{"id":"https://openalex.org/W4413392831","doi":"https://doi.org/10.23919/acc63710.2025.11107677","title":"Towards \"tighter\" titer: model predictive control in fed-batch bioreactors","display_name":"Towards \"tighter\" titer: model predictive control in fed-batch bioreactors","publication_year":2025,"publication_date":"2025-07-08","ids":{"openalex":"https://openalex.org/W4413392831","doi":"https://doi.org/10.23919/acc63710.2025.11107677"},"language":"en","primary_location":{"id":"doi:10.23919/acc63710.2025.11107677","is_oa":false,"landing_page_url":"https://doi.org/10.23919/acc63710.2025.11107677","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 American Control Conference (ACC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045221562","display_name":"\u0391\u03bd\u03b1\u03c3\u03c4\u03b1\u03c3\u03af\u03b1 \u039d\u03b9\u03ba\u03bf\u03bb\u03b1\u03ba\u03bf\u03c0\u03bf\u03cd\u03bb\u03bf\u03c5","orcid":"https://orcid.org/0000-0002-9651-8888"},"institutions":[{"id":"https://openalex.org/I4210115161","display_name":"Glaxosmithkline (Finland)","ror":"https://ror.org/01jxkq910","country_code":"FI","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210115161"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Anastasia Nikolakopoulou","raw_affiliation_strings":["GSK, Process Engineering &amp; Analytics,Collegeville,PA,USA"],"affiliations":[{"raw_affiliation_string":"GSK, Process Engineering &amp; Analytics,Collegeville,PA,USA","institution_ids":["https://openalex.org/I4210115161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101407245","display_name":"Yu Luo","orcid":"https://orcid.org/0000-0002-9570-796X"},"institutions":[{"id":"https://openalex.org/I4210157644","display_name":"International Drug Development","ror":"https://ror.org/056thpa20","country_code":"FR","type":"other","lineage":["https://openalex.org/I4210157644"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Yu Luo","raw_affiliation_strings":["GSK, Biopharm Drug Substance Development,Upper Merior,PA,USA"],"affiliations":[{"raw_affiliation_string":"GSK, Biopharm Drug Substance Development,Upper Merior,PA,USA","institution_ids":["https://openalex.org/I4210157644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5119374864","display_name":"Zach Hatzenbeller","orcid":null},"institutions":[{"id":"https://openalex.org/I4210157644","display_name":"International Drug Development","ror":"https://ror.org/056thpa20","country_code":"FR","type":"other","lineage":["https://openalex.org/I4210157644"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Zach Hatzenbeller","raw_affiliation_strings":["GSK, Biopharm Drug Substance Development,Upper Merior,PA,USA"],"affiliations":[{"raw_affiliation_string":"GSK, Biopharm Drug Substance Development,Upper Merior,PA,USA","institution_ids":["https://openalex.org/I4210157644"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5045221562"],"corresponding_institution_ids":["https://openalex.org/I4210115161"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.32113219,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"2329","last_page":"2335"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10791","display_name":"Advanced Control Systems Optimization","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10791","display_name":"Advanced Control Systems Optimization","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10876","display_name":"Fault Detection and Control Systems","score":0.9825000166893005,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bioreactor","display_name":"Bioreactor","score":0.7760976552963257},{"id":"https://openalex.org/keywords/model-predictive-control","display_name":"Model predictive control","score":0.6160131692886353},{"id":"https://openalex.org/keywords/titer","display_name":"Titer","score":0.5717971920967102},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4107382893562317},{"id":"https://openalex.org/keywords/biochemical-engineering","display_name":"Biochemical engineering","score":0.3911810517311096},{"id":"https://openalex.org/keywords/control","display_name":"Control (management)","score":0.36311277747154236},{"id":"https://openalex.org/keywords/process-engineering","display_name":"Process engineering","score":0.33309632539749146},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.3246028423309326},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.22936490178108215},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.22789159417152405},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.15752515196800232},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.11926800012588501},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.11006373167037964}],"concepts":[{"id":"https://openalex.org/C168170006","wikidata":"https://www.wikidata.org/wiki/Q864699","display_name":"Bioreactor","level":2,"score":0.7760976552963257},{"id":"https://openalex.org/C172205157","wikidata":"https://www.wikidata.org/wiki/Q1782962","display_name":"Model predictive control","level":3,"score":0.6160131692886353},{"id":"https://openalex.org/C32611913","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Titer","level":3,"score":0.5717971920967102},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4107382893562317},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.3911810517311096},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.36311277747154236},{"id":"https://openalex.org/C21880701","wikidata":"https://www.wikidata.org/wiki/Q2144042","display_name":"Process engineering","level":1,"score":0.33309632539749146},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.3246028423309326},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.22936490178108215},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.22789159417152405},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15752515196800232},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.11926800012588501},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.11006373167037964},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.23919/acc63710.2025.11107677","is_oa":false,"landing_page_url":"https://doi.org/10.23919/acc63710.2025.11107677","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 American Control Conference (ACC)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W2028847290","https://openalex.org/W2066400947","https://openalex.org/W2122825543","https://openalex.org/W2134673975","https://openalex.org/W3081679370","https://openalex.org/W3126869566","https://openalex.org/W4220940590","https://openalex.org/W4294541781","https://openalex.org/W4294692003","https://openalex.org/W4321084191","https://openalex.org/W4378193085","https://openalex.org/W4378550329","https://openalex.org/W4379162539","https://openalex.org/W4382919287","https://openalex.org/W4399887105"],"related_works":["https://openalex.org/W4411060914","https://openalex.org/W1980740090","https://openalex.org/W2818141943","https://openalex.org/W4285187183","https://openalex.org/W2552994593","https://openalex.org/W2892231651","https://openalex.org/W19926866","https://openalex.org/W2092409665","https://openalex.org/W1519332797","https://openalex.org/W2376673900"],"abstract_inverted_index":{"Cell":[0],"culture":[1],"processes":[2],"for":[3,100,140,160],"the":[4,18,22,26,33,85,93],"production":[5],"of":[6,21,35,61,106,129],"therapeutic":[7],"monoclonal":[8],"antibodies":[9],"(mAbs)":[10],"often":[11],"suffer":[12],"from":[13,126],"high":[14],"batch-to-batch":[15],"variability":[16],"in":[17,25,58,156],"final":[19],"concentration":[20],"mAb":[23],"(titer)":[24],"bioreactor.":[27],"In":[28],"this":[29,42],"study,":[30],"we":[31],"investigated":[32],"adoption":[34],"model":[36,90],"predictive":[37],"control":[38,154],"(MPC)":[39],"to":[40,91,135],"reduce":[41],"variability,":[43],"even":[44],"under":[45],"process":[46,94,119],"disturbances.":[47],"Both":[48],"Linear":[49],"MPC":[50,54,102,116,134,151],"(LMPC)":[51],"and":[52,143,163],"Nonlinear":[53],"(NMPC)":[55],"were":[56,98],"tested":[57],"a":[59,68,80,88,127],"Design":[60],"Experiments":[62],"(DoE)":[63],"involving":[64],"24":[65],"bioreactors":[66],"at":[67],"250":[69],"mL":[70],"scale":[71],"using":[72],"human-in-the-loop":[73],"(HITL)":[74],"tracking":[75,123],"MPC.":[76],"The":[77,104],"LMPC":[78,142],"used":[79],"linear":[81],"state-space":[82],"model,":[83],"while":[84],"NMPC":[86,144],"employed":[87],"polynomial-NARX":[89],"describe":[92],"dynamics.":[95],"Different":[96],"estimators":[97],"applied":[99],"each":[101],"scheme.":[103],"effect":[105],"two":[107],"different":[108],"disturbances":[109],"was":[110],"evaluated.":[111],"Experimental":[112],"results":[113],"showed":[114],"that":[115,150],"significantly":[117],"reduced":[118],"variation,":[120],"with":[121],"titer":[122,155],"error":[124],"decreasing":[125],"range":[128],"18":[130],"percentage":[131,138],"points":[132,139],"without":[133],"approximately":[136],"5":[137],"both":[141],"case":[145],"studies.":[146],"These":[147],"findings":[148],"suggest":[149],"can":[152],"effectively":[153],"bioprocessing,":[157],"offering":[158],"potential":[159],"increased":[161],"efficiency":[162],"productivity.":[164]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
