{"id":"https://openalex.org/W4294691710","doi":"https://doi.org/10.23919/acc53348.2022.9867225","title":"Robust set-point regulation of gene expression using resource competition couplings in mammalian cells","display_name":"Robust set-point regulation of gene expression using resource competition couplings in mammalian cells","publication_year":2022,"publication_date":"2022-06-08","ids":{"openalex":"https://openalex.org/W4294691710","doi":"https://doi.org/10.23919/acc53348.2022.9867225"},"language":"en","primary_location":{"id":"doi:10.23919/acc53348.2022.9867225","is_oa":false,"landing_page_url":"https://doi.org/10.23919/acc53348.2022.9867225","pdf_url":null,"source":{"id":"https://openalex.org/S4363607732","display_name":"2022 American Control Conference (ACC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 American Control Conference (ACC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052528670","display_name":"Giansimone Perrino","orcid":"https://orcid.org/0000-0001-8095-9139"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Giansimone Perrino","raw_affiliation_strings":["Imperial College London,the Imperial College Centre for Synthetic Biology,Department of Bioengineering,London,United Kingdom,SW7 2AZ"],"affiliations":[{"raw_affiliation_string":"Imperial College London,the Imperial College Centre for Synthetic Biology,Department of Bioengineering,London,United Kingdom,SW7 2AZ","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086007559","display_name":"Guy\u2010Bart Stan","orcid":"https://orcid.org/0000-0002-5560-902X"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Guy-Bart Stan","raw_affiliation_strings":["Imperial College London,the Imperial College Centre for Synthetic Biology,Department of Bioengineering,London,United Kingdom,SW7 2AZ"],"affiliations":[{"raw_affiliation_string":"Imperial College London,the Imperial College Centre for Synthetic Biology,Department of Bioengineering,London,United Kingdom,SW7 2AZ","institution_ids":["https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5052528670"],"corresponding_institution_ids":["https://openalex.org/I47508984"],"apc_list":null,"apc_paid":null,"fwci":1.7636,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.85365854,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"1373","last_page":"1378"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.9934999942779541,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.8410377502441406},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.620130181312561},{"id":"https://openalex.org/keywords/resource","display_name":"Resource (disambiguation)","score":0.46975257992744446},{"id":"https://openalex.org/keywords/regulation-of-gene-expression","display_name":"Regulation of gene expression","score":0.4316927492618561},{"id":"https://openalex.org/keywords/distributed-computing","display_name":"Distributed computing","score":0.4115154445171356},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3964040279388428},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.36205658316612244},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3394082188606262},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.33013978600502014},{"id":"https://openalex.org/keywords/control","display_name":"Control (management)","score":0.20487099885940552},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.183447003364563},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.12902000546455383},{"id":"https://openalex.org/keywords/computer-network","display_name":"Computer network","score":0.12208506464958191}],"concepts":[{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.8410377502441406},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.620130181312561},{"id":"https://openalex.org/C206345919","wikidata":"https://www.wikidata.org/wiki/Q20380951","display_name":"Resource (disambiguation)","level":2,"score":0.46975257992744446},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4316927492618561},{"id":"https://openalex.org/C120314980","wikidata":"https://www.wikidata.org/wiki/Q180634","display_name":"Distributed computing","level":1,"score":0.4115154445171356},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3964040279388428},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.36205658316612244},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3394082188606262},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.33013978600502014},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.20487099885940552},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.183447003364563},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12902000546455383},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.12208506464958191}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.23919/acc53348.2022.9867225","is_oa":false,"landing_page_url":"https://doi.org/10.23919/acc53348.2022.9867225","pdf_url":null,"source":{"id":"https://openalex.org/S4363607732","display_name":"2022 American Control Conference (ACC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 American Control Conference (ACC)","raw_type":"proceedings-article"},{"id":"pmh:oai:spiral.imperial.ac.uk:10044/1/101637","is_oa":false,"landing_page_url":"http://hdl.handle.net/10044/1/101637","pdf_url":null,"source":{"id":"https://openalex.org/S4306401396","display_name":"Spiral (Imperial College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I47508984","host_organization_name":"Imperial College London","host_organization_lineage":["https://openalex.org/I47508984"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Control Conference (ACC)","raw_type":"Conference Paper"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320005","display_name":"Royal Academy of Engineering","ror":"https://ror.org/0526snb40"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1963204303","https://openalex.org/W1966645118","https://openalex.org/W2013200276","https://openalex.org/W2068962163","https://openalex.org/W2076477598","https://openalex.org/W2127793379","https://openalex.org/W2192151272","https://openalex.org/W2747801569","https://openalex.org/W2759254532","https://openalex.org/W2792353080","https://openalex.org/W2889985834","https://openalex.org/W2921508993","https://openalex.org/W2949263858","https://openalex.org/W2951697204","https://openalex.org/W2952545994","https://openalex.org/W3000219831","https://openalex.org/W3087683406","https://openalex.org/W3103811267","https://openalex.org/W3127085701","https://openalex.org/W3165837477","https://openalex.org/W3172623022"],"related_works":["https://openalex.org/W2770593030","https://openalex.org/W3154990682","https://openalex.org/W1982160337","https://openalex.org/W2560201613","https://openalex.org/W1971380437","https://openalex.org/W2171975302","https://openalex.org/W2022352247","https://openalex.org/W1983548084","https://openalex.org/W2488129135","https://openalex.org/W2141691317"],"abstract_inverted_index":{"Gene":[0],"expression":[1,12,77],"depends":[2],"on":[3,91,115],"the":[4,92,97,100,132],"cellular":[5],"con-text.":[6],"One":[7],"major":[8],"contributor":[9],"to":[10,39,81,95,123],"gene":[11,76],"variability":[13],"is":[14],"competition":[15,54,117],"for":[16],"limited":[17],"transcriptional":[18],"and":[19,37,64,106],"translational":[20],"re-sources,":[21],"which":[22],"may":[23],"induce":[24],"indirect":[25],"couplings":[26,118],"among":[27],"otherwise":[28],"independently-regulated":[29],"genes.":[30],"Here,":[31],"we":[32,61],"apply":[33],"control":[34,128],"theoretical":[35,112],"concepts":[36],"tools":[38],"design":[40,69,98,113],"an":[41,88],"incoherent":[42],"feedforward":[43],"loop":[44],"(iFFL)":[45],"biomolecular":[46],"controller":[47,103],"operating":[48,130],"in":[49,108],"mammalian":[50],"cells":[51],"using":[52],"translational-resource":[53,116],"couplings.":[55],"Harnessing":[56],"a":[57,120],"resource-aware":[58,68,101,127],"mathematical":[59],"model,":[60],"demonstrate":[62],"analytically":[63],"computationally":[65],"that":[66],"our":[67],"can":[70],"achieve":[71],"near-constant":[72],"set-point":[73,109],"regulation":[74],"of":[75,99],"whilst":[78],"ensuring":[79,104],"robustness":[80,105],"plasmid":[82],"uptake":[83],"variation.":[84],"We":[85],"also":[86],"provide":[87],"analytical":[89],"condition":[90],"model":[93],"parameters":[94],"guide":[96],"iFFL":[102],"performance":[107],"regulation.":[110],"Our":[111],"based":[114],"represents":[119],"promising":[121],"approach":[122],"build":[124],"more":[125],"sophisticated":[126],"circuits":[129],"at":[131],"host-cell":[133],"level.":[134]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}
