{"id":"https://openalex.org/W3208341005","doi":"https://doi.org/10.23919/acc53348.2022.9867859","title":"Internal Feedback in Biological Control: Architectures and Examples","display_name":"Internal Feedback in Biological Control: Architectures and Examples","publication_year":2022,"publication_date":"2022-06-08","ids":{"openalex":"https://openalex.org/W3208341005","doi":"https://doi.org/10.23919/acc53348.2022.9867859","mag":"3208341005"},"language":"en","primary_location":{"id":"doi:10.23919/acc53348.2022.9867859","is_oa":false,"landing_page_url":"https://doi.org/10.23919/acc53348.2022.9867859","pdf_url":null,"source":{"id":"https://openalex.org/S4363607732","display_name":"2022 American Control Conference (ACC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 American Control Conference (ACC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103273718","display_name":"Anish A. Sarma","orcid":"https://orcid.org/0000-0003-1261-0589"},"institutions":[{"id":"https://openalex.org/I4210140498","display_name":"AdTech Systems Research (United States)","ror":"https://ror.org/04v77td31","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140498"]},{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Anish A. Sarma","raw_affiliation_strings":["Caltech,Computation and Neural Systems","Computation and Neural Systems, Caltech"],"affiliations":[{"raw_affiliation_string":"Caltech,Computation and Neural Systems","institution_ids":["https://openalex.org/I4210140498"]},{"raw_affiliation_string":"Computation and Neural Systems, Caltech","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015845354","display_name":"Jing Shuang Li","orcid":"https://orcid.org/0000-0003-4931-8709"},"institutions":[{"id":"https://openalex.org/I4210124601","display_name":"Department of Mathematical Sciences","ror":"https://ror.org/02xkdev90","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210124601"]},{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["RU","US"],"is_corresponding":false,"raw_author_name":"Jing Shuang Lisa Li","raw_affiliation_strings":["Caltech,Computing and Mathematical Sciences","Computing and Mathematical Sciences, Caltech"],"affiliations":[{"raw_affiliation_string":"Caltech,Computing and Mathematical Sciences","institution_ids":["https://openalex.org/I4210124601"]},{"raw_affiliation_string":"Computing and Mathematical Sciences, Caltech","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035228327","display_name":"Josefin Stenberg","orcid":null},"institutions":[{"id":"https://openalex.org/I86987016","display_name":"KTH Royal Institute of Technology","ror":"https://ror.org/026vcq606","country_code":"SE","type":"education","lineage":["https://openalex.org/I86987016"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Josefin Stenberg","raw_affiliation_strings":["KTH Royal Institute of Technology,Engineering Physics","Engineering Physics, KTH Royal Institute of Technology"],"affiliations":[{"raw_affiliation_string":"KTH Royal Institute of Technology,Engineering Physics","institution_ids":["https://openalex.org/I86987016"]},{"raw_affiliation_string":"Engineering Physics, KTH Royal Institute of Technology","institution_ids":["https://openalex.org/I86987016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029018726","display_name":"Gwyneth M Card","orcid":"https://orcid.org/0000-0002-7679-3639"},"institutions":[{"id":"https://openalex.org/I195573530","display_name":"Janelia Research Campus","ror":"https://ror.org/013sk6x84","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410","https://openalex.org/I195573530"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gwyneth Card","raw_affiliation_strings":["HHMI Janelia Research Campus"],"affiliations":[{"raw_affiliation_string":"HHMI Janelia Research Campus","institution_ids":["https://openalex.org/I195573530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053799831","display_name":"Elizabeth S. Heckscher","orcid":null},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth S. Heckscher","raw_affiliation_strings":["University of Chicago,Molecular Genetics and Cell Biology","Molecular Genetics and Cell Biology, University of Chicago"],"affiliations":[{"raw_affiliation_string":"University of Chicago,Molecular Genetics and Cell Biology","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Molecular Genetics and Cell Biology, University of Chicago","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091300565","display_name":"Narayanan Kasthuri","orcid":"https://orcid.org/0000-0003-3825-931X"},"institutions":[{"id":"https://openalex.org/I4210160857","display_name":"Institute of Neurobiology","ror":"https://ror.org/05q9yze82","country_code":"BG","type":"facility","lineage":["https://openalex.org/I24768866","https://openalex.org/I4210160857"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["BG","US"],"is_corresponding":false,"raw_author_name":"Narayanan Kasthuri","raw_affiliation_strings":["University of Chicago,Neurobiology","Neurobiology, University of Chicago"],"affiliations":[{"raw_affiliation_string":"University of Chicago,Neurobiology","institution_ids":["https://openalex.org/I4210160857","https://openalex.org/I40347166"]},{"raw_affiliation_string":"Neurobiology, University of Chicago","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044141636","display_name":"Terrence J. Sejnowski","orcid":"https://orcid.org/0000-0002-0622-7391"},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]},{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Terrence Sejnowski","raw_affiliation_strings":["The Salk Institute for Biological Studies,Computational Neurobiology Laboratory","Computational Neurobiology Laboratory, The Salk Institute for Biological Studies","Biological Sciences, University of California San Diego"],"affiliations":[{"raw_affiliation_string":"The Salk Institute for Biological Studies,Computational Neurobiology Laboratory","institution_ids":["https://openalex.org/I1307098950"]},{"raw_affiliation_string":"Computational Neurobiology Laboratory, The Salk Institute for Biological Studies","institution_ids":["https://openalex.org/I1307098950"]},{"raw_affiliation_string":"Biological Sciences, University of California San Diego","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085737537","display_name":"John C. Doyle","orcid":"https://orcid.org/0000-0002-1828-2486"},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]},{"id":"https://openalex.org/I4210124601","display_name":"Department of Mathematical Sciences","ror":"https://ror.org/02xkdev90","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210124601"]}],"countries":["RU","US"],"is_corresponding":false,"raw_author_name":"John C. Doyle","raw_affiliation_strings":["Caltech,Computing and Mathematical Sciences","Computing and Mathematical Sciences, Caltech"],"affiliations":[{"raw_affiliation_string":"Caltech,Computing and Mathematical Sciences","institution_ids":["https://openalex.org/I4210124601"]},{"raw_affiliation_string":"Computing and Mathematical Sciences, Caltech","institution_ids":["https://openalex.org/I122411786"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5103273718"],"corresponding_institution_ids":["https://openalex.org/I122411786","https://openalex.org/I4210140498"],"apc_list":null,"apc_paid":null,"fwci":3.0864,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.92009494,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":null,"issue":null,"first_page":"456","last_page":"461"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9959999918937683,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12813","display_name":"Plant and Biological Electrophysiology Studies","score":0.9402999877929688,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sketch","display_name":"Sketch","score":0.6792983412742615},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6783949732780457},{"id":"https://openalex.org/keywords/controller","display_name":"Controller (irrigation)","score":0.6373692154884338},{"id":"https://openalex.org/keywords/feedback-control","display_name":"Feedback control","score":0.5400036573410034},{"id":"https://openalex.org/keywords/synthetic-biology","display_name":"Synthetic biology","score":0.5320364832878113},{"id":"https://openalex.org/keywords/internal-model","display_name":"Internal model","score":0.5256503820419312},{"id":"https://openalex.org/keywords/complex-system","display_name":"Complex system","score":0.4810607433319092},{"id":"https://openalex.org/keywords/control-system","display_name":"Control system","score":0.4809648096561432},{"id":"https://openalex.org/keywords/control","display_name":"Control (management)","score":0.4530068635940552},{"id":"https://openalex.org/keywords/control-engineering","display_name":"Control engineering","score":0.3783014118671417},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.37828075885772705},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1696198582649231},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.16508245468139648},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.12071678042411804},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.10805583000183105}],"concepts":[{"id":"https://openalex.org/C2779231336","wikidata":"https://www.wikidata.org/wiki/Q7534724","display_name":"Sketch","level":2,"score":0.6792983412742615},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6783949732780457},{"id":"https://openalex.org/C203479927","wikidata":"https://www.wikidata.org/wiki/Q5165939","display_name":"Controller (irrigation)","level":2,"score":0.6373692154884338},{"id":"https://openalex.org/C3018651601","wikidata":"https://www.wikidata.org/wiki/Q183635","display_name":"Feedback control","level":2,"score":0.5400036573410034},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.5320364832878113},{"id":"https://openalex.org/C28427503","wikidata":"https://www.wikidata.org/wiki/Q13580300","display_name":"Internal model","level":3,"score":0.5256503820419312},{"id":"https://openalex.org/C47822265","wikidata":"https://www.wikidata.org/wiki/Q854457","display_name":"Complex system","level":2,"score":0.4810607433319092},{"id":"https://openalex.org/C17500928","wikidata":"https://www.wikidata.org/wiki/Q959968","display_name":"Control system","level":2,"score":0.4809648096561432},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.4530068635940552},{"id":"https://openalex.org/C133731056","wikidata":"https://www.wikidata.org/wiki/Q4917288","display_name":"Control engineering","level":1,"score":0.3783014118671417},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.37828075885772705},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1696198582649231},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.16508245468139648},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.12071678042411804},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.10805583000183105},{"id":"https://openalex.org/C6557445","wikidata":"https://www.wikidata.org/wiki/Q173113","display_name":"Agronomy","level":1,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.23919/acc53348.2022.9867859","is_oa":false,"landing_page_url":"https://doi.org/10.23919/acc53348.2022.9867859","pdf_url":null,"source":{"id":"https://openalex.org/S4363607732","display_name":"2022 American Control Conference (ACC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 American Control Conference (ACC)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1637936532","https://openalex.org/W1969547738","https://openalex.org/W1969962426","https://openalex.org/W1977675569","https://openalex.org/W1984209164","https://openalex.org/W1997177885","https://openalex.org/W2000869878","https://openalex.org/W2025128915","https://openalex.org/W2032139276","https://openalex.org/W2041042514","https://openalex.org/W2065313971","https://openalex.org/W2066951766","https://openalex.org/W2069525910","https://openalex.org/W2076367743","https://openalex.org/W2095849074","https://openalex.org/W2102869475","https://openalex.org/W2117056464","https://openalex.org/W2119885245","https://openalex.org/W2120079537","https://openalex.org/W2125663122","https://openalex.org/W2133254839","https://openalex.org/W2158893758","https://openalex.org/W2281574543","https://openalex.org/W2497092386","https://openalex.org/W2580201952","https://openalex.org/W2699457337","https://openalex.org/W2919639595","https://openalex.org/W2935277128","https://openalex.org/W2949512190","https://openalex.org/W2952738056","https://openalex.org/W2963752224","https://openalex.org/W2964066074","https://openalex.org/W2971485948","https://openalex.org/W2976024218","https://openalex.org/W2984152148","https://openalex.org/W3041725488","https://openalex.org/W3165062819","https://openalex.org/W3195133498","https://openalex.org/W3206801783","https://openalex.org/W3207847651","https://openalex.org/W6802874435"],"related_works":["https://openalex.org/W2378994405","https://openalex.org/W2385974820","https://openalex.org/W2373478030","https://openalex.org/W2378679551","https://openalex.org/W3149739944","https://openalex.org/W2392363776","https://openalex.org/W2063051341","https://openalex.org/W2591066345","https://openalex.org/W1494563618","https://openalex.org/W2357022711"],"abstract_inverted_index":{"Feedback":[0],"is":[1],"ubiquitous":[2],"in":[3,12,41,89,111,132,150,152],"both":[4],"biological":[5],"and":[6,19,70,120,136],"engineered":[7],"control":[8,27,122],"systems.":[9],"In":[10,61],"biology,":[11],"addition":[13],"to":[14,56,75],"typical":[15],"feedback":[16,24,33],"between":[17],"plant":[18],"controller,":[20],"we":[21,30,64],"observe":[22],"complex":[23,78],"pathways":[25,34],"within":[26],"systems,":[28,43],"which":[29],"call":[31],"internal":[32],"(IFPs).":[35],"These":[36],"IFPs":[37,79,131],"are":[38],"most":[39],"familiar":[40],"neural":[42],"our":[44],"primary":[45],"case":[46],"study,":[47],"but":[48],"they":[49],"appear":[50],"everywhere":[51],"from":[52],"bacterial":[53],"signal":[54],"transduction":[55],"the":[57,72,82,104,113,137],"human":[58],"immune":[59],"system.":[60],"this":[62],"paper,":[63],"describe":[65],"these":[66,145],"very":[67],"different":[68],"examples":[69],"introduce":[71],"concepts":[73],"necessary":[74],"explain":[76],"their":[77],"\u2013":[80],"particularly":[81],"severe":[83],"speed-accuracy":[84],"tradeoffs":[85],"that":[86,102],"constrain":[87],"hardware":[88,116],"biology.":[90],"We":[91],"also":[92],"sketch":[93],"some":[94,126],"minimal":[95],"theory":[96,123,142],"for":[97],"extremely":[98],"simplified":[99],"toy":[100],"models":[101],"highlight":[103],"importance":[105],"of":[106,115],"diversity-enabled":[107],"sweet":[108],"spots":[109],"(DESS)":[110],"mitigating":[112],"impact":[114],"tradeoffs.":[117],"Standard":[118],"modern":[119],"robust":[121],"can":[124],"offer":[125],"insights":[127,146],"into":[128],"previously":[129],"cryptic":[130],"more":[133],"realistic":[134],"models,":[135],"new":[138],"System":[139],"Level":[140],"Synthesis":[141],"expands":[143],"on":[144],"substantially,":[147],"as":[148],"explored":[149],"detail":[151],"companion":[153],"papers.":[154]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
