{"id":"https://openalex.org/W4205785444","doi":"https://doi.org/10.23919/cinc53138.2021.9662675","title":"Influence of Hydroxychloroquine Dosage on the Occurrence of Arrhythmia in COVID-19 Infected Ventricle","display_name":"Influence of Hydroxychloroquine Dosage on the Occurrence of Arrhythmia in COVID-19 Infected Ventricle","publication_year":2021,"publication_date":"2021-09-13","ids":{"openalex":"https://openalex.org/W4205785444","doi":"https://doi.org/10.23919/cinc53138.2021.9662675"},"language":"en","primary_location":{"id":"doi:10.23919/cinc53138.2021.9662675","is_oa":false,"landing_page_url":"https://doi.org/10.23919/cinc53138.2021.9662675","pdf_url":null,"source":{"id":"https://openalex.org/S4363605378","display_name":"2021 Computing in Cardiology (CinC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 Computing in Cardiology (CinC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078280918","display_name":"Ponnuraj Kirthi Priya","orcid":"https://orcid.org/0000-0003-4366-8599"},"institutions":[{"id":"https://openalex.org/I55215948","display_name":"Tata Consultancy Services (India)","ror":"https://ror.org/01b9n8m42","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210086519","https://openalex.org/I55215948"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Ponnuraj Kirthi Priya","raw_affiliation_strings":["Life Sciences, Tata Consultancy Services Limited, Bangalore, Karnataka, India"],"affiliations":[{"raw_affiliation_string":"Life Sciences, Tata Consultancy Services Limited, Bangalore, Karnataka, India","institution_ids":["https://openalex.org/I55215948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112560957","display_name":"Srinivasan Jayaraman","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Srinivasan Jayaraman","raw_affiliation_strings":["Life Sciences, Tata Consultancy Services Limited, Portland, USA"],"affiliations":[{"raw_affiliation_string":"Life Sciences, Tata Consultancy Services Limited, Portland, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5078280918"],"corresponding_institution_ids":["https://openalex.org/I55215948"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.21415929,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.9778000116348267,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydroxychloroquine","display_name":"Hydroxychloroquine","score":0.870350182056427},{"id":"https://openalex.org/keywords/ventricle","display_name":"Ventricle","score":0.7988506555557251},{"id":"https://openalex.org/keywords/qt-interval","display_name":"QT interval","score":0.7138780355453491},{"id":"https://openalex.org/keywords/qrs-complex","display_name":"QRS complex","score":0.680767297744751},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.6601604223251343},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.6546006798744202},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.6320645809173584},{"id":"https://openalex.org/keywords/coronavirus-disease-2019","display_name":"Coronavirus disease 2019 (COVID-19)","score":0.6040547490119934},{"id":"https://openalex.org/keywords/ventricular-tachycardia","display_name":"Ventricular tachycardia","score":0.4808412492275238},{"id":"https://openalex.org/keywords/electrocardiography","display_name":"Electrocardiography","score":0.479263037443161},{"id":"https://openalex.org/keywords/reentry","display_name":"Reentry","score":0.4215620756149292}],"concepts":[{"id":"https://openalex.org/C2779123688","wikidata":"https://www.wikidata.org/wiki/Q421094","display_name":"Hydroxychloroquine","level":5,"score":0.870350182056427},{"id":"https://openalex.org/C2778921608","wikidata":"https://www.wikidata.org/wiki/Q2002035","display_name":"Ventricle","level":2,"score":0.7988506555557251},{"id":"https://openalex.org/C118441451","wikidata":"https://www.wikidata.org/wiki/Q12074763","display_name":"QT interval","level":2,"score":0.7138780355453491},{"id":"https://openalex.org/C111773187","wikidata":"https://www.wikidata.org/wiki/Q1969239","display_name":"QRS complex","level":2,"score":0.680767297744751},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6601604223251343},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6546006798744202},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6320645809173584},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.6040547490119934},{"id":"https://openalex.org/C2776331378","wikidata":"https://www.wikidata.org/wiki/Q56002","display_name":"Ventricular tachycardia","level":2,"score":0.4808412492275238},{"id":"https://openalex.org/C2780040984","wikidata":"https://www.wikidata.org/wiki/Q79785","display_name":"Electrocardiography","level":2,"score":0.479263037443161},{"id":"https://openalex.org/C2777720157","wikidata":"https://www.wikidata.org/wiki/Q7306947","display_name":"Reentry","level":2,"score":0.4215620756149292},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.23919/cinc53138.2021.9662675","is_oa":false,"landing_page_url":"https://doi.org/10.23919/cinc53138.2021.9662675","pdf_url":null,"source":{"id":"https://openalex.org/S4363605378","display_name":"2021 Computing in Cardiology (CinC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 Computing in Cardiology (CinC)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1988355217","https://openalex.org/W2073521043","https://openalex.org/W2076063279","https://openalex.org/W2102211538","https://openalex.org/W2163071496","https://openalex.org/W2583574296","https://openalex.org/W2789621260","https://openalex.org/W3013355240","https://openalex.org/W3022358203","https://openalex.org/W3042330959","https://openalex.org/W6675256631","https://openalex.org/W6777934732"],"related_works":["https://openalex.org/W3206208216","https://openalex.org/W3135831413","https://openalex.org/W3121830174","https://openalex.org/W3161369364","https://openalex.org/W3217614282","https://openalex.org/W4294200465","https://openalex.org/W2460357111","https://openalex.org/W2414033226","https://openalex.org/W3020506420","https://openalex.org/W1895886412"],"abstract_inverted_index":{"The":[0],"interaction":[1],"mechanisms":[2],"of":[3,35,55,79,141,189,199,209],"Hydroxychloroquine":[4],"(HCQ)":[5],"in":[6,139,165,187,215],"a":[7,27,136],"COVID-19":[8,46,93,152,167],"infected":[9],"ventricle":[10],"and":[11,38,44,63,72,124,154,159,169,212],"its":[12],"vulnerability":[13],"to":[14],"arrhythmogenesis":[15],"for":[16,51,135],"different":[17],"dosage":[18,53,78,198],"levels":[19,54],"is":[20,108,148,163],"not":[21],"clearly":[22],"understood.":[23],"To":[24],"address":[25],"this,":[26],"2D":[28],"transmural":[29],"anisotropic":[30],"ventricular":[31,115,193],"tissue":[32],"model":[33,194],"consisting":[34],"endocardial,":[36],"midmyocardial":[37],"epicardial":[39],"myocytes":[40],"are":[41,97,118,133],"config-uredfor":[42],"mild":[43,73,151],"severe":[45,92,166],"conditions":[47,153,168],"as":[48,50,85,87,201,203],"well":[49,86,202],"three":[52],"HCQ":[56,80,158,173,181,200,217],"<tex>$1":[57,121,155],"\\mu":[58,61,122,127,143,156,171,179],"M,":[59],"10":[60],"M$</tex>":[62,123,128,144,157,172,180],"<tex>100</tex>":[64],"<tex>$\\mu":[65],"M)$</tex>.":[66],"Results":[67],"show":[68],"that":[69,110,196],"under":[70,91,111,150],"control":[71],"COVID":[74],"conditions,":[75,94,177],"increasing":[76],"the":[77,82,131,197,207],"prolongs":[81],"QT":[83],"interval":[84],"QRS":[88],"duration,":[89],"although":[90],"inverted":[95],"T-waves":[96],"observed.":[98],"In":[99],"addition,":[100],"on":[101],"pacing":[102,204],"with":[103],"premature":[104,114],"beats":[105],"(PBs),":[106],"it":[107],"observed":[109,149],"all":[112,176],"condition,":[113],"complexes":[116],"(PVCs)":[117],"created":[119],"at":[120],"<tex>":[125],"$10":[126],"HCQ.":[129,145],"However,":[130],"PVCs":[132,186],"sustained":[134],"longer":[137],"duration":[138],"presence":[140,188],"<tex>$10":[142,170],"ST":[146],"elevation":[147],"reentrant":[160],"arrhythmic":[161,210],"activity":[162,211],"generated":[164],"dosage.":[174],"Under":[175],"<tex>$100":[178],"doesn&#x0027;t":[182],"generate":[183],"arrhythmia":[184],"or":[185],"PBs.":[190],"This":[191],"in-silico":[192],"indicates":[195],"sequence":[205],"influences":[206],"appearance":[208],"could":[213],"help":[214],"guiding":[216],"therapy.":[218]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}