{"id":"https://openalex.org/W4400946646","doi":"https://doi.org/10.23919/ecc64448.2024.10590971","title":"A Compartmental Modelling Framework for Drug Distribution in Lean and Obese Patients in Long-Term General Anesthesia<sup>*</sup>","display_name":"A Compartmental Modelling Framework for Drug Distribution in Lean and Obese Patients in Long-Term General Anesthesia<sup>*</sup>","publication_year":2024,"publication_date":"2024-06-25","ids":{"openalex":"https://openalex.org/W4400946646","doi":"https://doi.org/10.23919/ecc64448.2024.10590971"},"language":"en","primary_location":{"id":"doi:10.23919/ecc64448.2024.10590971","is_oa":false,"landing_page_url":"http://dx.doi.org/10.23919/ecc64448.2024.10590971","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 European Control Conference (ECC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://biblio.ugent.be/publication/01JQTK89EAP0BEWZ886J4J738X/file/01JQTKN7CT22RAC9REZHSE70E8.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063197926","display_name":"Amani R. Ynineb","orcid":"https://orcid.org/0009-0004-9642-2810"},"institutions":[{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Amani R. Ynineb","raw_affiliation_strings":["Ghent University, Systems and Metal Engineering, Research Group on Dynamical Systems and Control, Tech Lane Science Park 125,Department of Electromechanics,Zwijnaarde,Belgium,9052"],"affiliations":[{"raw_affiliation_string":"Ghent University, Systems and Metal Engineering, Research Group on Dynamical Systems and Control, Tech Lane Science Park 125,Department of Electromechanics,Zwijnaarde,Belgium,9052","institution_ids":["https://openalex.org/I32597200"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046106298","display_name":"Erhan Yumuk","orcid":"https://orcid.org/0000-0001-9416-6690"},"institutions":[{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Erhan Yumuk","raw_affiliation_strings":["Ghent University, Systems and Metal Engineering, Research Group on Dynamical Systems and Control, Tech Lane Science Park 125,Department of Electromechanics,Zwijnaarde,Belgium,9052"],"affiliations":[{"raw_affiliation_string":"Ghent University, Systems and Metal Engineering, Research Group on Dynamical Systems and Control, Tech Lane Science Park 125,Department of Electromechanics,Zwijnaarde,Belgium,9052","institution_ids":["https://openalex.org/I32597200"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014252078","display_name":"Hamed Farbakhsh","orcid":"https://orcid.org/0000-0001-5550-8889"},"institutions":[{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Hamed Farbakhsh","raw_affiliation_strings":["Ghent University, Systems and Metal Engineering, Research Group on Dynamical Systems and Control, Tech Lane Science Park 125,Department of Electromechanics,Zwijnaarde,Belgium,9052"],"affiliations":[{"raw_affiliation_string":"Ghent University, Systems and Metal Engineering, Research Group on Dynamical Systems and Control, Tech Lane Science Park 125,Department of Electromechanics,Zwijnaarde,Belgium,9052","institution_ids":["https://openalex.org/I32597200"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086502873","display_name":"Ghada Ben Othman","orcid":"https://orcid.org/0000-0001-6481-0537"},"institutions":[{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Ghada Ben Othman","raw_affiliation_strings":["Ghent University, Systems and Metal Engineering, Research Group on Dynamical Systems and Control, Tech Lane Science Park 125,Department of Electromechanics,Zwijnaarde,Belgium,9052"],"affiliations":[{"raw_affiliation_string":"Ghent University, Systems and Metal Engineering, Research Group on Dynamical Systems and Control, Tech Lane Science Park 125,Department of Electromechanics,Zwijnaarde,Belgium,9052","institution_ids":["https://openalex.org/I32597200"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073964670","display_name":"Dana Copo\u0163","orcid":"https://orcid.org/0000-0002-6010-830X"},"institutions":[{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Dana Copot","raw_affiliation_strings":["Ghent University, Systems and Metal Engineering, Research Group on Dynamical Systems and Control, Tech Lane Science Park 125,Department of Electromechanics,Zwijnaarde,Belgium,9052"],"affiliations":[{"raw_affiliation_string":"Ghent University, Systems and Metal Engineering, Research Group on Dynamical Systems and Control, Tech Lane Science Park 125,Department of Electromechanics,Zwijnaarde,Belgium,9052","institution_ids":["https://openalex.org/I32597200"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050819340","display_name":"Isabela Birs","orcid":"https://orcid.org/0000-0001-5658-850X"},"institutions":[{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Isabela R. Birs","raw_affiliation_strings":["Ghent University, Systems and Metal Engineering, Research Group on Dynamical Systems and Control, Tech Lane Science Park 125,Department of Electromechanics,Zwijnaarde,Belgium,9052"],"affiliations":[{"raw_affiliation_string":"Ghent University, Systems and Metal Engineering, Research Group on Dynamical Systems and Control, Tech Lane Science Park 125,Department of Electromechanics,Zwijnaarde,Belgium,9052","institution_ids":["https://openalex.org/I32597200"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079587319","display_name":"Cristina I. Mure\u015fan","orcid":"https://orcid.org/0000-0003-2301-4133"},"institutions":[{"id":"https://openalex.org/I158333966","display_name":"Technical University of Cluj-Napoca","ror":"https://ror.org/03r8nwp71","country_code":"RO","type":"education","lineage":["https://openalex.org/I158333966"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Cristina I. Muresan","raw_affiliation_strings":["Technical University of Cluj Napoca, Romania,Department of Automation,Cluj,Romania"],"affiliations":[{"raw_affiliation_string":"Technical University of Cluj Napoca, Romania,Department of Automation,Cluj,Romania","institution_ids":["https://openalex.org/I158333966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013255393","display_name":"Robin De Keyser","orcid":null},"institutions":[{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Robin De Keyser","raw_affiliation_strings":["Ghent University, Systems and Metal Engineering, Research Group on Dynamical Systems and Control, Tech Lane Science Park 125,Department of Electromechanics,Zwijnaarde,Belgium,9052"],"affiliations":[{"raw_affiliation_string":"Ghent University, Systems and Metal Engineering, Research Group on Dynamical Systems and Control, Tech Lane Science Park 125,Department of Electromechanics,Zwijnaarde,Belgium,9052","institution_ids":["https://openalex.org/I32597200"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075599238","display_name":"Samir Ladaci","orcid":"https://orcid.org/0000-0001-6931-4911"},"institutions":[{"id":"https://openalex.org/I2802493600","display_name":"Polytechnic School of Algiers","ror":"https://ror.org/05t0zwy08","country_code":"DZ","type":"education","lineage":["https://openalex.org/I2802493600"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Samir Ladaci","raw_affiliation_strings":["National Polytechnic School,Department of Automatics and Control Engineering,Algiers,Algeria,16200"],"affiliations":[{"raw_affiliation_string":"National Polytechnic School,Department of Automatics and Control Engineering,Algiers,Algeria,16200","institution_ids":["https://openalex.org/I2802493600"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004573956","display_name":"Clara M. Ionescu","orcid":"https://orcid.org/0000-0001-7685-035X"},"institutions":[{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Clara M. Ionescu","raw_affiliation_strings":["Ghent University, Systems and Metal Engineering, Research Group on Dynamical Systems and Control, Tech Lane Science Park 125,Department of Electromechanics,Zwijnaarde,Belgium,9052"],"affiliations":[{"raw_affiliation_string":"Ghent University, Systems and Metal Engineering, Research Group on Dynamical Systems and Control, Tech Lane Science Park 125,Department of Electromechanics,Zwijnaarde,Belgium,9052","institution_ids":["https://openalex.org/I32597200"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045009356","display_name":"Martine Neckebroek","orcid":null},"institutions":[{"id":"https://openalex.org/I2801227569","display_name":"Ghent University Hospital","ror":"https://ror.org/00xmkp704","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801227569"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Martine Neckebroek","raw_affiliation_strings":["Ghent University Hospital,Department of Anesthesia,Ghent,Belgium,9000"],"affiliations":[{"raw_affiliation_string":"Ghent University Hospital,Department of Anesthesia,Ghent,Belgium,9000","institution_ids":["https://openalex.org/I2801227569"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5063197926"],"corresponding_institution_ids":["https://openalex.org/I32597200"],"apc_list":null,"apc_paid":null,"fwci":1.0936,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.77692386,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"3033","last_page":"3038"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11700","display_name":"Hemodynamic Monitoring and Therapy","score":0.9096999764442444,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11700","display_name":"Hemodynamic Monitoring and Therapy","score":0.9096999764442444,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/term","display_name":"Term (time)","score":0.6968063712120056},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.5730207562446594},{"id":"https://openalex.org/keywords/distribution","display_name":"Distribution (mathematics)","score":0.5283632874488831},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4535159170627594},{"id":"https://openalex.org/keywords/anesthesia","display_name":"Anesthesia","score":0.40612801909446716},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.391070693731308},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.27215075492858887},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.2443941831588745},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.21907764673233032},{"id":"https://openalex.org/keywords/mathematical-analysis","display_name":"Mathematical analysis","score":0.07697156071662903}],"concepts":[{"id":"https://openalex.org/C61797465","wikidata":"https://www.wikidata.org/wiki/Q1188986","display_name":"Term (time)","level":2,"score":0.6968063712120056},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5730207562446594},{"id":"https://openalex.org/C110121322","wikidata":"https://www.wikidata.org/wiki/Q865811","display_name":"Distribution (mathematics)","level":2,"score":0.5283632874488831},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4535159170627594},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.40612801909446716},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.391070693731308},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.27215075492858887},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2443941831588745},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.21907764673233032},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.07697156071662903},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.23919/ecc64448.2024.10590971","is_oa":false,"landing_page_url":"http://dx.doi.org/10.23919/ecc64448.2024.10590971","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 European Control Conference (ECC)","raw_type":"proceedings-article"},{"id":"pmh:oai:archive.ugent.be:01JQTK89EAP0BEWZ886J4J738X","is_oa":true,"landing_page_url":"http://hdl.handle.net/1854/LU-01JQTK89EAP0BEWZ886J4J738X","pdf_url":"https://biblio.ugent.be/publication/01JQTK89EAP0BEWZ886J4J738X/file/01JQTKN7CT22RAC9REZHSE70E8.pdf","source":{"id":"https://openalex.org/S4306400478","display_name":"Ghent University Academic Bibliography (Ghent University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I32597200","host_organization_name":"Ghent University","host_organization_lineage":["https://openalex.org/I32597200"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISBN: 9783907144107","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":{"id":"pmh:oai:archive.ugent.be:01JQTK89EAP0BEWZ886J4J738X","is_oa":true,"landing_page_url":"http://hdl.handle.net/1854/LU-01JQTK89EAP0BEWZ886J4J738X","pdf_url":"https://biblio.ugent.be/publication/01JQTK89EAP0BEWZ886J4J738X/file/01JQTKN7CT22RAC9REZHSE70E8.pdf","source":{"id":"https://openalex.org/S4306400478","display_name":"Ghent University Academic Bibliography (Ghent University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I32597200","host_organization_name":"Ghent University","host_organization_lineage":["https://openalex.org/I32597200"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISBN: 9783907144107","raw_type":"info:eu-repo/semantics/publishedVersion"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2121609774","display_name":"Adaptive Multi-Drug Infusion Control System for General Anesthesia in Major Surgery","funder_award_id":"101043225","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4317384102","display_name":null,"funder_award_id":"043225","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G552600353","display_name":null,"funder_award_id":"43225","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G6950085076","display_name":null,"funder_award_id":"PN-III-P1-1.1-PD-2021-0204","funder_id":"https://openalex.org/F4320318622","funder_display_name":"Ministerul Cercet\u0103rii, Inov\u0103rii \u015fi Digitaliz\u0103rii"}],"funders":[{"id":"https://openalex.org/F4320318622","display_name":"Ministerul Cercet\u0103rii, Inov\u0103rii \u015fi Digitaliz\u0103rii","ror":null},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320327336","display_name":"Vlaamse regering","ror":null}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4400946646.pdf"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1980752513","https://openalex.org/W2003988116","https://openalex.org/W2016533177","https://openalex.org/W2105336635","https://openalex.org/W2161853498","https://openalex.org/W2176539500","https://openalex.org/W2523220027","https://openalex.org/W2619995730","https://openalex.org/W2897669098","https://openalex.org/W2986390854","https://openalex.org/W2994145352","https://openalex.org/W3080725906","https://openalex.org/W3119775508","https://openalex.org/W3127028327","https://openalex.org/W3147019584","https://openalex.org/W3164792458","https://openalex.org/W3208295289","https://openalex.org/W4210804302","https://openalex.org/W4308757891","https://openalex.org/W4310092554","https://openalex.org/W4315471955"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W3108674512","https://openalex.org/W1506200166","https://openalex.org/W1489783725","https://openalex.org/W2148612803"],"abstract_inverted_index":{"In":[0,83],"personalized":[1],"medicine":[2],"applications":[3],"such":[4],"as":[5,44,104],"general":[6],"anesthesia,":[7],"an":[8],"individualised":[9],"pharmacokinetic":[10,87],"(PK)":[11],"model":[12,35,89,135],"requires":[13],"to":[14,93,131],"move":[15],"away":[16],"from":[17,40],"the":[18,30,67,86,121,142],"classical":[19],"assumption":[20],"of":[21,47,73,98,108,117,155],"homogeneous":[22],"drug":[23,63,118],"mixing":[24],"in":[25,29,66,80,102,120,140],"various":[26,71,77],"tissue":[27],"compartments":[28],"body.":[31],"By":[32],"default,":[33],"these":[34],"coefficients":[36],"are":[37,113],"pre-surgery":[38],"initialized":[39],"population":[41],"based":[42],"models":[43,150],"a":[45,105,137],"function":[46,107],"age,":[48],"gender,":[49],"weight,":[50],"height,":[51],"lean":[52],"body":[53,109,122],"mass":[54,110],"and":[55,123],"do":[56],"not":[57],"include":[58],"at":[59],"this":[60,84],"moment":[61],"specific":[62],"diffusion":[64],"patterns":[65,116],"fat":[68,74],"compartment,":[69],"whereas":[70],"types":[72],"will":[75],"induce":[76],"time":[78,100],"constants":[79,101],"non-lean":[81],"patients.":[82],"work,":[85],"compartmental":[88],"structure":[90],"is":[91,136],"revisited":[92],"account":[94,125],"for":[95,126,151],"non-uniform":[96],"distribution":[97,119],"uptake/clearance":[99],"patients":[103],"nonlinear":[106],"index.":[111],"Simulations":[112],"confirming":[114],"expected":[115],"can":[124],"post-anesthesia":[127],"side":[128],"effects":[129],"up":[130],"72":[132],"hours.":[133],"The":[134],"novel":[138],"advance":[139],"providing":[141],"control":[143,154],"community":[144],"with":[145],"yet":[146],"increasingly":[147],"realistic":[148],"patient":[149],"closed":[152],"loop":[153],"anesthesia.":[156]},"counts_by_year":[{"year":2025,"cited_by_count":2}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}