{"id":"https://openalex.org/W2913248954","doi":"https://doi.org/10.1515/jib-2018-0063","title":"QSAR Modelling to Identify LRRK2 Inhibitors for Parkinson\u2019s Disease","display_name":"QSAR Modelling to Identify LRRK2 Inhibitors for Parkinson\u2019s Disease","publication_year":2019,"publication_date":"2019-02-14","ids":{"openalex":"https://openalex.org/W2913248954","doi":"https://doi.org/10.1515/jib-2018-0063","mag":"2913248954","pmid":"https://pubmed.ncbi.nlm.nih.gov/30763264"},"language":"en","primary_location":{"id":"doi:10.1515/jib-2018-0063","is_oa":true,"landing_page_url":"https://doi.org/10.1515/jib-2018-0063","pdf_url":"https://www.degruyter.com/downloadpdf/journals/jib/16/1/article-20180063.pdf","source":{"id":"https://openalex.org/S4393917359","display_name":"Berichte aus der medizinischen Informatik und Bioinformatik/Journal of integrative bioinformatics","issn_l":"1432-4385","issn":["1432-4385","1613-4516"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Integrative Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.degruyter.com/downloadpdf/journals/jib/16/1/article-20180063.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048300959","display_name":"V\u00edctor Sebasti\u00e1n-P\u00e9rez","orcid":"https://orcid.org/0000-0002-8248-4496"},"institutions":[{"id":"https://openalex.org/I4210147680","display_name":"Centro de Investigaciones Biol\u00f3gicas Margarita Salas","ror":"https://ror.org/04advdf21","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210147680"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"V\u00edctor Sebasti\u00e1n-P\u00e9rez","raw_affiliation_strings":["Centro de Investigaciones Biol\u00f3gicas (CIB-CSIC) , Ramiro de Maeztu 9 , 28040 Madrid , Spain"],"affiliations":[{"raw_affiliation_string":"Centro de Investigaciones Biol\u00f3gicas (CIB-CSIC) , Ramiro de Maeztu 9 , 28040 Madrid , Spain","institution_ids":["https://openalex.org/I4210147680"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036900590","display_name":"Mar\u00eda Jimena Mart\u00ednez","orcid":"https://orcid.org/0000-0002-0443-5795"},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I56858762","display_name":"Universidad Nacional del Sur","ror":"https://ror.org/028crwz56","country_code":"AR","type":"education","lineage":["https://openalex.org/I56858762"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Mar\u00eda Jimena Mart\u00ednez","raw_affiliation_strings":["Instituto de Ciencias e Ingenier\u00eda de la Computaci\u00f3n (UNS\u2013CONICET), Departamento de Ciencias e Ingenier\u00eda de la Computaci\u00f3n , Universidad Nacional del Sur (UNS) , Bah\u00eda Blanca , Argentina"],"affiliations":[{"raw_affiliation_string":"Instituto de Ciencias e Ingenier\u00eda de la Computaci\u00f3n (UNS\u2013CONICET), Departamento de Ciencias e Ingenier\u00eda de la Computaci\u00f3n , Universidad Nacional del Sur (UNS) , Bah\u00eda Blanca , Argentina","institution_ids":["https://openalex.org/I56858762","https://openalex.org/I151201029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060896107","display_name":"Carmen Gil","orcid":"https://orcid.org/0000-0002-3882-6081"},"institutions":[{"id":"https://openalex.org/I4210147680","display_name":"Centro de Investigaciones Biol\u00f3gicas Margarita Salas","ror":"https://ror.org/04advdf21","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210147680"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carmen Gil","raw_affiliation_strings":["Centro de Investigaciones Biol\u00f3gicas (CIB-CSIC) , Ramiro de Maeztu 9 , 28040 Madrid , Spain"],"affiliations":[{"raw_affiliation_string":"Centro de Investigaciones Biol\u00f3gicas (CIB-CSIC) , Ramiro de Maeztu 9 , 28040 Madrid , Spain","institution_ids":["https://openalex.org/I4210147680"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007294350","display_name":"Nuria E. Campillo","orcid":null},"institutions":[{"id":"https://openalex.org/I4210147680","display_name":"Centro de Investigaciones Biol\u00f3gicas Margarita Salas","ror":"https://ror.org/04advdf21","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210147680"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Nuria Eugenia Campillo","raw_affiliation_strings":["Centro de Investigaciones Biol\u00f3gicas (CIB-CSIC) , Ramiro de Maeztu 9 , 28040 Madrid , Spain"],"affiliations":[{"raw_affiliation_string":"Centro de Investigaciones Biol\u00f3gicas (CIB-CSIC) , Ramiro de Maeztu 9 , 28040 Madrid , Spain","institution_ids":["https://openalex.org/I4210147680"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028669057","display_name":"Ana Mart\u0131\u0301nez","orcid":"https://orcid.org/0000-0002-2707-8110"},"institutions":[{"id":"https://openalex.org/I4210147680","display_name":"Centro de Investigaciones Biol\u00f3gicas Margarita Salas","ror":"https://ror.org/04advdf21","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210147680"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ana Mart\u00ednez","raw_affiliation_strings":["Centro de Investigaciones Biol\u00f3gicas (CIB-CSIC) , Ramiro de Maeztu 9 , 28040 Madrid , Spain"],"affiliations":[{"raw_affiliation_string":"Centro de Investigaciones Biol\u00f3gicas (CIB-CSIC) , Ramiro de Maeztu 9 , 28040 Madrid , Spain","institution_ids":["https://openalex.org/I4210147680"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008182880","display_name":"Ignacio Ponzoni","orcid":"https://orcid.org/0000-0002-6923-9592"},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I56858762","display_name":"Universidad Nacional del Sur","ror":"https://ror.org/028crwz56","country_code":"AR","type":"education","lineage":["https://openalex.org/I56858762"]}],"countries":["AR"],"is_corresponding":true,"raw_author_name":"Ignacio Ponzoni","raw_affiliation_strings":["Instituto de Ciencias e Ingenier\u00eda de la Computaci\u00f3n (UNS\u2013CONICET), Departamento de Ciencias e Ingenier\u00eda de la Computaci\u00f3n , Universidad Nacional del Sur (UNS) , Bah\u00eda Blanca , Argentina"],"affiliations":[{"raw_affiliation_string":"Instituto de Ciencias e Ingenier\u00eda de la Computaci\u00f3n (UNS\u2013CONICET), Departamento de Ciencias e Ingenier\u00eda de la Computaci\u00f3n , Universidad Nacional del Sur (UNS) , Bah\u00eda Blanca , Argentina","institution_ids":["https://openalex.org/I56858762","https://openalex.org/I151201029"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5008182880","https://openalex.org/A5048300959"],"corresponding_institution_ids":["https://openalex.org/I151201029","https://openalex.org/I4210147680","https://openalex.org/I56858762"],"apc_list":null,"apc_paid":null,"fwci":1.2534,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.78640804,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"16","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9843000173568726,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9843000173568726,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12673","display_name":"Microbial Metabolism and Applications","score":0.9768000245094299,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9713000059127808,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quantitative-structure\u2013activity-relationship","display_name":"Quantitative structure\u2013activity relationship","score":0.7767276763916016},{"id":"https://openalex.org/keywords/parkinsons-disease","display_name":"Parkinson's disease","score":0.6278482675552368},{"id":"https://openalex.org/keywords/lrrk2","display_name":"LRRK2","score":0.5495830178260803},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.5342499613761902},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4615597128868103},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.283732533454895},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.1581728160381317},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.1542763113975525}],"concepts":[{"id":"https://openalex.org/C164126121","wikidata":"https://www.wikidata.org/wiki/Q766383","display_name":"Quantitative structure\u2013activity relationship","level":2,"score":0.7767276763916016},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.6278482675552368},{"id":"https://openalex.org/C2780427247","wikidata":"https://www.wikidata.org/wiki/Q409961","display_name":"LRRK2","level":4,"score":0.5495830178260803},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5342499613761902},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4615597128868103},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.283732533454895},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1581728160381317},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.1542763113975525}],"mesh":[{"descriptor_ui":"D000071158","descriptor_name":"Leucine-Rich Repeat Serine-Threonine Protein Kinase-2","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000071158","descriptor_name":"Leucine-Rich Repeat Serine-Threonine Protein Kinase-2","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000071158","descriptor_name":"Leucine-Rich Repeat Serine-Threonine Protein Kinase-2","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021281","descriptor_name":"Quantitative Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D021281","descriptor_name":"Quantitative Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D021281","descriptor_name":"Quantitative Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1515/jib-2018-0063","is_oa":true,"landing_page_url":"https://doi.org/10.1515/jib-2018-0063","pdf_url":"https://www.degruyter.com/downloadpdf/journals/jib/16/1/article-20180063.pdf","source":{"id":"https://openalex.org/S4393917359","display_name":"Berichte aus der medizinischen Informatik und Bioinformatik/Journal of integrative bioinformatics","issn_l":"1432-4385","issn":["1432-4385","1613-4516"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Integrative Bioinformatics","raw_type":"journal-article"},{"id":"pmid:30763264","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30763264","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of integrative bioinformatics","raw_type":null},{"id":"pmh:oai:digital.csic.es:10261/176397","is_oa":true,"landing_page_url":"http://hdl.handle.net/10261/176397","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"art\u00edculo"},{"id":"pmh:oai:doaj.org/article:9b1474920d204372903a29fb1af1079a","is_oa":true,"landing_page_url":"https://doaj.org/article/9b1474920d204372903a29fb1af1079a","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Integrative Bioinformatics, Vol 16, Iss 1, Pp 601-7 (2019)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6798859","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6798859","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Integr Bioinform","raw_type":"Text"},{"id":"pmh:oai:ri.conicet.gov.ar:11336/117434","is_oa":true,"landing_page_url":"http://hdl.handle.net/11336/117434","pdf_url":null,"source":{"id":"https://openalex.org/S4306401400","display_name":"Conicet","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210104196","host_organization_name":"Centro Cient\u00edfico Tecnol\u00f3gico - Nordeste","host_organization_lineage":["https://openalex.org/I4210104196"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:CONICET Digital (CONICET)","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1515/jib-2018-0063","is_oa":true,"landing_page_url":"https://doi.org/10.1515/jib-2018-0063","pdf_url":"https://www.degruyter.com/downloadpdf/journals/jib/16/1/article-20180063.pdf","source":{"id":"https://openalex.org/S4393917359","display_name":"Berichte aus der medizinischen Informatik und Bioinformatik/Journal of integrative bioinformatics","issn_l":"1432-4385","issn":["1432-4385","1613-4516"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Integrative Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5099999904632568,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G1047533720","display_name":null,"funder_award_id":"24/ZM17","funder_id":"https://openalex.org/F4320321594","funder_display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas"},{"id":"https://openalex.org/G3280004625","display_name":null,"funder_award_id":"10.13039/501100002923","funder_id":"https://openalex.org/F4320321594","funder_display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas"},{"id":"https://openalex.org/G3889882178","display_name":null,"funder_award_id":"24/N042","funder_id":"https://openalex.org/F4320321594","funder_display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas"},{"id":"https://openalex.org/G4239584176","display_name":null,"funder_award_id":"PGI 24/N042 and PGI 24/ZM17","funder_id":"https://openalex.org/F4320335287","funder_display_name":"Secretar\u00eda General de Ciencia y Tecnolog\u00eda , Universidad Nacional del Sur"},{"id":"https://openalex.org/G4359570771","display_name":null,"funder_award_id":"PIP 112","funder_id":"https://openalex.org/F4320321594","funder_display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas"},{"id":"https://openalex.org/G5419334147","display_name":null,"funder_award_id":"112-2012-0100471","funder_id":"https://openalex.org/F4320321594","funder_display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas"},{"id":"https://openalex.org/G5768296160","display_name":null,"funder_award_id":"PIP 112-2012-0100471","funder_id":"https://openalex.org/F4320321594","funder_display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas"},{"id":"https://openalex.org/G7879699816","display_name":null,"funder_award_id":"FPU15","funder_id":"https://openalex.org/F4320321764","funder_display_name":"Ministerio de Educaci\u00f3n, Cultura y Deporte"},{"id":"https://openalex.org/G8015720348","display_name":null,"funder_award_id":"FPU15/01465","funder_id":"https://openalex.org/F4320321764","funder_display_name":"Ministerio de Educaci\u00f3n, Cultura y Deporte"},{"id":"https://openalex.org/G832291442","display_name":null,"funder_award_id":"AY21/17-D-27","funder_id":"https://openalex.org/F4320312331","funder_display_name":"Banco Santander"}],"funders":[{"id":"https://openalex.org/F4320312331","display_name":"Banco Santander","ror":"https://ror.org/017d1hs72"},{"id":"https://openalex.org/F4320321594","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59"},{"id":"https://openalex.org/F4320321764","display_name":"Ministerio de Educaci\u00f3n, Cultura y Deporte","ror":"https://ror.org/03nc27g21"},{"id":"https://openalex.org/F4320335287","display_name":"Secretar\u00eda General de Ciencia y Tecnolog\u00eda , Universidad Nacional del Sur","ror":"https://ror.org/028crwz56"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2913248954.pdf","grobid_xml":"https://content.openalex.org/works/W2913248954.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W388419421","https://openalex.org/W1570448133","https://openalex.org/W2003883601","https://openalex.org/W2041189078","https://openalex.org/W2063127941","https://openalex.org/W2081320283","https://openalex.org/W2127726658","https://openalex.org/W2135732933","https://openalex.org/W2312539984","https://openalex.org/W2330702681","https://openalex.org/W2340782621","https://openalex.org/W2406786593","https://openalex.org/W2472421578","https://openalex.org/W2615180420","https://openalex.org/W2731106759","https://openalex.org/W2886536218","https://openalex.org/W4242372416"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W4210963704","https://openalex.org/W2297229933","https://openalex.org/W4377042959","https://openalex.org/W3173661759","https://openalex.org/W3016262356","https://openalex.org/W2559766006","https://openalex.org/W3134596587","https://openalex.org/W3216329096","https://openalex.org/W2416973532"],"abstract_inverted_index":{"Parkinson's":[0],"disease":[1],"is":[2,20],"one":[3],"of":[4,38,41,69,103],"the":[5,14,114],"most":[6],"common":[7],"neurodegenerative":[8],"illnesses":[9],"in":[10,60,119],"older":[11],"persons":[12],"and":[13,52,94,113,121],"leucine-rich":[15],"repeat":[16],"kinase":[17],"2":[18],"(LRRK2)":[19],"an":[21,48],"auspicious":[22],"target":[23],"for":[24,36,73,98],"its":[25],"pharmacological":[26],"treatment.":[27],"In":[28],"this":[29,61],"work,":[30],"quantitative":[31],"structure-activity":[32],"relationship":[33],"(QSAR)":[34],"models":[35,87,107,116],"identification":[37],"putative":[39],"inhibitors":[40,76],"LRRK2":[42,75],"protein":[43],"are":[44,77,88,108,117],"developed":[45],"by":[46,79,90,110],"using":[47,91],"in-house":[49],"chemical":[50],"library":[51],"several":[53],"machine":[54],"learning":[55],"techniques.":[56],"The":[57,101],"methodology":[58],"applied":[59],"paper":[62],"has":[63],"two":[64],"steps:":[65],"first,":[66],"alternative":[67],"subsets":[68,93],"molecular":[70],"descriptors":[71],"useful":[72],"characterizing":[74],"chosen":[78],"a":[80],"multi-objective":[81],"feature":[82],"selection":[83],"method;":[84],"secondly,":[85],"QSAR":[86,106],"learned":[89],"these":[92,105],"three":[95],"different":[96],"strategies":[97],"supervised":[99],"learning.":[100],"qualities":[102],"all":[104],"compared":[109],"classical":[111],"metrics":[112],"best":[115],"discussed":[118],"statistical":[120],"physicochemical":[122],"terms.":[123]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}
