{"id":"https://openalex.org/W4388800256","doi":"https://doi.org/10.1515/jib-2023-0013","title":"Reconstruction of the regulatory hypermethylation network controlling hepatocellular carcinoma development during hepatitis C viral infection","display_name":"Reconstruction of the regulatory hypermethylation network controlling hepatocellular carcinoma development during hepatitis C viral infection","publication_year":2023,"publication_date":"2023-09-01","ids":{"openalex":"https://openalex.org/W4388800256","doi":"https://doi.org/10.1515/jib-2023-0013","pmid":"https://pubmed.ncbi.nlm.nih.gov/37978846"},"language":"en","primary_location":{"id":"doi:10.1515/jib-2023-0013","is_oa":true,"landing_page_url":"https://doi.org/10.1515/jib-2023-0013","pdf_url":"https://www.degruyter.com/document/doi/10.1515/jib-2023-0013/pdf","source":{"id":"https://openalex.org/S4393917359","display_name":"Berichte aus der medizinischen Informatik und Bioinformatik/Journal of integrative bioinformatics","issn_l":"1432-4385","issn":["1432-4385","1613-4516"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Integrative Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.degruyter.com/document/doi/10.1515/jib-2023-0013/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041167717","display_name":"\u0415. \u0410. \u041e\u0449\u0435\u043f\u043a\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0003-2158-3252"},"institutions":[{"id":"https://openalex.org/I4210116466","display_name":"Institute of Cytology and Genetics","ror":"https://ror.org/0277xgb12","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I1313323035","https://openalex.org/I188973947","https://openalex.org/I4210116466","https://openalex.org/I4210127387","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Evgeniya A. Antropova","raw_affiliation_strings":["Institute of Cytology and Genetics, Siberian Branch of RAS , Novosibirsk , Russia"],"affiliations":[{"raw_affiliation_string":"Institute of Cytology and Genetics, Siberian Branch of RAS , Novosibirsk , Russia","institution_ids":["https://openalex.org/I4210116466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056460726","display_name":"\u0422. \u041c. \u0425\u043b\u0435\u0431\u043e\u0434\u0430\u0440\u043e\u0432\u0430","orcid":null},"institutions":[{"id":"https://openalex.org/I4210116466","display_name":"Institute of Cytology and Genetics","ror":"https://ror.org/0277xgb12","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I1313323035","https://openalex.org/I188973947","https://openalex.org/I4210116466","https://openalex.org/I4210127387","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Tamara M. Khlebodarova","raw_affiliation_strings":["Institute of Cytology and Genetics, Siberian Branch of RAS , Novosibirsk , Russia","Kurchatov Genomic Center of the Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences , Novosibirsk , Russia"],"affiliations":[{"raw_affiliation_string":"Institute of Cytology and Genetics, Siberian Branch of RAS , Novosibirsk , Russia","institution_ids":["https://openalex.org/I4210116466"]},{"raw_affiliation_string":"Kurchatov Genomic Center of the Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences , Novosibirsk , Russia","institution_ids":["https://openalex.org/I4210116466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055758776","display_name":"\u041f. \u0421. \u0414\u0435\u043c\u0435\u043d\u043a\u043e\u0432","orcid":"https://orcid.org/0000-0001-9433-8341"},"institutions":[{"id":"https://openalex.org/I188973947","display_name":"Novosibirsk State University","ror":"https://ror.org/04t2ss102","country_code":"RU","type":"education","lineage":["https://openalex.org/I188973947"]},{"id":"https://openalex.org/I4210116466","display_name":"Institute of Cytology and Genetics","ror":"https://ror.org/0277xgb12","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I1313323035","https://openalex.org/I188973947","https://openalex.org/I4210116466","https://openalex.org/I4210127387","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Pavel S. Demenkov","raw_affiliation_strings":["Institute of Cytology and Genetics, Siberian Branch of RAS , Novosibirsk , Russia","Kurchatov Genomic Center of the Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences , Novosibirsk , Russia","Novosibirsk State University , Novosibirsk , Russia"],"affiliations":[{"raw_affiliation_string":"Institute of Cytology and Genetics, Siberian Branch of RAS , Novosibirsk , Russia","institution_ids":["https://openalex.org/I4210116466"]},{"raw_affiliation_string":"Kurchatov Genomic Center of the Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences , Novosibirsk , Russia","institution_ids":["https://openalex.org/I4210116466"]},{"raw_affiliation_string":"Novosibirsk State University , Novosibirsk , Russia","institution_ids":["https://openalex.org/I188973947"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093288904","display_name":"Anastasiia R. Volianskaia","orcid":null},"institutions":[{"id":"https://openalex.org/I188973947","display_name":"Novosibirsk State University","ror":"https://ror.org/04t2ss102","country_code":"RU","type":"education","lineage":["https://openalex.org/I188973947"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Anastasiia R. Volianskaia","raw_affiliation_strings":["Novosibirsk State University , Novosibirsk , Russia"],"affiliations":[{"raw_affiliation_string":"Novosibirsk State University , Novosibirsk , Russia","institution_ids":["https://openalex.org/I188973947"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033968445","display_name":"A. S. Venzel","orcid":"https://orcid.org/0000-0002-7419-5168"},"institutions":[{"id":"https://openalex.org/I4210116466","display_name":"Institute of Cytology and Genetics","ror":"https://ror.org/0277xgb12","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I1313323035","https://openalex.org/I188973947","https://openalex.org/I4210116466","https://openalex.org/I4210127387","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Artur S. Venzel","raw_affiliation_strings":["Institute of Cytology and Genetics, Siberian Branch of RAS , Novosibirsk , Russia","Kurchatov Genomic Center of the Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences , Novosibirsk , Russia"],"affiliations":[{"raw_affiliation_string":"Institute of Cytology and Genetics, Siberian Branch of RAS , Novosibirsk , Russia","institution_ids":["https://openalex.org/I4210116466"]},{"raw_affiliation_string":"Kurchatov Genomic Center of the Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences , Novosibirsk , Russia","institution_ids":["https://openalex.org/I4210116466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076841276","display_name":"Nikita V. Ivanisenko","orcid":"https://orcid.org/0000-0002-0333-8117"},"institutions":[{"id":"https://openalex.org/I4210116466","display_name":"Institute of Cytology and Genetics","ror":"https://ror.org/0277xgb12","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I1313323035","https://openalex.org/I188973947","https://openalex.org/I4210116466","https://openalex.org/I4210127387","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Nikita V. Ivanisenko","raw_affiliation_strings":["Institute of Cytology and Genetics, Siberian Branch of RAS , Novosibirsk , Russia","Kurchatov Genomic Center of the Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences , Novosibirsk , Russia"],"affiliations":[{"raw_affiliation_string":"Institute of Cytology and Genetics, Siberian Branch of RAS , Novosibirsk , Russia","institution_ids":["https://openalex.org/I4210116466"]},{"raw_affiliation_string":"Kurchatov Genomic Center of the Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences , Novosibirsk , Russia","institution_ids":["https://openalex.org/I4210116466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091762129","display_name":"Alexandr D. Gavrilenko","orcid":null},"institutions":[{"id":"https://openalex.org/I188973947","display_name":"Novosibirsk State University","ror":"https://ror.org/04t2ss102","country_code":"RU","type":"education","lineage":["https://openalex.org/I188973947"]},{"id":"https://openalex.org/I4210116466","display_name":"Institute of Cytology and Genetics","ror":"https://ror.org/0277xgb12","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I1313323035","https://openalex.org/I188973947","https://openalex.org/I4210116466","https://openalex.org/I4210127387","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Alexandr D. Gavrilenko","raw_affiliation_strings":["Institute of Cytology and Genetics, Siberian Branch of RAS , Novosibirsk , Russia","Novosibirsk State University , Novosibirsk , Russia"],"affiliations":[{"raw_affiliation_string":"Institute of Cytology and Genetics, Siberian Branch of RAS , Novosibirsk , Russia","institution_ids":["https://openalex.org/I4210116466"]},{"raw_affiliation_string":"Novosibirsk State University , Novosibirsk , Russia","institution_ids":["https://openalex.org/I188973947"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035489500","display_name":"Timofey Ivanisenko","orcid":"https://orcid.org/0000-0002-0005-9155"},"institutions":[{"id":"https://openalex.org/I4210116466","display_name":"Institute of Cytology and Genetics","ror":"https://ror.org/0277xgb12","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I1313323035","https://openalex.org/I188973947","https://openalex.org/I4210116466","https://openalex.org/I4210127387","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Timofey V. Ivanisenko","raw_affiliation_strings":["Institute of Cytology and Genetics, Siberian Branch of RAS , Novosibirsk , Russia","Kurchatov Genomic Center of the Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences , Novosibirsk , Russia"],"affiliations":[{"raw_affiliation_string":"Institute of Cytology and Genetics, Siberian Branch of RAS , Novosibirsk , Russia","institution_ids":["https://openalex.org/I4210116466"]},{"raw_affiliation_string":"Kurchatov Genomic Center of the Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences , Novosibirsk , Russia","institution_ids":["https://openalex.org/I4210116466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090207742","display_name":"A. V. Adamovskaya","orcid":null},"institutions":[{"id":"https://openalex.org/I188973947","display_name":"Novosibirsk State University","ror":"https://ror.org/04t2ss102","country_code":"RU","type":"education","lineage":["https://openalex.org/I188973947"]},{"id":"https://openalex.org/I4210116466","display_name":"Institute of Cytology and Genetics","ror":"https://ror.org/0277xgb12","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I1313323035","https://openalex.org/I188973947","https://openalex.org/I4210116466","https://openalex.org/I4210127387","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Anna V. Adamovskaya","raw_affiliation_strings":["Kurchatov Genomic Center of the Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences , Novosibirsk , Russia","Novosibirsk State University , Novosibirsk , Russia"],"affiliations":[{"raw_affiliation_string":"Kurchatov Genomic Center of the Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences , Novosibirsk , Russia","institution_ids":["https://openalex.org/I4210116466"]},{"raw_affiliation_string":"Novosibirsk State University , Novosibirsk , Russia","institution_ids":["https://openalex.org/I188973947"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069690702","display_name":"Polina M. Revva","orcid":null},"institutions":[{"id":"https://openalex.org/I188973947","display_name":"Novosibirsk State University","ror":"https://ror.org/04t2ss102","country_code":"RU","type":"education","lineage":["https://openalex.org/I188973947"]},{"id":"https://openalex.org/I4210116466","display_name":"Institute of Cytology and Genetics","ror":"https://ror.org/0277xgb12","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I1313323035","https://openalex.org/I188973947","https://openalex.org/I4210116466","https://openalex.org/I4210127387","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Polina M. Revva","raw_affiliation_strings":["Kurchatov Genomic Center of the Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences , Novosibirsk , Russia","Novosibirsk State University , Novosibirsk , Russia"],"affiliations":[{"raw_affiliation_string":"Kurchatov Genomic Center of the Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences , Novosibirsk , Russia","institution_ids":["https://openalex.org/I4210116466"]},{"raw_affiliation_string":"Novosibirsk State University , Novosibirsk , Russia","institution_ids":["https://openalex.org/I188973947"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038764591","display_name":"\u041d. \u0410. \u041a\u043e\u043b\u0447\u0430\u043d\u043e\u0432","orcid":"https://orcid.org/0000-0001-6800-8787"},"institutions":[{"id":"https://openalex.org/I188973947","display_name":"Novosibirsk State University","ror":"https://ror.org/04t2ss102","country_code":"RU","type":"education","lineage":["https://openalex.org/I188973947"]},{"id":"https://openalex.org/I4210116466","display_name":"Institute of Cytology and Genetics","ror":"https://ror.org/0277xgb12","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I1313323035","https://openalex.org/I188973947","https://openalex.org/I4210116466","https://openalex.org/I4210127387","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Nikolay A. Kolchanov","raw_affiliation_strings":["Institute of Cytology and Genetics, Siberian Branch of RAS , Novosibirsk , Russia","Novosibirsk State University , Novosibirsk , Russia"],"affiliations":[{"raw_affiliation_string":"Institute of Cytology and Genetics, Siberian Branch of RAS , Novosibirsk , Russia","institution_ids":["https://openalex.org/I4210116466"]},{"raw_affiliation_string":"Novosibirsk State University , Novosibirsk , Russia","institution_ids":["https://openalex.org/I188973947"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054417011","display_name":"Inna N. Lavrik","orcid":null},"institutions":[{"id":"https://openalex.org/I95793202","display_name":"Otto-von-Guericke-Universit\u00e4t Magdeburg","ror":"https://ror.org/00ggpsq73","country_code":"DE","type":"education","lineage":["https://openalex.org/I95793202"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Inna N. Lavrik","raw_affiliation_strings":["Translational Inflammation Research, Medical Faculty , Otto von Guericke University Magdeburg , 39106 Magdeburg , Germany"],"affiliations":[{"raw_affiliation_string":"Translational Inflammation Research, Medical Faculty , Otto von Guericke University Magdeburg , 39106 Magdeburg , Germany","institution_ids":["https://openalex.org/I95793202"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014655081","display_name":"\u0412. \u0410. \u0418\u0432\u0430\u043d\u0438\u0441\u0435\u043d\u043a\u043e","orcid":"https://orcid.org/0000-0002-1859-4631"},"institutions":[{"id":"https://openalex.org/I188973947","display_name":"Novosibirsk State University","ror":"https://ror.org/04t2ss102","country_code":"RU","type":"education","lineage":["https://openalex.org/I188973947"]},{"id":"https://openalex.org/I4210116466","display_name":"Institute of Cytology and Genetics","ror":"https://ror.org/0277xgb12","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I1313323035","https://openalex.org/I188973947","https://openalex.org/I4210116466","https://openalex.org/I4210127387","https://openalex.org/I4210129690"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Vladimir A. Ivanisenko","raw_affiliation_strings":["Institute of Cytology and Genetics, Siberian Branch of RAS , Novosibirsk , Russia","Kurchatov Genomic Center of the Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences , Novosibirsk , Russia","Novosibirsk State University , Novosibirsk , Russia"],"affiliations":[{"raw_affiliation_string":"Institute of Cytology and Genetics, Siberian Branch of RAS , Novosibirsk , Russia","institution_ids":["https://openalex.org/I4210116466"]},{"raw_affiliation_string":"Kurchatov Genomic Center of the Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences , Novosibirsk , Russia","institution_ids":["https://openalex.org/I4210116466"]},{"raw_affiliation_string":"Novosibirsk State University , Novosibirsk , Russia","institution_ids":["https://openalex.org/I188973947"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5041167717"],"corresponding_institution_ids":["https://openalex.org/I4210116466"],"apc_list":null,"apc_paid":null,"fwci":1.0084,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.77301676,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"20","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9739999771118164,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9434999823570251,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6896176338195801},{"id":"https://openalex.org/keywords/hepatitis-c-virus","display_name":"Hepatitis C virus","score":0.5907558798789978},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"Hepatocellular carcinoma","score":0.5455240607261658},{"id":"https://openalex.org/keywords/ns5a","display_name":"NS5A","score":0.525009274482727},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.4711809456348419},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.45161110162734985},{"id":"https://openalex.org/keywords/cdkn2a","display_name":"CDKN2A","score":0.446475625038147},{"id":"https://openalex.org/keywords/regulation-of-gene-expression","display_name":"Regulation of gene expression","score":0.44281792640686035},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3859937787055969},{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.31211668252944946},{"id":"https://openalex.org/keywords/hepacivirus","display_name":"Hepacivirus","score":0.25223076343536377},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1752544641494751}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6896176338195801},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.5907558798789978},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.5455240607261658},{"id":"https://openalex.org/C2777103181","wikidata":"https://www.wikidata.org/wiki/Q83141840","display_name":"NS5A","level":5,"score":0.525009274482727},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4711809456348419},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.45161110162734985},{"id":"https://openalex.org/C2780265364","wikidata":"https://www.wikidata.org/wiki/Q5009957","display_name":"CDKN2A","level":3,"score":0.446475625038147},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.44281792640686035},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3859937787055969},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.31211668252944946},{"id":"https://openalex.org/C2781463415","wikidata":"https://www.wikidata.org/wiki/Q2082778","display_name":"Hepacivirus","level":4,"score":0.25223076343536377},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1752544641494751}],"mesh":[{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011495","descriptor_name":"Histone-Lysine N-Methyltransferase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011495","descriptor_name":"Histone-Lysine N-Methyltransferase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011495","descriptor_name":"Histone-Lysine N-Methyltransferase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011495","descriptor_name":"Histone-Lysine N-Methyltransferase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011495","descriptor_name":"Histone-Lysine N-Methyltransferase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011495","descriptor_name":"Histone-Lysine N-Methyltransferase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011495","descriptor_name":"Histone-Lysine N-Methyltransferase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014777","descriptor_name":"Virus Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014777","descriptor_name":"Virus Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014777","descriptor_name":"Virus Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014777","descriptor_name":"Virus Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014777","descriptor_name":"Virus Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014777","descriptor_name":"Virus Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014777","descriptor_name":"Virus Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017361","descriptor_name":"Viral Nonstructural Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1515/jib-2023-0013","is_oa":true,"landing_page_url":"https://doi.org/10.1515/jib-2023-0013","pdf_url":"https://www.degruyter.com/document/doi/10.1515/jib-2023-0013/pdf","source":{"id":"https://openalex.org/S4393917359","display_name":"Berichte aus der medizinischen Informatik und Bioinformatik/Journal of integrative bioinformatics","issn_l":"1432-4385","issn":["1432-4385","1613-4516"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Integrative Bioinformatics","raw_type":"journal-article"},{"id":"pmid:37978846","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37978846","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of integrative bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10757076","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10757076","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10757076/pdf/jib-20-3-jib-2023-0013.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Integr Bioinform","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:7113a3f25d9d439788d411759f2c4c79","is_oa":true,"landing_page_url":"https://doaj.org/article/7113a3f25d9d439788d411759f2c4c79","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Integrative Bioinformatics, Vol 20, Iss 3, Pp 597-600 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1515/jib-2023-0013","is_oa":true,"landing_page_url":"https://doi.org/10.1515/jib-2023-0013","pdf_url":"https://www.degruyter.com/document/doi/10.1515/jib-2023-0013/pdf","source":{"id":"https://openalex.org/S4393917359","display_name":"Berichte aus der medizinischen Informatik und Bioinformatik/Journal of integrative bioinformatics","issn_l":"1432-4385","issn":["1432-4385","1613-4516"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Integrative Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8100000023841858,"id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G6444257319","display_name":null,"funder_award_id":"075-15-","funder_id":"https://openalex.org/F4320327494","funder_display_name":"Ministry of Science and Higher Education of the Russian Federation"},{"id":"https://openalex.org/G788940644","display_name":null,"funder_award_id":"075-15-2021-944","funder_id":"https://openalex.org/F4320327494","funder_display_name":"Ministry of Science and Higher Education of the Russian Federation"}],"funders":[{"id":"https://openalex.org/F4320327494","display_name":"Ministry of Science and Higher Education of the Russian Federation","ror":null}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388800256.pdf"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W1496761780","https://openalex.org/W1498417717","https://openalex.org/W1508717233","https://openalex.org/W1563819414","https://openalex.org/W1571309209","https://openalex.org/W1965117277","https://openalex.org/W1977065907","https://openalex.org/W1980640138","https://openalex.org/W1985454650","https://openalex.org/W1986838855","https://openalex.org/W1986922789","https://openalex.org/W1987246411","https://openalex.org/W1989700986","https://openalex.org/W1990294304","https://openalex.org/W1999099454","https://openalex.org/W2013352943","https://openalex.org/W2014139160","https://openalex.org/W2019574453","https://openalex.org/W2024345822","https://openalex.org/W2042644795","https://openalex.org/W2045934614","https://openalex.org/W2096801725","https://openalex.org/W2107055030","https://openalex.org/W2114840351","https://openalex.org/W2118258530","https://openalex.org/W2152379507","https://openalex.org/W2170248514","https://openalex.org/W2190548957","https://openalex.org/W2194570961","https://openalex.org/W2213448039","https://openalex.org/W2327057097","https://openalex.org/W2342728829","https://openalex.org/W2347179078","https://openalex.org/W2411078334","https://openalex.org/W2493614923","https://openalex.org/W2548822967","https://openalex.org/W2554634780","https://openalex.org/W2772032611","https://openalex.org/W2810690816","https://openalex.org/W2886288610","https://openalex.org/W2890534939","https://openalex.org/W2894045715","https://openalex.org/W2898944573","https://openalex.org/W2912105929","https://openalex.org/W2952761908","https://openalex.org/W2956390370","https://openalex.org/W2959814421","https://openalex.org/W2965528851","https://openalex.org/W2969802526","https://openalex.org/W2979983023","https://openalex.org/W2980454391","https://openalex.org/W2986037217","https://openalex.org/W2998871098","https://openalex.org/W3038276781","https://openalex.org/W3084639004","https://openalex.org/W3087162760","https://openalex.org/W3092429882","https://openalex.org/W3094871321","https://openalex.org/W3120040760","https://openalex.org/W3194027626","https://openalex.org/W3200845079","https://openalex.org/W4210310163","https://openalex.org/W4210730865","https://openalex.org/W4225328471","https://openalex.org/W4281655244","https://openalex.org/W4281790061","https://openalex.org/W4307136493","https://openalex.org/W4309425106"],"related_works":["https://openalex.org/W2148272545","https://openalex.org/W2779324484","https://openalex.org/W2953494464","https://openalex.org/W2995437357","https://openalex.org/W2529135407","https://openalex.org/W2541260794","https://openalex.org/W3113728432","https://openalex.org/W2038987068","https://openalex.org/W2158233773","https://openalex.org/W1976786264"],"abstract_inverted_index":{"Hepatocellular":[0],"carcinoma":[1],"(HCC)":[2],"has":[3],"been":[4],"associated":[5,92],"with":[6,93],"hepatitis":[7],"C":[8],"viral":[9,88,120],"(HCV)":[10],"infection":[11],"as":[12],"a":[13],"potential":[14],"risk":[15],"factor.":[16],"Nonetheless,":[17],"the":[18,25,40,65,118,185],"precise":[19],"genetic":[20],"regulatory":[21,48,51,169],"mechanisms":[22,170],"triggered":[23],"by":[24,87],"virus,":[26],"leading":[27],"to":[28,183],"virus-induced":[29],"hepatocarcinogenesis,":[30],"remain":[31],"unclear.":[32],"We":[33],"hypothesized":[34],"that":[35],"HCV":[36,127,191],"proteins":[37,89],"might":[38,171],"modulate":[39],"activity":[41],"of":[42,79,175,187],"aberrantly":[43],"methylated":[44],"HCC":[45,81,188],"genes":[46,83],"through":[47],"pathways.":[49],"Virus-host":[50],"pathways,":[52],"interactions":[53],"between":[54],"proteins,":[55],"gene":[56],"expression,":[57],"transport,":[58],"and":[59,111,133,138,145,151,160,180],"stability":[60],"regulation,":[61],"were":[62],"reconstructed":[63],"using":[64],"ANDSystem.":[66],"Gene":[67,73],"expression":[68,85],"regulation":[69,86],"was":[70],"statistically":[71],"significant.":[72],"network":[74],"analysis":[75],"identified":[76],"four":[77],"out":[78],"70":[80],"marker":[82],"whose":[84],"may":[90],"be":[91,172],"HCC:":[94],"<i>DNA-binding":[95],"protein":[96,121,125,129],"inhibitor":[97,108],"ID":[98],"-":[99],"1":[100,104],"(ID1)</i>,":[101],"<i>flap":[102],"endonuclease":[103],"(FEN1)</i>,":[105],"<i>cyclin-dependent":[106],"kinase":[107],"2A":[109],"(CDKN2A)</i>,":[110],"<i>telomerase":[112],"reverse":[113],"transcriptase":[114],"(TERT)</i>.":[115],"It":[116],"suggested":[117],"following":[119],"effects":[122],"in":[123],"HCV/human":[124],"heterocomplexes:":[126],"NS3(p70)":[128],"activates":[130],"human":[131],"STAT3":[132],"NOTC1;":[134],"NS2-3(p23),":[135],"NS5B(p68),":[136],"NS1(E2),":[137],"core(p21)":[139],"activate":[140,153],"SETD2;":[141],"NS5A":[142],"inhibits":[143,147],"SMYD3;":[144],"NS3":[146,150],"CCN2.":[148],"Interestingly,":[149],"E1(gp32)":[152],"c-Jun":[154],"when":[155,163],"it":[156,162,164],"positively":[157],"regulates":[158],"<i>CDKN2A</i>":[159],"inhibit":[161],"represses":[165],"<i>TERT</i>.":[166],"The":[167],"discovered":[168],"key":[173],"areas":[174],"focus":[176],"for":[177],"creating":[178],"medications":[179],"preventative":[181],"therapies":[182],"decrease":[184],"likelihood":[186],"development":[189],"during":[190],"infection.":[192]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2023,"cited_by_count":1}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}