{"id":"https://openalex.org/W4403331868","doi":"https://doi.org/10.23919/fusion59988.2024.10706334","title":"Enhanced Kinetochore Detection During Mitotic Human Cell Division using CFAR","display_name":"Enhanced Kinetochore Detection During Mitotic Human Cell Division using CFAR","publication_year":2024,"publication_date":"2024-07-08","ids":{"openalex":"https://openalex.org/W4403331868","doi":"https://doi.org/10.23919/fusion59988.2024.10706334"},"language":"en","primary_location":{"id":"doi:10.23919/fusion59988.2024.10706334","is_oa":false,"landing_page_url":"https://doi.org/10.23919/fusion59988.2024.10706334","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 27th International Conference on Information Fusion (FUSION)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109025414","display_name":"Abdullahi Daniyan","orcid":null},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Abdullahi Daniyan","raw_affiliation_strings":["Mathematics Institute, University of Warwick,Coventry,United Kingdom,CV4 7AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mathematics Institute, University of Warwick,Coventry,United Kingdom,CV4 7AL","institution_ids":["https://openalex.org/I39555362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040687039","display_name":"Alessio V. Inchingolo","orcid":null},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alessio V. Inchingolo","raw_affiliation_strings":["Warwick Medical School, University of Warwick,Centre for Mechanochemical Cell Biology and Division of Biomedical Sciences,United Kingdom,CV4 7AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Warwick Medical School, University of Warwick,Centre for Mechanochemical Cell Biology and Division of Biomedical Sciences,United Kingdom,CV4 7AL","institution_ids":["https://openalex.org/I39555362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045705655","display_name":"Andrew D. McAinsh","orcid":"https://orcid.org/0000-0001-6808-0711"},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrew McAinsh","raw_affiliation_strings":["Warwick Medical School, University of Warwick,Centre for Mechanochemical Cell Biology and Division of Biomedical Sciences,United Kingdom,CV4 7AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Warwick Medical School, University of Warwick,Centre for Mechanochemical Cell Biology and Division of Biomedical Sciences,United Kingdom,CV4 7AL","institution_ids":["https://openalex.org/I39555362"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081582588","display_name":"Nigel J. Burroughs","orcid":"https://orcid.org/0000-0002-4632-1550"},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nigel Burroughs","raw_affiliation_strings":["Mathematics Institute, University of Warwick,Coventry,United Kingdom,CV4 7AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mathematics Institute, University of Warwick,Coventry,United Kingdom,CV4 7AL","institution_ids":["https://openalex.org/I39555362"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I39555362"],"apc_list":null,"apc_paid":null,"fwci":3.1974,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.93410692,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":97},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.9424999952316284,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.9424999952316284,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitosis","display_name":"Mitosis","score":0.6285238265991211},{"id":"https://openalex.org/keywords/kinetochore","display_name":"Kinetochore","score":0.562659502029419},{"id":"https://openalex.org/keywords/division","display_name":"Division (mathematics)","score":0.5313981771469116},{"id":"https://openalex.org/keywords/centromere","display_name":"Centromere","score":0.442465215921402},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4270704686641693},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.3303091526031494},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.20353543758392334},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.11638644337654114},{"id":"https://openalex.org/keywords/chromosome","display_name":"Chromosome","score":0.10140809416770935},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.06810218095779419},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.06206387281417847}],"concepts":[{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.6285238265991211},{"id":"https://openalex.org/C192838845","wikidata":"https://www.wikidata.org/wiki/Q908912","display_name":"Kinetochore","level":4,"score":0.562659502029419},{"id":"https://openalex.org/C60798267","wikidata":"https://www.wikidata.org/wiki/Q1226939","display_name":"Division (mathematics)","level":2,"score":0.5313981771469116},{"id":"https://openalex.org/C63491729","wikidata":"https://www.wikidata.org/wiki/Q14762596","display_name":"Centromere","level":4,"score":0.442465215921402},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4270704686641693},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3303091526031494},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20353543758392334},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11638644337654114},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.10140809416770935},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.06810218095779419},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06206387281417847},{"id":"https://openalex.org/C94375191","wikidata":"https://www.wikidata.org/wiki/Q11205","display_name":"Arithmetic","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.23919/fusion59988.2024.10706334","is_oa":false,"landing_page_url":"https://doi.org/10.23919/fusion59988.2024.10706334","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 27th International Conference on Information Fusion (FUSION)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1970800786","https://openalex.org/W1995583822","https://openalex.org/W2053270078","https://openalex.org/W2113904010","https://openalex.org/W2156650489","https://openalex.org/W2302299163","https://openalex.org/W2475771804","https://openalex.org/W3213162328","https://openalex.org/W4245193022","https://openalex.org/W4245769464","https://openalex.org/W4294542528"],"related_works":["https://openalex.org/W2002037873","https://openalex.org/W1586174670","https://openalex.org/W2009362775","https://openalex.org/W1957377060","https://openalex.org/W2495570492","https://openalex.org/W2001978323","https://openalex.org/W2075749722","https://openalex.org/W2355721012","https://openalex.org/W2003303838","https://openalex.org/W2085407032"],"abstract_inverted_index":{"In":[0],"this":[1],"paper,":[2],"we":[3,98],"present":[4,99],"an":[5],"innovative":[6],"application":[7],"of":[8,28,39,46,75,92,114,118,133,173,185],"the":[9,24,43,70,85,89,119,126,152,155,171,174,183],"Constant":[10],"False":[11],"Alarm":[12],"Rate":[13],"(CFAR)":[14],"algorithm,":[15],"traditionally":[16],"utilized":[17],"in":[18,32,55,96,108,167,181],"radar":[19],"signal":[20],"processing,":[21],"to":[22,78,88,125,151],"enhance":[23],"accuracy":[25],"and":[26,72,106,162],"reliability":[27],"kinetochore":[29],"(KT)":[30],"tracking":[31,168],"live-cell":[33],"lattice":[34],"light-sheet":[35],"microscopy":[36],"(LLSM)":[37],"imaging":[38],"human":[40],"cells":[41],"during":[42],"mitotic":[44],"phase":[45],"cell":[47,175],"division.":[48],"Fluorescently":[49],"labelled":[50],"KTs":[51,110,169],"appear":[52],"as":[53,64],"spots":[54],"diffraction-limited":[56],"light":[57],"microscopy.":[58],"Traditional":[59],"KT":[60,81],"detection":[61,95,141,148],"methods,":[62],"such":[63],"adaptive":[65,127,153],"thresholding,":[66],"often":[67],"struggle":[68],"with":[69,136],"dynamic":[71],"noisy":[73],"backgrounds":[74],"cells,":[76,135],"leading":[77],"less":[79],"efficient":[80],"identification.":[82],"By":[83],"adapting":[84],"CFAR":[86],"algorithm":[87],"specific":[90],"challenges":[91],"$K":[93],"T$":[94],"3D,":[97],"a":[100,131,144,163],"method":[101,121,157],"that":[102],"offers":[103],"improved":[104],"precision":[105],"stability":[107],"detecting":[109],"across":[111,130],"different":[112],"stages":[113],"mitosis.":[115],"The":[116],"performance":[117],"CFAR-KT":[120,156],"was":[122],"rigorously":[123],"compared":[124,150],"thresholding":[128],"approach":[129],"cohort":[132],"31":[134],"results":[137],"highlighting":[138],"CFAR-KT\u2019s":[139],"enhanced":[140],"efficiency.":[142],"Despite":[143],"slightly":[145],"lower":[146,159],"mean":[147],"count":[149],"method,":[154],"achieved":[158],"false":[160],"positives":[161],"higher":[164],"success":[165],"rate":[166],"over":[170],"duration":[172],"division":[176],"process,":[177],"underscoring":[178],"its":[179],"effectiveness":[180],"capturing":[182],"dynamics":[184],"KTs.":[186]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}