{"id":"https://openalex.org/W1826790760","doi":"https://doi.org/10.17169/refubium-10495","title":"Algorithms for knowledge integration in biomedical sciences","display_name":"Algorithms for knowledge integration in biomedical sciences","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W1826790760","doi":"https://doi.org/10.17169/refubium-10495","mag":"1826790760"},"language":"en","primary_location":{"id":"pmh:oai:diss.fu-berlin.de:FUDISS_thesis_000000039006","is_oa":false,"landing_page_url":"http://edocs.fu-berlin.de/diss/receive/FUDISS_thesis_000000039006","pdf_url":null,"source":{"id":"https://openalex.org/S7407052913","display_name":"Universit\u00e4tsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"doc-type:doctoralThesis"},"type":"dissertation","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://refubium.fu-berlin.de/handle/fub188/6296","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081693588","display_name":"Sebastian Bauer","orcid":"https://orcid.org/0000-0001-7571-8496"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Bauer, Sebastian","raw_affiliation_strings":[],"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5081693588"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13937","display_name":"Genetics, Bioinformatics, and Biomedical Research","score":0.4702000021934509,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13937","display_name":"Genetics, Bioinformatics, and Biomedical Research","score":0.4702000021934509,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13280","display_name":"Biomedical and Engineering Education","score":0.41100001335144043,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.41667401790618896},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.4049077033996582}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.41667401790618896},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.4049077033996582}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:oai:diss.fu-berlin.de:FUDISS_thesis_000000039006","is_oa":false,"landing_page_url":"http://edocs.fu-berlin.de/diss/receive/FUDISS_thesis_000000039006","pdf_url":null,"source":{"id":"https://openalex.org/S7407052913","display_name":"Universit\u00e4tsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"doc-type:doctoralThesis"},{"id":"pmh:oai:refubium.fu-berlin.de:fub188/6296","is_oa":true,"landing_page_url":"https://refubium.fu-berlin.de/handle/fub188/6296","pdf_url":"https://refubium.fu-berlin.de/handle/fub188/6296","source":{"id":"https://openalex.org/S4306402444","display_name":"Refubium (Universit\u00e4tsbibliothek der Freien Universit\u00e4t Berlin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I75951250","host_organization_name":"Freie Universit\u00e4t Berlin","host_organization_lineage":["https://openalex.org/I75951250"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},{"id":"pmh:oai:aleph.bib-bvb.de:BVB01-025275100","is_oa":false,"landing_page_url":"http://www.diss.fu-berlin.de/diss/receive/FUDISS_thesis_000000039006","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Hochschulschrift"},{"id":"doi:10.17169/refubium-10495","is_oa":true,"landing_page_url":"https://doi.org/10.17169/refubium-10495","pdf_url":null,"source":{"id":"https://openalex.org/S7407052913","display_name":"Universit\u00e4tsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article"},{"id":"mag:1826790760","is_oa":false,"landing_page_url":"http://www.diss.fu-berlin.de/diss/servlets/MCRFileNodeServlet/FUDISS_derivate_000000012145/dissertation.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:refubium.fu-berlin.de:fub188/6296","is_oa":true,"landing_page_url":"https://refubium.fu-berlin.de/handle/fub188/6296","pdf_url":"https://refubium.fu-berlin.de/handle/fub188/6296","source":{"id":"https://openalex.org/S4306402444","display_name":"Refubium (Universit\u00e4tsbibliothek der Freien Universit\u00e4t Berlin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I75951250","host_organization_name":"Freie Universit\u00e4t Berlin","host_organization_lineage":["https://openalex.org/I75951250"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W1826790760.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2211786730","https://openalex.org/W3184301084","https://openalex.org/W1497493339","https://openalex.org/W2125850925","https://openalex.org/W2440300016","https://openalex.org/W3107258056","https://openalex.org/W2476237588","https://openalex.org/W160822844","https://openalex.org/W2783810175","https://openalex.org/W2127354570","https://openalex.org/W1592759360","https://openalex.org/W2442645966","https://openalex.org/W2293201737","https://openalex.org/W2087046134","https://openalex.org/W2123593707","https://openalex.org/W2964478958","https://openalex.org/W1513558726","https://openalex.org/W2167214840","https://openalex.org/W2103355425","https://openalex.org/W2417051153"],"abstract_inverted_index":{"In":[0,48,163,300],"this":[1,135,137,201,253,284,322,379,396],"work,":[2],"approaches":[3],"that":[4,31,39,87,150,174,183,200,235,252,283,308,392],"integrate":[5,326,385],"different":[6,74],"kinds":[7],"of":[8,23,36,44,90,109,155,206,220,225,246,258,333,336,395],"observations":[9],"together":[10],"with":[11,63],"knowledge":[12,64,80,148,397],"bases":[13,149],"are":[14,70,101,161,175,194,229],"presented.":[15],"Two":[16],"methods":[17],"have":[18],"applications":[19],"in":[20,41,66,95,134,171,177,215,317,355],"the":[21,42,84,119,172,178,184,204,217,223,243,259,269,275,301,334,340,344,356,365,393],"post-processing":[22],"results":[24],"obtained":[25],"from":[26],"high-throughput":[27],"molecular":[28],"biological":[29,37,68],"experiments":[30],"usually":[32],"deliver":[33],"long":[34],"list":[35],"entities":[38,69],"respond":[40],"context":[43],"a":[45,96,129,169,189,212,232,256,264,318,331,371,374],"given":[46],"experiment.":[47],"order":[49],"to":[50,59,73,117,123,140,146,272,288,311,369],"justify":[51],"and":[52,92,104,191,241,330,388],"interpret":[53],"results,":[54],"it":[55],"has":[56,236],"become":[57],"standard":[58,115],"combine":[60],"these":[61],"lists":[62],"bases,":[65],"which":[67,216],"categorized":[71],"according":[72],"criteria.":[75],"The":[76,99,114],"most":[77],"prominent":[78],"biomedical":[79],"base":[81],"provider":[82],"is":[83,255,286,306],"Gene":[85],"Ontology":[86,368],"conceptualizes":[88],"features":[89],"genes":[91],"their":[93],"products":[94],"species-independent":[97],"manner.":[98],"concepts":[100],"called":[102],"terms":[103,160,238],"structured":[105,147],"by":[106],"various":[107],"types":[108],"semantically":[110],"meaningful":[111],"parent-child":[112],"relationships.":[113],"approach":[116,138,254,285],"address":[118],"integration":[120],"problem":[121],"was":[122],"apply":[124],"Fisher's":[125,179],"exact":[126,180],"test":[127,181],"on":[128,268,364],"term-for-term":[130],"basis.":[131],"As":[132],"discussed":[133],"thesis,":[136],"tends":[139],"produce":[141],"many":[142],"false-positives":[143],"when":[144],"applied":[145],"contains":[151],"more":[152],"than":[153,296],"thousands":[154],"terms,":[156],"as":[157,231,239],"relations":[158,187],"between":[159,188],"ignored.":[162],"our":[164],"first":[165],"contribution,":[166],"we":[167,198,210,281,324,360,383],"proposed":[168,307],"change":[170],"quantities":[173],"used":[176,348],"such":[182],"direct":[185],"dependency":[186],"term":[190],"its":[192,362],"parent":[193],"considered.":[195],"Via":[196,279],"simulations":[197,391],"show":[199,251,389],"indeed":[202],"reduces":[203],"number":[205],"false":[207],"positives.":[208],"Furthermore,":[209],"propose":[211,263],"Bayesian":[213,276,341],"network,":[214],"observed":[218],"feature":[219,224],"genes,":[221],"i.e.,":[222],"being":[226],"differentially":[227],"regulated,":[228],"expressed":[230],"generative":[233],"process":[234],"active":[237],"input":[240],"respects":[242],"noisy":[244],"nature":[245],"experimentally":[247],"gained":[248],"data.":[249],"We":[250,262],"generalization":[257],"SetCover":[260],"problem.":[261,278],"stochastic":[265],"procedure":[266],"based":[267],"Metropolis-Hastings":[270],"framework":[271],"actually":[273],"approximate":[274],"inference":[277,338],"simulations,":[280],"verify":[282],"able":[287],"maintain":[289],"precise":[290],"predictions":[291],"at":[292],"much":[293],"higher":[294],"recalls":[295],"previous":[297],"algorithms":[298],"did.":[299],"second":[302],"part,":[303],"another":[304],"model-approach":[305],"allows":[309],"one":[310],"query":[312],"attribute":[313],"ontologies":[314],"for":[315,349,353,373],"items":[316],"target":[319],"domain.":[320],"For":[321,378],"purpose,":[323],"directly":[325],"an":[327],"error":[328],"model":[329],"subset":[332],"implications":[335],"logical":[337],"within":[339],"network.":[342],"Although":[343],"algorithm":[345],"can":[346],"be":[347],"arbitrary":[350],"domains,":[351],"including":[352],"searches":[354],"World":[357],"Wide":[358],"Web,":[359],"focus":[361],"application":[363],"Human":[366],"Phenotype":[367],"provide":[370],"basis":[372],"clinical":[375],"expert":[376],"system.":[377],"particular":[380],"use":[381],"case,":[382],"also":[384],"frequency":[386],"information":[387],"via":[390],"inclusion":[394],"improves":[398],"classification":[399],"performance.":[400]},"counts_by_year":[{"year":2016,"cited_by_count":2}],"updated_date":"2026-04-05T17:49:38.594831","created_date":"2025-10-10T00:00:00"}