{"id":"https://openalex.org/W2155492529","doi":"https://doi.org/10.2390/biecoll-jib-2010-146","title":"Reconstruction of biological networks based on life science data integration","display_name":"Reconstruction of biological networks based on life science data integration","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2155492529","doi":"https://doi.org/10.2390/biecoll-jib-2010-146","mag":"2155492529","pmid":"https://pubmed.ncbi.nlm.nih.gov/20978286"},"language":"en","primary_location":{"id":"pmid:20978286","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20978286","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of integrative bioinformatics","raw_type":null},"type":"article","indexed_in":["datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.2390/biecoll-jib-2010-146","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044680921","display_name":"Benjamin Kormeier","orcid":null},"institutions":[{"id":"https://openalex.org/I20121455","display_name":"Bielefeld University","ror":"https://ror.org/02hpadn98","country_code":"DE","type":"education","lineage":["https://openalex.org/I20121455"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Kormeier, Benjamin","raw_affiliation_strings":["Bioinformatics Department, Bielefeld University, PO Box 100131, 33501 Bielefeld, Germany"],"affiliations":[{"raw_affiliation_string":"Bioinformatics Department, Bielefeld University, PO Box 100131, 33501 Bielefeld, Germany","institution_ids":["https://openalex.org/I20121455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010761596","display_name":"Klaus Hippe","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hippe, Klaus","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019364964","display_name":"Patrizio Arrigo","orcid":"https://orcid.org/0000-0002-6735-0211"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arrigo, Patrizio","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Toepel, Thoralf","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Toepel, Thoralf","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012497786","display_name":"Sebastian Jan Janowski","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Janowski, Sebastian","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Hofestaedt, Ralf","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hofestaedt, Ralf","raw_affiliation_strings":[],"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5044680921"],"corresponding_institution_ids":["https://openalex.org/I20121455"],"apc_list":null,"apc_paid":null,"fwci":0.5422,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.67254977,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"7","issue":"2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9898999929428101,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9764000177383423,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.8665344715118408},{"id":"https://openalex.org/keywords/biological-data","display_name":"Biological data","score":0.834160327911377},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7764909267425537},{"id":"https://openalex.org/keywords/data-integration","display_name":"Data integration","score":0.6449218392372131},{"id":"https://openalex.org/keywords/biological-database","display_name":"Biological database","score":0.5885794758796692},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.5686326622962952},{"id":"https://openalex.org/keywords/data-warehouse","display_name":"Data warehouse","score":0.4561131000518799},{"id":"https://openalex.org/keywords/system-integration","display_name":"System integration","score":0.43946895003318787},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.3602002263069153},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3213626742362976},{"id":"https://openalex.org/keywords/database","display_name":"Database","score":0.3008818030357361},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.15756866335868835},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.13032150268554688},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.08162575960159302}],"concepts":[{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.8665344715118408},{"id":"https://openalex.org/C201797286","wikidata":"https://www.wikidata.org/wiki/Q4914986","display_name":"Biological data","level":2,"score":0.834160327911377},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7764909267425537},{"id":"https://openalex.org/C72634772","wikidata":"https://www.wikidata.org/wiki/Q386824","display_name":"Data integration","level":2,"score":0.6449218392372131},{"id":"https://openalex.org/C20901353","wikidata":"https://www.wikidata.org/wiki/Q4117139","display_name":"Biological database","level":2,"score":0.5885794758796692},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.5686326622962952},{"id":"https://openalex.org/C135572916","wikidata":"https://www.wikidata.org/wiki/Q193351","display_name":"Data warehouse","level":2,"score":0.4561131000518799},{"id":"https://openalex.org/C19527686","wikidata":"https://www.wikidata.org/wiki/Q1665453","display_name":"System integration","level":2,"score":0.43946895003318787},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.3602002263069153},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3213626742362976},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.3008818030357361},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.15756866335868835},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.13032150268554688},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08162575960159302},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001690","descriptor_name":"Biological Science Disciplines","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D001690","descriptor_name":"Biological Science Disciplines","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D001690","descriptor_name":"Biological Science Disciplines","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019108","descriptor_name":"Tight Junctions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019108","descriptor_name":"Tight Junctions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019108","descriptor_name":"Tight Junctions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"pmid:20978286","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20978286","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of integrative bioinformatics","raw_type":null},{"id":"pmh:oai:biecoll.ub.uni-bielefeld.de:5047","is_oa":false,"landing_page_url":"http://biecoll.ub.uni-bielefeld.de/volltexte/2010/5047/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://journal.imbio.de/article.php?aid=146","raw_type":"Journal Article"},{"id":"pmh:oai:pub.librecat.org:1945096","is_oa":false,"landing_page_url":"https://pub.uni-bielefeld.de/record/1945096","pdf_url":null,"source":{"id":"https://openalex.org/S4306401671","display_name":"PUB \u2013 Publications at Bielefeld University (Bielefeld University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I20121455","host_organization_name":"Bielefeld University","host_organization_lineage":["https://openalex.org/I20121455"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Kormeier B, Hippe K, Arrigo P, T\u00f6pel T, Janowski SJ, Hofest\u00e4dt R. Reconstruction of biological networks based on life science data integration. <em>Journal of Integrative Bioinformatics</em>. 2010;7(2).","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.2390/biecoll-jib-2010-146","is_oa":true,"landing_page_url":"https://doi.org/10.2390/biecoll-jib-2010-146","pdf_url":null,"source":{"id":"https://openalex.org/S4306401670","display_name":"PUB \u2013 Publications at Bielefeld University (Bielefeld University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I20121455","host_organization_name":"Bielefeld University","host_organization_lineage":["https://openalex.org/I20121455"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.2390/biecoll-jib-2010-146","is_oa":true,"landing_page_url":"https://doi.org/10.2390/biecoll-jib-2010-146","pdf_url":null,"source":{"id":"https://openalex.org/S4306401670","display_name":"PUB \u2013 Publications at Bielefeld University (Bielefeld University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I20121455","host_organization_name":"Bielefeld University","host_organization_lineage":["https://openalex.org/I20121455"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},"sustainable_development_goals":[{"score":0.5799999833106995,"id":"https://metadata.un.org/sdg/12","display_name":"Responsible consumption and production"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1730348256","https://openalex.org/W1835571316","https://openalex.org/W1983594585","https://openalex.org/W2101791557","https://openalex.org/W2108781775","https://openalex.org/W2119958068","https://openalex.org/W2121520198","https://openalex.org/W2125816119","https://openalex.org/W2127291714","https://openalex.org/W2132349196","https://openalex.org/W2145825942","https://openalex.org/W2149194035","https://openalex.org/W2155991374"],"related_works":[],"abstract_inverted_index":{"For":[0],"the":[1,4,7,45,80,83],"implementation":[2],"of":[3,72,85,92],"virtual":[5],"cell,":[6],"fundamental":[8],"question":[9],"is":[10,31,99],"how":[11],"to":[12],"model":[13],"and":[14,25,64,70],"simulate":[15],"complex":[16],"biological":[17,28,37,60,73,86,97],"networks.":[18,38,74],"Therefore,":[19],"based":[20],"on":[21,76],"relevant":[22],"molecular":[23],"database":[24],"information":[26,57],"systems,":[27],"data":[29,54,61],"integration":[30,48,78],"an":[32],"essential":[33],"step":[34],"in":[35,62],"constructing":[36],"In":[39],"this":[40,77],"paper,":[41],"we":[42],"will":[43],"motivate":[44],"applications":[46],"BioDWH--an":[47],"toolkit":[49],"for":[50,59,68],"building":[51],"life":[52],"science":[53],"warehouses,":[55],"CardioVINEdb--a":[56],"system":[58,81],"cardiovascular-disease":[63,94],"VANESA--a":[65],"network":[66,87,98],"editor":[67],"modeling":[69],"simulation":[71],"Based":[75],"process,":[79],"supports":[82],"generation":[84],"models.":[88],"A":[89],"case":[90],"study":[91],"a":[93],"related":[95],"gene-regulated":[96],"also":[100],"presented.":[101]},"counts_by_year":[{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}