{"id":"https://openalex.org/W4413393273","doi":"https://doi.org/10.23919/acc63710.2025.11107840","title":"Probabilistically Robust Uncertainty Analysis and Optimal Control of Continuous Lyophilization via Polynomial Chaos Theory","display_name":"Probabilistically Robust Uncertainty Analysis and Optimal Control of Continuous Lyophilization via Polynomial Chaos Theory","publication_year":2025,"publication_date":"2025-07-08","ids":{"openalex":"https://openalex.org/W4413393273","doi":"https://doi.org/10.23919/acc63710.2025.11107840"},"language":"en","primary_location":{"id":"doi:10.23919/acc63710.2025.11107840","is_oa":false,"landing_page_url":"https://doi.org/10.23919/acc63710.2025.11107840","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 American Control Conference (ACC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000576101","display_name":"Prakitr Srisuma","orcid":"https://orcid.org/0000-0002-6791-3942"},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Prakitr Srisuma","raw_affiliation_strings":["Massachusetts Institute of Technology,Cambridge,MA,02139"],"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology,Cambridge,MA,02139","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034049110","display_name":"George Barbastathis","orcid":null},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George Barbastathis","raw_affiliation_strings":["Massachusetts Institute of Technology,Cambridge,MA,02139"],"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology,Cambridge,MA,02139","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083684552","display_name":"Richard D. Braatz","orcid":"https://orcid.org/0000-0003-4304-3484"},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard D. Braatz","raw_affiliation_strings":["Massachusetts Institute of Technology,Cambridge,MA,02139"],"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology,Cambridge,MA,02139","institution_ids":["https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5000576101"],"corresponding_institution_ids":["https://openalex.org/I63966007"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.27120855,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1425","last_page":"1430"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11870","display_name":"Structural Analysis and Optimization","score":0.4302999973297119,"subfield":{"id":"https://openalex.org/subfields/2205","display_name":"Civil and Structural Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11870","display_name":"Structural Analysis and Optimization","score":0.4302999973297119,"subfield":{"id":"https://openalex.org/subfields/2205","display_name":"Civil and Structural Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polynomial-chaos","display_name":"Polynomial chaos","score":0.7176837921142578},{"id":"https://openalex.org/keywords/chaos","display_name":"CHAOS (operating system)","score":0.6526827812194824},{"id":"https://openalex.org/keywords/polynomial","display_name":"Polynomial","score":0.4951836168766022},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.4724239110946655},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4646235406398773},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.4351353347301483},{"id":"https://openalex.org/keywords/control","display_name":"Control (management)","score":0.41997525095939636},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3866594135761261},{"id":"https://openalex.org/keywords/applied-mathematics","display_name":"Applied mathematics","score":0.36760300397872925},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.1851116418838501},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.16521790623664856},{"id":"https://openalex.org/keywords/monte-carlo-method","display_name":"Monte Carlo method","score":0.08307623863220215},{"id":"https://openalex.org/keywords/mathematical-analysis","display_name":"Mathematical analysis","score":0.08240389823913574},{"id":"https://openalex.org/keywords/computer-security","display_name":"Computer security","score":0.07795295119285583}],"concepts":[{"id":"https://openalex.org/C197656079","wikidata":"https://www.wikidata.org/wiki/Q17147719","display_name":"Polynomial chaos","level":3,"score":0.7176837921142578},{"id":"https://openalex.org/C2779374083","wikidata":"https://www.wikidata.org/wiki/Q5011038","display_name":"CHAOS (operating system)","level":2,"score":0.6526827812194824},{"id":"https://openalex.org/C90119067","wikidata":"https://www.wikidata.org/wiki/Q43260","display_name":"Polynomial","level":2,"score":0.4951836168766022},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.4724239110946655},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4646235406398773},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.4351353347301483},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.41997525095939636},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3866594135761261},{"id":"https://openalex.org/C28826006","wikidata":"https://www.wikidata.org/wiki/Q33521","display_name":"Applied mathematics","level":1,"score":0.36760300397872925},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.1851116418838501},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.16521790623664856},{"id":"https://openalex.org/C19499675","wikidata":"https://www.wikidata.org/wiki/Q232207","display_name":"Monte Carlo method","level":2,"score":0.08307623863220215},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.08240389823913574},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.07795295119285583}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.23919/acc63710.2025.11107840","is_oa":false,"landing_page_url":"https://doi.org/10.23919/acc63710.2025.11107840","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 American Control Conference (ACC)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332813","display_name":"Food and Drug Administration","ror":"https://ror.org/0250say61"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W345263468","https://openalex.org/W1538878949","https://openalex.org/W1980632657","https://openalex.org/W1986232056","https://openalex.org/W2016064225","https://openalex.org/W2018159038","https://openalex.org/W2047328135","https://openalex.org/W2125222534","https://openalex.org/W2266676676","https://openalex.org/W2300565961","https://openalex.org/W2321957512","https://openalex.org/W2557055507","https://openalex.org/W2760567406","https://openalex.org/W2793259539","https://openalex.org/W2907358011","https://openalex.org/W2913546575","https://openalex.org/W2954703082","https://openalex.org/W2972732449","https://openalex.org/W2996763548","https://openalex.org/W3007317161","https://openalex.org/W3036410945","https://openalex.org/W3117924354","https://openalex.org/W3155856540","https://openalex.org/W4200100823","https://openalex.org/W4210741764","https://openalex.org/W4360814885","https://openalex.org/W4402264234"],"related_works":["https://openalex.org/W339217817","https://openalex.org/W2797263970","https://openalex.org/W2891782306","https://openalex.org/W2287391662","https://openalex.org/W4381886630","https://openalex.org/W2142056387","https://openalex.org/W2971126152","https://openalex.org/W2789381754","https://openalex.org/W2103244625","https://openalex.org/W108297729"],"abstract_inverted_index":{"Lyophilization,":[0],"aka":[1],"freeze":[2],"drying,":[3],"is":[4,78,93,130],"a":[5,51,57],"process":[6,107],"commonly":[7],"used":[8,140],"to":[9,95,141],"increase":[10],"the":[11,29,33,40,62,66,81,100,110,122,143],"stability":[12],"of":[13,42,102,116,121,147],"various":[14],"drug":[15],"products":[16],"in":[17,32,50,72],"biotherapeutics":[18],"manufacturing,":[19,39],"e.g.,":[20],"mRNA":[21],"vaccines,":[22],"allowing":[23],"for":[24,61,152],"higher":[25],"storage":[26],"temperature.":[27],"While":[28],"current":[30],"trends":[31],"industry":[34],"are":[35,46],"moving":[36],"towards":[37],"continuous":[38,73,148],"majority":[41],"industrial":[43],"lyophilization":[44,149],"processes":[45],"still":[47],"being":[48],"operated":[49],"batch":[52],"mode.":[53],"This":[54],"article":[55],"presents":[56],"framework":[58,134],"that":[59],"accounts":[60],"probabilistic":[63,76,153],"uncertainty":[64,77,103],"during":[65],"primary":[67],"and":[68,97,114,128,135,145],"secondary":[69],"drying":[70],"steps":[71],"lyophilization.":[74],"The":[75,89,119,132],"incorporated":[79],"into":[80,125],"mechanistic":[82],"model":[83,92,124],"via":[84],"polynomial":[85],"chaos":[86],"theory":[87],"(PCT).":[88],"resulting":[90],"PCT-based":[91,123],"able":[94],"accurately":[96],"efficiently":[98],"quantify":[99],"effects":[101],"on":[104],"several":[105],"critical":[106],"variables,":[108],"including":[109],"temperature,":[111],"sublimation":[112],"front,":[113],"concentration":[115],"bound":[117],"water.":[118],"integration":[120],"stochastic":[126],"optimization":[127],"control":[129,146],"demonstrated.":[131],"proposed":[133],"case":[136],"studies":[137],"can":[138],"be":[139],"guide":[142],"design":[144],"while":[150],"accounting":[151],"uncertainty.":[154]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
