{"id":"https://openalex.org/W6944745545","doi":"https://doi.org/10.2390/biecoll-jib-2004-4","title":"A Multi-Scale Modeling Concept and Computational Tools for the Integrative Analysis of Stationary Metabolic Data","display_name":"A Multi-Scale Modeling Concept and Computational Tools for the Integrative Analysis of Stationary Metabolic Data","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W6944745545","doi":"https://doi.org/10.2390/biecoll-jib-2004-4"},"language":"en","primary_location":{"id":"pmh:oai:biecoll.ub.uni-bielefeld.de:185","is_oa":false,"landing_page_url":"http://biecoll.ub.uni-bielefeld.de/volltexte/2007/185/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://journal.imbio.de/index.php?paper_id=4","raw_type":"Journal Article"},"type":"article","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.2390/biecoll-jib-2004-4","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Lieres, Eric Von","orcid":null},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lieres, Eric Von","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Petersen, S\u00f6ren","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Petersen, S\u00f6ren","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Wiechert, Wolfgang","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wiechert, Wolfgang","raw_affiliation_strings":[],"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.38925298,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9444000124931335,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9444000124931335,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.01140000019222498,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13539","display_name":"thermodynamics and calorimetric analyses","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/field","display_name":"Field (mathematics)","score":0.3005000054836273},{"id":"https://openalex.org/keywords/key","display_name":"Key (lock)","score":0.2809000015258789},{"id":"https://openalex.org/keywords/computational-model","display_name":"Computational model","score":0.2799000144004822},{"id":"https://openalex.org/keywords/focus","display_name":"Focus (optics)","score":0.2745000123977661},{"id":"https://openalex.org/keywords/data-modeling","display_name":"Data modeling","score":0.2705000042915344}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5925999879837036},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3912999927997589},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.32919999957084656},{"id":"https://openalex.org/C9652623","wikidata":"https://www.wikidata.org/wiki/Q190109","display_name":"Field (mathematics)","level":2,"score":0.3005000054836273},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.2809000015258789},{"id":"https://openalex.org/C66024118","wikidata":"https://www.wikidata.org/wiki/Q1122506","display_name":"Computational model","level":2,"score":0.2799000144004822},{"id":"https://openalex.org/C192209626","wikidata":"https://www.wikidata.org/wiki/Q190909","display_name":"Focus (optics)","level":2,"score":0.2745000123977661},{"id":"https://openalex.org/C67186912","wikidata":"https://www.wikidata.org/wiki/Q367664","display_name":"Data modeling","level":2,"score":0.2705000042915344},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.26600000262260437},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.24150000512599945}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:biecoll.ub.uni-bielefeld.de:185","is_oa":false,"landing_page_url":"http://biecoll.ub.uni-bielefeld.de/volltexte/2007/185/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://journal.imbio.de/index.php?paper_id=4","raw_type":"Journal Article"},{"id":"doi:10.2390/biecoll-jib-2004-4","is_oa":true,"landing_page_url":"https://doi.org/10.2390/biecoll-jib-2004-4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401670","display_name":"PUB \u2013 Publications at Bielefeld University (Bielefeld University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I20121455","host_organization_name":"Bielefeld University","host_organization_lineage":["https://openalex.org/I20121455"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.2390/biecoll-jib-2004-4","is_oa":true,"landing_page_url":"https://doi.org/10.2390/biecoll-jib-2004-4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401670","display_name":"PUB \u2013 Publications at Bielefeld University (Bielefeld University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I20121455","host_organization_name":"Bielefeld University","host_organization_lineage":["https://openalex.org/I20121455"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},"sustainable_development_goals":[{"display_name":"Zero hunger","score":0.45375311374664307,"id":"https://metadata.un.org/sdg/2"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Metabolic":[0],"Engineering":[1],"aims":[2],"at":[3,47],"the":[4,11,40,44,82,107,122,129,140,146],"systematic":[5],"analysis":[6,42],"and":[7,29,56,95,103,126,157,163],"targeted":[8],"manipulation":[9],"of":[10,24,43,85,131,138,143,149],"metabolism":[12],"in":[13,20,110,145],"biotechnologically":[14],"utilized":[15],"microorganisms.":[16],"Recently,":[17],"consistent":[18],"stationary":[19],"vivo":[21],"data":[22,46,65,125],"sets":[23],"intracellular":[25],"metabolite":[26],"concentrations,":[27],"fluxes":[28],"specific":[30,147],"enzyme":[31],"activities":[32],"have":[33],"become":[34],"available":[35,63,123],"for":[36,81],"this":[37],"purpose.":[38],"For":[39],"integrative":[41],"metabolic":[45,64],"hand,":[48],"a":[49],"novel":[50],"multi-scale":[51,115],"modeling":[52],"concept,":[53],"computer-algebraic":[54],"methods":[55,94,102],"efficient":[57],"numerical":[58],"algorithms":[59,96],"are":[60,66,79,97],"proposed.":[61],"The":[62,92],"typically":[67],"afflicted":[68],"with":[69],"comparatively":[70],"large":[71],"measurement":[72],"errors.":[73],"Therefore,":[74],"reliable":[75],"comprehensive":[76],"error":[77],"estimations":[78],"essential":[80],"reasonable":[83],"interpretation":[84],"consecutive":[86],"outcomes,":[87],"such":[88],"as":[89,100],"simulation":[90],"results.":[91],"concepts,":[93],"first":[98],"presented":[99],"universal":[101],"subsequently":[104],"applied":[105],"to":[106,121],"anaplerotic":[108,150],"regulation":[109],"lysine-producing":[111],"Corynebacterium":[112],"glutamicum.":[113],"A":[114],"model":[116,135],"is":[117,136],"set":[118],"up,":[119],"fitted":[120],"experimental":[124],"validated":[127],"by":[128],"prediction":[130],"further":[132],"experiments.":[133],"This":[134],"capable":[137],"forecasting":[139],"quantitative":[141],"effect":[142],"changes":[144],"activity":[148],"enzymes,":[151],"namely":[152],"phosphoenolpyruvate":[153,158],"carboxylase,":[154],"pyruvate":[155],"carboxylase":[156],"carboxykinase,":[159],"on":[160],"lysine":[161],"productivity":[162],"yield.":[164]},"counts_by_year":[],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}