{"id":"https://openalex.org/W2612491493","doi":"https://doi.org/10.23919/date.2017.7927285","title":"Scheduling and optimization of genetic logic circuits on flow-based microfluidic biochips","display_name":"Scheduling and optimization of genetic logic circuits on flow-based microfluidic biochips","publication_year":2017,"publication_date":"2017-03-01","ids":{"openalex":"https://openalex.org/W2612491493","doi":"https://doi.org/10.23919/date.2017.7927285","mag":"2612491493"},"language":"en","primary_location":{"id":"doi:10.23919/date.2017.7927285","is_oa":false,"landing_page_url":"https://doi.org/10.23919/date.2017.7927285","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Design, Automation & Test in Europe Conference & Exhibition (DATE), 2017","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015056071","display_name":"Yu-Jhih Chen","orcid":null},"institutions":[{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yu-Jhih Chen","raw_affiliation_strings":["Dept. of Computer Science, National Tsing Hua University, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Computer Science, National Tsing Hua University, Taiwan","institution_ids":["https://openalex.org/I25846049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061518107","display_name":"Sumit Sharma","orcid":"https://orcid.org/0000-0003-0552-2994"},"institutions":[{"id":"https://openalex.org/I154851008","display_name":"Indian Institute of Technology Roorkee","ror":"https://ror.org/00582g326","country_code":"IN","type":"education","lineage":["https://openalex.org/I154851008"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sumit Sharma","raw_affiliation_strings":["Dept. of Computer Science & Engineering, Indian Institute of Technology Roorkee, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Computer Science & Engineering, Indian Institute of Technology Roorkee, India","institution_ids":["https://openalex.org/I154851008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083074030","display_name":"Sudip Roy","orcid":"https://orcid.org/0000-0001-7873-3069"},"institutions":[{"id":"https://openalex.org/I154851008","display_name":"Indian Institute of Technology Roorkee","ror":"https://ror.org/00582g326","country_code":"IN","type":"education","lineage":["https://openalex.org/I154851008"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sudip Roy","raw_affiliation_strings":["Dept. of Computer Science & Engineering, Indian Institute of Technology Roorkee, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Computer Science & Engineering, Indian Institute of Technology Roorkee, India","institution_ids":["https://openalex.org/I154851008"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062800747","display_name":"Tsung-Yi Ho","orcid":"https://orcid.org/0000-0001-7348-5625"},"institutions":[{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Tsung-Yi Ho","raw_affiliation_strings":["Dept. of Computer Science, National Tsing Hua University, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Computer Science, National Tsing Hua University, Taiwan","institution_ids":["https://openalex.org/I25846049"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1805","last_page":"1810"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12452","display_name":"Electrowetting and Microfluidic Technologies","score":0.9952999949455261,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12452","display_name":"Electrowetting and Microfluidic Technologies","score":0.9952999949455261,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9950000047683716,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9933000206947327,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biochip","display_name":"Biochip","score":0.862981915473938},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5916439890861511},{"id":"https://openalex.org/keywords/logic-gate","display_name":"Logic gate","score":0.5492722988128662},{"id":"https://openalex.org/keywords/microfluidics","display_name":"Microfluidics","score":0.5306576490402222},{"id":"https://openalex.org/keywords/logic-synthesis","display_name":"Logic synthesis","score":0.4939461350440979},{"id":"https://openalex.org/keywords/scheduling","display_name":"Scheduling (production processes)","score":0.4319976568222046},{"id":"https://openalex.org/keywords/electronic-circuit","display_name":"Electronic circuit","score":0.42951372265815735},{"id":"https://openalex.org/keywords/logic-family","display_name":"Logic family","score":0.42513108253479004},{"id":"https://openalex.org/keywords/genetic-algorithm","display_name":"Genetic algorithm","score":0.4192041754722595},{"id":"https://openalex.org/keywords/crosstalk","display_name":"Crosstalk","score":0.4136996567249298},{"id":"https://openalex.org/keywords/electronic-engineering","display_name":"Electronic engineering","score":0.3886456787586212},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.22929009795188904},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.2260327935218811},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.1922932267189026},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.18179157376289368},{"id":"https://openalex.org/keywords/electrical-engineering","display_name":"Electrical engineering","score":0.1721661388874054},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.15896597504615784},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.11989858746528625}],"concepts":[{"id":"https://openalex.org/C87892846","wikidata":"https://www.wikidata.org/wiki/Q864256","display_name":"Biochip","level":2,"score":0.862981915473938},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5916439890861511},{"id":"https://openalex.org/C131017901","wikidata":"https://www.wikidata.org/wiki/Q170451","display_name":"Logic gate","level":2,"score":0.5492722988128662},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.5306576490402222},{"id":"https://openalex.org/C157922185","wikidata":"https://www.wikidata.org/wiki/Q173198","display_name":"Logic synthesis","level":3,"score":0.4939461350440979},{"id":"https://openalex.org/C206729178","wikidata":"https://www.wikidata.org/wiki/Q2271896","display_name":"Scheduling (production processes)","level":2,"score":0.4319976568222046},{"id":"https://openalex.org/C134146338","wikidata":"https://www.wikidata.org/wiki/Q1815901","display_name":"Electronic circuit","level":2,"score":0.42951372265815735},{"id":"https://openalex.org/C162454741","wikidata":"https://www.wikidata.org/wiki/Q173359","display_name":"Logic family","level":4,"score":0.42513108253479004},{"id":"https://openalex.org/C8880873","wikidata":"https://www.wikidata.org/wiki/Q187787","display_name":"Genetic algorithm","level":2,"score":0.4192041754722595},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.4136996567249298},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.3886456787586212},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.22929009795188904},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.2260327935218811},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.1922932267189026},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.18179157376289368},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.1721661388874054},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.15896597504615784},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.11989858746528625},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.23919/date.2017.7927285","is_oa":false,"landing_page_url":"https://doi.org/10.23919/date.2017.7927285","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Design, Automation & Test in Europe Conference & Exhibition (DATE), 2017","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1601042747","https://openalex.org/W1998190982","https://openalex.org/W2027576577","https://openalex.org/W2078444049","https://openalex.org/W2083344954","https://openalex.org/W2083456183","https://openalex.org/W2118464978","https://openalex.org/W2129183345","https://openalex.org/W2132207273","https://openalex.org/W2141564052","https://openalex.org/W2168142693","https://openalex.org/W2520990067","https://openalex.org/W2536225727","https://openalex.org/W4230065389"],"related_works":["https://openalex.org/W1966764473","https://openalex.org/W2098419840","https://openalex.org/W2526300902","https://openalex.org/W2121963733","https://openalex.org/W1977171228","https://openalex.org/W2170504327","https://openalex.org/W4249951793","https://openalex.org/W1990901299","https://openalex.org/W2542337934","https://openalex.org/W2789349722"],"abstract_inverted_index":{"Synthetic":[0],"biologists":[1],"design":[2,171],"genetic":[3,71,115],"logic":[4,20,72,116,130],"circuit":[5,117],"using":[6],"living":[7,24],"cells.":[8,34],"A":[9],"challenge":[10],"in":[11,17,69,100,162,167],"this":[12,98,110],"task":[13],"is":[14,44,76],"the":[15,28,32,39,103,136,140,148,155,163,170],"difficulty":[16],"constructing":[18],"bigger":[19],"circuits":[21],"with":[22],"several":[23],"cells":[25],"due":[26],"to":[27,37,45,54],"crosstalk":[29,40],"effect":[30],"among":[31],"biological":[33],"In":[35,109],"order":[36],"remove":[38],"effect,":[41],"current":[42],"practice":[43],"use":[46],"separate":[47],"chambers":[48],"on":[49],"a":[50,70,114],"flow-based":[51,121],"microfluidic":[52,122],"biochip":[53,123],"isolate":[55],"each":[56,67,79,129],"reaction":[57,64,83,126],"zone.":[58],"The":[59],"state-of-the-art":[60],"technique":[61,119],"assumes":[62],"different":[63,82,125],"times":[65],"for":[66,94,120],"gates":[68,96],"circuit.":[73],"This":[74],"assumption":[75],"pessimistic":[77],"as":[78],"gate":[80],"has":[81],"rate":[84],"from":[85],"others.":[86],"Hence,":[87],"it":[88],"will":[89],"cause":[90],"unnecessary":[91],"waiting":[92],"time":[93,107,127],"faster":[95],"and":[97,153,159],"may":[99],"turn":[101,168],"increase":[102],"total":[104,141],"experiment":[105,142],"completion":[106,143],"significantly.":[108],"paper,":[111],"we":[112],"propose":[113],"synthesis":[118],"considering":[124],"of":[128,150,157],"gate.":[131],"Simulation":[132],"results":[133],"show":[134],"that":[135],"proposed":[137],"scheme":[138],"reduces":[139,169],"time.":[144],"We":[145],"further":[146],"minimize":[147],"number":[149],"control":[151,160],"valves":[152],"optimize":[154],"routing":[156],"flow":[158],"layers":[161],"chip":[164],"layout,":[165],"which":[166],"cost.":[172]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}