{"id":"https://openalex.org/W4206146634","doi":"https://doi.org/10.23919/cinc53138.2021.9662840","title":"Alternans and 2-D Spiral Wave Dynamics in Human Atria with Short QT Syndrome Variant 3: A Simulation Study","display_name":"Alternans and 2-D Spiral Wave Dynamics in Human Atria with Short QT Syndrome Variant 3: A Simulation Study","publication_year":2021,"publication_date":"2021-09-13","ids":{"openalex":"https://openalex.org/W4206146634","doi":"https://doi.org/10.23919/cinc53138.2021.9662840"},"language":"en","primary_location":{"id":"doi:10.23919/cinc53138.2021.9662840","is_oa":false,"landing_page_url":"https://doi.org/10.23919/cinc53138.2021.9662840","pdf_url":null,"source":{"id":"https://openalex.org/S4363605378","display_name":"2021 Computing in Cardiology (CinC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 Computing in Cardiology (CinC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100679217","display_name":"Yizhou Liu","orcid":"https://orcid.org/0000-0003-3099-3077"},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Yizhou Liu","raw_affiliation_strings":["Department of Physics & Astronomy, The University of Manchester, Manchester, UK","School of Physics and Astronomy, the University of Manchester, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics & Astronomy, The University of Manchester, Manchester, UK","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"School of Physics and Astronomy, the University of Manchester, Manchester, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002935700","display_name":"Yacong Li","orcid":"https://orcid.org/0000-0001-5313-9733"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yacong Li","raw_affiliation_strings":["School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067590266","display_name":"Cunjing Luo","orcid":null},"institutions":[{"id":"https://openalex.org/I110002522","display_name":"University of Essex","ror":"https://ror.org/02nkf1q06","country_code":"GB","type":"education","lineage":["https://openalex.org/I110002522"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Cunjing Luo","raw_affiliation_strings":["School of Computer Science and Electronic Engineering, University of Essex, Colchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Electronic Engineering, University of Essex, Colchester, UK","institution_ids":["https://openalex.org/I110002522"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043271142","display_name":"Henggui Zhang","orcid":"https://orcid.org/0000-0002-0863-5807"},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]},{"id":"https://openalex.org/I3017480383","display_name":"Southwest Medical University","ror":"https://ror.org/00g2rqs52","country_code":"CN","type":"funder","lineage":["https://openalex.org/I3017480383"]},{"id":"https://openalex.org/I4210113896","display_name":"Qingdao National Laboratory for Marine Science and Technology","ror":"https://ror.org/026sv7t11","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210113896"]}],"countries":["CN","GB"],"is_corresponding":false,"raw_author_name":"Henggui Zhang","raw_affiliation_strings":["Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, China","Qingdao National Laboratory for Marine Science and Technology, Qingdao, China","School of Physics and Astronomy, the University of Manchester, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, China","institution_ids":["https://openalex.org/I3017480383"]},{"raw_affiliation_string":"Qingdao National Laboratory for Marine Science and Technology, Qingdao, China","institution_ids":["https://openalex.org/I4210113896"]},{"raw_affiliation_string":"School of Physics and Astronomy, the University of Manchester, Manchester, UK","institution_ids":["https://openalex.org/I28407311"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.24955117,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9776999950408936,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11021","display_name":"ECG Monitoring and Analysis","score":0.970300018787384,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spiral-wave","display_name":"Spiral wave","score":0.6184053421020508},{"id":"https://openalex.org/keywords/optical-mapping","display_name":"Optical mapping","score":0.5329509973526001},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.5159721970558167},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.49805212020874023},{"id":"https://openalex.org/keywords/short-qt-syndrome","display_name":"Short QT syndrome","score":0.4968273937702179},{"id":"https://openalex.org/keywords/t-wave-alternans","display_name":"T wave alternans","score":0.4475725293159485},{"id":"https://openalex.org/keywords/repolarization","display_name":"Repolarization","score":0.44046714901924133},{"id":"https://openalex.org/keywords/sudden-cardiac-death","display_name":"Sudden cardiac death","score":0.4076290726661682},{"id":"https://openalex.org/keywords/long-qt-syndrome","display_name":"Long QT syndrome","score":0.3714086711406708},{"id":"https://openalex.org/keywords/spiral","display_name":"Spiral (railway)","score":0.3494635820388794},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.33242636919021606},{"id":"https://openalex.org/keywords/qt-interval","display_name":"QT interval","score":0.30513471364974976},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.27091777324676514},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.22724851965904236},{"id":"https://openalex.org/keywords/electrophysiology","display_name":"Electrophysiology","score":0.18382671475410461},{"id":"https://openalex.org/keywords/mathematical-analysis","display_name":"Mathematical analysis","score":0.12109062075614929}],"concepts":[{"id":"https://openalex.org/C2777485032","wikidata":"https://www.wikidata.org/wiki/Q22908993","display_name":"Spiral wave","level":3,"score":0.6184053421020508},{"id":"https://openalex.org/C28289500","wikidata":"https://www.wikidata.org/wiki/Q7098868","display_name":"Optical mapping","level":2,"score":0.5329509973526001},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5159721970558167},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.49805212020874023},{"id":"https://openalex.org/C2779578097","wikidata":"https://www.wikidata.org/wiki/Q1484058","display_name":"Short QT syndrome","level":4,"score":0.4968273937702179},{"id":"https://openalex.org/C2777325121","wikidata":"https://www.wikidata.org/wiki/Q3613169","display_name":"T wave alternans","level":3,"score":0.4475725293159485},{"id":"https://openalex.org/C146403970","wikidata":"https://www.wikidata.org/wiki/Q205729","display_name":"Repolarization","level":3,"score":0.44046714901924133},{"id":"https://openalex.org/C2775935837","wikidata":"https://www.wikidata.org/wiki/Q202837","display_name":"Sudden cardiac death","level":2,"score":0.4076290726661682},{"id":"https://openalex.org/C2779703243","wikidata":"https://www.wikidata.org/wiki/Q653924","display_name":"Long QT syndrome","level":3,"score":0.3714086711406708},{"id":"https://openalex.org/C174128100","wikidata":"https://www.wikidata.org/wiki/Q846907","display_name":"Spiral (railway)","level":2,"score":0.3494635820388794},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.33242636919021606},{"id":"https://openalex.org/C118441451","wikidata":"https://www.wikidata.org/wiki/Q12074763","display_name":"QT interval","level":2,"score":0.30513471364974976},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27091777324676514},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.22724851965904236},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.18382671475410461},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.12109062075614929}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.23919/cinc53138.2021.9662840","is_oa":false,"landing_page_url":"https://doi.org/10.23919/cinc53138.2021.9662840","pdf_url":null,"source":{"id":"https://openalex.org/S4363605378","display_name":"2021 Computing in Cardiology (CinC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 Computing in Cardiology (CinC)","raw_type":"proceedings-article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/c6019373-2ac0-4096-a973-007026fe173a","is_oa":false,"landing_page_url":"https://research.manchester.ac.uk/en/publications/c6019373-2ac0-4096-a973-007026fe173a","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liu, Y, Li, Y, Luo, C & Zhang, H 2021, Alternans and 2-D Spiral Wave Dynamics in Human Atria with Short QT Syndrome Variant 3: A Simulation Study. in 2021 Computing in Cardiology (CinC).","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.699999988079071,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1482350832","https://openalex.org/W1944065708","https://openalex.org/W1964047030","https://openalex.org/W1972424378","https://openalex.org/W2018256150","https://openalex.org/W2045548568","https://openalex.org/W2104749146","https://openalex.org/W2161424604","https://openalex.org/W2627089767"],"related_works":["https://openalex.org/W2004187359","https://openalex.org/W1979365920","https://openalex.org/W2016815227","https://openalex.org/W2755755292","https://openalex.org/W2442419682","https://openalex.org/W1944065708","https://openalex.org/W2002772820","https://openalex.org/W2104714866","https://openalex.org/W133528620","https://openalex.org/W4285600863"],"abstract_inverted_index":{"The":[0,39,57,156],"short":[1],"QT":[2],"syndrome":[3],"(SQTS)":[4],"is":[5,178],"a":[6,179],"genetic":[7],"disease":[8],"of":[9,17,128,160,182],"heart":[10,93],"which":[11],"leads":[12],"to":[13,32,43,47,103,130,164,189],"an":[14],"increased":[15,192],"risk":[16],"atrial":[18,37],"arrhythmias":[19],"and":[20,26,51,79,84,97,133,185],"sudden":[21],"cardiac":[22],"death.":[23],"Cardiac":[24],"alternans":[25,50,135,144,183],"high-frequency":[27],"spiral":[28,53],"waves":[29],"are":[30],"believed":[31],"be":[33],"strongly":[34],"associated":[35],"with":[36],"arrhythmias.":[38],"present":[40],"study":[41],"aims":[42],"use":[44],"computational":[45],"models":[46],"investigate":[48],"the":[49,75,98,115,170,186],"re-entrant":[52,105],"wave":[54,107],"in":[55,91,108,114,138,153,193],"SQTS.":[56],"Colman-Zhang":[58],"(CZ)":[59],"human":[60],"atria":[61],"cell":[62],"model":[63],"was":[64,89,101,136,148,167],"implemented":[65],"for":[66],"simulation.":[67],"Newly":[68],"developed":[69],"<tex":[70,119],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[71,120],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">${I_{\\text{K1}}}$</tex>":[72],"formulations":[73],"describing":[74],"wide":[76],"type":[77],"(WT)":[78],"two":[80],"SQTS":[81,194],"mutations":[82],"(D172N":[83],"E299V)":[85],"were":[86,112],"incorporated.":[87],"Alternans":[88,111],"studied":[90],"rapid":[92],"beat":[94],"rate":[95],"conditions,":[96],"S1-S2":[99],"protocol":[100],"used":[102],"initiated":[104],"excitation":[106],"2D":[109],"tissue.":[110],"found":[113],"intracellular":[116],"calcium":[117],"concentration":[118],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">${\\left[Ca^{2+}\\right]i}$</tex>":[121],"traces":[122],"from":[123],"basic":[124],"cycle":[125],"length":[126],"(BCL)":[127],"250":[129],"300":[131],"ms,":[132],"no":[134],"observed":[137],"E299V":[139],"mutation":[140],"condition.":[141,155],"In":[142],"contrast,":[143],"emerged":[145],"when":[146],"BCL":[147],"smaller":[149],"than":[150],"410":[151],"ms":[152],"WT":[154],"minimal":[157],"spatial":[158,187],"lengths":[159],"S2":[161],"stimulus":[162],"required":[163],"initiate":[165],"re-entry":[166,190],"reduced":[168],"by":[169],"mutations.":[171],"Therefore,":[172],"our":[173],"findings":[174],"show":[175],"that":[176],"there":[177],"decreased":[180],"observation":[181],"phenomena":[184],"vulnerability":[188],"significantly":[191],"conditions.":[195]},"counts_by_year":[],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
