{"id":"https://openalex.org/W4323795792","doi":"https://doi.org/10.15302/j-qb-022-0311","title":"A cell marker\u2010based clustering strategy (cmCluster) for precise cell type identification of scRNA\u2010seq data","display_name":"A cell marker\u2010based clustering strategy (cmCluster) for precise cell type identification of scRNA\u2010seq data","publication_year":2023,"publication_date":"2023-03-10","ids":{"openalex":"https://openalex.org/W4323795792","doi":"https://doi.org/10.15302/j-qb-022-0311","pmid":"https://pubmed.ncbi.nlm.nih.gov/41675663"},"language":"en","primary_location":{"id":"doi:10.15302/j-qb-022-0311","is_oa":true,"landing_page_url":"https://doi.org/10.15302/j-qb-022-0311","pdf_url":"https://journal.hep.com.cn/qb/EN/PDF/10.15302/J-QB-022-0311","source":{"id":"https://openalex.org/S4210172333","display_name":"Quantitative Biology","issn_l":"2095-4689","issn":["2095-4689","2095-4697"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Quantitative Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://journal.hep.com.cn/qb/EN/PDF/10.15302/J-QB-022-0311","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020159889","display_name":"Yuwei Huang","orcid":"https://orcid.org/0000-0002-6274-0237"},"institutions":[{"id":"https://openalex.org/I4210096013","display_name":"Shanghai Institute of Nutrition and Health","ror":"https://ror.org/00rytkh49","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210096013"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuwei Huang","raw_affiliation_strings":["<!--1--> CAS Key Laboratory of Computational Biology Bio\u2010Med Big Data Center Shanghai Institute of Nutrition and Health University of Chinese Academy of Sciences Chinese Academy of Science Shanghai 200031 China","1. CAS Key Laboratory of Computational Biology, Bio-Med Big Data Center, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Science, Shanghai 200031, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--1--> CAS Key Laboratory of Computational Biology Bio\u2010Med Big Data Center Shanghai Institute of Nutrition and Health University of Chinese Academy of Sciences Chinese Academy of Science Shanghai 200031 China","institution_ids":["https://openalex.org/I4210096013"]},{"raw_affiliation_string":"1. CAS Key Laboratory of Computational Biology, Bio-Med Big Data Center, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Science, Shanghai 200031, China","institution_ids":["https://openalex.org/I4210096013","https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055991406","display_name":"Huidan Chang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210096013","display_name":"Shanghai Institute of Nutrition and Health","ror":"https://ror.org/00rytkh49","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210096013"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huidan Chang","raw_affiliation_strings":["<!--1--> CAS Key Laboratory of Computational Biology Bio\u2010Med Big Data Center Shanghai Institute of Nutrition and Health University of Chinese Academy of Sciences Chinese Academy of Science Shanghai 200031 China","1. CAS Key Laboratory of Computational Biology, Bio-Med Big Data Center, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Science, Shanghai 200031, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--1--> CAS Key Laboratory of Computational Biology Bio\u2010Med Big Data Center Shanghai Institute of Nutrition and Health University of Chinese Academy of Sciences Chinese Academy of Science Shanghai 200031 China","institution_ids":["https://openalex.org/I4210096013"]},{"raw_affiliation_string":"1. CAS Key Laboratory of Computational Biology, Bio-Med Big Data Center, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Science, Shanghai 200031, China","institution_ids":["https://openalex.org/I4210096013","https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100650025","display_name":"Xiaoyi Chen","orcid":"https://orcid.org/0000-0002-7378-5158"},"institutions":[{"id":"https://openalex.org/I109935558","display_name":"Ningbo University","ror":"https://ror.org/03et85d35","country_code":"CN","type":"education","lineage":["https://openalex.org/I109935558"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"id":"https://openalex.org/I4210165339","display_name":"Ningbo Institute of Industrial Technology","ror":"https://ror.org/05nqg3g04","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165339"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoyi Chen","raw_affiliation_strings":["<!--2--> Ningbo Institute of Life and Health Industry University of Chinese Academy of Sciences Ningbo 315000 China","2. Ningbo Institute of Life and Health Industry, University of Chinese Academy of Sciences, Ningbo 315000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--2--> Ningbo Institute of Life and Health Industry University of Chinese Academy of Sciences Ningbo 315000 China","institution_ids":["https://openalex.org/I4210165339","https://openalex.org/I109935558"]},{"raw_affiliation_string":"2. Ningbo Institute of Life and Health Industry, University of Chinese Academy of Sciences, Ningbo 315000, China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014192337","display_name":"Jiayue Meng","orcid":"https://orcid.org/0009-0003-5744-063X"},"institutions":[{"id":"https://openalex.org/I4210096013","display_name":"Shanghai Institute of Nutrition and Health","ror":"https://ror.org/00rytkh49","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210096013"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiayue Meng","raw_affiliation_strings":["<!--1--> CAS Key Laboratory of Computational Biology Bio\u2010Med Big Data Center Shanghai Institute of Nutrition and Health University of Chinese Academy of Sciences Chinese Academy of Science Shanghai 200031 China","1. CAS Key Laboratory of Computational Biology, Bio-Med Big Data Center, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Science, Shanghai 200031, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--1--> CAS Key Laboratory of Computational Biology Bio\u2010Med Big Data Center Shanghai Institute of Nutrition and Health University of Chinese Academy of Sciences Chinese Academy of Science Shanghai 200031 China","institution_ids":["https://openalex.org/I4210096013"]},{"raw_affiliation_string":"1. CAS Key Laboratory of Computational Biology, Bio-Med Big Data Center, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Science, Shanghai 200031, China","institution_ids":["https://openalex.org/I4210096013","https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083258836","display_name":"Mengyao Han","orcid":"https://orcid.org/0000-0003-1136-6270"},"institutions":[{"id":"https://openalex.org/I4210096013","display_name":"Shanghai Institute of Nutrition and Health","ror":"https://ror.org/00rytkh49","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210096013"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengyao Han","raw_affiliation_strings":["<!--1--> CAS Key Laboratory of Computational Biology Bio\u2010Med Big Data Center Shanghai Institute of Nutrition and Health University of Chinese Academy of Sciences Chinese Academy of Science Shanghai 200031 China","1. CAS Key Laboratory of Computational Biology, Bio-Med Big Data Center, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Science, Shanghai 200031, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--1--> CAS Key Laboratory of Computational Biology Bio\u2010Med Big Data Center Shanghai Institute of Nutrition and Health University of Chinese Academy of Sciences Chinese Academy of Science Shanghai 200031 China","institution_ids":["https://openalex.org/I4210096013"]},{"raw_affiliation_string":"1. CAS Key Laboratory of Computational Biology, Bio-Med Big Data Center, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Science, Shanghai 200031, China","institution_ids":["https://openalex.org/I4210096013","https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074123573","display_name":"Tao Huang","orcid":"https://orcid.org/0000-0003-3934-1649"},"institutions":[{"id":"https://openalex.org/I4210096013","display_name":"Shanghai Institute of Nutrition and Health","ror":"https://ror.org/00rytkh49","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210096013"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tao Huang","raw_affiliation_strings":["<!--1--> CAS Key Laboratory of Computational Biology Bio\u2010Med Big Data Center Shanghai Institute of Nutrition and Health University of Chinese Academy of Sciences Chinese Academy of Science Shanghai 200031 China","1. CAS Key Laboratory of Computational Biology, Bio-Med Big Data Center, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Science, Shanghai 200031, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--1--> CAS Key Laboratory of Computational Biology Bio\u2010Med Big Data Center Shanghai Institute of Nutrition and Health University of Chinese Academy of Sciences Chinese Academy of Science Shanghai 200031 China","institution_ids":["https://openalex.org/I4210096013"]},{"raw_affiliation_string":"1. CAS Key Laboratory of Computational Biology, Bio-Med Big Data Center, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Science, Shanghai 200031, China","institution_ids":["https://openalex.org/I4210096013","https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033418772","display_name":"Liyun Yuan","orcid":"https://orcid.org/0000-0001-9122-6782"},"institutions":[{"id":"https://openalex.org/I4210096013","display_name":"Shanghai Institute of Nutrition and Health","ror":"https://ror.org/00rytkh49","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210096013"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liyun Yuan","raw_affiliation_strings":["<!--1--> CAS Key Laboratory of Computational Biology Bio\u2010Med Big Data Center Shanghai Institute of Nutrition and Health University of Chinese Academy of Sciences Chinese Academy of Science Shanghai 200031 China","1. CAS Key Laboratory of Computational Biology, Bio-Med Big Data Center, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Science, Shanghai 200031, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--1--> CAS Key Laboratory of Computational Biology Bio\u2010Med Big Data Center Shanghai Institute of Nutrition and Health University of Chinese Academy of Sciences Chinese Academy of Science Shanghai 200031 China","institution_ids":["https://openalex.org/I4210096013"]},{"raw_affiliation_string":"1. CAS Key Laboratory of Computational Biology, Bio-Med Big Data Center, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Science, Shanghai 200031, China","institution_ids":["https://openalex.org/I4210096013","https://openalex.org/I4210165038"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100419052","display_name":"Guoqing Zhang","orcid":"https://orcid.org/0000-0001-8827-7546"},"institutions":[{"id":"https://openalex.org/I4210096013","display_name":"Shanghai Institute of Nutrition and Health","ror":"https://ror.org/00rytkh49","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210096013"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guoqing Zhang","raw_affiliation_strings":["<!--1--> CAS Key Laboratory of Computational Biology Bio\u2010Med Big Data Center Shanghai Institute of Nutrition and Health University of Chinese Academy of Sciences Chinese Academy of Science Shanghai 200031 China","1. CAS Key Laboratory of Computational Biology, Bio-Med Big Data Center, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Science, Shanghai 200031, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--1--> CAS Key Laboratory of Computational Biology Bio\u2010Med Big Data Center Shanghai Institute of Nutrition and Health University of Chinese Academy of Sciences Chinese Academy of Science Shanghai 200031 China","institution_ids":["https://openalex.org/I4210096013"]},{"raw_affiliation_string":"1. CAS Key Laboratory of Computational Biology, Bio-Med Big Data Center, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Science, Shanghai 200031, China","institution_ids":["https://openalex.org/I4210096013","https://openalex.org/I4210165038"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.428,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.65202135,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"11","issue":"2","first_page":"163","last_page":"174"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.8517651557922363},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.6552472114562988},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6281290054321289},{"id":"https://openalex.org/keywords/annotation","display_name":"Annotation","score":0.6240483522415161},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.5041390657424927},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4751560389995575},{"id":"https://openalex.org/keywords/biclustering","display_name":"Biclustering","score":0.4566243886947632},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.351912260055542},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3491936922073364},{"id":"https://openalex.org/keywords/fuzzy-clustering","display_name":"Fuzzy clustering","score":0.26453590393066406},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.21415871381759644},{"id":"https://openalex.org/keywords/cure-data-clustering-algorithm","display_name":"CURE data clustering algorithm","score":0.15124285221099854}],"concepts":[{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.8517651557922363},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.6552472114562988},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6281290054321289},{"id":"https://openalex.org/C2776321320","wikidata":"https://www.wikidata.org/wiki/Q857525","display_name":"Annotation","level":2,"score":0.6240483522415161},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.5041390657424927},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4751560389995575},{"id":"https://openalex.org/C144817290","wikidata":"https://www.wikidata.org/wiki/Q2976575","display_name":"Biclustering","level":5,"score":0.4566243886947632},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.351912260055542},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3491936922073364},{"id":"https://openalex.org/C17212007","wikidata":"https://www.wikidata.org/wiki/Q5511111","display_name":"Fuzzy clustering","level":3,"score":0.26453590393066406},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21415871381759644},{"id":"https://openalex.org/C33704608","wikidata":"https://www.wikidata.org/wiki/Q5014717","display_name":"CURE data clustering algorithm","level":4,"score":0.15124285221099854},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.15302/j-qb-022-0311","is_oa":true,"landing_page_url":"https://doi.org/10.15302/j-qb-022-0311","pdf_url":"https://journal.hep.com.cn/qb/EN/PDF/10.15302/J-QB-022-0311","source":{"id":"https://openalex.org/S4210172333","display_name":"Quantitative Biology","issn_l":"2095-4689","issn":["2095-4689","2095-4697"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Quantitative Biology","raw_type":"journal-article"},{"id":"pmid:41675663","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41675663","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Quantitative biology (Beijing, China)","raw_type":null},{"id":"pmh:oai:doaj.org/article:f7539a87a6744c5780c8d63327670514","is_oa":true,"landing_page_url":"https://doaj.org/article/f7539a87a6744c5780c8d63327670514","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Quantitative Biology, Vol 11, Iss 2, Pp 163-174 (2023)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:11693425","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12807422","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12807422","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12807422/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Quant Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.15302/j-qb-022-0311","is_oa":true,"landing_page_url":"https://doi.org/10.15302/j-qb-022-0311","pdf_url":"https://journal.hep.com.cn/qb/EN/PDF/10.15302/J-QB-022-0311","source":{"id":"https://openalex.org/S4210172333","display_name":"Quantitative Biology","issn_l":"2095-4689","issn":["2095-4689","2095-4697"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Quantitative Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1180467953","display_name":null,"funder_award_id":"2017SHZDZX01","funder_id":"https://openalex.org/F4320321133","funder_display_name":"Chinese Academy of Sciences"},{"id":"https://openalex.org/G2349219937","display_name":null,"funder_award_id":"XDB38050200","funder_id":"https://openalex.org/F4320321133","funder_display_name":"Chinese Academy of Sciences"},{"id":"https://openalex.org/G2883768802","display_name":null,"funder_award_id":"XDB38030100","funder_id":"https://openalex.org/F4320321133","funder_display_name":"Chinese Academy of Sciences"},{"id":"https://openalex.org/G3292149396","display_name":null,"funder_award_id":"81827901","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6044760167","display_name":null,"funder_award_id":"2017SHZDZX01","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8207283681","display_name":null,"funder_award_id":"XDB38050200","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321133","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35"},{"id":"https://openalex.org/F4320326972","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1813068103","https://openalex.org/W1988391018","https://openalex.org/W2149573463","https://openalex.org/W2403156809","https://openalex.org/W2591733518","https://openalex.org/W2598326928","https://openalex.org/W2601723752","https://openalex.org/W2612519453","https://openalex.org/W2729843964","https://openalex.org/W2778345128","https://openalex.org/W2794480084","https://openalex.org/W2800392236","https://openalex.org/W2886555678","https://openalex.org/W2894687190","https://openalex.org/W2895456557","https://openalex.org/W2902652978","https://openalex.org/W2907783748","https://openalex.org/W2914451825","https://openalex.org/W2936052783","https://openalex.org/W2939093246","https://openalex.org/W2949237386","https://openalex.org/W2949693884","https://openalex.org/W2951506174","https://openalex.org/W2951764674","https://openalex.org/W2952303649","https://openalex.org/W2954434934","https://openalex.org/W2971398276","https://openalex.org/W2971653850","https://openalex.org/W2973034691","https://openalex.org/W2978934711","https://openalex.org/W2979595830","https://openalex.org/W2995410603","https://openalex.org/W2997038947","https://openalex.org/W2999681746","https://openalex.org/W3002770500","https://openalex.org/W3007166960","https://openalex.org/W3016787828","https://openalex.org/W3022184763","https://openalex.org/W3084289412","https://openalex.org/W3105146463","https://openalex.org/W3139106654","https://openalex.org/W3178911446","https://openalex.org/W4210840193"],"related_works":["https://openalex.org/W1974340769","https://openalex.org/W2900595096","https://openalex.org/W4289277241","https://openalex.org/W2979322793","https://openalex.org/W2765801824","https://openalex.org/W2188068678","https://openalex.org/W2157302779","https://openalex.org/W4236723217","https://openalex.org/W2611629964","https://openalex.org/W2113284213"],"abstract_inverted_index":{"Background:":[0],"The":[1,24,72,161],"precise":[2],"and":[3,27,33,43,60,67,95,129,154,191,195],"efficient":[4],"analysis":[5,196],"of":[6,17,35,41,112,126,131,138,184,197],"single-cell":[7,22,113],"transcriptome":[8,114],"data":[9,145],"provides":[10,175],"powerful":[11],"support":[12],"for":[13,123],"studying":[14],"the":[15,21,39,88,100,116,124,136,182,193],"diversity":[16],"cell":[18,31,36,73,101,127,140],"functions":[19],"at":[20],"level.":[23],"most":[25,49],"important":[26],"challenging":[28],"steps":[29],"are":[30,45],"clustering":[32,42,65,75,83],"recognition":[34,125],"populations.":[37],"While":[38],"precision":[40],"annotation":[44,103],"considered":[46],"separately":[47],"in":[48,166],"current":[50],"studies,":[51],"it":[52,120],"is":[53,79,164],"worth":[54],"attempting":[55],"to":[56,63,86,180],"develop":[57],"an":[58],"extensive":[59],"flexible":[61],"strategy":[62,76],"balance":[64],"accuracy":[66,183],"biological":[68,132,186],"explanation":[69,130],"comprehensively.":[70],"Methods:":[71],"marker-based":[74],"(cmCluster),":[77],"which":[78],"a":[80,110],"modified":[81],"Louvain":[82],"method,":[84],"aims":[85],"search":[87,97],"optimal":[89],"clusters":[90],"through":[91],"genetic":[92],"algorithm":[93],"(GA)":[94],"grid":[96],"based":[98],"on":[99,109,135],"type":[102,141],"results.":[104],"Results:":[105],"By":[106],"applying":[107],"cmCluster":[108,149,174],"set":[111],"data,":[115],"results":[117],"showed":[118],"that":[119,173],"was":[121],"beneficial":[122],"populations":[128],"function":[133],"even":[134],"occasion":[137],"incomplete":[139],"information":[142],"or":[143],"multiple":[144,198],"resources.":[146],"In":[147],"addition,":[148],"also":[150],"produced":[151],"clear":[152],"boundaries":[153],"appropriate":[155],"subtypes":[156],"with":[157],"potential":[158],"marker":[159],"genes.":[160],"relevant":[162],"code":[163],"available":[165],"GitHub":[167],"website":[168],"(huangyuwei301/cmCluster).":[169],"Conclusions:":[170],"We":[171],"speculate":[172],"researchers":[176],"effective":[177],"screening":[178],"strategies":[179],"improve":[181],"subsequent":[185],"analysis,":[187],"reduce":[188],"artificial":[189],"bias,":[190],"facilitate":[192],"comparison":[194],"studies.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}