{"id":"https://openalex.org/W2905538068","doi":"https://doi.org/10.1609/aaai.v33i01.3301630","title":"ReAl-LiFE: Accelerating the Discovery of Individualized Brain Connectomes on GPUs","display_name":"ReAl-LiFE: Accelerating the Discovery of Individualized Brain Connectomes on GPUs","publication_year":2019,"publication_date":"2019-07-17","ids":{"openalex":"https://openalex.org/W2905538068","doi":"https://doi.org/10.1609/aaai.v33i01.3301630","mag":"2905538068","pmid":"https://pubmed.ncbi.nlm.nih.gov/31355051"},"language":"en","primary_location":{"id":"doi:10.1609/aaai.v33i01.3301630","is_oa":true,"landing_page_url":"https://doi.org/10.1609/aaai.v33i01.3301630","pdf_url":"https://aaai.org/ojs/index.php/AAAI/article/download/3839/3717","source":{"id":"https://openalex.org/S4210191458","display_name":"Proceedings of the AAAI Conference on Artificial Intelligence","issn_l":"2159-5399","issn":["2159-5399","2374-3468"],"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/P4310320058","host_organization_name":"Association for the Advancement of Artificial Intelligence","host_organization_lineage":["https://openalex.org/P4310320058"],"host_organization_lineage_names":["Association for the Advancement of Artificial Intelligence"],"type":"conference"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the AAAI Conference on Artificial Intelligence","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://aaai.org/ojs/index.php/AAAI/article/download/3839/3717","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104274124","display_name":"Sawan Kumar","orcid":null},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Sawan Kumar","raw_affiliation_strings":["Computational and Data Sciences, Indian Institute of Science Bangalore, India","Indian Institute of Science"],"affiliations":[{"raw_affiliation_string":"Computational and Data Sciences, Indian Institute of Science Bangalore, India","institution_ids":[]},{"raw_affiliation_string":"Indian Institute of Science","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072614705","display_name":"Varsha Sreenivasan","orcid":"https://orcid.org/0000-0003-3225-7057"},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Varsha Sreenivasan","raw_affiliation_strings":["Centre for Neuroscience, Indian Institute of Science Bangalore, India","Indian Institute of Science"],"affiliations":[{"raw_affiliation_string":"Centre for Neuroscience, Indian Institute of Science Bangalore, India","institution_ids":[]},{"raw_affiliation_string":"Indian Institute of Science","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033696194","display_name":"Partha Talukdar","orcid":"https://orcid.org/0000-0001-8825-589X"},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Partha Talukdar","raw_affiliation_strings":["Computational and Data Sciences, and Computer Science and Automation, Indian Institute of Science Bangalore, India","Indian Institute of Science"],"affiliations":[{"raw_affiliation_string":"Computational and Data Sciences, and Computer Science and Automation, Indian Institute of Science Bangalore, India","institution_ids":[]},{"raw_affiliation_string":"Indian Institute of Science","institution_ids":["https://openalex.org/I59270414"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070135653","display_name":"Franco Pestilli","orcid":"https://orcid.org/0000-0002-2469-0494"},"institutions":[{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Franco Pestilli","raw_affiliation_strings":["Psychological and Brain Sciences, Indiana University Bloomington, USA","Indiana University"],"affiliations":[{"raw_affiliation_string":"Psychological and Brain Sciences, Indiana University Bloomington, USA","institution_ids":["https://openalex.org/I4210119109"]},{"raw_affiliation_string":"Indiana University","institution_ids":["https://openalex.org/I592451"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026580199","display_name":"Devarajan Sridharan","orcid":"https://orcid.org/0000-0003-1998-9018"},"institutions":[{"id":"https://openalex.org/I59270414","display_name":"Indian Institute of Science Bangalore","ror":"https://ror.org/04dese585","country_code":"IN","type":"education","lineage":["https://openalex.org/I59270414"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Devarajan Sridharan","raw_affiliation_strings":["Centre for Neuroscience, and Computer Science and Automation, Indian Institute of Science Bangalore, India","Indian Institute of Science"],"affiliations":[{"raw_affiliation_string":"Centre for Neuroscience, and Computer Science and Automation, Indian Institute of Science Bangalore, India","institution_ids":[]},{"raw_affiliation_string":"Indian Institute of Science","institution_ids":["https://openalex.org/I59270414"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5104274124"],"corresponding_institution_ids":["https://openalex.org/I59270414"],"apc_list":null,"apc_paid":null,"fwci":1.3544,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.85628743,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"33","issue":"01","first_page":"630","last_page":"638"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/connectome","display_name":"Connectome","score":0.9477810859680176},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7643727660179138},{"id":"https://openalex.org/keywords/pruning","display_name":"Pruning","score":0.6018940806388855},{"id":"https://openalex.org/keywords/human-connectome-project","display_name":"Human Connectome Project","score":0.5473265647888184},{"id":"https://openalex.org/keywords/connectomics","display_name":"Connectomics","score":0.5314188003540039},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3962039351463318},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.34718233346939087},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.33990317583084106},{"id":"https://openalex.org/keywords/parallel-computing","display_name":"Parallel computing","score":0.32459115982055664},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.13897347450256348},{"id":"https://openalex.org/keywords/functional-connectivity","display_name":"Functional connectivity","score":0.08830752968788147}],"concepts":[{"id":"https://openalex.org/C45715564","wikidata":"https://www.wikidata.org/wiki/Q1292103","display_name":"Connectome","level":3,"score":0.9477810859680176},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7643727660179138},{"id":"https://openalex.org/C108010975","wikidata":"https://www.wikidata.org/wiki/Q500094","display_name":"Pruning","level":2,"score":0.6018940806388855},{"id":"https://openalex.org/C97820695","wikidata":"https://www.wikidata.org/wiki/Q387749","display_name":"Human Connectome Project","level":3,"score":0.5473265647888184},{"id":"https://openalex.org/C2779097318","wikidata":"https://www.wikidata.org/wiki/Q2993446","display_name":"Connectomics","level":4,"score":0.5314188003540039},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3962039351463318},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.34718233346939087},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.33990317583084106},{"id":"https://openalex.org/C173608175","wikidata":"https://www.wikidata.org/wiki/Q232661","display_name":"Parallel computing","level":1,"score":0.32459115982055664},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.13897347450256348},{"id":"https://openalex.org/C3018011982","wikidata":"https://www.wikidata.org/wiki/Q7316120","display_name":"Functional connectivity","level":2,"score":0.08830752968788147},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C6557445","wikidata":"https://www.wikidata.org/wiki/Q173113","display_name":"Agronomy","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1609/aaai.v33i01.3301630","is_oa":true,"landing_page_url":"https://doi.org/10.1609/aaai.v33i01.3301630","pdf_url":"https://aaai.org/ojs/index.php/AAAI/article/download/3839/3717","source":{"id":"https://openalex.org/S4210191458","display_name":"Proceedings of the AAAI Conference on Artificial Intelligence","issn_l":"2159-5399","issn":["2159-5399","2374-3468"],"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/P4310320058","host_organization_name":"Association for the Advancement of Artificial Intelligence","host_organization_lineage":["https://openalex.org/P4310320058"],"host_organization_lineage_names":["Association for the Advancement of Artificial Intelligence"],"type":"conference"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the AAAI Conference on Artificial Intelligence","raw_type":"journal-article"},{"id":"pmid:31355051","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31355051","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the ... AAAI Conference on Artificial Intelligence. AAAI Conference on Artificial Intelligence","raw_type":null},{"id":"pmh:oai::78259","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306401429","display_name":"ePrints@IISc (Indian Institute of Science)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I59270414","host_organization_name":"Indian Institute of Science Bangalore","host_organization_lineage":["https://openalex.org/I59270414"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Conference Paper"},{"id":"pmh:oai:pubmedcentral.nih.gov:6660316","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6660316","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc Conf AAAI Artif Intell","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1609/aaai.v33i01.3301630","is_oa":true,"landing_page_url":"https://doi.org/10.1609/aaai.v33i01.3301630","pdf_url":"https://aaai.org/ojs/index.php/AAAI/article/download/3839/3717","source":{"id":"https://openalex.org/S4210191458","display_name":"Proceedings of the AAAI Conference on Artificial Intelligence","issn_l":"2159-5399","issn":["2159-5399","2374-3468"],"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/P4310320058","host_organization_name":"Association for the Advancement of Artificial Intelligence","host_organization_lineage":["https://openalex.org/P4310320058"],"host_organization_lineage_names":["Association for the Advancement of Artificial Intelligence"],"type":"conference"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the AAAI Conference on Artificial Intelligence","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2525627679","display_name":null,"funder_award_id":"BCS-1734853","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G343156164","display_name":null,"funder_award_id":"India","funder_id":"https://openalex.org/F4320322724","funder_display_name":"Ministry of Education, India"},{"id":"https://openalex.org/G7800732931","display_name":null,"funder_award_id":"Science","funder_id":"https://openalex.org/F4320334771","funder_display_name":"Science and Engineering Research Board"},{"id":"https://openalex.org/G836630860","display_name":null,"funder_award_id":"IIS-1636893","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G8446028771","display_name":null,"funder_award_id":"1734853","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G848032724","display_name":null,"funder_award_id":"Science","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G8754380281","display_name":null,"funder_award_id":"fellowship","funder_id":"https://openalex.org/F4320334771","funder_display_name":"Science and Engineering Research Board"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320310071","display_name":"Indian Institute of Science","ror":"https://ror.org/04dese585"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320322724","display_name":"Ministry of Education, India","ror":"https://ror.org/048xjjh50"},{"id":"https://openalex.org/F4320323504","display_name":"Tata Trusts","ror":"https://ror.org/057kjcb31"},{"id":"https://openalex.org/F4320325580","display_name":"The Wellcome Trust DBT India Alliance","ror":"https://ror.org/04reqzt68"},{"id":"https://openalex.org/F4320334771","display_name":"Science and Engineering Research Board","ror":"https://ror.org/03ffdsr55"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2905538068.pdf","grobid_xml":"https://content.openalex.org/works/W2905538068.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W795339718","https://openalex.org/W1543878663","https://openalex.org/W1969116741","https://openalex.org/W1995138343","https://openalex.org/W2013115634","https://openalex.org/W2019767285","https://openalex.org/W2020519533","https://openalex.org/W2053292397","https://openalex.org/W2058085357","https://openalex.org/W2082704080","https://openalex.org/W2101135654","https://openalex.org/W2123927491","https://openalex.org/W2124190705","https://openalex.org/W2149092213","https://openalex.org/W2151130155","https://openalex.org/W2151471453","https://openalex.org/W2165840723","https://openalex.org/W2768669180","https://openalex.org/W2782556780","https://openalex.org/W2787173038","https://openalex.org/W2950660979","https://openalex.org/W3187755177","https://openalex.org/W4235269030","https://openalex.org/W6732969017","https://openalex.org/W6799643182"],"related_works":["https://openalex.org/W3210800206","https://openalex.org/W1744057168","https://openalex.org/W2091472861","https://openalex.org/W2945607120","https://openalex.org/W4323359826","https://openalex.org/W2741941708","https://openalex.org/W2114571052","https://openalex.org/W2079635207","https://openalex.org/W2611561168","https://openalex.org/W2885436153"],"abstract_inverted_index":{"Diffusion":[0],"imaging":[1],"and":[2,178],"tractography":[3],"enable":[4],"mapping":[5],"structural":[6,28,153,205],"connections":[7,24],"in":[8,25,50,155,193,228],"the":[9,26,35,82,137,143,212,218,224],"human":[10],"brain,":[11],"<i>in-vivo</i>.":[12],"Linear":[13,182],"Fascicle":[14],"Evaluation":[15],"(LiFE)":[16],"is":[17],"a":[18,59,89,111,238],"state-of-the-art":[19],"approach":[20,147,236],"for":[21,72,172,242],"pruning":[22,169],"spurious":[23],"estimated":[27,115,162],"connectome,":[29,220,227],"by":[30,109,148,168],"optimizing":[31],"its":[32,48],"fit":[33],"to":[34,77,136],"measured":[36],"diffusion":[37,139],"data.":[38],"Yet,":[39],"LiFE":[40,63,124,225],"imposes":[41],"heavy":[42],"demands":[43],"on":[44,88,114,185,201,211],"computing":[45],"time,":[46],"precluding":[47],"use":[49],"analyses":[51],"of":[52,62,75,145,152,230],"large":[53],"connectome":[54,73,119,215],"databases.":[55],"Here,":[56],"we":[57,105],"introduce":[58],"GPU-based":[60],"implementation":[61],"that":[64,130],"achieves":[65],"50-100x":[66],"speedups":[67],"over":[68,190],"conventional":[69],"CPU-based":[70],"implementations":[71],"sizes":[74],"up":[76],"several":[78],"million":[79,163],"fibers.":[80],"Briefly,":[81],"algorithm":[83,108,125],"accelerates":[84],"generalized":[85],"matrix":[86],"multiplications":[87],"compressed":[90],"tensor":[91],"through":[92],"efficient":[93],"GPU":[94],"kernels,":[95],"while":[96],"ensuring":[97],"favorable":[98],"memory":[99],"access":[100],"patterns.":[101],"Leveraging":[102],"these":[103],"speedups,":[104],"advance":[106],"LiFE's":[107],"imposing":[110],"regularization":[112],"constraint":[113],"fiber":[116,164],"weights":[117],"during":[118],"pruning.":[120],"Our":[121],"regularized,":[122],"accelerated,":[123],"(\"ReAl-LiFE\")":[126],"estimates":[127],"sparser":[128],"connectomes":[129,206],"also":[131],"provide":[132],"more":[133],"accurate":[134],"fits":[135],"underlying":[138],"signal.":[140],"We":[141,161,232],"demonstrate":[142],"utility":[144],"our":[146,234],"classifying":[149,194],"pathological":[150],"signatures":[151],"connectivity":[154],"patients":[156,177,196],"with":[157,170],"Alzheimer's":[158],"Disease":[159],"(AD).":[160],"whole-brain":[165],"connectomes,":[166],"followed":[167],"ReAl-LiFE,":[171],"90":[173],"individuals":[174],"(45":[175],"AD":[176,195],"45":[179],"healthy":[180,198],"controls).":[181],"classifiers,":[183],"based":[184,200,210],"support":[186],"vector":[187],"machines,":[188],"achieved":[189],"80%":[191],"accuracy":[192],"from":[197],"controls":[199],"their":[202],"ReAl-LiFE":[203,213],"pruned":[204,214,226],"alone.":[207],"Moreover,":[208],"classification":[209],"outperformed":[216],"both":[217],"unpruned":[219],"as":[221,223,237],"well":[222],"terms":[229],"accuracy.":[231],"propose":[233],"GPU-accelerated":[235],"widely":[239],"relevant":[240],"tool":[241],"non-negative":[243],"least":[244],"squares":[245],"optimization,":[246],"across":[247],"many":[248],"domains.":[249]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}
