{"id":"https://openalex.org/W2969036547","doi":"https://doi.org/10.23919/ecc.2019.8796210","title":"Mathematical Model of the Release of the cTnT and CK-MB cardiac biomarkers in patients with acute myocardial infarction","display_name":"Mathematical Model of the Release of the cTnT and CK-MB cardiac biomarkers in patients with acute myocardial infarction","publication_year":2019,"publication_date":"2019-06-01","ids":{"openalex":"https://openalex.org/W2969036547","doi":"https://doi.org/10.23919/ecc.2019.8796210","mag":"2969036547"},"language":"en","primary_location":{"id":"doi:10.23919/ecc.2019.8796210","is_oa":false,"landing_page_url":"https://doi.org/10.23919/ecc.2019.8796210","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 18th European Control Conference (ECC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102825181","display_name":"Anna Procopio","orcid":"https://orcid.org/0000-0002-3639-8714"},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Anna Procopio","raw_affiliation_strings":["Dept. of Experimental and Clinical Medicine, Universit\u00e0 degli Studi Magna Gn\u00e6cia, Catanzaro, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Experimental and Clinical Medicine, Universit\u00e0 degli Studi Magna Gn\u00e6cia, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039638412","display_name":"Salvatore De Rosa","orcid":"https://orcid.org/0000-0001-5388-942X"},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Salvatore De Rosa","raw_affiliation_strings":["Interventional Cardiology Unit, Universit\u00e0 degli Studi Magna Gn\u00e6cia, Catanzaro, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interventional Cardiology Unit, Universit\u00e0 degli Studi Magna Gn\u00e6cia, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112552822","display_name":"C. Covello","orcid":null},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Caterina Covello","raw_affiliation_strings":["Interventional Cardiology Unit, Universit\u00e0 degli Studi Magna Gn\u00e6cia, Catanzaro, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interventional Cardiology Unit, Universit\u00e0 degli Studi Magna Gn\u00e6cia, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042934091","display_name":"Alessio Merola","orcid":"https://orcid.org/0000-0002-8728-2084"},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessio Merola","raw_affiliation_strings":["Dept. of Experimental and Clinical Medicine, Universit\u00e0 degli Studi Magna Gn\u00e6cia, Catanzaro, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Experimental and Clinical Medicine, Universit\u00e0 degli Studi Magna Gn\u00e6cia, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000680805","display_name":"Jolanda Sabatino","orcid":"https://orcid.org/0000-0002-1661-5419"},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Jolanda Sabatino","raw_affiliation_strings":["Interventional Cardiology Unit, Universit\u00e0 degli Studi Magna Gn\u00e6cia, Catanzaro, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interventional Cardiology Unit, Universit\u00e0 degli Studi Magna Gn\u00e6cia, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018709081","display_name":"Alessia De Luca","orcid":null},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessia De Luca","raw_affiliation_strings":["Interventional Cardiology Unit, Universit\u00e0 degli Studi Magna Gn\u00e6cia, Catanzaro, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interventional Cardiology Unit, Universit\u00e0 degli Studi Magna Gn\u00e6cia, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ciro Indolfi","orcid":null},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ciro Indolfi","raw_affiliation_strings":["Interventional Cardiology Unit, Universit\u00e0 degli Studi Magna Gn\u00e6cia, Catanzaro, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interventional Cardiology Unit, Universit\u00e0 degli Studi Magna Gn\u00e6cia, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030101234","display_name":"Francesco Amato","orcid":"https://orcid.org/0000-0002-9053-3139"},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Amato","raw_affiliation_strings":["Dept. of Experimental and Clinical Medicine, Universit\u00e0 degli Studi Magna Gn\u00e6cia, Catanzaro, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Experimental and Clinical Medicine, Universit\u00e0 degli Studi Magna Gn\u00e6cia, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085080876","display_name":"Carlo Cosentino","orcid":"https://orcid.org/0000-0001-5768-1829"},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carlo Cosentino","raw_affiliation_strings":["Dept. of Experimental and Clinical Medicine, Universit\u00e0 degli Studi Magna Gn\u00e6cia, Catanzaro, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Experimental and Clinical Medicine, Universit\u00e0 degli Studi Magna Gn\u00e6cia, Catanzaro, Italy","institution_ids":["https://openalex.org/I36443711"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I36443711"],"apc_list":null,"apc_paid":null,"fwci":0.8217,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.76386755,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.9836000204086304,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.9625999927520752,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/troponin-complex","display_name":"Troponin complex","score":0.8823279738426208},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"Myocardial infarction","score":0.7204892635345459},{"id":"https://openalex.org/keywords/identifiability","display_name":"Identifiability","score":0.7154862880706787},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.6236822009086609},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.5859674215316772},{"id":"https://openalex.org/keywords/biomarker","display_name":"Biomarker","score":0.5664324164390564},{"id":"https://openalex.org/keywords/creatine-kinase","display_name":"Creatine kinase","score":0.5085607767105103},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4834783673286438},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3626980185508728},{"id":"https://openalex.org/keywords/troponin","display_name":"Troponin","score":0.3370758891105652},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.14352601766586304},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.10474628210067749}],"concepts":[{"id":"https://openalex.org/C8880881","wikidata":"https://www.wikidata.org/wiki/Q7846262","display_name":"Troponin complex","level":4,"score":0.8823279738426208},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.7204892635345459},{"id":"https://openalex.org/C122770356","wikidata":"https://www.wikidata.org/wiki/Q1656753","display_name":"Identifiability","level":2,"score":0.7154862880706787},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6236822009086609},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5859674215316772},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5664324164390564},{"id":"https://openalex.org/C36880943","wikidata":"https://www.wikidata.org/wiki/Q409458","display_name":"Creatine kinase","level":2,"score":0.5085607767105103},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4834783673286438},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3626980185508728},{"id":"https://openalex.org/C36036425","wikidata":"https://www.wikidata.org/wiki/Q7846262","display_name":"Troponin","level":3,"score":0.3370758891105652},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.14352601766586304},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.10474628210067749},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.23919/ecc.2019.8796210","is_oa":false,"landing_page_url":"https://doi.org/10.23919/ecc.2019.8796210","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2019 18th European Control Conference (ECC)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7599999904632568,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W139968527","https://openalex.org/W1591593323","https://openalex.org/W2022564385","https://openalex.org/W2035072927","https://openalex.org/W2117493639","https://openalex.org/W2126921853","https://openalex.org/W2169990865","https://openalex.org/W2321998191","https://openalex.org/W2402846924","https://openalex.org/W2541490590","https://openalex.org/W2595302436","https://openalex.org/W2998675358","https://openalex.org/W4300106150","https://openalex.org/W6682642761","https://openalex.org/W6772286124"],"related_works":["https://openalex.org/W4281782385","https://openalex.org/W2402927453","https://openalex.org/W2754268774","https://openalex.org/W2013195452","https://openalex.org/W2157047587","https://openalex.org/W2334709023","https://openalex.org/W2065602237","https://openalex.org/W2898372520","https://openalex.org/W2550153895","https://openalex.org/W2002261647"],"abstract_inverted_index":{"The":[0],"diagnosis":[1],"of":[2,16,19,34,62,67,84,87,99,122,134,150],"an":[3],"acute":[4],"myocardial":[5],"infarction":[6],"(AMI)":[7],"is":[8,70,126,137],"based,":[9],"among":[10],"other":[11],"things,":[12],"on":[13,58,142],"the":[14,17,23,32,52,65,73,75,82,91,97,114,123,132,135,148,151],"measurement":[15],"level":[18],"cardiac":[20,35,88],"biomarkers":[21],"in":[22,113],"plasma.":[24,119],"In":[25],"order":[26],"to":[27,50,77,118,146],"optimize":[28],"and":[29,128,140],"speed":[30],"up":[31,139],"analysis":[33],"Troponin":[36],"T":[37],"(cTnT),":[38],"we":[39],"have":[40],"previously":[41],"developed":[42],"a":[43,59,110,129,143],"mathematical":[44],"model,":[45],"which":[46],"can":[47],"be":[48],"used":[49],"estimate":[51],"patient-specific":[53],"cTnT":[54,100],"release":[55,83,101,115],"curve,":[56],"based":[57],"discrete":[60],"number":[61],"acquisitions.":[63],"Here,":[64],"effectiveness":[66,149],"our":[68],"approach":[69],"improved":[71],"by":[72],"extending":[74],"model":[76,125],"take":[78],"into":[79,108],"account":[80,109],"also":[81,104],"another":[85],"biomarker":[86],"damage,":[89],"namely":[90],"creatine":[92],"kinase":[93],"MB":[94],"(CK-MB).":[95],"Moreover,":[96],"description":[98],"dynamics":[102],"has":[103],"been":[105],"improved,":[106],"taking":[107],"delay":[111],"mechanism":[112],"from":[116],"cytoplasm":[117],"Structural":[120],"identifiability":[121],"devised":[124],"studied":[127],"procedure":[130],"for":[131],"identification":[133],"parameters":[136],"set":[138],"tested":[141],"clinical":[144],"dataset":[145],"assess":[147],"proposed":[152],"approach.":[153]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2}],"updated_date":"2026-06-26T08:34:08.712188","created_date":"2025-10-10T00:00:00"}