{"id":"https://openalex.org/W3206228248","doi":"https://doi.org/10.15302/j-qb-021-0237","title":"Systems analysis of the \u201cweights\u201d of Bcl\u20102 and Mcl\u20101\u00a0in mitochondrial apoptosis pathway establishes a predictor for best drug combination ratio","display_name":"Systems analysis of the \u201cweights\u201d of Bcl\u20102 and Mcl\u20101\u00a0in mitochondrial apoptosis pathway establishes a predictor for best drug combination ratio","publication_year":2021,"publication_date":"2021-02-05","ids":{"openalex":"https://openalex.org/W3206228248","doi":"https://doi.org/10.15302/j-qb-021-0237","mag":"3206228248"},"language":"en","primary_location":{"id":"doi:10.15302/j-qb-021-0237","is_oa":true,"landing_page_url":"https://doi.org/10.15302/j-qb-021-0237","pdf_url":null,"source":{"id":"https://openalex.org/S4210172333","display_name":"Quantitative Biology","issn_l":"2095-4689","issn":["2095-4689","2095-4697"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Quantitative Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.15302/j-qb-021-0237","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104173380","display_name":"Zongwei Guo","orcid":null},"institutions":[{"id":"https://openalex.org/I27357992","display_name":"Dalian University of Technology","ror":"https://ror.org/023hj5876","country_code":"CN","type":"education","lineage":["https://openalex.org/I27357992"]},{"id":"https://openalex.org/I4210092944","display_name":"Dalian University","ror":"https://ror.org/00g2ypp58","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092944"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zongwei Guo","raw_affiliation_strings":["<!--1--> School of Bioengineering Dalian University of Technology Dalian 116024 China","1. School of Bioengineering, Dalian University of Technology, Dalian 116024, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--1--> School of Bioengineering Dalian University of Technology Dalian 116024 China","institution_ids":["https://openalex.org/I4210092944"]},{"raw_affiliation_string":"1. School of Bioengineering, Dalian University of Technology, Dalian 116024, China","institution_ids":["https://openalex.org/I4210092944","https://openalex.org/I27357992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075272300","display_name":"Fangkui Yin","orcid":null},"institutions":[{"id":"https://openalex.org/I27357992","display_name":"Dalian University of Technology","ror":"https://ror.org/023hj5876","country_code":"CN","type":"education","lineage":["https://openalex.org/I27357992"]},{"id":"https://openalex.org/I4210092944","display_name":"Dalian University","ror":"https://ror.org/00g2ypp58","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092944"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fangkui Yin","raw_affiliation_strings":["<!--2--> State Key Laboratory of Fine Chemicals School of Chemistry Dalian University of Technology Dalian 116024 China","2. State Key Laboratory of Fine Chemicals, School of Chemistry, Dalian University of Technology, Dalian 116024, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--2--> State Key Laboratory of Fine Chemicals School of Chemistry Dalian University of Technology Dalian 116024 China","institution_ids":["https://openalex.org/I4210092944","https://openalex.org/I27357992"]},{"raw_affiliation_string":"2. State Key Laboratory of Fine Chemicals, School of Chemistry, Dalian University of Technology, Dalian 116024, China","institution_ids":["https://openalex.org/I4210092944","https://openalex.org/I27357992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007109266","display_name":"Peiran Wang","orcid":"https://orcid.org/0000-0003-4575-2719"},"institutions":[{"id":"https://openalex.org/I27357992","display_name":"Dalian University of Technology","ror":"https://ror.org/023hj5876","country_code":"CN","type":"education","lineage":["https://openalex.org/I27357992"]},{"id":"https://openalex.org/I4210092944","display_name":"Dalian University","ror":"https://ror.org/00g2ypp58","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092944"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peiran Wang","raw_affiliation_strings":["<!--2--> State Key Laboratory of Fine Chemicals School of Chemistry Dalian University of Technology Dalian 116024 China","2. State Key Laboratory of Fine Chemicals, School of Chemistry, Dalian University of Technology, Dalian 116024, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--2--> State Key Laboratory of Fine Chemicals School of Chemistry Dalian University of Technology Dalian 116024 China","institution_ids":["https://openalex.org/I4210092944","https://openalex.org/I27357992"]},{"raw_affiliation_string":"2. State Key Laboratory of Fine Chemicals, School of Chemistry, Dalian University of Technology, Dalian 116024, China","institution_ids":["https://openalex.org/I4210092944","https://openalex.org/I27357992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101776938","display_name":"Ting Song","orcid":"https://orcid.org/0000-0002-5952-180X"},"institutions":[{"id":"https://openalex.org/I27357992","display_name":"Dalian University of Technology","ror":"https://ror.org/023hj5876","country_code":"CN","type":"education","lineage":["https://openalex.org/I27357992"]},{"id":"https://openalex.org/I4210092944","display_name":"Dalian University","ror":"https://ror.org/00g2ypp58","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092944"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ting Song","raw_affiliation_strings":["<!--2--> State Key Laboratory of Fine Chemicals School of Chemistry Dalian University of Technology Dalian 116024 China","2. State Key Laboratory of Fine Chemicals, School of Chemistry, Dalian University of Technology, Dalian 116024, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--2--> State Key Laboratory of Fine Chemicals School of Chemistry Dalian University of Technology Dalian 116024 China","institution_ids":["https://openalex.org/I4210092944","https://openalex.org/I27357992"]},{"raw_affiliation_string":"2. State Key Laboratory of Fine Chemicals, School of Chemistry, Dalian University of Technology, Dalian 116024, China","institution_ids":["https://openalex.org/I4210092944","https://openalex.org/I27357992"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100363606","display_name":"Zhichao Zhang","orcid":"https://orcid.org/0000-0002-2774-2384"},"institutions":[{"id":"https://openalex.org/I27357992","display_name":"Dalian University of Technology","ror":"https://ror.org/023hj5876","country_code":"CN","type":"education","lineage":["https://openalex.org/I27357992"]},{"id":"https://openalex.org/I4210092944","display_name":"Dalian University","ror":"https://ror.org/00g2ypp58","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092944"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhichao Zhang","raw_affiliation_strings":["<!--2--> State Key Laboratory of Fine Chemicals School of Chemistry Dalian University of Technology Dalian 116024 China","2. State Key Laboratory of Fine Chemicals, School of Chemistry, Dalian University of Technology, Dalian 116024, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--2--> State Key Laboratory of Fine Chemicals School of Chemistry Dalian University of Technology Dalian 116024 China","institution_ids":["https://openalex.org/I4210092944","https://openalex.org/I27357992"]},{"raw_affiliation_string":"2. State Key Laboratory of Fine Chemicals, School of Chemistry, Dalian University of Technology, Dalian 116024, China","institution_ids":["https://openalex.org/I4210092944","https://openalex.org/I27357992"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5100363606","https://openalex.org/A5101776938"],"corresponding_institution_ids":["https://openalex.org/I27357992","https://openalex.org/I4210092944"],"apc_list":null,"apc_paid":null,"fwci":0.0814,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.44971821,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"9","issue":"3","first_page":"329","last_page":"340"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9684000015258789,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9684000015258789,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9659000039100647,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apoptosis","display_name":"Apoptosis","score":0.6009933948516846},{"id":"https://openalex.org/keywords/myeloid","display_name":"Myeloid","score":0.46874740719795227},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.46105659008026123},{"id":"https://openalex.org/keywords/dependency","display_name":"Dependency (UML)","score":0.4470587968826294},{"id":"https://openalex.org/keywords/downregulation-and-upregulation","display_name":"Downregulation and upregulation","score":0.4411928355693817},{"id":"https://openalex.org/keywords/myeloid-leukemia","display_name":"Myeloid leukemia","score":0.4411580562591553},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.42555859684944153},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.3839137554168701},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3637486398220062},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.33502399921417236},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.2530944347381592},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.24898383021354675},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2231670320034027},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.22083023190498352}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6009933948516846},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.46874740719795227},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.46105659008026123},{"id":"https://openalex.org/C19768560","wikidata":"https://www.wikidata.org/wiki/Q320727","display_name":"Dependency (UML)","level":2,"score":0.4470587968826294},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4411928355693817},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.4411580562591553},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42555859684944153},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3839137554168701},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3637486398220062},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33502399921417236},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2530944347381592},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.24898383021354675},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2231670320034027},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22083023190498352},{"id":"https://openalex.org/C115903868","wikidata":"https://www.wikidata.org/wiki/Q80993","display_name":"Software engineering","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.15302/j-qb-021-0237","is_oa":true,"landing_page_url":"https://doi.org/10.15302/j-qb-021-0237","pdf_url":null,"source":{"id":"https://openalex.org/S4210172333","display_name":"Quantitative Biology","issn_l":"2095-4689","issn":["2095-4689","2095-4697"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Quantitative Biology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.15302/j-qb-021-0237","is_oa":true,"landing_page_url":"https://doi.org/10.15302/j-qb-021-0237","pdf_url":null,"source":{"id":"https://openalex.org/S4210172333","display_name":"Quantitative Biology","issn_l":"2095-4689","issn":["2095-4689","2095-4697"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Quantitative Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8199999928474426}],"awards":[{"id":"https://openalex.org/G2581056923","display_name":null,"funder_award_id":"2018M641694","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"},{"id":"https://openalex.org/G2781587832","display_name":null,"funder_award_id":"DUT20YG133","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G5047156528","display_name":"\u57fa\u4e8eBcl-2\u5bb6\u65cf\u86cb\u767d-\u86cb\u767d\u76f8\u4e92\u4f5c\u7528\u7f51\u7edc\u7814\u7a76\u7684\u591a\u9776\u6807\u6297\u80bf\u7624\u6d3b\u6027\u5316\u5408\u7269","funder_award_id":"81430083","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G745021678","display_name":null,"funder_award_id":"DUT20LK28","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G8329216512","display_name":null,"funder_award_id":"81903462","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1489498714","https://openalex.org/W1933867057","https://openalex.org/W1975738390","https://openalex.org/W1977258127","https://openalex.org/W1977323318","https://openalex.org/W1981466043","https://openalex.org/W1983820911","https://openalex.org/W1986688227","https://openalex.org/W2009158642","https://openalex.org/W2010902097","https://openalex.org/W2027395744","https://openalex.org/W2028703351","https://openalex.org/W2036411709","https://openalex.org/W2046279786","https://openalex.org/W2059416155","https://openalex.org/W2069860553","https://openalex.org/W2085419794","https://openalex.org/W2094942223","https://openalex.org/W2097007474","https://openalex.org/W2097290512","https://openalex.org/W2100762532","https://openalex.org/W2111076982","https://openalex.org/W2125963106","https://openalex.org/W2128084665","https://openalex.org/W2136910701","https://openalex.org/W2139347878","https://openalex.org/W2142098498","https://openalex.org/W2145955296","https://openalex.org/W2147318282","https://openalex.org/W2150048195","https://openalex.org/W2165208382","https://openalex.org/W2521503538","https://openalex.org/W2528270895","https://openalex.org/W2763510705","https://openalex.org/W2785859194","https://openalex.org/W2793308615","https://openalex.org/W2811148759","https://openalex.org/W2884268220","https://openalex.org/W2888730977","https://openalex.org/W2889850618","https://openalex.org/W2890850288","https://openalex.org/W2902850283","https://openalex.org/W2942007182","https://openalex.org/W2945824284","https://openalex.org/W2964193656","https://openalex.org/W2964430254","https://openalex.org/W2982030496"],"related_works":["https://openalex.org/W2592007767","https://openalex.org/W2026862129","https://openalex.org/W582905479","https://openalex.org/W2080599553","https://openalex.org/W2996239022","https://openalex.org/W2900494214","https://openalex.org/W4214698807","https://openalex.org/W4327518501","https://openalex.org/W3176872974","https://openalex.org/W2012639655"],"abstract_inverted_index":{"Background":[0],"Inhibitors":[1],"of":[2,29,43,79,169,172,201],"B\u2010cell":[3],"CLL/lymphoma":[4],"2":[5],"(Bcl\u20102)":[6],"family":[7,33],"proteins":[8],"have":[9,51],"shown":[10],"hope":[11],"as":[12,112,114,206],"antitumor":[13],"drugs.":[14],"While":[15],"the":[16,30,41,44,58,77,103,123,139,153,181,217],"notion":[17],"that":[18,191],"it":[19],"is":[20],"efficient":[21],"to":[22,48,75,101,121,179,208,215],"coordinate,":[23],"balance,":[24],"and":[25,84,89,95,109,130,135,145,158,165,174,193,211],"neutralize":[26],"both":[27,82],"arms":[28,46],"anti\u2010apoptotic":[31],"Bcl\u20102":[32,64,80,83,108,127,144,173,186],"has":[34],"been":[35,53],"validated":[36],"in":[37,86,163],"many":[38],"cancer":[39],"cells,":[40],"weights":[42,78],"two":[45,199],"contributing":[47],"apoptosis":[49],"inhibition":[50],"not":[52],"explored.":[54],"This":[55],"study":[56,76],"analyzed":[57],"best":[59,182,218],"combination":[60,161,183,220],"ratio":[61,184,221],"for":[62,107,143,156,185,222],"different":[63],"selective":[65],"inhibitors.":[66],"Methods":[67],"We":[68],"used":[69,100,120,205],"a":[70],"previously":[71],"established":[72],"mathematical":[73,124],"model":[74,149],"(representing":[81],"Bcl\u2010xL":[85],"this":[87],"study)":[88],"myeloid":[90],"cell":[91],"leukemia\u20101":[92],"(Mcl\u20101).":[93],"Correlation":[94],"single\u2010parameter":[96],"sensitivity":[97],"analysis":[98],"were":[99,119,138,177],"find":[102],"major":[104,140],"molecular":[105,141],"determinants":[106,142],"Mcl\u20101":[110,131,146,175,189],"dependency,":[111],"well":[113],"their":[115],"weights.":[116],"Biological":[117],"experiments":[118],"verify":[122],"model.":[125],"Results":[126],"protein":[128,132],"level":[129],"level,":[133],"production,":[134],"degradation":[136],"rates":[137],"dependency.":[147],"The":[148,198],"gained":[150],"agreement":[151],"with":[152,188],"experimental":[154,213],"assays":[155],"ABT\u2010737/A\u20101210477":[157],"ABT\u2010737/compound":[159],"5":[160],"effect":[162],"MCF\u20107":[164],"MDA\u2010MB\u2010231.":[166],"Two":[167],"sets":[168,200],"equations":[170,202],"composed":[171],"levels":[176],"obtained":[178],"predict":[180,216],"inhibitors":[187,190],"stabilize":[192],"downregulate":[194],"Mcl\u20101,":[195],"respectively.":[196],"Conclusions":[197],"can":[203],"be":[204],"tools":[207],"bypass":[209],"time\u2010consuming":[210],"laborious":[212],"screening":[214],"drug":[219],"treatment.":[223]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-06-15T08:34:33.830935","created_date":"2025-10-10T00:00:00"}