{"id":"https://openalex.org/W4413393039","doi":"https://doi.org/10.23919/acc63710.2025.11107602","title":"A Mechanical Ventilation Decision Support Algorithm that Mitigates Organ Failure during Acute Respiratory Distress Syndrome<sup>*</sup>","display_name":"A Mechanical Ventilation Decision Support Algorithm that Mitigates Organ Failure during Acute Respiratory Distress Syndrome<sup>*</sup>","publication_year":2025,"publication_date":"2025-07-08","ids":{"openalex":"https://openalex.org/W4413393039","doi":"https://doi.org/10.23919/acc63710.2025.11107602"},"language":"en","primary_location":{"id":"doi:10.23919/acc63710.2025.11107602","is_oa":false,"landing_page_url":"https://doi.org/10.23919/acc63710.2025.11107602","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 American Control Conference (ACC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060067447","display_name":"Stefanos-Iordanis Papadopoulos","orcid":"https://orcid.org/0000-0002-1424-2647"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stefanos Papadopoulos","raw_affiliation_strings":["University of Pittsburgh,Swanson School of Engineering,Department of Chemical and Petroleum Engineering,Pittsburgh,PA,USA,15261"],"affiliations":[{"raw_affiliation_string":"University of Pittsburgh,Swanson School of Engineering,Department of Chemical and Petroleum Engineering,Pittsburgh,PA,USA,15261","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082272833","display_name":"Gilles Clermont","orcid":"https://orcid.org/0000-0002-0163-1379"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gilles Clermont","raw_affiliation_strings":["University of Pittsburgh,Swanson School of Engineering,Department of Chemical and Petroleum Engineering,Pittsburgh,PA,USA,15261"],"affiliations":[{"raw_affiliation_string":"University of Pittsburgh,Swanson School of Engineering,Department of Chemical and Petroleum Engineering,Pittsburgh,PA,USA,15261","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046365845","display_name":"Robert S. Parker","orcid":null},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert S. Parker","raw_affiliation_strings":["University of Pittsburgh,Department of Critical Care Medicine,Pittsburgh,PA,USA,15261"],"affiliations":[{"raw_affiliation_string":"University of Pittsburgh,Department of Critical Care Medicine,Pittsburgh,PA,USA,15261","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5060067447"],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.40617833,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"2041","last_page":"2046"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10867","display_name":"Intensive Care Unit Cognitive Disorders","score":0.9761999845504761,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10645","display_name":"Cardiac Arrest and Resuscitation","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-respiratory-distress","display_name":"Acute respiratory distress","score":0.6793544888496399},{"id":"https://openalex.org/keywords/mechanical-ventilation","display_name":"Mechanical ventilation","score":0.5807194113731384},{"id":"https://openalex.org/keywords/respiratory-distress","display_name":"Respiratory distress","score":0.5426318049430847},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.48429054021835327},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4577568471431732},{"id":"https://openalex.org/keywords/intensive-care-medicine","display_name":"Intensive care medicine","score":0.45357030630111694},{"id":"https://openalex.org/keywords/respiratory-failure","display_name":"Respiratory failure","score":0.4334403872489929},{"id":"https://openalex.org/keywords/ventilation","display_name":"Ventilation (architecture)","score":0.42404115200042725},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.376340389251709},{"id":"https://openalex.org/keywords/anesthesia","display_name":"Anesthesia","score":0.2157493531703949},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.206743061542511},{"id":"https://openalex.org/keywords/lung","display_name":"Lung","score":0.1626279056072235},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.15920346975326538},{"id":"https://openalex.org/keywords/mechanical-engineering","display_name":"Mechanical engineering","score":0.0774204432964325}],"concepts":[{"id":"https://openalex.org/C2909621147","wikidata":"https://www.wikidata.org/wiki/Q344873","display_name":"Acute respiratory distress","level":3,"score":0.6793544888496399},{"id":"https://openalex.org/C2777080012","wikidata":"https://www.wikidata.org/wiki/Q3766250","display_name":"Mechanical ventilation","level":2,"score":0.5807194113731384},{"id":"https://openalex.org/C141983124","wikidata":"https://www.wikidata.org/wiki/Q188008","display_name":"Respiratory distress","level":2,"score":0.5426318049430847},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.48429054021835327},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4577568471431732},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.45357030630111694},{"id":"https://openalex.org/C2776888751","wikidata":"https://www.wikidata.org/wiki/Q767485","display_name":"Respiratory failure","level":2,"score":0.4334403872489929},{"id":"https://openalex.org/C200457457","wikidata":"https://www.wikidata.org/wiki/Q584049","display_name":"Ventilation (architecture)","level":2,"score":0.42404115200042725},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.376340389251709},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.2157493531703949},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.206743061542511},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.1626279056072235},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.15920346975326538},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0774204432964325}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.23919/acc63710.2025.11107602","is_oa":false,"landing_page_url":"https://doi.org/10.23919/acc63710.2025.11107602","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 American Control Conference (ACC)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W2055332728","https://openalex.org/W2097141283","https://openalex.org/W2134573759","https://openalex.org/W2149890675","https://openalex.org/W2154581887","https://openalex.org/W2159606687","https://openalex.org/W2163351130","https://openalex.org/W2333411966","https://openalex.org/W2334704549","https://openalex.org/W2597070792","https://openalex.org/W2606350880","https://openalex.org/W2905952513","https://openalex.org/W3111911371","https://openalex.org/W3171791689","https://openalex.org/W4211250103","https://openalex.org/W4224240954","https://openalex.org/W4296471666","https://openalex.org/W4319436535","https://openalex.org/W4379881995","https://openalex.org/W4382182198"],"related_works":["https://openalex.org/W2385236099","https://openalex.org/W1975810351","https://openalex.org/W3005838342","https://openalex.org/W2077771712","https://openalex.org/W2382907023","https://openalex.org/W2356112316","https://openalex.org/W2350261372","https://openalex.org/W2348840217","https://openalex.org/W2353667050","https://openalex.org/W2035271293"],"abstract_inverted_index":{"Mechanical":[0,22,117],"ventilation":[1,23,67,118,142],"is":[2,175],"the":[3,32,36,95],"primary":[4],"treatment":[5],"to":[6,41,72,110,125],"support":[7],"lung":[8,96,114],"function":[9,115],"during":[10],"acute":[11],"respiratory":[12,20],"distress":[13],"syndrome":[14],"(ARDS),":[15],"a":[16,73,84,99,105,170],"form":[17],"of":[18,38,43],"severe":[19],"dysfunction.":[21],"protocols":[24,124,143,162],"can":[25,34],"vary":[26],"significantly":[27],"across":[28,169],"hospital":[29],"systems,":[30],"and":[31,70,79,103,135],"variability":[33],"impact":[35],"quality":[37],"care.":[39],"Up":[40],"40%":[42],"patients":[44],"with":[45,52,177],"ARDS":[46,60],"develop":[47],"multiple":[48],"organ":[49],"dysfunction":[50],"syndrome,":[51],"patient":[53,152],"mortality":[54],"ranging":[55],"from":[56,138],"30-50%":[57],"dependent":[58],"on":[59],"severity.":[61],"A":[62,91],"control":[63],"algorithm":[64],"for":[65,76,88],"mechanical":[66,141],"was":[68],"developed":[69],"applied":[71],"physiologically-motivated":[74],"model":[75],"oxygen,":[77],"waste,":[78],"inflammation":[80],"trafficking":[81],"that":[82],"integrates":[83],"game":[85],"theoretic":[86],"approach":[87],"cellular":[89],"decision-making.":[90],"pathogen":[92],"insult":[93],"within":[94,129],"acts":[97],"as":[98,113,154],"disturbance":[100],"decreasing":[101],"oxygenation":[102],"triggering":[104],"systemic":[106],"response,":[107],"which":[108,174],"leads":[109],"controller":[111],"activation":[112],"declines.":[116],"settings":[119],"are":[120,144],"adjusted":[121],"along":[122],"clinically-validated":[123],"maintain":[126],"oxygen":[127],"saturation":[128],"desired":[130],"bounds,":[131],"thereby":[132],"prolonging":[133],"survival":[134],"allowing":[136],"recovery":[137,168],"ARDS.":[139],"Two":[140],"compared":[145],"in":[146,150,167],"their":[147],"respective":[148],"improvement":[149],"virtual":[151],"outcome,":[153],"measured":[155],"by":[156],"recovery,":[157],"survival,":[158],"or":[159],"mortality.":[160],"Both":[161],"produced":[163],"an":[164],"equivalent":[165],"increase":[166],"two-dimensional":[171],"parameter":[172],"space,":[173],"consistent":[176],"clinical":[178],"trial":[179],"outcomes.":[180]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}