{"id":"https://openalex.org/W4322490116","doi":"https://doi.org/10.1515/jib-2022-0056","title":"On the identification of potential novel therapeutic targets for spinocerebellar ataxia type 1 (SCA1) neurodegenerative disease using EvoPPI3","display_name":"On the identification of potential novel therapeutic targets for spinocerebellar ataxia type 1 (SCA1) neurodegenerative disease using EvoPPI3","publication_year":2023,"publication_date":"2023-02-27","ids":{"openalex":"https://openalex.org/W4322490116","doi":"https://doi.org/10.1515/jib-2022-0056","pmid":"https://pubmed.ncbi.nlm.nih.gov/36848492"},"language":"en","primary_location":{"id":"doi:10.1515/jib-2022-0056","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1515/jib-2022-0056","pdf_url":"https://www.degruyterbrill.com/document/doi/10.1515/jib-2022-0056/pdf","source":{"id":"https://openalex.org/S4393917359","display_name":"Berichte aus der medizinischen Informatik und Bioinformatik/Journal of integrative bioinformatics","issn_l":"1432-4385","issn":["1432-4385","1613-4516"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Integrative Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.degruyterbrill.com/document/doi/10.1515/jib-2022-0056/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035325355","display_name":"Andr\u00e9 D. Sousa","orcid":"https://orcid.org/0000-0003-4016-2189"},"institutions":[{"id":"https://openalex.org/I4210158732","display_name":"i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto","ror":"https://ror.org/04wjk1035","country_code":"PT","type":"facility","lineage":["https://openalex.org/I182534213","https://openalex.org/I4210158732"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Andr\u00e9 Sousa","raw_affiliation_strings":["Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (I3S), Universidade do Porto , Rua Alfredo Allen, 208, 4200-135 Porto , Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (I3S), Universidade do Porto , Rua Alfredo Allen, 208, 4200-135 Porto , Portugal","institution_ids":["https://openalex.org/I4210158732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066212058","display_name":"Sara Rocha","orcid":"https://orcid.org/0000-0003-1629-3584"},"institutions":[{"id":"https://openalex.org/I4210158732","display_name":"i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto","ror":"https://ror.org/04wjk1035","country_code":"PT","type":"facility","lineage":["https://openalex.org/I182534213","https://openalex.org/I4210158732"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Sara Rocha","raw_affiliation_strings":["Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (I3S), Universidade do Porto , Rua Alfredo Allen, 208, 4200-135 Porto , Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (I3S), Universidade do Porto , Rua Alfredo Allen, 208, 4200-135 Porto , Portugal","institution_ids":["https://openalex.org/I4210158732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015978945","display_name":"Jorge Vieira","orcid":"https://orcid.org/0000-0001-7032-5220"},"institutions":[{"id":"https://openalex.org/I4210158732","display_name":"i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto","ror":"https://ror.org/04wjk1035","country_code":"PT","type":"facility","lineage":["https://openalex.org/I182534213","https://openalex.org/I4210158732"]},{"id":"https://openalex.org/I4387153674","display_name":"Instituto de Biologia Molecular e Celular","ror":"https://ror.org/005dkht93","country_code":null,"type":"education","lineage":["https://openalex.org/I182534213","https://openalex.org/I4387153674"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Jorge Vieira","raw_affiliation_strings":["Instituto de Biologia Molecular e Celular (IBMC) , Rua Alfredo Allen, 208, 4200-135 Porto , Portugal","Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (I3S), Universidade do Porto , Rua Alfredo Allen, 208, 4200-135 Porto , Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Biologia Molecular e Celular (IBMC) , Rua Alfredo Allen, 208, 4200-135 Porto , Portugal","institution_ids":["https://openalex.org/I4387153674"]},{"raw_affiliation_string":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (I3S), Universidade do Porto , Rua Alfredo Allen, 208, 4200-135 Porto , Portugal","institution_ids":["https://openalex.org/I4210158732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026022133","display_name":"Miguel Reboiro\u2010Jato","orcid":"https://orcid.org/0000-0001-8749-2703"},"institutions":[{"id":"https://openalex.org/I4210091478","display_name":"Galicia Sur Biomedical Foundation","ror":"https://ror.org/00jdfsf63","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210091478"]},{"id":"https://openalex.org/I4210158352","display_name":"Servicio Gallego de Salud","ror":"https://ror.org/0591s4t67","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210158352"]},{"id":"https://openalex.org/I6289922","display_name":"Universidade de Vigo","ror":"https://ror.org/05rdf8595","country_code":"ES","type":"education","lineage":["https://openalex.org/I6289922"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Miguel Reboiro-Jato","raw_affiliation_strings":["Department of Computer Science , CINBIO, Universidade de Vigo, ESEI \u2013 Escuela Superior de Ingenier\u00eda Inform\u00e1tica , 32004 Ourense , Spain","SING Research Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO , 36213 Vigo , Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science , CINBIO, Universidade de Vigo, ESEI \u2013 Escuela Superior de Ingenier\u00eda Inform\u00e1tica , 32004 Ourense , Spain","institution_ids":["https://openalex.org/I6289922"]},{"raw_affiliation_string":"SING Research Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO , 36213 Vigo , Spain","institution_ids":["https://openalex.org/I4210091478","https://openalex.org/I4210158352"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038155908","display_name":"Hugo L\u00f3pez-Fern\u00e1ndez","orcid":"https://orcid.org/0000-0002-6476-7206"},"institutions":[{"id":"https://openalex.org/I4210091478","display_name":"Galicia Sur Biomedical Foundation","ror":"https://ror.org/00jdfsf63","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210091478"]},{"id":"https://openalex.org/I4210158352","display_name":"Servicio Gallego de Salud","ror":"https://ror.org/0591s4t67","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210158352"]},{"id":"https://openalex.org/I6289922","display_name":"Universidade de Vigo","ror":"https://ror.org/05rdf8595","country_code":"ES","type":"education","lineage":["https://openalex.org/I6289922"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Hugo L\u00f3pez-Fern\u00e1ndez","raw_affiliation_strings":["Department of Computer Science , CINBIO, Universidade de Vigo, ESEI \u2013 Escuela Superior de Ingenier\u00eda Inform\u00e1tica , 32004 Ourense , Spain","SING Research Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO , 36213 Vigo , Spain"],"raw_orcid":"https://orcid.org/0000-0002-6476-7206","affiliations":[{"raw_affiliation_string":"Department of Computer Science , CINBIO, Universidade de Vigo, ESEI \u2013 Escuela Superior de Ingenier\u00eda Inform\u00e1tica , 32004 Ourense , Spain","institution_ids":["https://openalex.org/I6289922"]},{"raw_affiliation_string":"SING Research Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO , 36213 Vigo , Spain","institution_ids":["https://openalex.org/I4210091478","https://openalex.org/I4210158352"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081065000","display_name":"Cristina P. Vieira","orcid":"https://orcid.org/0000-0002-7139-2107"},"institutions":[{"id":"https://openalex.org/I4210158732","display_name":"i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto","ror":"https://ror.org/04wjk1035","country_code":"PT","type":"facility","lineage":["https://openalex.org/I182534213","https://openalex.org/I4210158732"]},{"id":"https://openalex.org/I4387153674","display_name":"Instituto de Biologia Molecular e Celular","ror":"https://ror.org/005dkht93","country_code":null,"type":"education","lineage":["https://openalex.org/I182534213","https://openalex.org/I4387153674"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Cristina P. Vieira","raw_affiliation_strings":["Instituto de Biologia Molecular e Celular (IBMC) , Rua Alfredo Allen, 208, 4200-135 Porto , Portugal","Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (I3S), Universidade do Porto , Rua Alfredo Allen, 208, 4200-135 Porto , Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Biologia Molecular e Celular (IBMC) , Rua Alfredo Allen, 208, 4200-135 Porto , Portugal","institution_ids":["https://openalex.org/I4387153674"]},{"raw_affiliation_string":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (I3S), Universidade do Porto , Rua Alfredo Allen, 208, 4200-135 Porto , Portugal","institution_ids":["https://openalex.org/I4210158732"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5038155908","https://openalex.org/A5081065000"],"corresponding_institution_ids":["https://openalex.org/I4210091478","https://openalex.org/I4210158352","https://openalex.org/I4210158732","https://openalex.org/I4387153674","https://openalex.org/I6289922"],"apc_list":null,"apc_paid":null,"fwci":0.4336,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.5654647,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":96},"biblio":{"volume":"20","issue":"2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9832000136375427,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spinocerebellar-ataxia","display_name":"Spinocerebellar ataxia","score":0.7315579652786255},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6039523482322693},{"id":"https://openalex.org/keywords/polyglutamine-tract","display_name":"Polyglutamine tract","score":0.5792465209960938},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.5227413773536682},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.48124194145202637},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.4541165828704834},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.4485543668270111},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.37787356972694397},{"id":"https://openalex.org/keywords/mutant","display_name":"Mutant","score":0.34939050674438477},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3351562023162842},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.14916658401489258},{"id":"https://openalex.org/keywords/huntingtin","display_name":"Huntingtin","score":0.07993656396865845}],"concepts":[{"id":"https://openalex.org/C2779500118","wikidata":"https://www.wikidata.org/wiki/Q899726","display_name":"Spinocerebellar ataxia","level":3,"score":0.7315579652786255},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6039523482322693},{"id":"https://openalex.org/C2777616661","wikidata":"https://www.wikidata.org/wiki/Q7226416","display_name":"Polyglutamine tract","level":5,"score":0.5792465209960938},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5227413773536682},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48124194145202637},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.4541165828704834},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.4485543668270111},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.37787356972694397},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.34939050674438477},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3351562023162842},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14916658401489258},{"id":"https://openalex.org/C2781427258","wikidata":"https://www.wikidata.org/wiki/Q2620886","display_name":"Huntingtin","level":4,"score":0.07993656396865845},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000067696","descriptor_name":"Ataxin-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000067696","descriptor_name":"Ataxin-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000067696","descriptor_name":"Ataxin-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000067696","descriptor_name":"Ataxin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000067696","descriptor_name":"Ataxin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000067696","descriptor_name":"Ataxin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020754","descriptor_name":"Spinocerebellar Ataxias","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020754","descriptor_name":"Spinocerebellar Ataxias","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020754","descriptor_name":"Spinocerebellar Ataxias","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020754","descriptor_name":"Spinocerebellar Ataxias","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020754","descriptor_name":"Spinocerebellar Ataxias","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020754","descriptor_name":"Spinocerebellar Ataxias","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1515/jib-2022-0056","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1515/jib-2022-0056","pdf_url":"https://www.degruyterbrill.com/document/doi/10.1515/jib-2022-0056/pdf","source":{"id":"https://openalex.org/S4393917359","display_name":"Berichte aus der medizinischen Informatik und Bioinformatik/Journal of integrative bioinformatics","issn_l":"1432-4385","issn":["1432-4385","1613-4516"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Integrative Bioinformatics","raw_type":"journal-article"},{"id":"pmid:36848492","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36848492","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of integrative bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10561075","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10561075","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10561075/pdf/jib-20-2-jib-2022-0056.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Integr Bioinform","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:2456f4f7dfe2456588523958c9e6f6aa","is_oa":true,"landing_page_url":"https://doaj.org/article/2456f4f7dfe2456588523958c9e6f6aa","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Integrative Bioinformatics, Vol 20, Iss 2, Pp 2100190-32 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1515/jib-2022-0056","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1515/jib-2022-0056","pdf_url":"https://www.degruyterbrill.com/document/doi/10.1515/jib-2022-0056/pdf","source":{"id":"https://openalex.org/S4393917359","display_name":"Berichte aus der medizinischen Informatik und Bioinformatik/Journal of integrative bioinformatics","issn_l":"1432-4385","issn":["1432-4385","1613-4516"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Integrative Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5799999833106995}],"awards":[{"id":"https://openalex.org/G647086953","display_name":"Institute for Research and Innovation in Health","funder_award_id":"UIDB/04293/2020","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"}],"funders":[{"id":"https://openalex.org/F4320334779","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","ror":"https://ror.org/00snfqn58"},{"id":"https://openalex.org/F7296444849","display_name":"Ministerio de Universidades","ror":"https://ror.org/03zcny908"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4322490116.pdf","grobid_xml":"https://content.openalex.org/works/W4322490116.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W81769958","https://openalex.org/W143538493","https://openalex.org/W847373262","https://openalex.org/W1088597131","https://openalex.org/W1540620580","https://openalex.org/W1543265920","https://openalex.org/W1598616057","https://openalex.org/W1965379872","https://openalex.org/W1965975446","https://openalex.org/W1967475947","https://openalex.org/W1968874378","https://openalex.org/W1979146469","https://openalex.org/W1989684700","https://openalex.org/W1996285721","https://openalex.org/W2008990665","https://openalex.org/W2013444252","https://openalex.org/W2023010129","https://openalex.org/W2037442572","https://openalex.org/W2048966304","https://openalex.org/W2051001559","https://openalex.org/W2052404695","https://openalex.org/W2065808064","https://openalex.org/W2067964678","https://openalex.org/W2089350319","https://openalex.org/W2092123736","https://openalex.org/W2095867585","https://openalex.org/W2096525273","https://openalex.org/W2097978324","https://openalex.org/W2108504121","https://openalex.org/W2123375001","https://openalex.org/W2129003642","https://openalex.org/W2152416668","https://openalex.org/W2158534684","https://openalex.org/W2159178453","https://openalex.org/W2162329758","https://openalex.org/W2165947183","https://openalex.org/W2201927605","https://openalex.org/W2296755350","https://openalex.org/W2506851216","https://openalex.org/W2508344932","https://openalex.org/W2534390616","https://openalex.org/W2540583676","https://openalex.org/W2581185210","https://openalex.org/W2754753384","https://openalex.org/W2789973113","https://openalex.org/W2811149968","https://openalex.org/W2895575279","https://openalex.org/W2898204371","https://openalex.org/W2911953639","https://openalex.org/W2912911406","https://openalex.org/W2917858269","https://openalex.org/W2944545583","https://openalex.org/W2981749337","https://openalex.org/W3015964336","https://openalex.org/W3016046852","https://openalex.org/W3044319154","https://openalex.org/W3093053585","https://openalex.org/W3112376646","https://openalex.org/W3197707214","https://openalex.org/W3200477862","https://openalex.org/W3207785744","https://openalex.org/W3213409361","https://openalex.org/W4214550191","https://openalex.org/W4225246211","https://openalex.org/W4225318138","https://openalex.org/W4225329822","https://openalex.org/W4229074552","https://openalex.org/W4229333941","https://openalex.org/W4231170962","https://openalex.org/W4280575464","https://openalex.org/W4306845123"],"related_works":["https://openalex.org/W1999323145","https://openalex.org/W1147203815","https://openalex.org/W2009077902","https://openalex.org/W2119887971","https://openalex.org/W2128341112","https://openalex.org/W168898845","https://openalex.org/W1986865371","https://openalex.org/W2556325553","https://openalex.org/W2277451682","https://openalex.org/W4360866267"],"abstract_inverted_index":{"wt":[0],"and":[1,61,83],"exp":[2],"Ataxin-1":[3,15],"mutants":[4],"(also":[5],"available":[6],"at":[7,26],"EvoPPI3),":[8],"we":[9],"show":[10],"that,":[11],"in":[12,45,69,81,96],"humans,":[13],"the":[14,34,41,46,70,97],"network":[16],"is":[17,38],"much":[18],"larger":[19],"than":[20],"previously":[21],"thought":[22,92],"(380":[23],"interactors),":[24],"with":[25],"least":[27],"909":[28,53],"interactors.":[29],"The":[30,75],"functional":[31,89],"profiling":[32],"of":[33,52,72],"newly":[35],"identified":[36],"interactors":[37,54],"similar":[39],"to":[40,93],"ones":[42],"already":[43,66,91],"reported":[44],"main":[47],"PPI":[48],"databases.":[49],"16":[50,76],"out":[51],"are":[55,65,78],"putative":[56],"novel":[57],"SCA1":[58,98],"therapeutic":[59],"targets,":[60],"all":[62],"but":[63],"one":[64],"being":[67],"studied":[68],"context":[71],"this":[73],"disease.":[74,99],"proteins":[77],"mainly":[79],"involved":[80],"binding":[82],"catalytic":[84],"activity":[85],"(mainly":[86],"kinase":[87],"activity),":[88],"features":[90],"be":[94],"important":[95]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2}],"updated_date":"2026-04-28T14:05:53.105641","created_date":"2025-10-10T00:00:00"}