{"id":"https://openalex.org/W2794908723","doi":"https://doi.org/10.22489/cinc.2017.311-412","title":"Ranolazine Attenuates Stretch-induced Modifications of Electrophysiological Characteristics in HL-1 Cells","display_name":"Ranolazine Attenuates Stretch-induced Modifications of Electrophysiological Characteristics in HL-1 Cells","publication_year":2017,"publication_date":"2017-09-14","ids":{"openalex":"https://openalex.org/W2794908723","doi":"https://doi.org/10.22489/cinc.2017.311-412","mag":"2794908723"},"language":"en","primary_location":{"id":"doi:10.22489/cinc.2017.311-412","is_oa":false,"landing_page_url":"http://doi.org/10.22489/cinc.2017.311-412","pdf_url":null,"source":{"id":"https://openalex.org/S4220650825","display_name":"Computing in cardiology","issn_l":"2325-8861","issn":["2325-8861","2325-887X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320439","host_organization_name":"IEEE Computer Society","host_organization_lineage":["https://openalex.org/P4310320439","https://openalex.org/P4310319808"],"host_organization_lineage_names":["IEEE Computer Society","Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computing in Cardiology Conference (CinC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006175800","display_name":"Irene Del\u2010Canto","orcid":null},"institutions":[{"id":"https://openalex.org/I4210158373","display_name":"INCLIVA Health Research Institute","ror":"https://ror.org/059wbyv33","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210158373"]},{"id":"https://openalex.org/I4210095014","display_name":"Centro de Investigaci\u00f3n en Red en Enfermedades Cardiovasculares","ror":"https://ror.org/00s29fn93","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210095014"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Irene Del-Canto","raw_affiliation_strings":["Instituto de Investigaci\u00f3n Sanitaria INCLIVA, CIBERCV, Valencia, Spain"],"affiliations":[{"raw_affiliation_string":"Instituto de Investigaci\u00f3n Sanitaria INCLIVA, CIBERCV, Valencia, Spain","institution_ids":["https://openalex.org/I4210158373","https://openalex.org/I4210095014"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021015499","display_name":"L G\u00f3mez-Cid","orcid":"https://orcid.org/0000-0001-6520-5451"},"institutions":[{"id":"https://openalex.org/I4210095014","display_name":"Centro de Investigaci\u00f3n en Red en Enfermedades Cardiovasculares","ror":"https://ror.org/00s29fn93","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210095014"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Lidia Gomez-Cid","raw_affiliation_strings":["Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, CIBERCV, Madrid, Spain"],"affiliations":[{"raw_affiliation_string":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, CIBERCV, Madrid, Spain","institution_ids":["https://openalex.org/I4210095014"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052264232","display_name":"Ismael Hern\u00e1ndez\u2010Romero","orcid":"https://orcid.org/0000-0002-0525-7476"},"institutions":[{"id":"https://openalex.org/I4210095014","display_name":"Centro de Investigaci\u00f3n en Red en Enfermedades Cardiovasculares","ror":"https://ror.org/00s29fn93","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210095014"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ismael Hernandez-Romero","raw_affiliation_strings":["Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, CIBERCV, Madrid, Spain"],"affiliations":[{"raw_affiliation_string":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, CIBERCV, Madrid, Spain","institution_ids":["https://openalex.org/I4210095014"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087346265","display_name":"Mar\u00eda S. Guillem","orcid":"https://orcid.org/0000-0001-5660-3693"},"institutions":[{"id":"https://openalex.org/I60053951","display_name":"Universitat Polit\u00e8cnica de Val\u00e8ncia","ror":"https://ror.org/01460j859","country_code":"ES","type":"education","lineage":["https://openalex.org/I60053951"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mar\ufffda S Guillem","raw_affiliation_strings":["Universitat Polit\u00e9cnica de Val\u00e9ncia, Valencia, Spain"],"affiliations":[{"raw_affiliation_string":"Universitat Polit\u00e9cnica de Val\u00e9ncia, Valencia, Spain","institution_ids":["https://openalex.org/I60053951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5097389179","display_name":"Maria Eugenia Fern\ufffdndez-Santos","orcid":null},"institutions":[{"id":"https://openalex.org/I4210095014","display_name":"Centro de Investigaci\u00f3n en Red en Enfermedades Cardiovasculares","ror":"https://ror.org/00s29fn93","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210095014"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Maria Eugenia Fern\ufffdndez-Santos","raw_affiliation_strings":["Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, CIBERCV, Madrid, Spain"],"affiliations":[{"raw_affiliation_string":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, CIBERCV, Madrid, Spain","institution_ids":["https://openalex.org/I4210095014"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013168793","display_name":"Luis Such","orcid":"https://orcid.org/0000-0002-0582-5736"},"institutions":[{"id":"https://openalex.org/I4210158373","display_name":"INCLIVA Health Research Institute","ror":"https://ror.org/059wbyv33","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210158373"]},{"id":"https://openalex.org/I4210095014","display_name":"Centro de Investigaci\u00f3n en Red en Enfermedades Cardiovasculares","ror":"https://ror.org/00s29fn93","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210095014"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Luis Such","raw_affiliation_strings":["Instituto de Investigaci\u00f3n Sanitaria INCLIVA, CIBERCV, Valencia, Spain"],"affiliations":[{"raw_affiliation_string":"Instituto de Investigaci\u00f3n Sanitaria INCLIVA, CIBERCV, Valencia, Spain","institution_ids":["https://openalex.org/I4210158373","https://openalex.org/I4210095014"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107881244","display_name":"Francisco Fern\ufffdndez-Avil\ufffds","orcid":null},"institutions":[{"id":"https://openalex.org/I4210095014","display_name":"Centro de Investigaci\u00f3n en Red en Enfermedades Cardiovasculares","ror":"https://ror.org/00s29fn93","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210095014"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Francisco Fern\ufffdndez-Avil\ufffds","raw_affiliation_strings":["Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, CIBERCV, Madrid, Spain"],"affiliations":[{"raw_affiliation_string":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, CIBERCV, Madrid, Spain","institution_ids":["https://openalex.org/I4210095014"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022354296","display_name":"Felipe Atienza","orcid":"https://orcid.org/0000-0002-9596-7649"},"institutions":[{"id":"https://openalex.org/I4210095014","display_name":"Centro de Investigaci\u00f3n en Red en Enfermedades Cardiovasculares","ror":"https://ror.org/00s29fn93","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210095014"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Felipe Atienza","raw_affiliation_strings":["Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, CIBERCV, Madrid, Spain"],"affiliations":[{"raw_affiliation_string":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, CIBERCV, Madrid, Spain","institution_ids":["https://openalex.org/I4210095014"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071717309","display_name":"Francisco J. Chorro","orcid":"https://orcid.org/0000-0002-4613-5459"},"institutions":[{"id":"https://openalex.org/I4210158373","display_name":"INCLIVA Health Research Institute","ror":"https://ror.org/059wbyv33","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210158373"]},{"id":"https://openalex.org/I4210095014","display_name":"Centro de Investigaci\u00f3n en Red en Enfermedades Cardiovasculares","ror":"https://ror.org/00s29fn93","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210095014"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Francisco J Chorro","raw_affiliation_strings":["Instituto de Investigaci\u00f3n Sanitaria INCLIVA, CIBERCV, Valencia, Spain"],"affiliations":[{"raw_affiliation_string":"Instituto de Investigaci\u00f3n Sanitaria INCLIVA, CIBERCV, Valencia, Spain","institution_ids":["https://openalex.org/I4210158373","https://openalex.org/I4210095014"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068985341","display_name":"Andreu M. Climent","orcid":"https://orcid.org/0000-0002-7260-8811"},"institutions":[{"id":"https://openalex.org/I4210095014","display_name":"Centro de Investigaci\u00f3n en Red en Enfermedades Cardiovasculares","ror":"https://ror.org/00s29fn93","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210095014"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Andreu M Climent","raw_affiliation_strings":["Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, CIBERCV, Madrid, Spain"],"affiliations":[{"raw_affiliation_string":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, CIBERCV, Madrid, Spain","institution_ids":["https://openalex.org/I4210095014"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5006175800"],"corresponding_institution_ids":["https://openalex.org/I4210095014","https://openalex.org/I4210158373"],"apc_list":null,"apc_paid":null,"fwci":0.1752,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.60597476,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9929999709129333,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ranolazine","display_name":"Ranolazine","score":0.8218497037887573},{"id":"https://openalex.org/keywords/electrophysiology","display_name":"Electrophysiology","score":0.7389300465583801},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.4399992525577545},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3013034462928772},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.28349190950393677},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.13223132491111755}],"concepts":[{"id":"https://openalex.org/C2779177932","wikidata":"https://www.wikidata.org/wiki/Q907104","display_name":"Ranolazine","level":2,"score":0.8218497037887573},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.7389300465583801},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4399992525577545},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3013034462928772},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.28349190950393677},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.13223132491111755}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.22489/cinc.2017.311-412","is_oa":false,"landing_page_url":"http://doi.org/10.22489/cinc.2017.311-412","pdf_url":null,"source":{"id":"https://openalex.org/S4220650825","display_name":"Computing in cardiology","issn_l":"2325-8861","issn":["2325-8861","2325-887X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320439","host_organization_name":"IEEE Computer Society","host_organization_lineage":["https://openalex.org/P4310320439","https://openalex.org/P4310319808"],"host_organization_lineage_names":["IEEE Computer Society","Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computing in Cardiology Conference (CinC)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7400000095367432,"display_name":"Clean water and sanitation","id":"https://metadata.un.org/sdg/6"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1981497605","https://openalex.org/W1994446230","https://openalex.org/W2014040418","https://openalex.org/W2014113446","https://openalex.org/W2091983119","https://openalex.org/W2120117157","https://openalex.org/W2182749698","https://openalex.org/W2267163926","https://openalex.org/W2510058226"],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W3123595055","https://openalex.org/W1978276670","https://openalex.org/W2379102826","https://openalex.org/W3196941726","https://openalex.org/W2047098488","https://openalex.org/W2363636833","https://openalex.org/W2072265441"],"abstract_inverted_index":{"Mechanical":[0],"stretch":[1,41,79,131],"induces":[2],"an":[3],"increase":[4],"in":[5,23,42,64,103,118,132],"Na+":[6],"influx":[7],"into":[8],"myocytes,":[9],"related":[10],"to":[11,35,53,71,78],"mechanisms":[12],"including":[13],"stretch-activated":[14],"channels":[15],"or":[16],"activation":[17],"of":[18,31,39,73,108,125,136],"Na+/H+":[19],"exchanger,":[20],"involving":[21],"changes":[22],"electrophysiological":[24,126],"properties":[25],"favouring":[26],"arrhythmia":[27,117],"induction.":[28],"The":[29,76,106],"aim":[30],"this":[32,111],"study":[33],"is":[34],"investigate":[36],"the":[37,116,123],"effects":[38,86,127],"mechanical":[40],"cultured":[43,63],"atrial":[44,99],"murine":[45],"cells":[46,96,134],"(HL-1":[47],"myocytes)":[48],"and":[49,68,83,114],"its":[50],"pharmacological":[51],"response":[52,77],"ranolazine.":[54],"Confluent":[55],"HL-1":[56,95,133],"myocytes":[57],"with":[58],"spontaneous":[59],"fibrillatory":[60],"activity":[61],"was":[62,87],"silicone":[65],"membrane":[66],"plates,":[67],"were":[69],"stretched":[70],"110%":[72],"resting":[74],"length.":[75],"under":[80,84],"control":[81,104],"conditions":[82],"ranolazine":[85,109],"analyzed":[88],"using":[89],"a":[90],"high-resolution":[91],"optical":[92],"mapping":[93],"system.":[94],"stretching":[97],"increased":[98],"fibrillation":[100],"dominant":[101],"frequency":[102],"conditions.":[105,120],"administration":[107],"reduced":[110],"stretch-induced":[112],"effect,":[113],"slowed":[115],"baseline":[119],"Ranolazine":[121],"attenuates":[122],"modifications":[124],"induced":[128],"by":[129],"myocardial":[130],"model":[135],"AF.":[137]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}