{"id":"https://openalex.org/W1994893201","doi":"https://doi.org/10.2478/s13230-012-0002-7","title":"Spatio-temporal dependencies in functional connectivity in rodent cortical cultures","display_name":"Spatio-temporal dependencies in functional connectivity in rodent cortical cultures","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W1994893201","doi":"https://doi.org/10.2478/s13230-012-0002-7","mag":"1994893201"},"language":"en","primary_location":{"id":"doi:10.2478/s13230-012-0002-7","is_oa":true,"landing_page_url":"https://doi.org/10.2478/s13230-012-0002-7","pdf_url":"https://www.degruyter.com/document/doi/10.2478/s13230-012-0002-7/pdf","source":{"id":"https://openalex.org/S4210226531","display_name":"Paladyn Journal of Behavioral Robotics","issn_l":"2080-9778","issn":["2080-9778","2081-4836"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320322","host_organization_name":"De Gruyter Open","host_organization_lineage":["https://openalex.org/P4310320322","https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter Open","De Gruyter"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Paladyn, Journal of Behavioral Robotics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.degruyter.com/document/doi/10.2478/s13230-012-0002-7/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102720824","display_name":"Matthew C. Spencer","orcid":"https://orcid.org/0000-0002-8987-8391"},"institutions":[{"id":"https://openalex.org/I71052956","display_name":"University of Reading","ror":"https://ror.org/05v62cm79","country_code":"GB","type":"education","lineage":["https://openalex.org/I71052956"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Matthew C. Spencer","raw_affiliation_strings":["Cybernetic Research Group, School of Systems Engineering, University of Reading, Whiteknights, RG6 6AY, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cybernetic Research Group, School of Systems Engineering, University of Reading, Whiteknights, RG6 6AY, UK","institution_ids":["https://openalex.org/I71052956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108410800","display_name":"Julia H. Downes","orcid":null},"institutions":[{"id":"https://openalex.org/I71052956","display_name":"University of Reading","ror":"https://ror.org/05v62cm79","country_code":"GB","type":"education","lineage":["https://openalex.org/I71052956"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Julia H. Downes","raw_affiliation_strings":["Cybernetic Research Group, School of Systems Engineering, University of Reading, Whiteknights, RG6 6AY, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cybernetic Research Group, School of Systems Engineering, University of Reading, Whiteknights, RG6 6AY, UK","institution_ids":["https://openalex.org/I71052956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024536978","display_name":"Dimitris Xydas","orcid":null},"institutions":[{"id":"https://openalex.org/I71052956","display_name":"University of Reading","ror":"https://ror.org/05v62cm79","country_code":"GB","type":"education","lineage":["https://openalex.org/I71052956"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Dimitris Xydas","raw_affiliation_strings":["Cybernetic Research Group, School of Systems Engineering, University of Reading, Whiteknights, RG6 6AY, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cybernetic Research Group, School of Systems Engineering, University of Reading, Whiteknights, RG6 6AY, UK","institution_ids":["https://openalex.org/I71052956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032011681","display_name":"Mark W. Hammond","orcid":null},"institutions":[{"id":"https://openalex.org/I71052956","display_name":"University of Reading","ror":"https://ror.org/05v62cm79","country_code":"GB","type":"education","lineage":["https://openalex.org/I71052956"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mark W. Hammond","raw_affiliation_strings":["School of Pharmacy, University of Reading, Whiteknights, RG6 6AP, UK","Cybernetic Research Group, School of Systems Engineering, University of Reading, Whiteknights, RG6 6AY, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, University of Reading, Whiteknights, RG6 6AP, UK","institution_ids":["https://openalex.org/I71052956"]},{"raw_affiliation_string":"Cybernetic Research Group, School of Systems Engineering, University of Reading, Whiteknights, RG6 6AY, UK","institution_ids":["https://openalex.org/I71052956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033219106","display_name":"Victor M. Becerra","orcid":"https://orcid.org/0000-0002-3790-4236"},"institutions":[{"id":"https://openalex.org/I71052956","display_name":"University of Reading","ror":"https://ror.org/05v62cm79","country_code":"GB","type":"education","lineage":["https://openalex.org/I71052956"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Victor M. Becerra","raw_affiliation_strings":["Cybernetic Research Group, School of Systems Engineering, University of Reading, Whiteknights, RG6 6AY, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cybernetic Research Group, School of Systems Engineering, University of Reading, Whiteknights, RG6 6AY, UK","institution_ids":["https://openalex.org/I71052956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003343059","display_name":"Benjamin J. Whalley","orcid":null},"institutions":[{"id":"https://openalex.org/I71052956","display_name":"University of Reading","ror":"https://ror.org/05v62cm79","country_code":"GB","type":"education","lineage":["https://openalex.org/I71052956"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Benjamin J. Whalley","raw_affiliation_strings":["School of Pharmacy, University of Reading, Whiteknights, RG6 6AP, UK","Cybernetic Research Group, School of Systems Engineering, University of Reading, Whiteknights, RG6 6AY, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, University of Reading, Whiteknights, RG6 6AP, UK","institution_ids":["https://openalex.org/I71052956"]},{"raw_affiliation_string":"Cybernetic Research Group, School of Systems Engineering, University of Reading, Whiteknights, RG6 6AY, UK","institution_ids":["https://openalex.org/I71052956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105301578","display_name":"Kevin Warwick","orcid":null},"institutions":[{"id":"https://openalex.org/I71052956","display_name":"University of Reading","ror":"https://ror.org/05v62cm79","country_code":"GB","type":"education","lineage":["https://openalex.org/I71052956"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kevin Warwick","raw_affiliation_strings":["Cybernetic Research Group, School of Systems Engineering, University of Reading, Whiteknights, RG6 6AY, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cybernetic Research Group, School of Systems Engineering, University of Reading, Whiteknights, RG6 6AY, UK","institution_ids":["https://openalex.org/I71052956"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058704923","display_name":"Slawomir J. Nasuto","orcid":"https://orcid.org/0000-0001-9414-9049"},"institutions":[{"id":"https://openalex.org/I71052956","display_name":"University of Reading","ror":"https://ror.org/05v62cm79","country_code":"GB","type":"education","lineage":["https://openalex.org/I71052956"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Slawomir J. Nasuto","raw_affiliation_strings":["Cybernetic Research Group, School of Systems Engineering, University of Reading, Whiteknights, RG6 6AY, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cybernetic Research Group, School of Systems Engineering, University of Reading, Whiteknights, RG6 6AY, UK","institution_ids":["https://openalex.org/I71052956"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5102720824"],"corresponding_institution_ids":["https://openalex.org/I71052956"],"apc_list":{"value":1000,"currency":"EUR","value_usd":1078},"apc_paid":{"value":1000,"currency":"EUR","value_usd":1078},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.08653561,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9876000285148621,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/functional-dependency","display_name":"Functional dependency","score":0.7346424460411072},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7338727712631226},{"id":"https://openalex.org/keywords/functional-connectivity","display_name":"Functional connectivity","score":0.6114556193351746},{"id":"https://openalex.org/keywords/correlative","display_name":"Correlative","score":0.5030710101127625},{"id":"https://openalex.org/keywords/dependency","display_name":"Dependency (UML)","score":0.47861021757125854},{"id":"https://openalex.org/keywords/cognition","display_name":"Cognition","score":0.4225444197654724},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4104040861129761},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.3155989646911621},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.2212645709514618},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.11213609576225281}],"concepts":[{"id":"https://openalex.org/C26320393","wikidata":"https://www.wikidata.org/wiki/Q597053","display_name":"Functional dependency","level":3,"score":0.7346424460411072},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7338727712631226},{"id":"https://openalex.org/C3018011982","wikidata":"https://www.wikidata.org/wiki/Q7316120","display_name":"Functional connectivity","level":2,"score":0.6114556193351746},{"id":"https://openalex.org/C2776800370","wikidata":"https://www.wikidata.org/wiki/Q5172864","display_name":"Correlative","level":2,"score":0.5030710101127625},{"id":"https://openalex.org/C19768560","wikidata":"https://www.wikidata.org/wiki/Q320727","display_name":"Dependency (UML)","level":2,"score":0.47861021757125854},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.4225444197654724},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4104040861129761},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3155989646911621},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.2212645709514618},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11213609576225281},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C5655090","wikidata":"https://www.wikidata.org/wiki/Q192588","display_name":"Relational database","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.2478/s13230-012-0002-7","is_oa":true,"landing_page_url":"https://doi.org/10.2478/s13230-012-0002-7","pdf_url":"https://www.degruyter.com/document/doi/10.2478/s13230-012-0002-7/pdf","source":{"id":"https://openalex.org/S4210226531","display_name":"Paladyn Journal of Behavioral Robotics","issn_l":"2080-9778","issn":["2080-9778","2081-4836"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320322","host_organization_name":"De Gruyter Open","host_organization_lineage":["https://openalex.org/P4310320322","https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter Open","De Gruyter"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Paladyn, Journal of Behavioral Robotics","raw_type":"journal-article"},{"id":"pmh:oai:centaur.reading.ac.uk:27148","is_oa":true,"landing_page_url":"https://centaur.reading.ac.uk/view/creators/90004869.html>,","pdf_url":"https://centaur.reading.ac.uk/27148/1/paladyn2011.pdf","source":{"id":"https://openalex.org/S4306402273","display_name":"CentAUR (University of Reading)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I71052956","host_organization_name":"University of Reading","host_organization_lineage":["https://openalex.org/I71052956"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:d426a37a6a794b19b942ee6c00223d3d","is_oa":true,"landing_page_url":"https://doaj.org/article/d426a37a6a794b19b942ee6c00223d3d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Paladyn, Vol 2, Iss 3, Pp 156-163 (2011)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.2478/s13230-012-0002-7","is_oa":true,"landing_page_url":"https://doi.org/10.2478/s13230-012-0002-7","pdf_url":"https://www.degruyter.com/document/doi/10.2478/s13230-012-0002-7/pdf","source":{"id":"https://openalex.org/S4210226531","display_name":"Paladyn Journal of Behavioral Robotics","issn_l":"2080-9778","issn":["2080-9778","2081-4836"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320322","host_organization_name":"De Gruyter Open","host_organization_lineage":["https://openalex.org/P4310320322","https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter Open","De Gruyter"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Paladyn, Journal of Behavioral Robotics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1994893201.pdf","grobid_xml":"https://content.openalex.org/works/W1994893201.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W199455369","https://openalex.org/W1515500856","https://openalex.org/W1529448825","https://openalex.org/W1566787049","https://openalex.org/W1978957733","https://openalex.org/W1984465702","https://openalex.org/W1987387046","https://openalex.org/W1999653836","https://openalex.org/W2006312249","https://openalex.org/W2007580663","https://openalex.org/W2010677111","https://openalex.org/W2016954700","https://openalex.org/W2049161026","https://openalex.org/W2070722739","https://openalex.org/W2080647940","https://openalex.org/W2084790688","https://openalex.org/W2097722670","https://openalex.org/W2097725576","https://openalex.org/W2100018830","https://openalex.org/W2100243099","https://openalex.org/W2102297429","https://openalex.org/W2104476748","https://openalex.org/W2112090702","https://openalex.org/W2114079854","https://openalex.org/W2116089212","https://openalex.org/W2117384296","https://openalex.org/W2124637492","https://openalex.org/W2129229909","https://openalex.org/W2152664824"],"related_works":["https://openalex.org/W2392606101","https://openalex.org/W2072918301","https://openalex.org/W3162070149","https://openalex.org/W2489943546","https://openalex.org/W2385315033","https://openalex.org/W2362842011","https://openalex.org/W1845544376","https://openalex.org/W1839867872","https://openalex.org/W2085316814","https://openalex.org/W2048090520"],"abstract_inverted_index":{"Abstract":[0],"Models":[1],"of":[2,58,63,76,95,104,138],"functional":[3,52,88,106,125],"connectivity":[4,53],"in":[5,13,49,65,141,148],"cortical":[6],"cultures":[7],"on":[8,32],"multi-electrodes":[9],"arrays":[10],"may":[11],"aid":[12],"understanding":[14],"how":[15],"cognitive":[16],"pathways":[17,140],"form":[18],"and":[19,40,50,79,108,124],"improve":[20],"techniques":[21,71,83],"that":[22],"aim":[23],"to":[24,43,72,86,100],"interface":[25],"with":[26],"neuronal":[27,139],"systems.":[28],"To":[29],"enable":[30],"research":[31],"such":[33],"models,":[34],"this":[35],"study":[36],"uses":[37],"both":[38],"data-":[39],"model-driven":[41],"approaches":[42],"determine":[44],"what":[45],"dependencies":[46],"are":[47],"present":[48],"between":[51,120],"networks":[54,123,126],"derived":[55],"from":[56,127],"bursts":[57,66],"extracellularly":[59],"recorded":[60],"activity.":[61],"Properties":[62],"excitation":[64],"were":[67,84,98,111,131],"analysed":[68],"using":[69,113],"correlative":[70],"assess":[73,87],"the":[74,102,135],"degree":[75],"linear":[77],"dependence":[78],"then":[80],"two":[81],"parallel":[82],"used":[85,99],"connectivity.":[89],"Three":[90],"models":[91],"presenting":[92],"increasing":[93],"levels":[94],"spatio-temporal":[96],"dependency":[97],"capture":[101],"dynamics":[103],"individual":[105],"connections":[107],"their":[109],"consistencies":[110],"verified":[112],"surrogate":[114],"data.":[115],"By":[116],"comparing":[117],"network-wide":[118],"properties":[119],"model":[121],"generated":[122],"data,":[128],"complex":[129],"interdependencies":[130],"revealed.":[132],"This":[133],"indicates":[134],"persistent":[136],"co-activation":[137],"spontaneous":[142],"bursts,":[143],"as":[144],"can":[145],"be":[146],"found":[147],"whole":[149],"brain":[150],"structures.":[151]},"counts_by_year":[],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}
