{"id":"https://openalex.org/W1568139545","doi":"https://doi.org/10.23919/ecc.2003.7085188","title":"Optimal input design for low-dimensional systems: An Haldane kinetics example","display_name":"Optimal input design for low-dimensional systems: An Haldane kinetics example","publication_year":2003,"publication_date":"2003-09-01","ids":{"openalex":"https://openalex.org/W1568139545","doi":"https://doi.org/10.23919/ecc.2003.7085188","mag":"1568139545"},"language":"en","primary_location":{"id":"doi:10.23919/ecc.2003.7085188","is_oa":false,"landing_page_url":"https://doi.org/10.23919/ecc.2003.7085188","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2003 European Control Conference (ECC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://edepot.wur.nl/42645","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016277575","display_name":"Karel J. Keesman","orcid":"https://orcid.org/0000-0003-4505-8663"},"institutions":[{"id":"https://openalex.org/I913481162","display_name":"Wageningen University & Research","ror":"https://ror.org/04qw24q55","country_code":"NL","type":"education","lineage":["https://openalex.org/I913481162"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"K. J. Keesman","raw_affiliation_strings":["Systems and Control Group, Wageningen University, Wageningen, PA, THE NETHERLANDS","Systems and Control Group, Wageningen University, Mansholtlaan 10, 6708 PA Wageningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems and Control Group, Wageningen University, Wageningen, PA, THE NETHERLANDS","institution_ids":[]},{"raw_affiliation_string":"Systems and Control Group, Wageningen University, Mansholtlaan 10, 6708 PA Wageningen, The Netherlands","institution_ids":["https://openalex.org/I913481162"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043481570","display_name":"J.D. Stigter","orcid":"https://orcid.org/0000-0001-5210-5929"},"institutions":[{"id":"https://openalex.org/I913481162","display_name":"Wageningen University & Research","ror":"https://ror.org/04qw24q55","country_code":"NL","type":"education","lineage":["https://openalex.org/I913481162"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"J. D. Stigter","raw_affiliation_strings":["Systems and Control Group, Wageningen University, Wageningen, PA, THE NETHERLANDS","Systems and Control Group, Wageningen University, Mansholtlaan 10, 6708 PA Wageningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems and Control Group, Wageningen University, Wageningen, PA, THE NETHERLANDS","institution_ids":[]},{"raw_affiliation_string":"Systems and Control Group, Wageningen University, Mansholtlaan 10, 6708 PA Wageningen, The Netherlands","institution_ids":["https://openalex.org/I913481162"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I913481162"],"apc_list":null,"apc_paid":null,"fwci":1.6383,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.84197221,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":95},"biblio":{"volume":null,"issue":null,"first_page":"1583","last_page":"1588"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10791","display_name":"Advanced Control Systems Optimization","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10791","display_name":"Advanced Control Systems Optimization","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9807999730110168,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13539","display_name":"thermodynamics and calorimetric analyses","score":0.9703999757766724,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/affine-transformation","display_name":"Affine transformation","score":0.6744124293327332},{"id":"https://openalex.org/keywords/sensitivity","display_name":"Sensitivity (control systems)","score":0.5872634053230286},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.5289639830589294},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.5211443901062012},{"id":"https://openalex.org/keywords/biomass","display_name":"Biomass (ecology)","score":0.49999570846557617},{"id":"https://openalex.org/keywords/optimal-design","display_name":"Optimal design","score":0.45650583505630493},{"id":"https://openalex.org/keywords/applied-mathematics","display_name":"Applied mathematics","score":0.4496668577194214},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.44541504979133606},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.4163583517074585},{"id":"https://openalex.org/keywords/topology","display_name":"Topology (electrical circuits)","score":0.33441492915153503},{"id":"https://openalex.org/keywords/combinatorics","display_name":"Combinatorics","score":0.20928484201431274},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.18929588794708252},{"id":"https://openalex.org/keywords/pure-mathematics","display_name":"Pure mathematics","score":0.16330400109291077},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.10360735654830933},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.07221353054046631}],"concepts":[{"id":"https://openalex.org/C92757383","wikidata":"https://www.wikidata.org/wiki/Q382497","display_name":"Affine transformation","level":2,"score":0.6744124293327332},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.5872634053230286},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.5289639830589294},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.5211443901062012},{"id":"https://openalex.org/C115540264","wikidata":"https://www.wikidata.org/wiki/Q2945560","display_name":"Biomass (ecology)","level":2,"score":0.49999570846557617},{"id":"https://openalex.org/C186394612","wikidata":"https://www.wikidata.org/wiki/Q7098942","display_name":"Optimal design","level":2,"score":0.45650583505630493},{"id":"https://openalex.org/C28826006","wikidata":"https://www.wikidata.org/wiki/Q33521","display_name":"Applied mathematics","level":1,"score":0.4496668577194214},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.44541504979133606},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.4163583517074585},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.33441492915153503},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.20928484201431274},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.18929588794708252},{"id":"https://openalex.org/C202444582","wikidata":"https://www.wikidata.org/wiki/Q837863","display_name":"Pure mathematics","level":1,"score":0.16330400109291077},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.10360735654830933},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.07221353054046631},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.0},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.0},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.23919/ecc.2003.7085188","is_oa":false,"landing_page_url":"https://doi.org/10.23919/ecc.2003.7085188","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2003 European Control Conference (ECC)","raw_type":"proceedings-article"},{"id":"pmh:oai:library.wur.nl:wurpubs/326241","is_oa":true,"landing_page_url":"https://research.wur.nl/en/publications/optimal-input-design-for-low-dimensional-systems-an-haldane-kinet","pdf_url":"https://edepot.wur.nl/42645","source":{"id":"https://openalex.org/S4210201231","display_name":"Socio-Environmental Systems Modeling","issn_l":"2663-3027","issn":["2663-3027"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article in monograph or in proceedings"}],"best_oa_location":{"id":"pmh:oai:library.wur.nl:wurpubs/326241","is_oa":true,"landing_page_url":"https://research.wur.nl/en/publications/optimal-input-design-for-low-dimensional-systems-an-haldane-kinet","pdf_url":"https://edepot.wur.nl/42645","source":{"id":"https://openalex.org/S4210201231","display_name":"Socio-Environmental Systems Modeling","issn_l":"2663-3027","issn":["2663-3027"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article in monograph or in proceedings"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1568139545.pdf","grobid_xml":"https://content.openalex.org/works/W1568139545.grobid-xml"},"referenced_works_count":8,"referenced_works":["https://openalex.org/W294186936","https://openalex.org/W648194905","https://openalex.org/W1487160432","https://openalex.org/W1503444734","https://openalex.org/W1603277681","https://openalex.org/W1980052382","https://openalex.org/W2036650141","https://openalex.org/W2798737326"],"related_works":["https://openalex.org/W2038416447","https://openalex.org/W2364151838","https://openalex.org/W2378757965","https://openalex.org/W4224903346","https://openalex.org/W1623358412","https://openalex.org/W2066926363","https://openalex.org/W2354159744","https://openalex.org/W1593262897","https://openalex.org/W2372869593","https://openalex.org/W2351539857"],"abstract_inverted_index":{"In":[0],"this":[1,62],"paper":[2],"the":[3,31,50,53,57,86],"well-known":[4,87],"problem":[5,13,64],"of":[6,37,52],"optimal":[7],"input":[8],"design":[9],"is":[10,14,25,94],"considered.":[11,95],"The":[12],"formulated":[15],"as":[16],"follows:":[17],"given":[18],"a":[19,34,45,66,77,80],"dynamic":[20],"non-linear":[21],"model":[22,54,70],"structure":[23,71],"which":[24],"assumed":[26],"to":[27,56,61,85],"be":[28],"affine":[29],"in":[30],"input,":[32],"and":[33],"specific":[35,63],"parameter":[36],"interest":[38],"\u03b8":[39],"<inf":[40],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[41],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">k</inf>":[42],",":[43],"find":[44],"feedback":[46],"law":[47],"that":[48,82],"maximizes":[49],"sensitivity":[51],"output":[55],"parameter.":[58],"Analytical":[59],"solutions":[60],"for":[65],"general":[67],"single":[68],"state":[69],"are":[72],"presented.":[73],"As":[74],"an":[75],"example":[76],"bioreactor":[78],"with":[79],"biomass":[81,92],"grows":[83],"according":[84],"Haldane":[88],"kinetics":[89],"under":[90],"regulated":[91],"concentration":[93]},"counts_by_year":[{"year":2021,"cited_by_count":2}],"updated_date":"2026-06-26T08:34:08.712188","created_date":"2025-10-10T00:00:00"}