{"id":"https://openalex.org/W2887052906","doi":"https://doi.org/10.18653/v1/w18-2321","title":"CRF-LSTM Text Mining Method Unveiling the Pharmacological Mechanism of Off-target Side Effect of Anti-Multiple Myeloma Drugs","display_name":"CRF-LSTM Text Mining Method Unveiling the Pharmacological Mechanism of Off-target Side Effect of Anti-Multiple Myeloma Drugs","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2887052906","doi":"https://doi.org/10.18653/v1/w18-2321","mag":"2887052906"},"language":"en","primary_location":{"id":"doi:10.18653/v1/w18-2321","is_oa":true,"landing_page_url":"https://doi.org/10.18653/v1/w18-2321","pdf_url":"https://www.aclweb.org/anthology/W18-2321.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the BioNLP 2018 workshop","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.aclweb.org/anthology/W18-2321.pdf","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033258894","display_name":"Kaiyin Zhou","orcid":"https://orcid.org/0000-0002-7314-9776"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kaiyin Zhou","raw_affiliation_strings":[". College of Informatics, Huazhong Agricultural University, China"],"affiliations":[{"raw_affiliation_string":". College of Informatics, Huazhong Agricultural University, China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100394011","display_name":"Sheng Zhang","orcid":"https://orcid.org/0000-0002-2105-0627"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sheng Zhang","raw_affiliation_strings":[". College of Science, Huazhong Agricultural Univerisity, China"],"affiliations":[{"raw_affiliation_string":". College of Science, Huazhong Agricultural Univerisity, China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079299290","display_name":"Xiangyu Meng","orcid":"https://orcid.org/0000-0001-5669-3502"},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]},{"id":"https://openalex.org/I4210120234","display_name":"Zhongnan Hospital of Wuhan University","ror":"https://ror.org/01v5mqw79","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120234"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiangyu Meng","raw_affiliation_strings":[". Center for Evidence-based and Translational Medicine, Zhongnan Hospital of Wuhan University, China"],"affiliations":[{"raw_affiliation_string":". Center for Evidence-based and Translational Medicine, Zhongnan Hospital of Wuhan University, China","institution_ids":["https://openalex.org/I4210120234","https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003043966","display_name":"Qiquan Luo","orcid":"https://orcid.org/0000-0003-1450-2856"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qi Luo","raw_affiliation_strings":[". College of Science, Huazhong Agricultural Univerisity, China"],"affiliations":[{"raw_affiliation_string":". College of Science, Huazhong Agricultural Univerisity, China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100615783","display_name":"Yuxing Wang","orcid":"https://orcid.org/0000-0003-4510-2783"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuxing Wang","raw_affiliation_strings":[". College of Informatics, Huazhong Agricultural University, China"],"affiliations":[{"raw_affiliation_string":". College of Informatics, Huazhong Agricultural University, China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001466305","display_name":"Ke Ding","orcid":"https://orcid.org/0000-0001-9016-812X"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ke Ding","raw_affiliation_strings":[". College of Science, Huazhong Agricultural Univerisity, China"],"affiliations":[{"raw_affiliation_string":". College of Science, Huazhong Agricultural Univerisity, China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101088415","display_name":"Yukun Feng","orcid":null},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yukun Feng","raw_affiliation_strings":[". College of Science, Huazhong Agricultural Univerisity, China"],"affiliations":[{"raw_affiliation_string":". College of Science, Huazhong Agricultural Univerisity, China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100387244","display_name":"Mo Chen","orcid":"https://orcid.org/0000-0001-8506-3665"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mo Chen","raw_affiliation_strings":[". College of Informatics, Huazhong Agricultural University, China"],"affiliations":[{"raw_affiliation_string":". College of Informatics, Huazhong Agricultural University, China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062221063","display_name":"Kevin Bretonnel Cohen","orcid":"https://orcid.org/0000-0003-1749-8290"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kevin Cohen","raw_affiliation_strings":[". School of Medicine, University of Colorado, U.S"],"affiliations":[{"raw_affiliation_string":". School of Medicine, University of Colorado, U.S","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039800976","display_name":"Jingbo Xia","orcid":"https://orcid.org/0000-0002-7285-588X"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jingbo Xia","raw_affiliation_strings":[". College of Informatics, Huazhong Agricultural University, China"],"affiliations":[{"raw_affiliation_string":". College of Informatics, Huazhong Agricultural University, China","institution_ids":["https://openalex.org/I204823248"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5039800976"],"corresponding_institution_ids":["https://openalex.org/I204823248"],"apc_list":null,"apc_paid":null,"fwci":0.6412,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.71909734,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":null,"issue":null,"first_page":"166","last_page":"171"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9939000010490417,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9835000038146973,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.7759519815444946},{"id":"https://openalex.org/keywords/biomedical-text-mining","display_name":"Biomedical text mining","score":0.6661728024482727},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6636078357696533},{"id":"https://openalex.org/keywords/task","display_name":"Task (project management)","score":0.6232707500457764},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"Multiple myeloma","score":0.5553669333457947},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.45987147092819214},{"id":"https://openalex.org/keywords/side-effect","display_name":"Side effect (computer science)","score":0.45018965005874634},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3826925754547119},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.35220766067504883},{"id":"https://openalex.org/keywords/text-mining","display_name":"Text mining","score":0.3088182806968689},{"id":"https://openalex.org/keywords/natural-language-processing","display_name":"Natural language processing","score":0.2999786138534546},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.15758827328681946},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1252199113368988},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.12245422601699829},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.09273287653923035},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.07081806659698486},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.0681261420249939}],"concepts":[{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.7759519815444946},{"id":"https://openalex.org/C165141518","wikidata":"https://www.wikidata.org/wiki/Q4915126","display_name":"Biomedical text mining","level":3,"score":0.6661728024482727},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6636078357696533},{"id":"https://openalex.org/C2780451532","wikidata":"https://www.wikidata.org/wiki/Q759676","display_name":"Task (project management)","level":2,"score":0.6232707500457764},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.5553669333457947},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.45987147092819214},{"id":"https://openalex.org/C3454156","wikidata":"https://www.wikidata.org/wiki/Q1144241","display_name":"Side effect (computer science)","level":2,"score":0.45018965005874634},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3826925754547119},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35220766067504883},{"id":"https://openalex.org/C71472368","wikidata":"https://www.wikidata.org/wiki/Q676880","display_name":"Text mining","level":2,"score":0.3088182806968689},{"id":"https://openalex.org/C204321447","wikidata":"https://www.wikidata.org/wiki/Q30642","display_name":"Natural language processing","level":1,"score":0.2999786138534546},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15758827328681946},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1252199113368988},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.12245422601699829},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09273287653923035},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07081806659698486},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0681261420249939},{"id":"https://openalex.org/C201995342","wikidata":"https://www.wikidata.org/wiki/Q682496","display_name":"Systems engineering","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.18653/v1/w18-2321","is_oa":true,"landing_page_url":"https://doi.org/10.18653/v1/w18-2321","pdf_url":"https://www.aclweb.org/anthology/W18-2321.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the BioNLP 2018 workshop","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.18653/v1/w18-2321","is_oa":true,"landing_page_url":"https://doi.org/10.18653/v1/w18-2321","pdf_url":"https://www.aclweb.org/anthology/W18-2321.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the BioNLP 2018 workshop","raw_type":"proceedings-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G5328452302","display_name":null,"funder_award_id":"2662018PY096","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"}],"funders":[{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2887052906.pdf","grobid_xml":"https://content.openalex.org/works/W2887052906.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1491140266","https://openalex.org/W2040135138","https://openalex.org/W2070789802","https://openalex.org/W2120929463","https://openalex.org/W2138512826","https://openalex.org/W2147880316","https://openalex.org/W2154896031","https://openalex.org/W2168938595","https://openalex.org/W2250539671","https://openalex.org/W2296283641","https://openalex.org/W2484540398","https://openalex.org/W2557377160","https://openalex.org/W2557385283","https://openalex.org/W2596174047","https://openalex.org/W2734711322","https://openalex.org/W2792958396","https://openalex.org/W2794085611","https://openalex.org/W2962902328","https://openalex.org/W4239723065","https://openalex.org/W4298247648","https://openalex.org/W4300070702","https://openalex.org/W4389006886"],"related_works":["https://openalex.org/W2390762792","https://openalex.org/W3185751515","https://openalex.org/W1479703980","https://openalex.org/W2749535755","https://openalex.org/W1553529581","https://openalex.org/W4206039273","https://openalex.org/W4232119327","https://openalex.org/W2911489562","https://openalex.org/W2134429551","https://openalex.org/W3183808544"],"abstract_inverted_index":{"Off-target":[0],"effects":[1,65],"played":[2],"a":[3,45,115],"vital":[4],"role":[5],"in":[6],"the":[7,29,36,51,63,75,142],"pharmacological":[8,143],"understanding":[9],"of":[10,31,38,62,66,83,111,124,145,151],"drug":[11,71],"efficacy":[12],"and":[13,27,73,92,108,126],"this":[14],"research":[15],"aimed":[16],"to":[17,22,105],"use":[18],"text":[19],"mining":[20],"strategy":[21],"curate":[23],"molecular":[24],"level":[25],"information":[26],"unveil":[28],"mechanism":[30,144],"off-target":[32,130],"effect":[33,131,147],"caused":[34,132],"by":[35,88,133],"usage":[37],"anti-multiple":[39],"myeloma":[40],"(MM)":[41],"drugs.":[42,153],"After":[43],"training":[44,52],"hybrid":[46],"CNN-CRF-LSTM":[47],"neural":[48],"network":[49],"upon":[50,121],"data":[53],"from":[54,70,98],"TAC":[55],"2017":[56],"benchmark":[57],"database,":[58],"we":[59],"extracted":[60],"all":[61],"side":[64,146],"16":[67],"anti-MM":[68,84,152],"drugs":[69,85,113,125],"labels,":[72],"combined":[74],"results":[76],"with":[77,138],"existed":[78],"database.":[79],"Afterwards,":[80],"gene":[81],"targets":[82],"were":[86,96],"obtained":[87],"using":[89,149],"structure":[90],"similarity,":[91],"their":[93],"related":[94],"phenotypes":[95,104,123],"retrieved":[97],"Human":[99],"Phenotype":[100],"Ontology.":[101],"Furthermore,":[102],"linked":[103],"candidate":[106],"genes":[107],"adverse":[109],"reaction":[110],"known":[112],"formed":[114],"knowledge":[116],"graph.":[117],"Through":[118],"regulation":[119],"analysis":[120],"intersected":[122],"target":[127],"genes,":[128],"an":[129],"SLC7A7":[134],"was":[135],"found,":[136],"which":[137],"high":[139],"possibility":[140],"unveiled":[141],"after":[148],"combination":[150]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":3}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}
