199],"to":[200,219,245,250,301],"match":[201],"evolution":[204],"time.":[210],"Gaussian":[213],"components":[214],"converted":[218],"Laplacians,":[221],"formally":[222],"defining":[223],"network,":[225],"changes":[228],"Laplacians":[234],"yield":[236],"biologically-meaningful":[237],"interpretations":[238],"evolving":[241],"morphology.":[242],"hope":[244],"preliminary":[248],"results":[249],"implement":[251],"bioimaging":[253],"toolbox,":[254],"existing":[256],"open":[257],"source":[258],"packages":[259],"scientific":[262],"Python":[263],"ecosystem":[264],"(SciPy,":[265],"NumPy,":[266],"scikit-image,":[267],"OpenCV),":[268],"builds":[270],"dynamic":[271],"network":[273,293],"time":[276,296],"series":[277],"images":[279],"patterns.":[284],"This":[285],"will":[286],"enable":[287],"direct":[289],"comparison":[291],"structure":[294],"between":[298],"cells":[299],"exposed":[300],"different":[302],"conditions.":[303]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}