{"id":"https://openalex.org/W3118243008","doi":"https://doi.org/10.22489/cinc.2020.268","title":"QT Interval Variability and QT-HP Coupling Strength in Amyotrophic Lateral Sclerosis Patients","display_name":"QT Interval Variability and QT-HP Coupling Strength in Amyotrophic Lateral Sclerosis Patients","publication_year":2020,"publication_date":"2020-12-30","ids":{"openalex":"https://openalex.org/W3118243008","doi":"https://doi.org/10.22489/cinc.2020.268","mag":"3118243008"},"language":"en","primary_location":{"id":"doi:10.22489/cinc.2020.268","is_oa":true,"landing_page_url":"http://doi.org/10.22489/cinc.2020.268","pdf_url":"https://doi.org/10.22489/cinc.2020.268","source":{"id":"https://openalex.org/S4220650825","display_name":"Computing in cardiology","issn_l":"2325-8861","issn":["2325-8861","2325-887X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320439","host_organization_name":"IEEE Computer Society","host_organization_lineage":["https://openalex.org/P4310320439","https://openalex.org/P4310319808"],"host_organization_lineage_names":["IEEE Computer Society","Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computing in Cardiology Conference (CinC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.22489/cinc.2020.268","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050880536","display_name":"Beatrice De Maria","orcid":"https://orcid.org/0000-0001-5360-3137"},"institutions":[{"id":"https://openalex.org/I4210091499","display_name":"Istituti Clinici Scientifici Maugeri","ror":"https://ror.org/00mc77d93","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210091499","https://openalex.org/I4210105320","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Beatrice De Maria","raw_affiliation_strings":["IRCCS Istituti Clinici Scientifici Maugeri, Milan, Italy"],"affiliations":[{"raw_affiliation_string":"IRCCS Istituti Clinici Scientifici Maugeri, Milan, Italy","institution_ids":["https://openalex.org/I4210091499"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018020880","display_name":"Gabriele Mora","orcid":"https://orcid.org/0000-0002-8388-2373"},"institutions":[{"id":"https://openalex.org/I4210091499","display_name":"Istituti Clinici Scientifici Maugeri","ror":"https://ror.org/00mc77d93","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210091499","https://openalex.org/I4210105320","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gabriele Mora","raw_affiliation_strings":["IRCCS Istituti Clinici Scientifici Maugeri, Milan, Italy"],"affiliations":[{"raw_affiliation_string":"IRCCS Istituti Clinici Scientifici Maugeri, Milan, Italy","institution_ids":["https://openalex.org/I4210091499"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050694577","display_name":"Kalliopi Marinou","orcid":null},"institutions":[{"id":"https://openalex.org/I4210091499","display_name":"Istituti Clinici Scientifici Maugeri","ror":"https://ror.org/00mc77d93","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210091499","https://openalex.org/I4210105320","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Kalliopi Marinou","raw_affiliation_strings":["IRCCS Istituti Clinici Scientifici Maugeri, Milan, Italy"],"affiliations":[{"raw_affiliation_string":"IRCCS Istituti Clinici Scientifici Maugeri, Milan, Italy","institution_ids":["https://openalex.org/I4210091499"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083463721","display_name":"Riccardo Sideri","orcid":"https://orcid.org/0000-0002-3261-8062"},"institutions":[{"id":"https://openalex.org/I4210091499","display_name":"Istituti Clinici Scientifici Maugeri","ror":"https://ror.org/00mc77d93","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210091499","https://openalex.org/I4210105320","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Riccardo Sideri","raw_affiliation_strings":["IRCCS Istituti Clinici Scientifici Maugeri, Milan, Italy"],"affiliations":[{"raw_affiliation_string":"IRCCS Istituti Clinici Scientifici Maugeri, Milan, Italy","institution_ids":["https://openalex.org/I4210091499"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018102991","display_name":"Vlasta Bari","orcid":"https://orcid.org/0000-0002-5346-2677"},"institutions":[{"id":"https://openalex.org/I4210099239","display_name":"IRCCS Policlinico San Donato","ror":"https://ror.org/01220jp31","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210099239","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Vlasta Bari","raw_affiliation_strings":["Department of Cardiothoracic, Vascular Anesthesia and Intensive Care, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Cardiothoracic, Vascular Anesthesia and Intensive Care, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy","institution_ids":["https://openalex.org/I4210099239"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031902647","display_name":"Beatrice Cairo","orcid":"https://orcid.org/0000-0003-3396-6883"},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Beatrice Cairo","raw_affiliation_strings":["Department of Biomedical Sciences for Health, University of Milan, Milan, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences for Health, University of Milan, Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084919572","display_name":"Emanuele Vaini","orcid":"https://orcid.org/0000-0001-5873-6609"},"institutions":[{"id":"https://openalex.org/I4210099239","display_name":"IRCCS Policlinico San Donato","ror":"https://ror.org/01220jp31","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210099239","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Emanuele Vaini","raw_affiliation_strings":["Department of Cardiothoracic, Vascular Anesthesia and Intensive Care, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Cardiothoracic, Vascular Anesthesia and Intensive Care, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy","institution_ids":["https://openalex.org/I4210099239"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042892367","display_name":"Laura Adelaide Dalla Vecchia","orcid":"https://orcid.org/0000-0002-6516-0959"},"institutions":[{"id":"https://openalex.org/I4210091499","display_name":"Istituti Clinici Scientifici Maugeri","ror":"https://ror.org/00mc77d93","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210091499","https://openalex.org/I4210105320","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Laura Adelaide Dalla Vecchia","raw_affiliation_strings":["IRCCS Istituti Clinici Scientifici Maugeri, Milan, Italy"],"affiliations":[{"raw_affiliation_string":"IRCCS Istituti Clinici Scientifici Maugeri, Milan, Italy","institution_ids":["https://openalex.org/I4210091499"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033974415","display_name":"Alberto Porta","orcid":"https://orcid.org/0000-0002-6720-9824"},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I4210099239","display_name":"IRCCS Policlinico San Donato","ror":"https://ror.org/01220jp31","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210099239","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alberto Porta","raw_affiliation_strings":["Department of Biomedical Sciences for Health, University of Milan, Milan, Italy","Department of Cardiothoracic, Vascular Anesthesia and Intensive Care, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences for Health, University of Milan, Milan, Italy","institution_ids":["https://openalex.org/I189158943"]},{"raw_affiliation_string":"Department of Cardiothoracic, Vascular Anesthesia and Intensive Care, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy","institution_ids":["https://openalex.org/I4210099239"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5050880536"],"corresponding_institution_ids":["https://openalex.org/I4210091499"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.29972422,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9768000245094299,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9666000008583069,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"Amyotrophic lateral sclerosis","score":0.8299386501312256},{"id":"https://openalex.org/keywords/qt-interval","display_name":"QT interval","score":0.741533100605011},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.4667796194553375},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4513222575187683},{"id":"https://openalex.org/keywords/coupling","display_name":"Coupling (piping)","score":0.4145222306251526},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.3724394738674164},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.2311769723892212},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.09425947070121765},{"id":"https://openalex.org/keywords/composite-material","display_name":"Composite material","score":0.06871631741523743}],"concepts":[{"id":"https://openalex.org/C2780596555","wikidata":"https://www.wikidata.org/wiki/Q206901","display_name":"Amyotrophic lateral sclerosis","level":3,"score":0.8299386501312256},{"id":"https://openalex.org/C118441451","wikidata":"https://www.wikidata.org/wiki/Q12074763","display_name":"QT interval","level":2,"score":0.741533100605011},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4667796194553375},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4513222575187683},{"id":"https://openalex.org/C131584629","wikidata":"https://www.wikidata.org/wiki/Q4308705","display_name":"Coupling (piping)","level":2,"score":0.4145222306251526},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3724394738674164},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2311769723892212},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.09425947070121765},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.06871631741523743}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.22489/cinc.2020.268","is_oa":true,"landing_page_url":"http://doi.org/10.22489/cinc.2020.268","pdf_url":"https://doi.org/10.22489/cinc.2020.268","source":{"id":"https://openalex.org/S4220650825","display_name":"Computing in cardiology","issn_l":"2325-8861","issn":["2325-8861","2325-887X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320439","host_organization_name":"IEEE Computer Society","host_organization_lineage":["https://openalex.org/P4310320439","https://openalex.org/P4310319808"],"host_organization_lineage_names":["IEEE Computer Society","Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computing in Cardiology Conference (CinC)","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.22489/cinc.2020.268","is_oa":true,"landing_page_url":"http://doi.org/10.22489/cinc.2020.268","pdf_url":"https://doi.org/10.22489/cinc.2020.268","source":{"id":"https://openalex.org/S4220650825","display_name":"Computing in cardiology","issn_l":"2325-8861","issn":["2325-8861","2325-887X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320439","host_organization_name":"IEEE Computer Society","host_organization_lineage":["https://openalex.org/P4310320439","https://openalex.org/P4310319808"],"host_organization_lineage_names":["IEEE Computer Society","Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computing in Cardiology Conference (CinC)","raw_type":"proceedings-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6000000238418579}],"awards":[],"funders":[{"id":"https://openalex.org/F4320324698","display_name":"Fondazione Italiana di Ricerca per la Sclerosi Laterale Amiotrofica","ror":"https://ror.org/058f84k27"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3118243008.pdf","grobid_xml":"https://content.openalex.org/works/W3118243008.grobid-xml"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W1976103187","https://openalex.org/W2016230869","https://openalex.org/W2041732692","https://openalex.org/W2050860956","https://openalex.org/W2062618262","https://openalex.org/W2088720900","https://openalex.org/W2098359894","https://openalex.org/W2133589238","https://openalex.org/W2285072859","https://openalex.org/W2286298762","https://openalex.org/W2563501954","https://openalex.org/W2605464857","https://openalex.org/W2921658797"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W3183948672","https://openalex.org/W3173606202","https://openalex.org/W3110381201","https://openalex.org/W2948807893","https://openalex.org/W2935909890","https://openalex.org/W2778153218","https://openalex.org/W2758277628","https://openalex.org/W1531601525","https://openalex.org/W2070831599"],"abstract_inverted_index":{"In":[0,60],"the":[1,23,36,43,54,66,98,114,162],"recent":[2],"years":[3],"we":[4,63],"have":[5],"witnessed":[6],"an":[7,200],"increasing":[8],"interest":[9],"in":[10,14,71,77,161,196],"studying":[11],"cardiac":[12,27,44],"control":[13,45],"amyotrophic":[15],"lateral":[16],"sclerosis":[17],"(ALS)":[18],"patients.":[19],"The":[20,87,136],"variability":[21,55,157,172,191,211],"of":[22,26,46,56],"overall":[24],"duration":[25],"electrical":[28],"activity":[29],"comprising":[30],"depolarization":[31],"and":[32,68,81,94,104,107,123,132,138,150,181,192],"repolarization":[33],"periods,":[34],"namely":[35],"QT":[37,69,88,156,190],"interval,":[38],"could":[39],"provide":[40],"information":[41],"about":[42],"ALS":[47,73,197],"patients":[48,74,198],"complementary":[49],"to":[50,178,204],"that":[51,148],"derived":[52,154],"from":[53,155],"heart":[57],"period":[58],"(HP).":[59],"this":[61],"study":[62],"evaluate":[64],"first":[65],"HP":[67,110,171,210],"variabilities":[70],"10":[72],"at":[75],"rest":[76],"supine":[78],"position":[79],"(REST)":[80],"during":[82,159,188],"75":[83],"head-up":[84],"tilt":[85],"(TILT).":[86],"interval":[89],"was":[90,111,142],"approximated":[91],"as":[92,113,144],"RTapex":[93],"RTend":[95],"intervals,":[96],"representing":[97],"temporal":[99],"distance":[100,116],"between":[101,117],"R-wave":[102,120],"peak":[103],"T-wave":[105],"apex":[106],"end,":[108],"respectively.":[109],"taken":[112],"time":[115,149],"two":[118],"consecutive":[119],"peaks.":[121],"Time":[122],"frequency":[124,151],"domain":[125,152,170],"markers":[126,173,195],"were":[127],"computed":[128],"over":[129],"HP,":[130],"RTa":[131],"RTe":[133],"beat-to-beat":[134],"series.":[135],"RTa-HP":[137,180],"RTe-HP":[139,182],"squared":[140,183],"coherence":[141,184],"calculated":[143],"well.":[145],"We":[146],"found":[147],"indexes":[153],"changed":[158],"TILT":[160,205],"direction":[163],"expected":[164],"for":[165],"a":[166,175],"healthy":[167],"population.":[168],"Frequency":[169],"showed":[174,199],"blunted":[176],"response":[177,203],"TILT.":[179,189],"did":[185],"not":[186,206],"vary":[187],"QT-HP":[193],"coupling":[194],"apparently":[201],"normal":[202],"fully":[207],"mirrored":[208],"by":[209],"indexes.":[212]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}