{"id":"https://openalex.org/W4413393335","doi":"https://doi.org/10.23919/acc63710.2025.11107909","title":"Seamless integration of target-controlled infusion and closed-loop anesthesia","display_name":"Seamless integration of target-controlled infusion and closed-loop anesthesia","publication_year":2025,"publication_date":"2025-07-08","ids":{"openalex":"https://openalex.org/W4413393335","doi":"https://doi.org/10.23919/acc63710.2025.11107909"},"language":"en","primary_location":{"id":"doi:10.23919/acc63710.2025.11107909","is_oa":false,"landing_page_url":"https://doi.org/10.23919/acc63710.2025.11107909","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 American Control Conference (ACC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://lup.lub.lu.se/search/files/206408299/root.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033021355","display_name":"Ylva Wahlquist","orcid":"https://orcid.org/0000-0001-7265-5012"},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Ylva Wahlquist","raw_affiliation_strings":["Lund University,Department of Automatic Control,Sweden"],"affiliations":[{"raw_affiliation_string":"Lund University,Department of Automatic Control,Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087697079","display_name":"Kristian Soltesz","orcid":"https://orcid.org/0000-0001-6378-7646"},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Kristian Soltesz","raw_affiliation_strings":["Lund University,Department of Automatic Control,Sweden"],"affiliations":[{"raw_affiliation_string":"Lund University,Department of Automatic Control,Sweden","institution_ids":["https://openalex.org/I187531555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5033021355"],"corresponding_institution_ids":["https://openalex.org/I187531555"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.2886958,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"674","last_page":"679"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.978600025177002,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.978600025177002,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9660999774932861,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.9635000228881836,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/closed-loop","display_name":"Closed loop","score":0.7492995262145996},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4621020555496216},{"id":"https://openalex.org/keywords/anesthesia","display_name":"Anesthesia","score":0.4453672170639038},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.4236398935317993},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.280353307723999},{"id":"https://openalex.org/keywords/control-engineering","display_name":"Control engineering","score":0.273476243019104},{"id":"https://openalex.org/keywords/control","display_name":"Control (management)","score":0.159124493598938},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.1568707823753357},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.15590763092041016}],"concepts":[{"id":"https://openalex.org/C3019251811","wikidata":"https://www.wikidata.org/wiki/Q5135346","display_name":"Closed loop","level":2,"score":0.7492995262145996},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4621020555496216},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4453672170639038},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.4236398935317993},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.280353307723999},{"id":"https://openalex.org/C133731056","wikidata":"https://www.wikidata.org/wiki/Q4917288","display_name":"Control engineering","level":1,"score":0.273476243019104},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.159124493598938},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.1568707823753357},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.15590763092041016}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.23919/acc63710.2025.11107909","is_oa":false,"landing_page_url":"https://doi.org/10.23919/acc63710.2025.11107909","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 American Control Conference (ACC)","raw_type":"proceedings-article"},{"id":"pmh:oai:lup.lub.lu.se:dd633fff-6717-46b8-b382-53419b4e3596","is_oa":true,"landing_page_url":"https://lup.lub.lu.se/record/dd633fff-6717-46b8-b382-53419b4e3596","pdf_url":"https://lup.lub.lu.se/search/files/206408299/root.pdf","source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:lup.lub.lu.se:dd633fff-6717-46b8-b382-53419b4e3596","is_oa":true,"landing_page_url":"https://lup.lub.lu.se/record/dd633fff-6717-46b8-b382-53419b4e3596","pdf_url":"https://lup.lub.lu.se/search/files/206408299/root.pdf","source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4413393335.pdf","grobid_xml":"https://content.openalex.org/works/W4413393335.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W1907794989","https://openalex.org/W1973373700","https://openalex.org/W2018799133","https://openalex.org/W2052952057","https://openalex.org/W2094659774","https://openalex.org/W2105336635","https://openalex.org/W2122171313","https://openalex.org/W2607921963","https://openalex.org/W2883595456","https://openalex.org/W2913471540","https://openalex.org/W2972493079","https://openalex.org/W3129924094","https://openalex.org/W3198449724","https://openalex.org/W4312361338","https://openalex.org/W4400946844","https://openalex.org/W4406384040"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W4391913857","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052"],"abstract_inverted_index":{"The":[0],"anesthetic":[1,92],"drug":[2],"propofol":[3,136],"is":[4,66,73],"commonly":[5],"used":[6],"to":[7,23,68,75,129],"control":[8,72,86,134],"hypnotic":[9],"depth":[10],"(suppression":[11],"of":[12,135],"awareness)":[13],"in":[14],"patients":[15],"undergoing":[16],"surgery":[17],"or":[18,132],"intensive":[19],"care.":[20],"In":[21],"addition":[22],"manual":[24],"titration,":[25],"a":[26,90,120],"model-based":[27],"open-loop":[28],"feed-forward":[29],"strategy":[30],"called":[31],"target-controlled":[32],"infusion":[33],"(TCI)":[34],"has":[35,52],"attained":[36],"some":[37],"clinical":[38,58],"popularity.":[39],"Research":[40],"on":[41],"closed-loop":[42,71,102,133],"control,":[43,103],"with":[44,83],"awareness":[45],"estimates":[46],"derived":[47],"from":[48],"an":[49,106],"electroencephalogram":[50],"(EEG),":[51],"proven":[53],"feasible":[54],"through":[55],"several":[56],"extensive":[57],"studies":[59],"over":[60],"the":[61],"past":[62],"decades.":[63],"While":[64],"TCI":[65,100,131],"vulnerable":[67],"model":[69,84,110],"imperfections,":[70],"susceptible":[74],"corrupt":[76],"measurements.":[77],"By":[78],"combining":[79],"Kalman-filter-based":[80],"state":[81],"estimation":[82],"predictive":[85],"(MPC),":[87],"we":[88],"introduce":[89,115],"novel":[91],"dosing":[93],"regimen":[94,117],"that":[95,124],"can":[96],"transition":[97],"seamlessly":[98],"between":[99,109],"and":[101,111,118],"thus":[104],"constituting":[105],"adequate":[107],"trade-off":[108],"measurement":[112],"reliance.":[113],"We":[114],"this":[116],"provide":[119],"realistic":[121],"simulation":[122],"example":[123],"highlights":[125],"its":[126],"strengths":[127],"compared":[128],"pure":[130],"infusion.":[137]},"counts_by_year":[],"updated_date":"2026-03-14T08:43:22.919905","created_date":"2025-10-10T00:00:00"}
