{"id":"https://openalex.org/W3046324384","doi":"https://doi.org/10.23919/ecc51009.2020.9143755","title":"Impulsive Control of Tumor Growth via Nonlinear Model Predictive Control Using Direct Multiple Shooting","display_name":"Impulsive Control of Tumor Growth via Nonlinear Model Predictive Control Using Direct Multiple Shooting","publication_year":2020,"publication_date":"2020-05-01","ids":{"openalex":"https://openalex.org/W3046324384","doi":"https://doi.org/10.23919/ecc51009.2020.9143755","mag":"3046324384"},"language":"en","primary_location":{"id":"doi:10.23919/ecc51009.2020.9143755","is_oa":false,"landing_page_url":"https://doi.org/10.23919/ecc51009.2020.9143755","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 European Control Conference (ECC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048102427","display_name":"Bence Czak\u00f3","orcid":"https://orcid.org/0000-0002-8356-5917"},"institutions":[{"id":"https://openalex.org/I103356709","display_name":"Obuda University","ror":"https://ror.org/00ax71d21","country_code":"HU","type":"education","lineage":["https://openalex.org/I103356709"]}],"countries":["HU"],"is_corresponding":true,"raw_author_name":"Bence Geza Czako","raw_affiliation_strings":["Physiological Controls Research Center within the Research, Innovation and Service Center of Obuda University, Budapest, Hungary"],"affiliations":[{"raw_affiliation_string":"Physiological Controls Research Center within the Research, Innovation and Service Center of Obuda University, Budapest, Hungary","institution_ids":["https://openalex.org/I103356709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071491835","display_name":"D\u00e1niel Andr\u00e1s Drexler","orcid":"https://orcid.org/0000-0001-6655-4354"},"institutions":[{"id":"https://openalex.org/I103356709","display_name":"Obuda University","ror":"https://ror.org/00ax71d21","country_code":"HU","type":"education","lineage":["https://openalex.org/I103356709"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Daniel Andras Drexler","raw_affiliation_strings":["Physiological Controls Research Center within the Research, Innovation and Service Center of Obuda University, Budapest, Hungary"],"affiliations":[{"raw_affiliation_string":"Physiological Controls Research Center within the Research, Innovation and Service Center of Obuda University, Budapest, Hungary","institution_ids":["https://openalex.org/I103356709"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021051122","display_name":"Levente Kov\u00e1cs","orcid":"https://orcid.org/0000-0002-3188-0800"},"institutions":[{"id":"https://openalex.org/I103356709","display_name":"Obuda University","ror":"https://ror.org/00ax71d21","country_code":"HU","type":"education","lineage":["https://openalex.org/I103356709"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Levente Kovacs","raw_affiliation_strings":["Physiological Controls Research Center within the Research, Innovation and Service Center of Obuda University, Budapest, Hungary"],"affiliations":[{"raw_affiliation_string":"Physiological Controls Research Center within the Research, Innovation and Service Center of Obuda University, Budapest, Hungary","institution_ids":["https://openalex.org/I103356709"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5048102427"],"corresponding_institution_ids":["https://openalex.org/I103356709"],"apc_list":null,"apc_paid":null,"fwci":0.105,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.50046739,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"755","last_page":"760"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9904999732971191,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9904999732971191,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9843000173568726,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9739999771118164,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/model-predictive-control","display_name":"Model predictive control","score":0.8549503087997437},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.6862730979919434},{"id":"https://openalex.org/keywords/computation","display_name":"Computation","score":0.6742507219314575},{"id":"https://openalex.org/keywords/nonlinear-system","display_name":"Nonlinear system","score":0.6082452535629272},{"id":"https://openalex.org/keywords/controller","display_name":"Controller (irrigation)","score":0.5857429504394531},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5575081706047058},{"id":"https://openalex.org/keywords/stability","display_name":"Stability (learning theory)","score":0.5202835202217102},{"id":"https://openalex.org/keywords/shooting-method","display_name":"Shooting method","score":0.5090615153312683},{"id":"https://openalex.org/keywords/nonlinear-model","display_name":"Nonlinear model","score":0.41703546047210693},{"id":"https://openalex.org/keywords/optimal-control","display_name":"Optimal control","score":0.4142634868621826},{"id":"https://openalex.org/keywords/control","display_name":"Control (management)","score":0.36915141344070435},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.3403308093547821},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.25253039598464966},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.23142319917678833},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.12931013107299805},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.09558466076850891}],"concepts":[{"id":"https://openalex.org/C172205157","wikidata":"https://www.wikidata.org/wiki/Q1782962","display_name":"Model predictive control","level":3,"score":0.8549503087997437},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.6862730979919434},{"id":"https://openalex.org/C45374587","wikidata":"https://www.wikidata.org/wiki/Q12525525","display_name":"Computation","level":2,"score":0.6742507219314575},{"id":"https://openalex.org/C158622935","wikidata":"https://www.wikidata.org/wiki/Q660848","display_name":"Nonlinear system","level":2,"score":0.6082452535629272},{"id":"https://openalex.org/C203479927","wikidata":"https://www.wikidata.org/wiki/Q5165939","display_name":"Controller (irrigation)","level":2,"score":0.5857429504394531},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5575081706047058},{"id":"https://openalex.org/C112972136","wikidata":"https://www.wikidata.org/wiki/Q7595718","display_name":"Stability (learning theory)","level":2,"score":0.5202835202217102},{"id":"https://openalex.org/C4195266","wikidata":"https://www.wikidata.org/wiki/Q1749769","display_name":"Shooting method","level":3,"score":0.5090615153312683},{"id":"https://openalex.org/C2984755018","wikidata":"https://www.wikidata.org/wiki/Q17118374","display_name":"Nonlinear model","level":3,"score":0.41703546047210693},{"id":"https://openalex.org/C91575142","wikidata":"https://www.wikidata.org/wiki/Q1971426","display_name":"Optimal control","level":2,"score":0.4142634868621826},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.36915141344070435},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.3403308093547821},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.25253039598464966},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.23142319917678833},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.12931013107299805},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.09558466076850891},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C6557445","wikidata":"https://www.wikidata.org/wiki/Q173113","display_name":"Agronomy","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C182310444","wikidata":"https://www.wikidata.org/wiki/Q1332643","display_name":"Boundary value problem","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.23919/ecc51009.2020.9143755","is_oa":false,"landing_page_url":"https://doi.org/10.23919/ecc51009.2020.9143755","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2020 European Control Conference (ECC)","raw_type":"proceedings-article"},{"id":"pmh:oai:real.mtak.hu:121215","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306400081","display_name":"Repository of the Academy's Library (Library of the Hungarian Academy of Sciences)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210140733","host_organization_name":"Library and Information Centre of the Hungarian Academy of Sciences","host_organization_lineage":["https://openalex.org/I4210140733"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Conference or Workshop Item"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8100000023841858,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1982815855","https://openalex.org/W2071290431","https://openalex.org/W2083937970","https://openalex.org/W2088521031","https://openalex.org/W2111054489","https://openalex.org/W2154410696","https://openalex.org/W2563378438","https://openalex.org/W2582437320","https://openalex.org/W2590857018","https://openalex.org/W2733703420","https://openalex.org/W2746253716","https://openalex.org/W2765553351","https://openalex.org/W2766673373","https://openalex.org/W2768806839","https://openalex.org/W2775240467","https://openalex.org/W2898239906","https://openalex.org/W2901212916","https://openalex.org/W2909174692","https://openalex.org/W2923463527","https://openalex.org/W2945990231","https://openalex.org/W2998248873","https://openalex.org/W3000598214","https://openalex.org/W3023483464","https://openalex.org/W3034579744","https://openalex.org/W4254751208"],"related_works":["https://openalex.org/W2510430985","https://openalex.org/W2135217555","https://openalex.org/W2385861654","https://openalex.org/W1921524261","https://openalex.org/W2105669785","https://openalex.org/W2077770696","https://openalex.org/W1510443315","https://openalex.org/W2090274084","https://openalex.org/W2356710096","https://openalex.org/W2382616948"],"abstract_inverted_index":{"Nonlinear":[0],"Model":[1],"Predictive":[2],"Control":[3],"(NMPC)":[4],"is":[5],"utilized":[6],"to":[7,41],"compute":[8],"optimal":[9],"administration":[10,53],"protocols":[11],"for":[12,101],"chemotherapeutic":[13],"treatment.":[14],"By":[15],"using":[16,56],"model-based":[17],"methods,":[18],"the":[19,23,43,46,61,66,69,80,84,91,94],"side":[20],"effects":[21,89],"of":[22,48,60,68,83,93],"drug":[24],"can":[25,51],"be":[26],"mitigated":[27],"in":[28,33,45,120],"conjunction":[29],"with":[30,98,113],"a":[31,57,99],"decrease":[32],"treatment":[34,122],"expenses.":[35],"The":[36,105],"designed":[37],"controller":[38,106],"was":[39,76,107],"able":[40],"provide":[42],"protocol":[44],"form":[47],"impulses":[49],"that":[50,79],"model":[52],"by":[54],"injection,":[55],"smooth":[58],"approximation":[59],"Dirac":[62],"delta":[63],"distribution.":[64],"For":[65],"implementation":[67],"NMPC":[70],"algorithm,":[71],"Direct":[72],"Multiple":[73],"Shooting":[74],"(DMS)":[75],"chosen":[77],"so":[78],"computational":[81],"time":[82],"problem":[85],"remains":[86],"reasonable.":[87],"Numerical":[88],"on":[90,110],"stability":[92],"computation":[95],"were":[96],"discussed,":[97],"solution":[100],"each":[102],"issue":[103],"present.":[104],"also":[108],"tested":[109],"virtual":[111],"patients,":[112],"data":[114],"from":[115],"mice":[116],"experiments,":[117],"which":[118],"concluded":[119],"applicable":[121],"protocols.":[123]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}