{"id":"https://openalex.org/W2794604195","doi":"https://doi.org/10.22489/cinc.2017.258-195","title":"Semantic Biomarker Selection for Functional Genomics of Heart Failure Model Organisms","display_name":"Semantic Biomarker Selection for Functional Genomics of Heart Failure Model Organisms","publication_year":2017,"publication_date":"2017-09-14","ids":{"openalex":"https://openalex.org/W2794604195","doi":"https://doi.org/10.22489/cinc.2017.258-195","mag":"2794604195"},"language":"en","primary_location":{"id":"doi:10.22489/cinc.2017.258-195","is_oa":true,"landing_page_url":"http://doi.org/10.22489/cinc.2017.258-195","pdf_url":"https://doi.org/10.22489/cinc.2017.258-195","source":{"id":"https://openalex.org/S4220650825","display_name":"Computing in cardiology","issn_l":"2325-8861","issn":["2325-8861","2325-887X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320439","host_organization_name":"IEEE Computer Society","host_organization_lineage":["https://openalex.org/P4310320439","https://openalex.org/P4310319808"],"host_organization_lineage_names":["IEEE Computer Society","Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computing in Cardiology Conference (CinC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.22489/cinc.2017.258-195","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025725951","display_name":"Ludwig Lausser","orcid":null},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Ludwig Lausser","raw_affiliation_strings":["Institute of Medical Systems Biology, Ulm University, 89069 Ulm, Germany"],"affiliations":[{"raw_affiliation_string":"Institute of Medical Systems Biology, Ulm University, 89069 Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088843548","display_name":"Steffen Just","orcid":"https://orcid.org/0000-0001-7396-1281"},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Steffen Just","raw_affiliation_strings":["Department of Internal Medicine II, Ulm University, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine II, Ulm University, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057642620","display_name":"Wolfgang Rottbauer","orcid":"https://orcid.org/0000-0003-4725-6217"},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wolfgang Rottbauer","raw_affiliation_strings":["Department of Internal Medicine II, Ulm University, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine II, Ulm University, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023316486","display_name":"Hans A. Kestler","orcid":"https://orcid.org/0000-0002-4759-5254"},"institutions":[{"id":"https://openalex.org/I4210127789","display_name":"Leibniz Institute on Aging - Fritz Lipmann Institute (FLI)","ror":"https://ror.org/039a53269","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210127789"]},{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hans Kestler","raw_affiliation_strings":["Institute of Medical Systems Biology, Ulm University, 89069 Ulm, Germany","Leibniz Institute on Aging -Fritz Lipmann Institute, 07745 Jena, Germany"],"affiliations":[{"raw_affiliation_string":"Institute of Medical Systems Biology, Ulm University, 89069 Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]},{"raw_affiliation_string":"Leibniz Institute on Aging -Fritz Lipmann Institute, 07745 Jena, Germany","institution_ids":["https://openalex.org/I4210127789"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5025725951"],"corresponding_institution_ids":["https://openalex.org/I196349391"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.16469198,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9807999730110168,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9807999730110168,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9807000160217285,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9805999994277954,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/selection","display_name":"Selection (genetic algorithm)","score":0.6645307540893555},{"id":"https://openalex.org/keywords/genomics","display_name":"Genomics","score":0.6586315035820007},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6474699974060059},{"id":"https://openalex.org/keywords/biomarker","display_name":"Biomarker","score":0.5400394201278687},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4969346821308136},{"id":"https://openalex.org/keywords/heart-failure","display_name":"Heart failure","score":0.436929851770401},{"id":"https://openalex.org/keywords/functional-genomics","display_name":"Functional genomics","score":0.43172669410705566},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.27952590584754944},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.24425563216209412},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.2211609184741974},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1824398934841156},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.14842623472213745},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.13426315784454346},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.12382137775421143}],"concepts":[{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.6645307540893555},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.6586315035820007},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6474699974060059},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5400394201278687},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4969346821308136},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.436929851770401},{"id":"https://openalex.org/C161078062","wikidata":"https://www.wikidata.org/wiki/Q1068690","display_name":"Functional genomics","level":5,"score":0.43172669410705566},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.27952590584754944},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24425563216209412},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.2211609184741974},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1824398934841156},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14842623472213745},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13426315784454346},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12382137775421143}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.22489/cinc.2017.258-195","is_oa":true,"landing_page_url":"http://doi.org/10.22489/cinc.2017.258-195","pdf_url":"https://doi.org/10.22489/cinc.2017.258-195","source":{"id":"https://openalex.org/S4220650825","display_name":"Computing in cardiology","issn_l":"2325-8861","issn":["2325-8861","2325-887X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320439","host_organization_name":"IEEE Computer Society","host_organization_lineage":["https://openalex.org/P4310320439","https://openalex.org/P4310319808"],"host_organization_lineage_names":["IEEE Computer Society","Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computing in Cardiology Conference (CinC)","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.22489/cinc.2017.258-195","is_oa":true,"landing_page_url":"http://doi.org/10.22489/cinc.2017.258-195","pdf_url":"https://doi.org/10.22489/cinc.2017.258-195","source":{"id":"https://openalex.org/S4220650825","display_name":"Computing in cardiology","issn_l":"2325-8861","issn":["2325-8861","2325-887X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320439","host_organization_name":"IEEE Computer Society","host_organization_lineage":["https://openalex.org/P4310320439","https://openalex.org/P4310319808"],"host_organization_lineage_names":["IEEE Computer Society","Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computing in Cardiology Conference (CinC)","raw_type":"proceedings-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1051887491","display_name":null,"funder_award_id":"Forschungskern SyStaR","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G2339884595","display_name":null,"funder_award_id":"0315894A","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G2428234236","display_name":null,"funder_award_id":"SFB 1074","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G3079401970","display_name":null,"funder_award_id":"01ZX1407A","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G4085581785","display_name":null,"funder_award_id":"e:Med, SYMBOL-HF, ID 01ZX1407A","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G4695681148","display_name":null,"funder_award_id":"Gerontosys II, Forschungskern SyStaR, ID 0315894A","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G4869689085","display_name":null,"funder_award_id":"FP7/2007-2013","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G6225918512","display_name":null,"funder_award_id":"project Z","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G6514743558","display_name":null,"funder_award_id":"602783","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G6644305583","display_name":null,"funder_award_id":"SFB 1074","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G7287710673","display_name":null,"funder_award_id":"0315894A","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G8287961583","display_name":null,"funder_award_id":"e:Med","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G875845673","display_name":null,"funder_award_id":"e:Med, SYMBOL-HF","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2794604195.pdf","grobid_xml":"https://content.openalex.org/works/W2794604195.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W111697688","https://openalex.org/W608314793","https://openalex.org/W1967320885","https://openalex.org/W1994449935","https://openalex.org/W2052503178","https://openalex.org/W2075916985","https://openalex.org/W2101209169","https://openalex.org/W2103017472","https://openalex.org/W2104758887","https://openalex.org/W2105953302","https://openalex.org/W2120220697","https://openalex.org/W2159482845","https://openalex.org/W2163648950","https://openalex.org/W2165340887","https://openalex.org/W2171580129","https://openalex.org/W2281153775","https://openalex.org/W2315104804","https://openalex.org/W2492761908","https://openalex.org/W2519644229","https://openalex.org/W2898676184","https://openalex.org/W4256561644","https://openalex.org/W6669440244","https://openalex.org/W6699044641"],"related_works":["https://openalex.org/W2360935227","https://openalex.org/W2364993072","https://openalex.org/W2115576822","https://openalex.org/W2356429006","https://openalex.org/W2155595079","https://openalex.org/W2380568150","https://openalex.org/W2385787406","https://openalex.org/W2411510900","https://openalex.org/W2263355832","https://openalex.org/W284518807"],"abstract_inverted_index":{"Genetic":[0],"model":[1],"organism":[2],"have":[3],"the":[4,8,42,52,69],"potential":[5],"of":[6,10,25,46,51],"increasing":[7],"understanding":[9],"malicious":[11],"human":[12],"genotypes":[13],"and":[14],"deregulated":[15],"molecular":[16],"processes.":[17,71],"In":[18,37],"this":[19],"context,":[20],"an":[21],"adequate":[22],"high-level":[23,66],"characterization":[24],"experimental":[26],"results":[27],"is":[28],"a":[29,33,65],"necessary":[30],"requirement":[31],"for":[32],"successful":[34],"trans-species":[35],"transfer.":[36],"classification":[38],"experiments,":[39],"we":[40],"analyze":[41],"gene":[43],"expression":[44],"profiles":[45],"six":[47],"heart":[48],"failure":[49],"phenotypes":[50],"zebrafish":[53],"danio":[54],"rerio.":[55],"We":[56],"train":[57],"semantic":[58],"multi":[59],"classifier":[60],"systems":[61],"that":[62],"directly":[63],"provide":[64],"hypotheses":[67],"on":[68],"underlying":[70]},"counts_by_year":[],"updated_date":"2026-04-16T08:26:57.006410","created_date":"2025-10-10T00:00:00"}