{"id":"https://openalex.org/W4205369725","doi":"https://doi.org/10.23919/cinc53138.2021.9662901","title":"Left Atrial Appendage Morphology Impacts Thrombus Formation Risks in Multi-Physics Atrial Models","display_name":"Left Atrial Appendage Morphology Impacts Thrombus Formation Risks in Multi-Physics Atrial Models","publication_year":2021,"publication_date":"2021-09-13","ids":{"openalex":"https://openalex.org/W4205369725","doi":"https://doi.org/10.23919/cinc53138.2021.9662901"},"language":"en","primary_location":{"id":"doi:10.23919/cinc53138.2021.9662901","is_oa":false,"landing_page_url":"https://doi.org/10.23919/cinc53138.2021.9662901","pdf_url":null,"source":{"id":"https://openalex.org/S4363605378","display_name":"2021 Computing in Cardiology (CinC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 Computing in Cardiology (CinC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056766454","display_name":"Ahmed Qureshi","orcid":"https://orcid.org/0000-0003-2788-9295"},"institutions":[{"id":"https://openalex.org/I4210144746","display_name":"The London College","ror":"https://ror.org/0546ajs61","country_code":"GB","type":"education","lineage":["https://openalex.org/I4210144746"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Ahmed Qureshi","raw_affiliation_strings":["School of Biomedical Engineering and Imaging Sciences, King's College London,United Kingdom","s College London, London, SE1 7EH, UK"],"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering and Imaging Sciences, King's College London,United Kingdom","institution_ids":[]},{"raw_affiliation_string":"s College London, London, SE1 7EH, UK","institution_ids":["https://openalex.org/I4210144746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041450854","display_name":"Maximilian Balmus","orcid":"https://orcid.org/0000-0002-6003-0178"},"institutions":[{"id":"https://openalex.org/I4210144746","display_name":"The London College","ror":"https://ror.org/0546ajs61","country_code":"GB","type":"education","lineage":["https://openalex.org/I4210144746"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Maximilian Balmus","raw_affiliation_strings":["School of Biomedical Engineering and Imaging Sciences, King's College London,United Kingdom","s College London, United Kingdom"],"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering and Imaging Sciences, King's College London,United Kingdom","institution_ids":[]},{"raw_affiliation_string":"s College London, United Kingdom","institution_ids":["https://openalex.org/I4210144746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015188455","display_name":"D. Yu. Nechipurenko","orcid":"https://orcid.org/0000-0002-8677-129X"},"institutions":[{"id":"https://openalex.org/I19880235","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69","country_code":"RU","type":"education","lineage":["https://openalex.org/I19880235"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Dmitry Nechipurenko","raw_affiliation_strings":["Lomonosov Moscow State University,Department of Physics,Russia","Department of Physics, Lomonosov Moscow State University, Russia"],"affiliations":[{"raw_affiliation_string":"Lomonosov Moscow State University,Department of Physics,Russia","institution_ids":["https://openalex.org/I19880235"]},{"raw_affiliation_string":"Department of Physics, Lomonosov Moscow State University, Russia","institution_ids":["https://openalex.org/I19880235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080077871","display_name":"\u0424\u0430\u0437\u043e\u0438\u043b \u0418. \u0410\u0442\u0430\u0443\u043b\u043b\u0430\u0445\u0430\u043d\u043e\u0432","orcid":"https://orcid.org/0000-0002-6668-0948"},"institutions":[{"id":"https://openalex.org/I19880235","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69","country_code":"RU","type":"education","lineage":["https://openalex.org/I19880235"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Fazoil Ataullakhanov","raw_affiliation_strings":["Lomonosov Moscow State University,Department of Physics,Russia","Department of Physics, Lomonosov Moscow State University, Russia"],"affiliations":[{"raw_affiliation_string":"Lomonosov Moscow State University,Department of Physics,Russia","institution_ids":["https://openalex.org/I19880235"]},{"raw_affiliation_string":"Department of Physics, Lomonosov Moscow State University, Russia","institution_ids":["https://openalex.org/I19880235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060467802","display_name":"Steven E. Williams","orcid":"https://orcid.org/0000-0002-7266-2084"},"institutions":[{"id":"https://openalex.org/I4210144746","display_name":"The London College","ror":"https://ror.org/0546ajs61","country_code":"GB","type":"education","lineage":["https://openalex.org/I4210144746"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Steven Williams","raw_affiliation_strings":["School of Biomedical Engineering and Imaging Sciences, King's College London,United Kingdom","s College London, United Kingdom"],"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering and Imaging Sciences, King's College London,United Kingdom","institution_ids":[]},{"raw_affiliation_string":"s College London, United Kingdom","institution_ids":["https://openalex.org/I4210144746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038405190","display_name":"Gregory Y.H. Lip","orcid":"https://orcid.org/0000-0002-7566-1626"},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]},{"id":"https://openalex.org/I4210086861","display_name":"Liverpool Heart and Chest Hospital","ror":"https://ror.org/000849h34","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800087592","https://openalex.org/I4210086861"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gregory Lip","raw_affiliation_strings":["University of Liverpool,Liverpool Heart and Chest Hospital,United Kingdom","Liverpool Heart and Chest Hospital, University of Liverpool, United Kingdom"],"affiliations":[{"raw_affiliation_string":"University of Liverpool,Liverpool Heart and Chest Hospital,United Kingdom","institution_ids":["https://openalex.org/I4210086861","https://openalex.org/I146655781"]},{"raw_affiliation_string":"Liverpool Heart and Chest Hospital, University of Liverpool, United Kingdom","institution_ids":["https://openalex.org/I4210086861","https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014029323","display_name":"David Nordsletten","orcid":"https://orcid.org/0000-0002-5363-4715"},"institutions":[{"id":"https://openalex.org/I4210144746","display_name":"The London College","ror":"https://ror.org/0546ajs61","country_code":"GB","type":"education","lineage":["https://openalex.org/I4210144746"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David Nordsletten","raw_affiliation_strings":["School of Biomedical Engineering and Imaging Sciences, King's College London,United Kingdom","s College London, United Kingdom"],"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering and Imaging Sciences, King's College London,United Kingdom","institution_ids":[]},{"raw_affiliation_string":"s College London, United Kingdom","institution_ids":["https://openalex.org/I4210144746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084556958","display_name":"Oleg Aslanidi","orcid":"https://orcid.org/0000-0003-4813-7682"},"institutions":[{"id":"https://openalex.org/I4210144746","display_name":"The London College","ror":"https://ror.org/0546ajs61","country_code":"GB","type":"education","lineage":["https://openalex.org/I4210144746"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Oleg Aslanidi","raw_affiliation_strings":["School of Biomedical Engineering and Imaging Sciences, King's College London,United Kingdom","s College London, United Kingdom"],"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering and Imaging Sciences, King's College London,United Kingdom","institution_ids":[]},{"raw_affiliation_string":"s College London, United Kingdom","institution_ids":["https://openalex.org/I4210144746"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086405693","display_name":"Adelaide de Vecchi","orcid":"https://orcid.org/0000-0002-4378-0401"},"institutions":[{"id":"https://openalex.org/I4210144746","display_name":"The London College","ror":"https://ror.org/0546ajs61","country_code":"GB","type":"education","lineage":["https://openalex.org/I4210144746"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Adelaide de Vecchi","raw_affiliation_strings":["School of Biomedical Engineering and Imaging Sciences, King's College London,United Kingdom","s College London, United Kingdom"],"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering and Imaging Sciences, King's College London,United Kingdom","institution_ids":[]},{"raw_affiliation_string":"s College London, United Kingdom","institution_ids":["https://openalex.org/I4210144746"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5056766454"],"corresponding_institution_ids":["https://openalex.org/I4210144746"],"apc_list":null,"apc_paid":null,"fwci":2.4159,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.89734513,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.9950000047683716,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.9922999739646912,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thrombus","display_name":"Thrombus","score":0.8566933870315552},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.7062104344367981},{"id":"https://openalex.org/keywords/fibrin","display_name":"Fibrin","score":0.6672935485839844},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.6497828364372253},{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"Atrial fibrillation","score":0.5749660730361938},{"id":"https://openalex.org/keywords/pulsatile-flow","display_name":"Pulsatile flow","score":0.5496675372123718},{"id":"https://openalex.org/keywords/fibrinogen","display_name":"Fibrinogen","score":0.48002496361732483},{"id":"https://openalex.org/keywords/blood-flow","display_name":"Blood flow","score":0.4616697132587433},{"id":"https://openalex.org/keywords/sinus-rhythm","display_name":"Sinus rhythm","score":0.4423696994781494},{"id":"https://openalex.org/keywords/appendage","display_name":"Appendage","score":0.43928760290145874},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.35294586420059204},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3353162109851837},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.2996979355812073}],"concepts":[{"id":"https://openalex.org/C2781362458","wikidata":"https://www.wikidata.org/wiki/Q1588755","display_name":"Thrombus","level":2,"score":0.8566933870315552},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7062104344367981},{"id":"https://openalex.org/C54173615","wikidata":"https://www.wikidata.org/wiki/Q27205","display_name":"Fibrin","level":2,"score":0.6672935485839844},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6497828364372253},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.5749660730361938},{"id":"https://openalex.org/C79191276","wikidata":"https://www.wikidata.org/wiki/Q7259620","display_name":"Pulsatile flow","level":2,"score":0.5496675372123718},{"id":"https://openalex.org/C2779036427","wikidata":"https://www.wikidata.org/wiki/Q381899","display_name":"Fibrinogen","level":2,"score":0.48002496361732483},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.4616697132587433},{"id":"https://openalex.org/C2775914520","wikidata":"https://www.wikidata.org/wiki/Q12335414","display_name":"Sinus rhythm","level":3,"score":0.4423696994781494},{"id":"https://openalex.org/C41451933","wikidata":"https://www.wikidata.org/wiki/Q13415392","display_name":"Appendage","level":2,"score":0.43928760290145874},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35294586420059204},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3353162109851837},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.2996979355812073},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.23919/cinc53138.2021.9662901","is_oa":false,"landing_page_url":"https://doi.org/10.23919/cinc53138.2021.9662901","pdf_url":null,"source":{"id":"https://openalex.org/S4363605378","display_name":"2021 Computing in Cardiology (CinC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 Computing in Cardiology (CinC)","raw_type":"proceedings-article"},{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/2ca7dbfa-06f9-4bf9-9d4a-8557f0b0f67c","is_oa":false,"landing_page_url":"http://www.scopus.com/inward/record.url?scp=85124745718&partnerID=8YFLogxK","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Qureshi, A, Balmus, M, Nechipurenko, D, Ataullakhanov, F, Williams, S, Lip, G, Nordsletten, D, Aslanidi, O & De Vecchi, A 2021, Left Atrial Appendage Morphology Impacts Thrombus Formation Risks in Multi-Physics Atrial Models. in 2021 Computing in Cardiology, CinC 2021. Computing in Cardiology, vol. 2021-September, IEEE Computer Society, 2021 Computing in Cardiology, CinC 2021, Brno, Czech Republic, 13/09/2021. https://doi.org/10.23919/CinC53138.2021.9662901","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2692987181","display_name":"DTP 2018-19 Kings College London","funder_award_id":"EP/R513064/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G8650243175","display_name":null,"funder_award_id":"EP/P013228/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W2000044487","https://openalex.org/W2025955560","https://openalex.org/W2053482681","https://openalex.org/W2114775432","https://openalex.org/W2121767516","https://openalex.org/W2156390580","https://openalex.org/W2158677411","https://openalex.org/W2410445967","https://openalex.org/W2587670613","https://openalex.org/W3042948068","https://openalex.org/W3120527086","https://openalex.org/W6733147407"],"related_works":["https://openalex.org/W621194568","https://openalex.org/W2945127487","https://openalex.org/W1972585653","https://openalex.org/W2082498220","https://openalex.org/W2395336416","https://openalex.org/W3036624957","https://openalex.org/W2022775994","https://openalex.org/W2017506418","https://openalex.org/W2042722294","https://openalex.org/W2414160344"],"abstract_inverted_index":{"Atrial":[0],"fibrillation":[1],"(AF)":[2],"is":[3],"a":[4,53,63,187],"major":[5],"cause":[6],"of":[7,24,34,56,65,68,77,101,130,171,182,189],"stroke":[8],"and":[9,48,88,94,123,133,199],"there":[10],"has":[11,167],"been":[12],"much":[13],"interest":[14],"in":[15,59,62,119,154,157,207],"the":[16,35,69,75,108,127,131,139,144,159,165,168,175,179,201],"underlying":[17],"mechanisms":[18],"leading":[19,112],"to":[20,73,106,113,186,204],"this":[21],"higher":[22],"risk":[23,29,170,181],"thrombus":[25,81,114,172,183,205],"formation.":[26,82,115,173],"The":[27],"latter":[28],"correlates":[30],"with":[31],"four":[32],"morphologies":[33],"left":[36,70],"atrial":[37],"appendage":[38],"(LAA),":[39],"i.e.":[40],"chicken":[41],"wing":[42],"(CW),":[43],"broccoli":[44],"(BR),":[45],"cactus":[46],"(CA)":[47],"windsock":[49],"(WS).":[50],"We":[51],"present":[52],"mechanistic":[54],"study":[55],"coagulation":[57],"dynamics":[58],"blood":[60,85,104,109],"flow":[61,105,191],"series":[64],"2D":[66],"models":[67],"atrium":[71],"(LA)":[72],"dissect":[74],"impact":[76],"LAA":[78,132,145],"shape":[79],"on":[80],"Interactions":[83],"between":[84],"flow,":[86],"viscosity":[87],"key":[89],"clotting":[90],"proteins":[91],"(thrombin,":[92],"fibrinogen":[93],"fibrin)":[95],"were":[96,117],"modelled":[97],"during":[98,197],"1":[99],"minute":[100],"pulsatile":[102],"LA":[103],"simulate":[107],"gelification":[110,160],"process":[111,161],"Simulations":[116],"performed":[118],"sinus":[120],"rhythm":[121],"(SR)":[122],"AF":[124,158],"by":[125],"varying":[126],"active":[128],"contraction":[129],"pulmonary":[134],"vein":[135],"inflow":[136],"velocities.":[137],"In":[138],"CW":[140,166],"morphology,":[141],"fibrin":[142,195],"inside":[143],"was":[146,162],"almost":[147],"completely":[148],"washed":[149],"out":[150],"after":[151],"28":[152],"seconds":[153],"SR,":[155],"while":[156],"slow,":[163],"suggesting":[164],"lowest":[169],"Conversely,":[174],"BR":[176],"morphology":[177],"had":[178],"highest":[180],"formation":[184,206],"due":[185],"region":[188],"sustained":[190],"stasis":[192],"which":[193],"prevented":[194],"washout":[196],"SR":[198],"facilitated":[200],"shortest":[202],"time":[203],"AF.":[208]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}