{"id":"https://openalex.org/W4206597039","doi":"https://doi.org/10.15302/j-qb-021-0253","title":"Recent progress in research and application of engineered implanted cells for biomedical applications","display_name":"Recent progress in research and application of engineered implanted cells for biomedical applications","publication_year":2021,"publication_date":"2021-05-20","ids":{"openalex":"https://openalex.org/W4206597039","doi":"https://doi.org/10.15302/j-qb-021-0253"},"language":"en","primary_location":{"id":"doi:10.15302/j-qb-021-0253","is_oa":true,"landing_page_url":"https://doi.org/10.15302/j-qb-021-0253","pdf_url":null,"source":{"id":"https://openalex.org/S4210172333","display_name":"Quantitative Biology","issn_l":"2095-4689","issn":["2095-4689","2095-4697"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Quantitative Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.15302/j-qb-021-0253","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060779881","display_name":"Tianying Chen","orcid":"https://orcid.org/0000-0001-5003-6405"},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Tianying Chen","raw_affiliation_strings":["<!--1--> MOE Key Laboratory of Bioinformatics School of Life Sciences Tsinghua University Beijing 100084 China","MOE Key Laboratory of Bioinformatics School of Life Sciences Tsinghua University Beijing 100084 China"],"affiliations":[{"raw_affiliation_string":"<!--1--> MOE Key Laboratory of Bioinformatics School of Life Sciences Tsinghua University Beijing 100084 China","institution_ids":["https://openalex.org/I99065089"]},{"raw_affiliation_string":"MOE Key Laboratory of Bioinformatics School of Life Sciences Tsinghua University Beijing 100084 China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102932170","display_name":"Xue Zhang","orcid":"https://orcid.org/0000-0002-6639-0852"},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xue Zhang","raw_affiliation_strings":["<!--1--> MOE Key Laboratory of Bioinformatics School of Life Sciences Tsinghua University Beijing 100084 China","MOE Key Laboratory of Bioinformatics School of Life Sciences Tsinghua University Beijing 100084 China"],"affiliations":[{"raw_affiliation_string":"<!--1--> MOE Key Laboratory of Bioinformatics School of Life Sciences Tsinghua University Beijing 100084 China","institution_ids":["https://openalex.org/I99065089"]},{"raw_affiliation_string":"MOE Key Laboratory of Bioinformatics School of Life Sciences Tsinghua University Beijing 100084 China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100638546","display_name":"Qiong Wu","orcid":"https://orcid.org/0000-0003-3305-6652"},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiong Wu","raw_affiliation_strings":["<!--1--> MOE Key Laboratory of Bioinformatics School of Life Sciences Tsinghua University Beijing 100084 China","<!--2--> Center for Synthetic and Systems Biology Tsinghua University Beijing 100084 China","Center for Synthetic and Systems Biology Tsinghua University Beijing 100084 China","MOE Key Laboratory of Bioinformatics School of Life Sciences Tsinghua University Beijing 100084 China"],"affiliations":[{"raw_affiliation_string":"<!--1--> MOE Key Laboratory of Bioinformatics School of Life Sciences Tsinghua University Beijing 100084 China","institution_ids":["https://openalex.org/I99065089"]},{"raw_affiliation_string":"<!--2--> Center for Synthetic and Systems Biology Tsinghua University Beijing 100084 China","institution_ids":["https://openalex.org/I99065089"]},{"raw_affiliation_string":"Center for Synthetic and Systems Biology Tsinghua University Beijing 100084 China","institution_ids":["https://openalex.org/I99065089"]},{"raw_affiliation_string":"MOE Key Laboratory of Bioinformatics School of Life Sciences Tsinghua University Beijing 100084 China","institution_ids":["https://openalex.org/I99065089"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5060779881"],"corresponding_institution_ids":["https://openalex.org/I99065089"],"apc_list":null,"apc_paid":null,"fwci":0.2093,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.58554856,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"9","issue":"3","first_page":"267","last_page":"291"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9416999816894531,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9416999816894531,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10729","display_name":"Electrospun Nanofibers in Biomedical Applications","score":0.9284999966621399,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genetically-engineered","display_name":"Genetically engineered","score":0.6307148933410645},{"id":"https://openalex.org/keywords/synthetic-biology","display_name":"Synthetic biology","score":0.6008303165435791},{"id":"https://openalex.org/keywords/tissue-engineering","display_name":"Tissue engineering","score":0.4966743588447571},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"Cell therapy","score":0.4853478968143463},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.462718665599823},{"id":"https://openalex.org/keywords/cell-function","display_name":"Cell function","score":0.45504820346832275},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.40728437900543213},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.3990105092525482},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.34768199920654297},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.31275421380996704},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.27708256244659424},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2157030701637268},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.1749693751335144},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.1704610288143158},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.15818679332733154},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.13915058970451355},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.08091273903846741}],"concepts":[{"id":"https://openalex.org/C3019111730","wikidata":"https://www.wikidata.org/wiki/Q159236","display_name":"Genetically engineered","level":3,"score":0.6307148933410645},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.6008303165435791},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.4966743588447571},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.4853478968143463},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.462718665599823},{"id":"https://openalex.org/C2994604686","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell function","level":3,"score":0.45504820346832275},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.40728437900543213},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3990105092525482},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.34768199920654297},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.31275421380996704},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.27708256244659424},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2157030701637268},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1749693751335144},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.1704610288143158},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.15818679332733154},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13915058970451355},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08091273903846741}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.15302/j-qb-021-0253","is_oa":true,"landing_page_url":"https://doi.org/10.15302/j-qb-021-0253","pdf_url":null,"source":{"id":"https://openalex.org/S4210172333","display_name":"Quantitative Biology","issn_l":"2095-4689","issn":["2095-4689","2095-4697"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Quantitative Biology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.15302/j-qb-021-0253","is_oa":true,"landing_page_url":"https://doi.org/10.15302/j-qb-021-0253","pdf_url":null,"source":{"id":"https://openalex.org/S4210172333","display_name":"Quantitative Biology","issn_l":"2095-4689","issn":["2095-4689","2095-4697"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Quantitative Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3205759590","display_name":null,"funder_award_id":"31961133019","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5883580587","display_name":null,"funder_award_id":"31670091","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":245,"referenced_works":["https://openalex.org/W92432531","https://openalex.org/W1255767896","https://openalex.org/W1484240761","https://openalex.org/W1574443686","https://openalex.org/W1647507681","https://openalex.org/W1751510803","https://openalex.org/W1753684754","https://openalex.org/W1877320158","https://openalex.org/W1879165674","https://openalex.org/W1896425879","https://openalex.org/W1911808314","https://openalex.org/W1939360714","https://openalex.org/W1963522404","https://openalex.org/W1965423091","https://openalex.org/W1968092893","https://openalex.org/W1968153285","https://openalex.org/W1968342623","https://openalex.org/W1968926710","https://openalex.org/W1968998853","https://openalex.org/W1976133526","https://openalex.org/W1976221714","https://openalex.org/W1979659851","https://openalex.org/W1982961252","https://openalex.org/W1984846777","https://openalex.org/W1986998207","https://openalex.org/W1987125576","https://openalex.org/W1988568788","https://openalex.org/W1988592246","https://openalex.org/W1996323262","https://openalex.org/W1996884864","https://openalex.org/W1998697301","https://openalex.org/W1999319278","https://openalex.org/W2001061492","https://openalex.org/W2002132740","https://openalex.org/W2003414091","https://openalex.org/W2004841304","https://openalex.org/W2006373538","https://openalex.org/W2007448214","https://openalex.org/W2007620617","https://openalex.org/W2008033906","https://openalex.org/W2008354940","https://openalex.org/W2010303814","https://openalex.org/W2010484682","https://openalex.org/W2011083779","https://openalex.org/W2013971421","https://openalex.org/W2014356856","https://openalex.org/W2015244769","https://openalex.org/W2017209592","https://openalex.org/W2017973039","https://openalex.org/W2018286352","https://openalex.org/W2019433804","https://openalex.org/W2020246410","https://openalex.org/W2021110745","https://openalex.org/W2022810557","https://openalex.org/W2022907036","https://openalex.org/W2023449596","https://openalex.org/W2025858316","https://openalex.org/W2026090536","https://openalex.org/W2026520402","https://openalex.org/W2026748222","https://openalex.org/W2027703497","https://openalex.org/W2028417270","https://openalex.org/W2028672737","https://openalex.org/W2028830817","https://openalex.org/W2030193551","https://openalex.org/W2030513350","https://openalex.org/W2030739010","https://openalex.org/W2032138237","https://openalex.org/W2032883153","https://openalex.org/W2032932429","https://openalex.org/W2035706135","https://openalex.org/W2036867468","https://openalex.org/W2039551908","https://openalex.org/W2041454553","https://openalex.org/W2045179744","https://openalex.org/W2045742275","https://openalex.org/W2045899482","https://openalex.org/W2047292103","https://openalex.org/W2050870581","https://openalex.org/W2051549641","https://openalex.org/W2051695659","https://openalex.org/W2054095354","https://openalex.org/W2055323054","https://openalex.org/W2056602419","https://openalex.org/W2057598532","https://openalex.org/W2059365691","https://openalex.org/W2060965112","https://openalex.org/W2061650108","https://openalex.org/W2062584484","https://openalex.org/W2063921800","https://openalex.org/W2064695428","https://openalex.org/W2064815984","https://openalex.org/W2067365522","https://openalex.org/W2068765585","https://openalex.org/W2069476277","https://openalex.org/W2070961268","https://openalex.org/W2075953769","https://openalex.org/W2076991609","https://openalex.org/W2077160573","https://openalex.org/W2077659966","https://openalex.org/W2080428594","https://openalex.org/W2080975442","https://openalex.org/W2081644109","https://openalex.org/W2082398508","https://openalex.org/W2083577929","https://openalex.org/W2084384103","https://openalex.org/W2085652695","https://openalex.org/W2085845614","https://openalex.org/W2085993152","https://openalex.org/W2086629515","https://openalex.org/W2086943348","https://openalex.org/W2090041902","https://openalex.org/W2093825185","https://openalex.org/W2094925460","https://openalex.org/W2097175022","https://openalex.org/W2097336577","https://openalex.org/W2098686083","https://openalex.org/W2099564459","https://openalex.org/W2099570622","https://openalex.org/W2103609218","https://openalex.org/W2103612759","https://openalex.org/W2105464583","https://openalex.org/W2107012251","https://openalex.org/W2108038398","https://openalex.org/W2110400822","https://openalex.org/W2110583027","https://openalex.org/W2110918588","https://openalex.org/W2111870329","https://openalex.org/W2111967568","https://openalex.org/W2112405899","https://openalex.org/W2112444085","https://openalex.org/W2115844597","https://openalex.org/W2116534141","https://openalex.org/W2116744112","https://openalex.org/W2117987556","https://openalex.org/W2118464978","https://openalex.org/W2118796952","https://openalex.org/W2119793652","https://openalex.org/W2120690461","https://openalex.org/W2122304523","https://openalex.org/W2122563582","https://openalex.org/W2125086964","https://openalex.org/W2125524975","https://openalex.org/W2125987139","https://openalex.org/W2126619407","https://openalex.org/W2128453858","https://openalex.org/W2128792807","https://openalex.org/W2130011407","https://openalex.org/W2131649670","https://openalex.org/W2134759932","https://openalex.org/W2136274459","https://openalex.org/W2136502605","https://openalex.org/W2136638400","https://openalex.org/W2139064489","https://openalex.org/W2139166113","https://openalex.org/W2142108003","https://openalex.org/W2143296478","https://openalex.org/W2146040216","https://openalex.org/W2146895715","https://openalex.org/W2147464758","https://openalex.org/W2149402050","https://openalex.org/W2150539666","https://openalex.org/W2151670940","https://openalex.org/W2158653361","https://openalex.org/W2160051211","https://openalex.org/W2160365835","https://openalex.org/W2162719345","https://openalex.org/W2165365045","https://openalex.org/W2165998489","https://openalex.org/W2166966954","https://openalex.org/W2166971328","https://openalex.org/W2167202160","https://openalex.org/W2167380395","https://openalex.org/W2168091280","https://openalex.org/W2219010784","https://openalex.org/W2221404162","https://openalex.org/W2256857837","https://openalex.org/W2258336271","https://openalex.org/W2265835549","https://openalex.org/W2280089777","https://openalex.org/W2313103425","https://openalex.org/W2328469110","https://openalex.org/W2336636899","https://openalex.org/W2342423058","https://openalex.org/W2345594933","https://openalex.org/W2399789944","https://openalex.org/W2410547162","https://openalex.org/W2465973558","https://openalex.org/W2473567065","https://openalex.org/W2479027661","https://openalex.org/W2494939990","https://openalex.org/W2510602644","https://openalex.org/W2530090297","https://openalex.org/W2561362082","https://openalex.org/W2564089345","https://openalex.org/W2580555388","https://openalex.org/W2587691649","https://openalex.org/W2589394758","https://openalex.org/W2589417329","https://openalex.org/W2604982880","https://openalex.org/W2609138125","https://openalex.org/W2618349602","https://openalex.org/W2626153771","https://openalex.org/W2733785896","https://openalex.org/W2734148025","https://openalex.org/W2740938625","https://openalex.org/W2755883063","https://openalex.org/W2762583307","https://openalex.org/W2765237233","https://openalex.org/W2767574526","https://openalex.org/W2768823259","https://openalex.org/W2774136216","https://openalex.org/W2790065985","https://openalex.org/W2790362095","https://openalex.org/W2790491347","https://openalex.org/W2792580051","https://openalex.org/W2800179315","https://openalex.org/W2804669050","https://openalex.org/W2805058565","https://openalex.org/W2805603674","https://openalex.org/W2806001790","https://openalex.org/W2807591162","https://openalex.org/W2809255947","https://openalex.org/W2809769744","https://openalex.org/W2810715813","https://openalex.org/W2885674199","https://openalex.org/W2886131798","https://openalex.org/W2893868211","https://openalex.org/W2901835229","https://openalex.org/W2908788147","https://openalex.org/W2914788525","https://openalex.org/W2917157662","https://openalex.org/W2917547201","https://openalex.org/W2918633605","https://openalex.org/W2927684362","https://openalex.org/W2945580095","https://openalex.org/W2953751486","https://openalex.org/W2956118984","https://openalex.org/W3030627391","https://openalex.org/W3040441267","https://openalex.org/W3081974299","https://openalex.org/W4210574564","https://openalex.org/W4235813374","https://openalex.org/W4248423784","https://openalex.org/W4249682837"],"related_works":["https://openalex.org/W3141738981","https://openalex.org/W2099102792","https://openalex.org/W4254255930","https://openalex.org/W2121624168","https://openalex.org/W2117019151","https://openalex.org/W2026977595","https://openalex.org/W1615749312","https://openalex.org/W4308212279","https://openalex.org/W2048096736","https://openalex.org/W2346906262"],"abstract_inverted_index":{"Background":[0],"The":[1,136],"core":[2],"concept":[3],"of":[4,10,56,63,80,105,117,131,139,149,162,174,190],"cell":[5,31,41,96,111,163,176],"engineering":[6,97],"is":[7],"the":[8,27,40,44,54,61,77,94,102,115,129,147,160,172,188],"use":[9,138],"synthetic":[11,140],"biological":[12],"methods":[13,142],"to":[14,51,85,143,178,181],"engineer":[15],"and":[16,30,58,121,145,165],"design":[17],"genetically":[18],"modified":[19],"cells":[20,34,48,66,107,151],"with":[21,73,152],"specific":[22],"functions,":[23],"which":[24],"has":[25,67],"revolutionized":[26],"biotechnology":[28],"industry":[29],"therapy.":[32],"Implanted":[33],"play":[35],"an":[36],"important":[37],"role":[38,185],"in":[39,109,114,186],"therapy,":[42,164],"but":[43],"currently":[45],"used":[46,108],"implanted":[47,65,81,110,133,150,175],"are":[49],"unable":[50],"fully":[52],"meet":[53],"needs":[55],"researchers":[57],"clinicians.":[59],"Therefore,":[60],"construction":[62,130],"engineered":[64,132],"become":[68],"a":[69],"new":[70,157,168],"research":[71],"area,":[72],"many":[74],"groups":[75],"exploring":[76,171],"working":[78],"principles":[79],"cells,":[82],"allowing":[83],"them":[84,180],"better":[86,182],"exert":[87,183],"their":[88,184],"repair":[89],"function.":[90],"Results":[91],"Based":[92],"on":[93],"existing":[95],"platforms,":[98],"this":[99],"paper":[100],"summarizes":[101],"main":[103],"types":[104],"chassis":[106],"engineering,":[112],"progress":[113,189],"development":[116,161],"gene":[118],"editing":[119],"tools":[120],"delivery":[122],"systems,":[123],"as":[124,126],"well":[125],"strategies":[127],"for":[128,159,170],"cells.":[134],"Conclusions":[135],"rational":[137],"biology":[141],"program":[144],"control":[146],"function":[148],"high":[153],"spatiotemporal":[154],"accuracy":[155],"provides":[156],"ideas":[158],"opens":[166],"up":[167],"possibilities":[169],"mechanism":[173],"action":[177],"allow":[179],"promoting":[187],"repair.":[191]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-04-09T08:11:56.329763","created_date":"2025-10-10T00:00:00"}