{"id":"https://openalex.org/W7137801964","doi":"https://doi.org/10.1609/aaai.v40i14.38170","title":"MUSE: Multi-Scale Dense Self-Distillation for Nucleus Detection and Classification","display_name":"MUSE: Multi-Scale Dense Self-Distillation for Nucleus Detection and Classification","publication_year":2026,"publication_date":"2026-03-14","ids":{"openalex":"https://openalex.org/W7137801964","doi":"https://doi.org/10.1609/aaai.v40i14.38170"},"language":null,"primary_location":{"id":"doi:10.1609/aaai.v40i14.38170","is_oa":true,"landing_page_url":"https://doi.org/10.1609/aaai.v40i14.38170","pdf_url":"https://ojs.aaai.org/index.php/AAAI/article/download/38170/42132","source":{"id":"https://openalex.org/S4210191458","display_name":"Proceedings of the AAAI Conference on Artificial Intelligence","issn_l":"2159-5399","issn":["2159-5399","2374-3468"],"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/P4310320058","host_organization_name":"Association for the Advancement of Artificial Intelligence","host_organization_lineage":["https://openalex.org/P4310320058"],"host_organization_lineage_names":["Association for the Advancement of Artificial Intelligence"],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the AAAI Conference on Artificial Intelligence","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://ojs.aaai.org/index.php/AAAI/article/download/38170/42132","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5129740041","display_name":"Zijiang Yang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210086143","display_name":"Alibaba Group (Cayman Islands)","ror":"https://ror.org/00mnrxf72","country_code":"KY","type":"company","lineage":["https://openalex.org/I4210086143","https://openalex.org/I45928872"]}],"countries":["KY"],"is_corresponding":true,"raw_author_name":"Zijiang Yang","raw_affiliation_strings":["University of Science and Technology Beijing\nDAMO Academy, Alibaba Group"],"affiliations":[{"raw_affiliation_string":"University of Science and Technology Beijing\nDAMO Academy, Alibaba Group","institution_ids":["https://openalex.org/I4210086143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070759471","display_name":"Hanqing Chao","orcid":"https://orcid.org/0000-0001-5973-2343"},"institutions":[{"id":"https://openalex.org/I4210086143","display_name":"Alibaba Group (Cayman Islands)","ror":"https://ror.org/00mnrxf72","country_code":"KY","type":"company","lineage":["https://openalex.org/I4210086143","https://openalex.org/I45928872"]}],"countries":["KY"],"is_corresponding":false,"raw_author_name":"Hanqing Chao","raw_affiliation_strings":["DAMO Academy, Alibaba Group\nHupan Lab\nFudan University"],"affiliations":[{"raw_affiliation_string":"DAMO Academy, Alibaba Group\nHupan Lab\nFudan University","institution_ids":["https://openalex.org/I4210086143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022773043","display_name":"Bokai Zhao","orcid":null},"institutions":[{"id":"https://openalex.org/I4210086143","display_name":"Alibaba Group (Cayman Islands)","ror":"https://ror.org/00mnrxf72","country_code":"KY","type":"company","lineage":["https://openalex.org/I4210086143","https://openalex.org/I45928872"]}],"countries":["KY"],"is_corresponding":false,"raw_author_name":"Bokai Zhao","raw_affiliation_strings":["DAMO Academy, Alibaba Group"],"affiliations":[{"raw_affiliation_string":"DAMO Academy, Alibaba Group","institution_ids":["https://openalex.org/I4210086143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103985025","display_name":"Yelin Yang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210137686","display_name":"Pancreatic Cancer UK","ror":"https://ror.org/04ad7pn51","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210137686"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Yelin Yang","raw_affiliation_strings":["Shanghai Institution of Pancreatic Disease"],"affiliations":[{"raw_affiliation_string":"Shanghai Institution of Pancreatic Disease","institution_ids":["https://openalex.org/I4210137686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041340452","display_name":"Yunshuo Zhang","orcid":"https://orcid.org/0000-0003-1972-0553"},"institutions":[{"id":"https://openalex.org/I4210137686","display_name":"Pancreatic Cancer UK","ror":"https://ror.org/04ad7pn51","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210137686"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Yunshuo Zhang","raw_affiliation_strings":["Shanghai Institution of Pancreatic Disease"],"affiliations":[{"raw_affiliation_string":"Shanghai Institution of Pancreatic Disease","institution_ids":["https://openalex.org/I4210137686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129744864","display_name":"Dongmei Fu","orcid":null},"institutions":[{"id":"https://openalex.org/I92403157","display_name":"University of Science and Technology Beijing","ror":"https://ror.org/02egmk993","country_code":"CN","type":"education","lineage":["https://openalex.org/I92403157"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dongmei Fu","raw_affiliation_strings":["University of Science and Technology Beijing"],"affiliations":[{"raw_affiliation_string":"University of Science and Technology Beijing","institution_ids":["https://openalex.org/I92403157"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121492060","display_name":"Junping Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junping Zhang","raw_affiliation_strings":["Fudan University"],"affiliations":[{"raw_affiliation_string":"Fudan University","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129683634","display_name":"Le Lu","orcid":null},"institutions":[{"id":"https://openalex.org/I4210086143","display_name":"Alibaba Group (Cayman Islands)","ror":"https://ror.org/00mnrxf72","country_code":"KY","type":"company","lineage":["https://openalex.org/I4210086143","https://openalex.org/I45928872"]}],"countries":["KY"],"is_corresponding":false,"raw_author_name":"Le Lu","raw_affiliation_strings":["DAMO Academy, Alibaba Group"],"affiliations":[{"raw_affiliation_string":"DAMO Academy, Alibaba Group","institution_ids":["https://openalex.org/I4210086143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129704294","display_name":"Ke Yan","orcid":null},"institutions":[{"id":"https://openalex.org/I4210086143","display_name":"Alibaba Group (Cayman Islands)","ror":"https://ror.org/00mnrxf72","country_code":"KY","type":"company","lineage":["https://openalex.org/I4210086143","https://openalex.org/I45928872"]}],"countries":["KY"],"is_corresponding":false,"raw_author_name":"Ke Yan","raw_affiliation_strings":["DAMO Academy, Alibaba Group\nHupan Lab"],"affiliations":[{"raw_affiliation_string":"DAMO Academy, Alibaba Group\nHupan Lab","institution_ids":["https://openalex.org/I4210086143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111378387","display_name":"Dakai Jin","orcid":null},"institutions":[{"id":"https://openalex.org/I4210086143","display_name":"Alibaba Group (Cayman Islands)","ror":"https://ror.org/00mnrxf72","country_code":"KY","type":"company","lineage":["https://openalex.org/I4210086143","https://openalex.org/I45928872"]}],"countries":["KY"],"is_corresponding":false,"raw_author_name":"Dakai Jin","raw_affiliation_strings":["DAMO Academy, Alibaba Group"],"affiliations":[{"raw_affiliation_string":"DAMO Academy, Alibaba Group","institution_ids":["https://openalex.org/I4210086143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129662982","display_name":"Minfeng Xu","orcid":null},"institutions":[{"id":"https://openalex.org/I4210086143","display_name":"Alibaba Group (Cayman Islands)","ror":"https://ror.org/00mnrxf72","country_code":"KY","type":"company","lineage":["https://openalex.org/I4210086143","https://openalex.org/I45928872"]}],"countries":["KY"],"is_corresponding":false,"raw_author_name":"Minfeng Xu","raw_affiliation_strings":["DAMO Academy, Alibaba Group"],"affiliations":[{"raw_affiliation_string":"DAMO Academy, Alibaba Group","institution_ids":["https://openalex.org/I4210086143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101000815","display_name":"Yun Bian","orcid":null},"institutions":[{"id":"https://openalex.org/I4210137686","display_name":"Pancreatic Cancer UK","ror":"https://ror.org/04ad7pn51","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210137686"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Yun Bian","raw_affiliation_strings":["Shanghai Institution of Pancreatic Disease"],"affiliations":[{"raw_affiliation_string":"Shanghai Institution of Pancreatic Disease","institution_ids":["https://openalex.org/I4210137686"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5129718840","display_name":"Hui Jiang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210137686","display_name":"Pancreatic Cancer UK","ror":"https://ror.org/04ad7pn51","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210137686"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Hui Jiang","raw_affiliation_strings":["Shanghai Institution of Pancreatic Disease"],"affiliations":[{"raw_affiliation_string":"Shanghai Institution of Pancreatic Disease","institution_ids":["https://openalex.org/I4210137686"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5129740041"],"corresponding_institution_ids":["https://openalex.org/I4210086143"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01231263,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"40","issue":"14","first_page":"11838","last_page":"11847"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12874","display_name":"Digital Imaging for Blood Diseases","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10036","display_name":"Advanced Neural Network Applications","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/discriminative-model","display_name":"Discriminative model","score":0.7114999890327454},{"id":"https://openalex.org/keywords/exploit","display_name":"Exploit","score":0.4684999883174896},{"id":"https://openalex.org/keywords/task","display_name":"Task (project management)","score":0.4616999924182892},{"id":"https://openalex.org/keywords/core","display_name":"Core (optical fiber)","score":0.40149998664855957},{"id":"https://openalex.org/keywords/nucleus","display_name":"Nucleus","score":0.37439998984336853},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.36390000581741333}],"concepts":[{"id":"https://openalex.org/C97931131","wikidata":"https://www.wikidata.org/wiki/Q5282087","display_name":"Discriminative model","level":2,"score":0.7114999890327454},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6851000189781189},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5547999739646912},{"id":"https://openalex.org/C165696696","wikidata":"https://www.wikidata.org/wiki/Q11287","display_name":"Exploit","level":2,"score":0.4684999883174896},{"id":"https://openalex.org/C2780451532","wikidata":"https://www.wikidata.org/wiki/Q759676","display_name":"Task (project management)","level":2,"score":0.4616999924182892},{"id":"https://openalex.org/C2164484","wikidata":"https://www.wikidata.org/wiki/Q5170150","display_name":"Core (optical fiber)","level":2,"score":0.40149998664855957},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.37439998984336853},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.36390000581741333},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.3215999901294708},{"id":"https://openalex.org/C2776145971","wikidata":"https://www.wikidata.org/wiki/Q30673951","display_name":"Labeled data","level":2,"score":0.2865999937057495},{"id":"https://openalex.org/C136389625","wikidata":"https://www.wikidata.org/wiki/Q334384","display_name":"Supervised learning","level":3,"score":0.28200000524520874},{"id":"https://openalex.org/C2777522853","wikidata":"https://www.wikidata.org/wiki/Q5276128","display_name":"Digital pathology","level":2,"score":0.27630001306533813},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.2676999866962433},{"id":"https://openalex.org/C2776291640","wikidata":"https://www.wikidata.org/wiki/Q2912517","display_name":"Value (mathematics)","level":2,"score":0.25589999556541443}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1609/aaai.v40i14.38170","is_oa":true,"landing_page_url":"https://doi.org/10.1609/aaai.v40i14.38170","pdf_url":"https://ojs.aaai.org/index.php/AAAI/article/download/38170/42132","source":{"id":"https://openalex.org/S4210191458","display_name":"Proceedings of the AAAI Conference on Artificial Intelligence","issn_l":"2159-5399","issn":["2159-5399","2374-3468"],"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/P4310320058","host_organization_name":"Association for the Advancement of Artificial Intelligence","host_organization_lineage":["https://openalex.org/P4310320058"],"host_organization_lineage_names":["Association for the Advancement of Artificial Intelligence"],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the AAAI Conference on Artificial Intelligence","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1609/aaai.v40i14.38170","is_oa":true,"landing_page_url":"https://doi.org/10.1609/aaai.v40i14.38170","pdf_url":"https://ojs.aaai.org/index.php/AAAI/article/download/38170/42132","source":{"id":"https://openalex.org/S4210191458","display_name":"Proceedings of the AAAI Conference on Artificial Intelligence","issn_l":"2159-5399","issn":["2159-5399","2374-3468"],"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/P4310320058","host_organization_name":"Association for the Advancement of Artificial Intelligence","host_organization_lineage":["https://openalex.org/P4310320058"],"host_organization_lineage_names":["Association for the Advancement of Artificial Intelligence"],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the AAAI Conference on Artificial Intelligence","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/10","score":0.7399470210075378,"display_name":"Reduced inequalities"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7137801964.pdf","grobid_xml":"https://content.openalex.org/works/W7137801964.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Nucleus":[0],"detection":[1],"and":[2,30,118],"classification":[3],"(NDC)":[4],"in":[5],"histopathology":[6],"analysis":[7],"is":[8,63],"a":[9,14,52,68,112,119],"fundamental":[10],"task":[11],"that":[12,71,125,142],"underpins":[13],"wide":[15],"range":[16],"of":[17,101,130,149],"high-level":[18],"pathology":[19,132,165],"applications.":[20],"However,":[21],"existing":[22],"methods":[23],"heavily":[24],"rely":[25],"on":[26,77,136],"labor-intensive":[27],"nucleus-level":[28,105],"annotations":[29],"struggle":[31],"to":[32],"fully":[33],"exploit":[34],"large-scale":[35],"unlabeled":[36,131],"data":[37],"for":[38,58,85,103],"learning":[39,55],"discriminative":[40],"nucleus":[41,79],"representations.":[42],"In":[43],"this":[44],"work,":[45],"we":[46,110],"propose":[47],"MUSE":[48,143],"(MUlti-scale":[49],"denSE":[50],"self-distillation),":[51,67],"novel":[53],"self-supervised":[54],"method":[56],"tailored":[57],"NDC.":[59,151],"At":[60],"its":[61],"core":[62,147],"NuLo":[64,92],"(Nucleus-based":[65],"Local":[66],"coordinate-guided":[69],"mechanism":[70],"enables":[72],"flexible":[73],"local":[74],"self-distillation":[75],"based":[76],"predicted":[78],"positions.":[80],"By":[81],"removing":[82],"the":[83,99,128,146],"need":[84],"strict":[86],"spatial":[87],"alignment":[88],"between":[89],"augmented":[90],"views,":[91],"allows":[93],"critical":[94],"cross-scale":[95],"alignment,":[96],"thus":[97],"unlocking":[98],"capacity":[100],"models":[102,154],"fine-grained":[104],"representation.":[106],"To":[107],"support":[108],"MUSE,":[109],"design":[111],"simple":[113],"yet":[114],"effective":[115],"encoder-decoder":[116],"architecture":[117],"large":[120],"field-of-view":[121],"semi-supervised":[122],"fine-tuning":[123],"strategy":[124],"together":[126],"maximize":[127],"value":[129],"images.":[133],"Extensive":[134],"experiments":[135],"three":[137],"widely":[138],"used":[139],"benchmarks":[140],"demonstrate":[141],"effectively":[144],"addresses":[145],"challenges":[148],"histopathological":[150],"The":[152],"resulting":[153],"not":[155],"only":[156],"surpass":[157],"state-of-the-art":[158],"supervised":[159],"baselines":[160],"but":[161],"also":[162],"outperform":[163],"generic":[164],"foundation":[166],"models.":[167]},"counts_by_year":[],"updated_date":"2026-03-20T20:47:17.329874","created_date":"2026-03-18T00:00:00"}