{"id":"https://openalex.org/W4292070428","doi":"https://doi.org/10.23919/ecc55457.2022.9837985","title":"Performance and robustness analysis of control strategies for ameliorating cellular host-circuit interactions","display_name":"Performance and robustness analysis of control strategies for ameliorating cellular host-circuit interactions","publication_year":2022,"publication_date":"2022-07-12","ids":{"openalex":"https://openalex.org/W4292070428","doi":"https://doi.org/10.23919/ecc55457.2022.9837985"},"language":"en","primary_location":{"id":"doi:10.23919/ecc55457.2022.9837985","is_oa":false,"landing_page_url":"https://doi.org/10.23919/ecc55457.2022.9837985","pdf_url":null,"source":{"id":"https://openalex.org/S4363607908","display_name":"2022 European Control Conference (ECC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 European Control Conference (ECC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067923983","display_name":"Alexander P. S. Darlington","orcid":"https://orcid.org/0000-0001-8025-6329"},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Alexander P. S. Darlington","raw_affiliation_strings":["University of Warwick,Warwick Integrative Synthetic Biology Centre, School of Engineering,Coventry,UK","Warwick Integrative Synthetic Biology Centre, School of Engineering, University of Warwick, Coventry, UK"],"affiliations":[{"raw_affiliation_string":"University of Warwick,Warwick Integrative Synthetic Biology Centre, School of Engineering,Coventry,UK","institution_ids":["https://openalex.org/I39555362"]},{"raw_affiliation_string":"Warwick Integrative Synthetic Biology Centre, School of Engineering, University of Warwick, Coventry, UK","institution_ids":["https://openalex.org/I39555362"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077819322","display_name":"Declan G. Bates","orcid":"https://orcid.org/0000-0003-1395-9846"},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Declan G. Bates","raw_affiliation_strings":["University of Warwick,Warwick Integrative Synthetic Biology Centre, School of Engineering,Coventry,UK","Warwick Integrative Synthetic Biology Centre, School of Engineering, University of Warwick, Coventry, UK"],"affiliations":[{"raw_affiliation_string":"University of Warwick,Warwick Integrative Synthetic Biology Centre, School of Engineering,Coventry,UK","institution_ids":["https://openalex.org/I39555362"]},{"raw_affiliation_string":"Warwick Integrative Synthetic Biology Centre, School of Engineering, University of Warwick, Coventry, UK","institution_ids":["https://openalex.org/I39555362"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5067923983"],"corresponding_institution_ids":["https://openalex.org/I39555362"],"apc_list":null,"apc_paid":null,"fwci":0.4412,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.56487342,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"233","last_page":"239"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9837999939918518,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.87017422914505},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6136919856071472},{"id":"https://openalex.org/keywords/electronic-circuit","display_name":"Electronic circuit","score":0.4607381224632263},{"id":"https://openalex.org/keywords/feedback-control","display_name":"Feedback control","score":0.46029552817344666},{"id":"https://openalex.org/keywords/synthetic-biology","display_name":"Synthetic biology","score":0.44065847992897034},{"id":"https://openalex.org/keywords/distributed-computing","display_name":"Distributed computing","score":0.39270567893981934},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2269611358642578},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.2037019431591034},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.19621407985687256},{"id":"https://openalex.org/keywords/control-engineering","display_name":"Control engineering","score":0.19057878851890564},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.18954217433929443},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.07947242259979248}],"concepts":[{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.87017422914505},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6136919856071472},{"id":"https://openalex.org/C134146338","wikidata":"https://www.wikidata.org/wiki/Q1815901","display_name":"Electronic circuit","level":2,"score":0.4607381224632263},{"id":"https://openalex.org/C3018651601","wikidata":"https://www.wikidata.org/wiki/Q183635","display_name":"Feedback control","level":2,"score":0.46029552817344666},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.44065847992897034},{"id":"https://openalex.org/C120314980","wikidata":"https://www.wikidata.org/wiki/Q180634","display_name":"Distributed computing","level":1,"score":0.39270567893981934},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2269611358642578},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2037019431591034},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19621407985687256},{"id":"https://openalex.org/C133731056","wikidata":"https://www.wikidata.org/wiki/Q4917288","display_name":"Control engineering","level":1,"score":0.19057878851890564},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.18954217433929443},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07947242259979248},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.23919/ecc55457.2022.9837985","is_oa":false,"landing_page_url":"https://doi.org/10.23919/ecc55457.2022.9837985","pdf_url":null,"source":{"id":"https://openalex.org/S4363607908","display_name":"2022 European Control Conference (ECC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 European Control Conference (ECC)","raw_type":"proceedings-article"},{"id":"pmh:oai:wrap.warwick.ac.uk:168605","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306400665","display_name":"Warwick Research Archive Portal (University of Warwick)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I39555362","host_organization_name":"University of Warwick","host_organization_lineage":["https://openalex.org/I39555362"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Conference Item"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2190445122","display_name":null,"funder_award_id":"RPG-2017-284","funder_id":"https://openalex.org/F4320319993","funder_display_name":"Leverhulme Trust"}],"funders":[{"id":"https://openalex.org/F4320319993","display_name":"Leverhulme Trust","ror":"https://ror.org/012mzw131"},{"id":"https://openalex.org/F4320320005","display_name":"Royal Academy of Engineering","ror":"https://ror.org/0526snb40"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1966645118","https://openalex.org/W2021099440","https://openalex.org/W2037913229","https://openalex.org/W2076477598","https://openalex.org/W2501736566","https://openalex.org/W2610276601","https://openalex.org/W2747801569","https://openalex.org/W2949263858","https://openalex.org/W2951697204","https://openalex.org/W2952545994","https://openalex.org/W2953122708","https://openalex.org/W3141205982","https://openalex.org/W3165074360","https://openalex.org/W3176730080"],"related_works":["https://openalex.org/W2072526354","https://openalex.org/W3141738981","https://openalex.org/W2099102792","https://openalex.org/W4254255930","https://openalex.org/W4377564965","https://openalex.org/W4205129443","https://openalex.org/W2009687716","https://openalex.org/W634364059","https://openalex.org/W4250188017","https://openalex.org/W2153650151"],"abstract_inverted_index":{"Recent":[0],"work":[1],"on":[2],"engineering":[3],"synthetic":[4],"cellular":[5],"circuitry":[6],"has":[7],"shown":[8],"that":[9],"non-regulatory":[10],"interactions":[11],"brought":[12],"about":[13],"through":[14],"competition":[15],"for":[16,90],"shared":[17],"gene":[18,82],"expression":[19,83],"re-sources,":[20],"such":[21],"as":[22],"ribosomes,":[23],"can":[24],"result":[25],"in":[26,53],"degraded":[27],"performance":[28],"(where":[29],"circuit":[30],"behaviour":[31],"deviates":[32],"from":[33,58],"design":[34],"specifications)":[35],"or":[36],"even":[37],"failure":[38],"(qualitatively":[39],"different":[40],"functionality).":[41],"Numerous":[42],"feedback":[43,59],"control":[44,88],"strategies":[45,89],"have":[46],"been":[47],"proposed":[48],"to":[49,85,93,106],"decouple":[50],"co-expressed":[51],"genes":[52],"simple":[54],"genetic":[55],"circuits;":[56],"ranging":[57],"within":[60],"the":[61,95],"circuit,":[62],"resource":[63,98],"allocation":[64],"schemes":[65],"and":[66,102,109],"growth-based":[67],"feedback.":[68],"In":[69],"this":[70],"work,":[71],"we":[72],"utilise":[73],"a":[74],"whole":[75],"cell":[76],"mathematical":[77],"model,":[78],"which":[79],"captures":[80],"key":[81],"trade-offs,":[84],"compare":[86],"these":[87],"their":[91,104],"ability":[92],"ame-liorate":[94],"impact":[96],"of":[97],"limitations,":[99],"maintain":[100],"growth":[101],"assess":[103],"robustness":[105],"host":[107],"uncertainty":[108],"environmental":[110],"variation.":[111]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
